Application of BiOClnBrm photocatalyst to cytostatic drugs removal from water; mechanism and toxicity assessment

Investigation to evaluate the toxicity of carbofuran pesticides on haematological parameters of third instar larvae of Oryctes rhinoceros L. Indicated alterations in total haemocyte count and differential haemocyte count for toxicity assessment. Various doses of carbofuran (0.05g, 0.010g and 0.015 g) applied on insect through oral route and its impact after 24 hours of its application revealed that various doses of carbofuran exert specific alterations in both total and differential haemocytes of insect haemolymph.

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Nanotechnologies. Aquatic toxicity assessment of manufactured nanomaterials in saltwater lakes using Artemia sp. Nauplii

10.3403/30333652u ◽

2018 ◽

Keyword(s):

Aquatic Toxicity ◽

Toxicity Assessment ◽

Manufactured Nanomaterials

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Protective influence of coded amino acids on the development of liver tissue culture in the presence of cytostatic

Токсикологический вестник ◽

10.36946/0869-7922-2020-2-47-52 ◽

2020 ◽

pp. 48-53

Author(s):

N. I. Chalisova ◽

V. K. Kozlov ◽

A. B. Mulik ◽

E. P. Zatsepin ◽

T. A. Kostrova

Keyword(s):

Amino Acids ◽

Tissue Culture ◽

Side Effects ◽

Liver Tissue ◽

Organotypic Culture ◽

Growth Zone ◽

Inhibitory Effect ◽

Cytostatic Drugs ◽

Urgent Problem ◽

Combined Exposure

An urgent problem is the search for substances that can provide a protective effect in cases of DNA synthesis and repair disorders that arise as a result of side effects of cytostatic drugs used in the treatment of cancer. The aim of this work was to study the effect of 20 encoded amino acids in the presence of Cyclophosphane on the development of organotypic culture of rat liver tissue. The results obtained indicate that Cyclophosphane; which simulates the action of such cytostatic substances; inhibits cell proliferation in the liver tissue. It was also found that the encoded amino acids: asparagine; arginine; and glutamic acid; eliminate the inhibitory effect of Cyclophosphane in liver tissue culture. The growth zone of explants after combined exposure to Cyclophosphane (whose isolated action suppressed the growth zone) and these amino acids increased significantly and reached control values. Thus; the experimental data create the basis for the development of methods for the therapeutic use of the three studied amino acids for the removal of side effects in the treatment with cytostatic drugs.

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ABATEMENT OF ANTICANCER DRUGS VIA ELECTROCHEMICAL OXIDATION PROCESS: A REVIEW

10.37516/global.j.sci.eng.2020.010 ◽

2020 ◽

pp. 1-4

Author(s):

CHARULATA SIVODIA ◽

ALOK SINHA

Keyword(s):

Anticancer Drugs ◽

Cell Function ◽

Electrochemical Techniques ◽

Aquatic Organisms ◽

Pharmaceutical Drugs ◽

Cytostatic Drugs ◽

Cancerous Cell ◽

Pharmaceutical Removal ◽

Mutagenic Effects ◽

Made In

The advancement made in biomedical industry upsurges the consumption rate of pharmaceutical drugs. The lack of proper monitoring and regulation methods leads to the unregulated discharge of pharmaceuticals in wastewater, where it can affect the aquatic organisms. Anticancer drugs are also known as cytostatic drugs mainly used for the treatment of cancer by disrupting the cell function and prevent multiplication of cancerous cell. Therefore, anticancer drugs are suspected to pose potential risk on environment by influencing mutagenic effects on the cells of aquatic organisms. An extensive research has been already made in the field of pharmaceutical removal, however their application on the removal of anticancer drugs is limited. This review paper elucidates about different electrochemical techniques for the mitigation of cytostatic drugs.

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