Positive effects of Nordic Walking on anthropometric and metabolic variables in women with type 2 diabetes mellitus

Currently, only two drugs for reducing uric acid (UA), allopurinol and febuxostat, are registered in the Russian Federation, but their use does not allow to achieve the target level of UA in all cases. According to the results of numerous randomized trials, hyperuricemia and gout are associated with the corresponding components of the metabolic syndrome, including diabetes mellitus. The influence of factors is due to the need to search for new drugs that have a complex effect on several components of metabolic syndrome at once. Potentially attractive in this regard is a new group of drugs for the treatment of type 2 diabetes mellitus inhibitors of the sodium-glucose cotransporter of type 2, which, in addition to the main hypoglycemic actions, showed positive effects on the cardiovascular system, kidneys, as well as lowering UA.

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The positive effects and underlying mechanisms of Undaria pinnatifida polysaccharides on type 2 diabetes mellitus in rats

Food & Function ◽

10.1039/d1fo01838h ◽

2021 ◽

Author(s):

Zhao-Rong Li ◽

Rui-Bo Jia ◽

Luo Donghui ◽

Lianzhu Lin ◽

Zheng Qianwen ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Rat Model ◽

Undaria Pinnatifida ◽

Current Work ◽

Loading Test ◽

Positive Effects ◽

Underlying Mechanisms

The aim of current work was to investigate the anti-diabetic effects and underlying mechanisms of Undaria pinnatifida polysaccharides (UPP) based on T2DM rat model. The starch loading test showed that...

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Type 2 diabetes mellitus, resistance training, and innate immunity: is there a common link?

Applied Physiology Nutrition and Metabolism ◽

10.1139/h07-094 ◽

2007 ◽

Vol 32 (6) ◽

pp. 1025-1035 ◽

Cited By ~ 10

Author(s):

Jennifer M. DiPenta ◽

Julia M. Green-Johnson ◽

René J.L. Murphy

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Older Adults ◽

Innate Immunity ◽

Type 2 Diabetes Mellitus ◽

Resistance Training ◽

Innate Immune ◽

Diabetic Patients ◽

Positive Effects

Type 2 diabetes mellitus is a serious chronic disease that is very prevalent in the developed world. The etiology of this disease is not well understood. Recently, the role of the innate immune system in the pathogenesis of type 2 diabetes and its complications has received a great deal of attention. Cytokines, acute phase proteins, and phagocytes have been implicated in this model. Resistance training has known benefits in type 2 diabetic patients and older adults, such as improved insulin action, insulin sensitivity, fasting blood glucose and insulin, and glucose tolerance levels. Actions of pro-inflammatory mediators linked to dysregulated innate immune activity have been associated with type 2 diabetes. The immunomodulatory effects of exercise, and in particular approaches such as resistance training, may provide a strategy to counter these pro-inflammatory effectors. However, the effects of resistance training on innate immunity have not been studied extensively in adults with type 2 diabetes or in older adults who are at increased risk for development of type 2 diabetes. This review discusses the possibility that resistance training may have positive effects on innate immunity in this population and so may provide benefits in addition to improving strength and functional abilities. In particular, the potential of resistance training to modulate pro-inflammatory parameters associated with type 2 diabetes, as a strategy that could provide multiple beneficial health outcomes, is addressed.

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A Comparative Study of High Sensitivity C-Reactive Protein and Metabolic Variables in Type 2 Diabetes Mellitus with and without Nephropathy

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2017/30272.10528 ◽

2017 ◽

Cited By ~ 2

Author(s):

Abid K Shaheer

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Comparative Study ◽

High Sensitivity ◽

C Reactive Protein ◽

Reactive Protein ◽

Metabolic Variables

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Association between Adiponectin and Insulin Resistance among Sudanese Males with Type 2 Diabetes Mellitus

10.21203/rs.3.rs-582913/v1 ◽

2021 ◽

Author(s):

Eman Ahamed Almakey ◽

Ahmed Mohamed Makeen ◽

Osman Khalafalla Saeed ◽

Khalid Abdelsamea Mohamedahmed

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Serum Adiponectin ◽

Control Group ◽

P Value ◽

Model Assessment ◽

Positive Effects

Abstract Background Adiponectin is associated with improved systemic insulin sensitivity and profound positive effects in adipose tissue, such as increasing mitochondrial density in adipocytes, reducing adipocyte size, and effective esterification of free fatty acids on lipid storage The factor performs forward transcriptional regulation. Diabetes and its complications are considered to be one of the main causes of morbidity and mortality worldwide. Objectives The aim of this study was to correlate serum levels of adiponectin with insulin resistance in Sudanese males' type 2 diabetes mellitus. Methodology: A case-control community-based study carried out among 126 patients with T2DM as cases group (mean ages 45.2 ± 5.4 years); and 126 normal healthy individuals as controls group (mean ages 44.7 ± 5.4 years as) in Aldaraga Diabetic Center, Wad Medani, Gezira State, Sudan. About Five mL of fasting venous blood was obtained from all participants. HbA1c, FPG, FPI, serum Adiponectin, and (HOMA)-IR were analyzed. SPSS (v 20.0) was used for data analysis. Results The mean of serum adiponectin in the cases group (3.03 ± 0.90µg/ml) was lower than the control group (6.02 ± 4.24µg/ml) giving highly significant differences -between them (P = value ≤ 0.000). HbA1c and Homeostasis Model Assessment of Insulin Resistance index (HOMA-IR) differed significantly between the two groups (P-value ≤ 0.000). Serum adiponectin concentrations correlated significantly negative with HOMA IR (r = -0.149, P-value = 0.002). Conclusion We concluded that low plasma adiponectin level was predictive of future development of Insulin resistance in Sudanese males.

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Vitamin B12 Deficit Status among Type 2 Diabetes Mellitus Patients - A Review

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/2021/370 ◽

2021 ◽

Vol 10 (23) ◽

pp. 1794-1798

Author(s):

Lata Kanyal Butola ◽

Roshan Kumar Jha ◽

Ranjit Ambad ◽

Deepika Kanyal ◽

Jayshri Jankar

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Vitamin B12 ◽

Plasma Concentrations ◽

Serum Vitamin ◽

Positive Effects ◽

Long Term Treatment

Several studies have confirmed the increased incidence of vitamin B12 deficiency in patients with type 2 diabetes mellitus. Metformin is currently the most commonly used anti-diabetic drug, metformin being prescribed as first-line therapy for patients with type 2 diabetes mellitus (T2DM) worldwide. Other disorders including insulin resistance, such as polycystic ovary syndrome (PCOS), can also be treated with metformin. Metformin has positive effects on metabolism, weight loss, and vascular defence of carbohydrates, but it also has significant side effects. Patients on long-term treatment with metformin, for example, have been shown to be at risk of anemia. This may be because of a decrease in metformin-related vitamin B12. It is estimated that 30 percent of patients undergoing long-term metformin treatment have experienced vitamin B12 malabsorption, with a 14 percent to 30 percent reduction in serum vitamin B12 concentration. A critical nutrient for wellbeing is vitamin B12. It plays a significant role in the functioning and the production of red blood cells in the brain and nervous system. In addition to anemia, a deficiency of vitamin B12 may increase the severity of peripheral neuropathy in T2DM patients. In addition, since vitamin B12 is involved in the most critical homocysteine (Hcy) metabolism pathway, a decrease in vitamin B12 will increase plasma concentrations of Hcy, which in patients with T2DM and PCOS is closely linked to cardiovascular disease. Evaluating serum vitamin B12 levels will also provide an early diagnosis of the status of the deficiency. This will offer an incentive for harm caused by routine screening and early detection to be reversed. KEY WORDS Vitamin B12, Metformin, Diabetes Mellitus, Glycated Hb

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Whole Alga, Algal Extracts, and Compounds as Ingredients of Functional Foods: Composition and Action Mechanism Relationships in the Prevention and Treatment of Type-2 Diabetes Mellitus

International Journal of Molecular Sciences ◽

10.3390/ijms22083816 ◽

2021 ◽

Vol 22 (8) ◽

pp. 3816

Author(s):

Aránzazu Bocanegra ◽

Adrián Macho-González ◽

Alba Garcimartín ◽

Juana Benedí ◽

Francisco José Sánchez-Muniz

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Systemic Disease ◽

Antioxidant Properties ◽

Bioactive Molecules ◽

Positive Effects ◽

Genetic Components ◽

Algal Extracts

Type-2 diabetes mellitus (T2DM) is a major systemic disease which involves impaired pancreatic function and currently affects half a billion people worldwide. Diet is considered the cornerstone to reduce incidence and prevalence of this disease. Algae contains fiber, polyphenols, ω-3 PUFAs, and bioactive molecules with potential antidiabetic activity. This review delves into the applications of algae and their components in T2DM, as well as to ascertain the mechanism involved (e.g., glucose absorption, lipids metabolism, antioxidant properties, etc.). PubMed, and Google Scholar databases were used. Papers in which whole alga, algal extracts, or their isolated compounds were studied in in vitro conditions, T2DM experimental models, and humans were selected and discussed. This review also focuses on meat matrices or protein concentrate-based products in which different types of alga were included, aimed to modulate carbohydrate digestion and absorption, blood glucose, gastrointestinal neurohormones secretion, glycosylation products, and insulin resistance. As microbiota dysbiosis in T2DM and metabolic alterations in different organs are related, the review also delves on the effects of several bioactive algal compounds on the colon/microbiota-liver-pancreas-brain axis. As the responses to therapeutic diets vary dramatically among individuals due to genetic components, it seems a priority to identify major gene polymorphisms affecting potential positive effects of algal compounds on T2DM treatment.

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