Oxidative stress, growth inhibition, and DNA damage in earthworms induced by the combined pollution of typical neonicotinoid insecticides and heavy metals

2021 ◽  
Vol 754 ◽  
pp. 141873
Author(s):  
Xiaojing Yan ◽  
Jinhua Wang ◽  
Lusheng Zhu ◽  
Jun Wang ◽  
Shuyan Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heavy Metals ◽  
Dna Damage ◽  
Growth Inhibition ◽  
Combined Pollution ◽  
Stress Growth ◽  
Neonicotinoid Insecticides

The impacts of heavy metals on oxidative stress and growth of spring barley

2012 ◽  
Vol 7 (2) ◽  
pp. 299-306 ◽  
Author(s):  
Romualdas Juknys ◽  
Giedrė Vitkauskaitė ◽  
Milda Račaitė ◽  
Jonė Venclovienė
Keyword(s):  
Oxidative Stress ◽  
Heavy Metals ◽  
Lipid Peroxidation ◽  
Growth Inhibition ◽  
Spring Barley ◽  
Hordeum Vulgare L ◽  
Exponential Relationship ◽  
Pronounced Increase ◽  
Lead And Cadmium ◽  
Wide Range

AbstractOxidative stress is accepted to play a significant role in stress symptoms, caused by different stressors in a variety of organisms. In this study seedlings of spring barley (Hordeum vulgare L.) were exposed to a wide range of copper, zinc, chromium, nickel, lead and cadmium concentrations in order to determine the relationships between heavy metals-induced oxidative stress and plant growth inhibition. All investigated heavy metals induced an essential increase in lipid peroxidation and a reduction of dry biomass along with an increase in metal concentration in the nutrient solution. A very close and statistically significant exponential relationship between lipid peroxidation and growth inhibition was detected in this study. According to the results of analysis of variance (ANOVA), the intensity of nonspecific oxidative stress is identified as the main factor of barley growth inhibition, explaining 75% of total variance. Almost 10% of growth inhibition is attributed to the specific impact of heavy metals. The most pronounced increase of malondialdehyde content and growth inhibition was observed in Cu and Cd treatments, whereas the lowest changes in observed indicators were detected after exposure to Zn and Pb.

scholarly journals Soft Coral-Derived Dihydrosinularin Exhibits Antiproliferative Effects Associated with Apoptosis and DNA Damage in Oral Cancer Cells

2021 ◽  
Vol 14 (10) ◽  
pp. 994
Author(s):  
Kun-Han Yang ◽  
Yu-Sheng Lin ◽  
Sheng-Chieh Wang ◽  
Min-Yu Lee ◽  
Jen-Yang Tang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Cell Growth ◽  
Oral Cancer ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Soft Coral ◽  
Oral Cancer Cells

Dihydrosinularin (DHS) is an analog of soft coral-derived sinularin; however, the anticancer effects and mechanisms of DHS have seldom been reported. This investigation examined the antiproliferation ability and mechanisms of DHS on oral cancer cells. In a cell viability assay, DHS showed growth inhibition against several types of oral cancer cell lines (Ca9-22, SCC-9, OECM-1, CAL 27, OC-2, and HSC-3) with no cytotoxic side effects on non-malignant oral cells (HGF-1). Ca9-22 and SCC-9 cell lines showing high susceptibility to DHS were selected to explore the antiproliferation mechanisms of DHS. DHS also causes apoptosis as detected by annexin V, pancaspase, and caspase 3 activation. DHS induces oxidative stress, leading to the generation of reactive oxygen species (ROS)/mitochondrial superoxide (MitoSOX) and mitochondrial membrane potential (MitoMP) depletion. DHS also induced DNA damage by probing γH2AX phosphorylation. Pretreatment with the ROS scavenger N-acetylcysteine (NAC) can partly counter these DHS-induced changes. We report that the marine natural product DHS can inhibit the cell growth of oral cancer cells. Exploring the mechanisms of this cancer cell growth inhibition, we demonstrate the prominent role DHS plays in oxidative stress.

Mechanistic insight for DBP induced growth inhibition in Vigna radiata via oxidative stress and DNA damage

Chemosphere ◽  
2021 ◽  
Vol 263 ◽  
pp. 128062
Author(s):  
Jyoti Ranjan ◽  
Tamal Mandal ◽  
Dalia Dasgupta Mandal
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Growth Inhibition ◽  
Vigna Radiata ◽  
Mechanistic Insight

Comparative Study of Cytotoxicity, DNA Damage and Oxidative Stress Induced by Heavy Metals Cd(II), Hg(II) and Cr(III) in Yeast

2021 ◽  
Author(s):  
Jingwen Wang ◽  
Zhijia Fang ◽  
Jian Gao ◽  
Lijun Sun ◽  
Yaling Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heavy Metals ◽  
Dna Damage ◽  
Comparative Study ◽  
And Oxidative Stress

scholarly journals Analysis of Saccharomyces cerevisiae null allele strains identifies a larger role for DNA damage versus oxidative stress pathways in growth inhibition by selenium

2008 ◽  
Vol 52 (11) ◽  
pp. 1305-1315 ◽  
Author(s):  
Eden Seitomer ◽  
Bharvi Balar ◽  
Dongming He ◽  
Paul R. Copeland ◽  
Terri Goss Kinzy
Keyword(s):  
Oxidative Stress ◽  
Saccharomyces Cerevisiae ◽  
Dna Damage ◽  
Growth Inhibition ◽  
Null Allele

Monitoring Oxidative Stress and DNA Damage Induced by Heavy Metals in Yeast Expressing a Redox-Sensitive Green Fluorescent Protein

2009 ◽  
Vol 58 (5) ◽  
pp. 504-510 ◽  
Author(s):  
Shanshan Yu ◽  
Wei Qin ◽  
Guoqiang Zhuang ◽  
Xianen Zhang ◽  
Guanjun Chen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heavy Metals ◽  
Dna Damage ◽  
Green Fluorescent Protein ◽  
Fluorescent Protein ◽  
Green Fluorescent
Sign in / Sign up

Export Citation Format

Share Document