scholarly journals Adverse effects of Atrazine on Blood parameters, Biochemical Profile and Genotoxicity of snow trout (Schizothorax plagiostomus)

2021 ◽  
Author(s):  
Naveed Akhtar ◽  
Muhammad Fiaz Khan ◽  
Sadia Tabassum ◽  
Eman Zahran
Keyword(s):  
Adverse Effects ◽  
Blood Parameters ◽  
Biochemical Profile ◽  
Snow Trout ◽  
Schizothorax Plagiostomus

Repetitive Propofol Administration in Dogs and Cats

2004 ◽  
Vol 40 (4) ◽  
pp. 255-260 ◽  
Author(s):  
Nora S. Matthews ◽  
Raquel M. Brown ◽  
Kerry S. Barling ◽  
Sandra L. Lovering ◽  
Brent W. Herrig
Keyword(s):  
Blood Pressure ◽  
Adverse Effects ◽  
Blood Count ◽  
Complete Blood Count ◽  
Biochemical Profile ◽  
Heinz Bodies ◽  
Pressure Time ◽  
Clinically Significant

A bolus of propofol was administered to 10 dogs (6 mg/kg intravenously [IV]) and 10 cats (10 mg/kg IV) on three consecutive days. The occurrence of apnea, heart and respiratory rates, blood pressure, time to movement, and changes in a complete blood count and biochemical profile were recorded. Apnea was not seen in the dogs but was seen in three cats. Slight increases in the number of Heinz bodies were seen in six cats, but the increases were not considered clinically significant. No apparent cumulative adverse effects were seen from a bolus of bisulfite-containing propofol, administered on three consecutive days.

scholarly journals Clinical biochemistry profile of American Quarter Horse broodmares fed Tifton-85 (Cynodon spp.) hay and haylage

2019 ◽  
Vol 39 (5) ◽  
pp. 317-323
Author(s):  
Taciano C. Guimarães ◽  
Adalgiza S.C. Rezende ◽  
Maria L.L. Costa ◽  
Marina G. Ferreira ◽  
Ana. L.S. Miranda ◽  
...  
Keyword(s):  
Dry Matter ◽  
Protein Digestibility ◽  
Serum Biochemistry ◽  
Blood Parameters ◽  
Normal Serum ◽  
Biochemical Profile ◽  
Lack Of Information ◽  
Increased Risk ◽  
Quarter Horse ◽  
Glutamyl Transferase

ABSTRACT: The conservation of haylage (a pre-dried feed) can be challenging, since there is an increased risk of mould growth, which can contaminate this foodstuff with mycotoxins. However, when the hygienic quality is secured, haylage enhances grass palatability and provide enough supply of dry matter throughout the year. Due to the lack of information regarding its effect on blood parameters in horses fed exclusively with this foodstuff, the aim of this study is to provide information regarding its use in comparison to hay and ensure that it does not affect horses’ biochemical profile. Twelve Quarter Horse broodmares were distributed into two groups, each fed with Tifton-85 (Cynodon spp.) hay or haylage for a period of 28 days, and the biochemical profile was done in five different times (T0 before the experiment started and, chronologically, seven days apart - T1, T2, T3 and T4), It was analyzed total protein (TP) and its fractioning; enzymes alanine aminotransferase, aspartate aminotransferase and γ-glutamyl-transferase; endogenous catabolism products urea and creatinine; and ions calcium and phosphorus. Mycotoxins in haylage were also investigated and remained below the legislation thresholds. Only TP was higher in the last sampling (T4) of the haylage group, which may be related to the foodstuff’s higher protein digestibility. No differences were observed between serum enzymes, urea, creatinine and Ca/P from both experimental groups. Haylage has proven to be safe, when well prepared for horses, without causing impairing side effects, as shown by the normal serum biochemistry parameters presented in this study.

scholarly journals Ferric citrate is a safe and digestible source of iron in broilers and piglets

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e12636
Author(s):  
Klaus Männer ◽  
Hannah Lester ◽  
Eliana Henriquez-Rodriguez
Keyword(s):  
Adverse Effects ◽  
Dose Group ◽  
Block Design ◽  
Blood Parameters ◽  
Negative Control ◽  
Ferric Citrate ◽  
Daily Weight Gain ◽  
Control Group ◽  
Weaned Piglets ◽  
Inclusion Rate

Background Iron (Fe) is traditionally supplemented in poultry and swine diets using inorganic forms (e.g. sulfates, oxides). However, research suggests that organic sources are more beneficial due to greater bioavailability. In this paper, we present results from four studies aimed at assessing ferric citrate (CI-FER™, Akeso Biomedical Inc., Burlington, MA, USA) as a safe and effective source of Fe for broilers and piglets. Methods A total of four studies were performed in Germany following standard farming practices for each species. One study in day-old broiler chicks and one study in weaned piglets were designed as target animal safety studies where animals were randomly allocated to one of three treatment groups: a negative control group, the proposed dose group and a multifold dose group. Broilers and pigs were fed the experimental diets for 35 and 42 days, respectively. In each study, average daily feed intake, average daily weight gain and feed conversion ratio were measured, and blood samples were taken at study end for routine biochemistry and haematology. The other two studies were designed to evaluate different sources of dietary Fe for weaned piglets bred and managed under standard farm conditions. All piglets received routine Fe injections (200 mg Fe dextran, intramuscular) on day 3 of age, as well as the experimental diets for 42 days. In both studies, performance parameters were measured. In one study, Fe digestibility and serum Fe, superoxide dismutase and haptoglobin were also measured. In all studies, the general health status of the animals was monitored daily and all culls and mortality recorded. Each study followed a complete randomised block design. Results In broilers, ferric citrate was well tolerated up to 2,000 mg/kg feed (×10 the recommended inclusion rate) and no adverse effects on growth, blood parameters or mortality were observed. In piglets, ferric citrate was well tolerated up to 5,000 mg/kg feed (×10 the recommended inclusion rate) with no adverse effects on growth, blood parameters or mortality. In addition, piglets fed ferric citrate performed significantly better than animals fed the negative control diet (containing only endogenous Fe) and those fed inorganic forms of Fe. Moreover, piglets fed ferric citrate demonstrated improved Fe digestibility and improved oxidative status. Altogether, these findings show that ferric citrate is a safe and easily digestible source of dietary Fe for broilers and piglets.

Effect of UV-curable and injectable dendrimer matrix on tumor pharmacokinetics and survival in a hepatocellular carcinoma mouse model using interstitial photodynamic therapy.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e15598-e15598
Author(s):  
Sauli Vuoti ◽  
Kumar Narasimha ◽  
Kai Reinikainen
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Adverse Effects ◽  
Systemic Therapy ◽  
Blood Parameters ◽  
Drug Accumulation ◽  
Uv Curable ◽  
Interstitial Photodynamic Therapy ◽  
The Matrix

e15598 Background: Intratumoral drug delivery in cancer treatment has shown to increase drug accumulation in tumors and decrease adverse effects of systemic therapies. The active agent is typically required to stay in contact with the tumor and thus attachment directly into the tumor or to the surrounding tissue is warranted. In addition, a long-acting release of the active drug is vital. Dendrimers are nano-sized, radially symmetric molecules with homogeneous and monodisperse structures, which can used to encapsulate drug molecules for controlled release with the aid of external stimuli at physiological pH. Methods: We prepared a dendrimeric drug delivery matrix based on a PEG-core. The model drug (5-fluorouracil or doxorubicin) was covalently bonded to the core. The release of the drug was observed up to 29 days in vitro. The outer shell of the matrix was partially modified to obtain a fast UV-curing and subsequent attachment to the tumor tissue utilizing interstitial photodynamic therapy. We compared the pharmacokinetics, tissue distribution and antitumor efficacy of conventional systemic therapy and the intratumoral therapy in xenograft-bearing mice. In addition, we monitored blood parameters and body weight of the animals for adverse effects. Results: The dendrimer matrix caused significantly greater inhibition of human hepatocellular carcinoma xenograft tumor growth when compared with systemic therapy, without increasing toxicity. The matrix enabled a significant increase in drug accumulation in tumors, and markedly extended the survival of mice compared with systemic treatments. A larger decrease in blood parameters as well as spleen weight was observed in the systemic therapy group especially when using 5-fluorouracil. Conclusions: Our study shows that the intratumoral treatment strategy based on a novel UV-curable dendrimer hydrogel matrix enhances antitumor activity by improving pharmacokinetics and drug accumulation and increases efficacy in comparison to conventional systemic therapy. These results highlight the potential use of dendrimer hydrogels in the treatment of hepatocellular carcinoma.

Electroencephalographic and blood parameters changes in anaesthetised goats subjected to slaughter without stunning and slaughter following different electrical stunning methods

2019 ◽  
Vol 59 (5) ◽  
pp. 849
Author(s):  
A. B. Sabow ◽  
Y. M. Goh ◽  
I. Zulkifli ◽  
M. Z. Ab Kadir ◽  
U. Kaka ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Adverse Effects ◽  
Meat Quality ◽  
Tissue Damage ◽  
High Frequency ◽  
Sensory Input ◽  
Low Frequency ◽  
Blood Parameters ◽  
Brain Electrical Activity ◽  
High Frequencies

Electrical stunning is the most widely used stunning method for sheep and goats. Because low frequency head-to-back electrical stunning induces cardiac arrest, it is non-compliant with halal requirements. In addition, conventional head-only electrical stunning method can have adverse effects on carcass and meat quality. To address these issues high-frequency electrical stunning systems were developed. High frequency head-to-back removes the potential for pain and distress compared with non-stunned slaughter and does not induce cardiac arrest like low frequency head-to-back stunning making it appropriate for halal. However, this claim is yet to be proven through a comprehensive neurophysiological study. Thus, the present study examined the effects of different pre-slaughter electrical stunning methods and slaughter without stunning on electroencephalographic and blood biochemistry changes. Thirty-two male Boer crossbred bucks were distributed into four groups of eight animals each and subjected to slaughter without stunning (SWS), low frequency head-only (LFHO) and low frequency head-to-back (LFHB) or high frequency head-to-back electrical stunning (HFHB). Slaughtering of animals with or without stunning was performed under minimal anaesthesia. Based on electroencephalograph results, at slaughter, the SWS animals showed an increase in brain electrical activity, which is consistent with the presence of post slaughter noxious sensory input associated with tissue damage. Meanwhile the electroencephalograph activities decreased immediately after application of electrical stunning in all animals, suggesting that they were insensible to pain during and after the neck cut. Electrical brain activities for goats subjected to HFHB were comparable to those for LFHO and those for LFHB. The percentage of animals that exhibited severe clonic activity was significantly lower after LFHB or HFHB stunning compared with LFHO. The concentrations of catecholamines and hyperglycemia in electrically stunned goats were higher compared with those from SWS. It was observed that LFHB caused cardiac arrest in all goats whereas all HFHB goats had no cardiac arrest. High frequency head-to-back electrical stunning may be an improvement on non-stunned slaughter and has advantages for meat quality. However, stunning effectiveness after head-to-back electrical stunning with high frequencies needs to be evaluated under industrial conditions before any recommendation is given.

scholarly journals Ontogenic Development Of Gills In Pre To Post-Flexion Stages Larvae Of Himalayan Snow Trout Schizothorax Plagiostomus (Heckel)

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Rajesh Rayal
Keyword(s):  
Incubation Temperature ◽  
General Pattern ◽  
Gill Arch ◽  
Gill Rakers ◽  
Pillar Cells ◽  
Secondary Lamellae ◽  
Snow Trout ◽  
Ontogenic Development ◽  
Gill Filaments ◽  
Schizothorax Plagiostomus

The ontogenic development of gills, including gill arch, gill filaments, and gill rakers in pre to postflexion stages larvae of Himalayan Snow Trout Schizothorax plagiostomus were studied with the objectives that this study could serve as a base for further studies about the early embryonic development and organogenesis in various fish species inhabiting hill stream environments. To obtain the pre to post-flexion stages larvae, an artificial breeding experiment was conducted during September- October on the bank of snow-fed river Alaknanda by stripping method. Further, the development of the gill apparatus was studied histologically, using light microscopy. Hatchling takes place 124-130 hours after fertilization at the incubation temperature of 19-200C. On second dph (day post-hatching), gill arches, gill filaments, and branchiostegal membrane began to differentiate. By the third dph, blood channels were observed in gill filaments as well as in pseudobranch. Formation of secondary lamellae, branchial arteries, elongation of the gill cover, cartilaginous rod formation in the gill arch, and the branchiostegal membrane was discernible by fourth-fifth dph. Pillar cells and afferent and efferent arteries with RBCs in primary and secondary lamellae were observed on the seventh dph. Around the onset of exclusive exogenous feeding (twelfth dph), gill rakers and a group of pillar cells with blood channels were recognizable. Well-organized and functional gill structures with increased number and size of secondary gill lamellae were present among the fifteenth-seventeenth dph larvae. The general pattern of structural and functional development of both the natural site and laboratory-reared larvae was similar, except a large amount of mucous and clustered epithelial cells among the laboratory-reared larvae, which may be due to the physiological as well as environmental stress posed by the adverse physicochemical conditions.

scholarly journals Assessment of ecto and endo parasites of Schizothorax plagiostomus inhabiting river Panjkora, Khyber Pakhtunkhwa, Pakistan

2020 ◽  
Author(s):  
A. Ahmad ◽  
W. Khan ◽  
S. N. Das ◽  
W. A. Pahanwar ◽  
S. Khalid ◽  
...  
Keyword(s):  
Natural Infection ◽  
Winter Season ◽  
Poor Quality ◽  
Summer Season ◽  
Fish Parasites ◽  
Helminth Parasites ◽  
High Quality Protein ◽  
Fish Samples ◽  
Snow Trout ◽  
Schizothorax Plagiostomus

Abstract Fish provides main source of high quality protein to more than one billion people in the world. Fish parasites directly affect the productivity of fish and indirectly on human health. This research was aimed to assess the helminth parasites in Schizothorax plagiostomus (the snow trout) from river Panjkora, KP, Pakistan. A total of 88 fish samples (n= 88) were collected from the upper, middle and lower regions of the river through cast nets, hand nets and hooks. All the collected fish samples were examined in the Parasitology Laboratory, Department of Zoology, University of Malakand for helminth parasites during July 2018 to February 2019.Among these fishes nematodes, trematodes, cestodes and acanthocephalan were isolated and identified. Overall prevalence of the fish parasites was 60.22% (53/88). The intensity of the parasite was observed from 1.7% to 4.61%. Highest prevalence was reported in summer season 86.36% while lowest in the winter season 36.36%. This study shows that summer season affects the fish business and result in poor quality fish meat with risk of zoonotic diseases. Adults were highly infected 82.25% while no infection was found in juvenile specimens. Female fish samples had higher prevalence 68.22% than males 48.22%. Fishes of the lower reaches had highest prevalence 60.22% than the upper reaches 40.0%. Fish samples with maximum length and weight were highly 76.92% infected than small sized fish with low body weight. Present study addresses that Rhabdochona schizothoracis in the intestine and Diplozoon paradoxum in gills of snow trout fish has a long term relationship and call as a natural infection in cyprinids and it is zoonotic threat to human.

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