scholarly journals Using the life course perspective to study the entry into the illness trajectory: The perspective of caregivers of people with Alzheimer's disease

2010 ◽  
Vol 70 (10) ◽  
pp. 1501-1508 ◽  
Author(s):  
Normand Carpentier ◽  
Paul Bernard ◽  
Amanda Grenier ◽  
Nancy Guberman
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Life Course ◽  
Life Course Perspective ◽  
Illness Trajectory ◽  
The Life Course

scholarly journals Design and overview of the Origins of Alzheimer’s Disease Across the Life course (ORACLE) study

2020 ◽  
Author(s):  
Sander Lamballais ◽  
Maria C. Adank ◽  
Rowina F. Hussainali ◽  
Sarah Schalekamp-Timmermans ◽  
Meike W. Vernooij ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Data Collection ◽  
Life Course ◽  
Population Based ◽  
Adult Brain ◽  
Elderly Persons ◽  
Fetal Life ◽  
Brain Health ◽  
The Life Course

AbstractBrain development and deterioration across the lifespan are integral to the etiology of late-life neurodegenerative disease. Factors that influence the health of the adult brain remain to be elucidated and include risk factors, protective factors, and factors related to cognitive and brain reserve. To address this knowledge gap we designed a life-course study on brain health, which received funding through the EU ERC Programme under the name Origins of Alzheimer’s Disease Across the Life course (ORACLE) Study. The ORACLE Study is embedded within Generation R, a prospective population-based cohort study of children and their parents, and links this with the Rotterdam Study, a population-based study in middle-aged and elderly persons. The studies are based in Rotterdam, the Netherlands. Generation R focuses on child health from fetal life until adolescence with repeated in-person examinations, but has also included data collection on the children’s parents. The ORACLE Study aims to extend the parental data collection in nearly 2000 parents with extensive measures on brain health, including neuroimaging, cognitive testing and motor testing. Additionally, questionnaires on migraine, depressive symptoms, sleep, and neurological family history were completed. These data allow for the investigation of longitudinal influences on adult brain health as well as intergenerational designs involving children and parents. As a secondary focus, the sampling is enriched by mothers (n = 356) that suffered from hypertensive disorders during pregnancy in order to study brain health in this high-risk population. This article provides an overview of the rationale and the design of the ORACLE Study.

scholarly journals Joint Family and Work Trajectories and Multidimensional Wellbeing

2021 ◽  
Author(s):  
C. L. Comolli ◽  
L. Bernardi ◽  
M. Voorpostel
Keyword(s):  
Life Course ◽  
Subjective Wellbeing ◽  
Work And Family ◽  
Life Course Perspective ◽  
Full Time ◽  
Social Origin ◽  
Employment Trajectories ◽  
Family And Work ◽  
The Life Course ◽  
Family Trajectories

AbstractInformed by the life course perspective, this paper investigates whether and how employment and family trajectories are jointly associated with subjective, relational and financial wellbeing later in life. We draw on data from the Swiss Household Panel which combines biographical retrospective information on work, partnership and childbearing trajectories with 19 annual waves containing a number of wellbeing indicators as well as detailed socio-demographic and social origin information. We use sequence analysis to identify the main family and work trajectories for men and women aged 20–50 years old. We use OLS regression models to assess the association between those trajectories and their interdependency with wellbeing. Results reveal a joint association between work and family trajectories and wellbeing at older age, even net of social origin and pre-trajectory resources. For women, but not for men, the association is also not fully explained by proximate (current family and work status) determinants of wellbeing. Women’s stable full-time employment combined with traditional family trajectories yields a subjective wellbeing premium, whereas childlessness and absence of a stable partnership over the life course is associated with lower levels of financial and subjective wellbeing after 50 especially in combination with a trajectory of weak labour market involvement. Relational wellbeing is not associated with employment trajectories, and only weakly linked to family trajectories among men.

Life Course Adiposity and Alzheimer’s Disease: A Mendelian Randomization Study

2021 ◽  
pp. 1-10
Author(s):  
Xian Li ◽  
Yan Tian ◽  
Yu-Xiang Yang ◽  
Ya-Hui Ma ◽  
Xue-Ning Shen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Life Course ◽  
Mendelian Randomization ◽  
Association Studies ◽  
Meta Analysis ◽  
Genome Wide Association Studies ◽  
Fat Percentage ◽  
Regression Methods ◽  
Weighted Median

Background: Several studies showed that life course adiposity was associated with Alzheimer’s disease (AD). However, the underlying causality remains unclear. Objective: We aimed to examine the causal relationship between life course adiposity and AD using Mendelian randomization (MR) analysis. Methods: Instrumental variants were obtained from large genome-wide association studies (GWAS) for life course adiposity, including birth weight (BW), childhood body mass index (BMI), adult BMI, waist circumference (WC), waist-to-hip ratio (WHR), and body fat percentage (BFP). A meta-analysis of GWAS for AD including 71,880 cases and 383,378 controls was used in this study. MR analyses were performed using inverse variance weighted (IVW), weighted median, and MR-Egger regression methods. We calculated odds ratios (ORs) per genetically predicted standard deviation (1-SD) unit increase in each trait for AD. Results: Genetically predicted 1-SD increase in adult BMI was significantly associated with higher risk of AD (IVW: OR = 1.03, 95% confidence interval [CI] = 1.01–1.05, p = 2.7×10–3) after Bonferroni correction. The weighted median method indicated a significant association between BW and AD (OR = 0.94, 95% CI = 0.90–0.98, p = 1.8×10–3). We also found suggestive associations of AD with WC (IVW: OR = 1.03, 95% CI = 1.00–1.07, p = 0.048) and WHR (weighted median: OR = 1.04, 95% CI = 1.00–1.07, p = 0.029). No association was detected of AD with childhood BMI and BFP. Conclusion: Our study demonstrated that lower BW and higher adult BMI had causal effects on increased AD risk.

scholarly journals Persistent short-term imprisonment: Belonging as a lens to understand its shifting meanings over the life course

Incarceration ◽  
2021 ◽  
Vol 2 (1) ◽  
pp. 263266632198901
Author(s):  
Marguerite Schinkel ◽  
Keyword(s):  
Life Course ◽  
Sense Of Belonging ◽  
Life Course Perspective ◽  
Criminal Punishment ◽  
Short Term ◽  
Men And Women ◽  
The Life Course ◽  
Looking Back

This article takes a life-course perspective to the meaning of persistent short-term imprisonment and introduces the significance of ‘penal careers’. Examining a total of 62 interviews with men and women in Scotland with long careers of (progression through) criminal punishment, it uses to the concept of belonging as a lens to interpret their experiences. While some participants already felt early on in their career that they belonged in prison because of their shared characteristics with other prisoners, the repetition of imprisonment meant that they increasingly felt displaced from life outside and saw life in prison as ‘easier’ and ‘safer’. Nevertheless, looking back on their many sentences, they felt their cumulative meaning was ‘a waste of life’. The article concludes by considering steps towards tackling the conditions that create this sense of belonging in a place of punishment.

Foster Care in a Life Course Perspective

2020 ◽  
Vol 692 (1) ◽  
pp. 227-252
Author(s):  
Fred Wulczyn
Keyword(s):  
Foster Care ◽  
Life Course ◽  
Social Services ◽  
Foster Children ◽  
Foster Parents ◽  
Local Variation ◽  
Life Course Perspective ◽  
State And Local ◽  
Policy Priority ◽  
The Life Course

To understand what placement outside of one’s home means to the young people involved, we must understand foster care from a life course perspective. I analyze young people’s experiences in foster care from this perspective, accounting for when foster care happens, how long it lasts, and what happens when foster care placements end. I show that the population of children coming into foster care is younger and less urban than it was 20 years ago. I also show reliable measures of exposure to foster care over the life course. Children who enter care early in life are the children who spend the largest proportion of their childhood in foster care—a fact that rarely weighs on the policymaking process. We know very little about state and local variation in foster care placement rates, not to mention the influence of social services, the courts, foster parents, and caseworkers over foster children, so I close by arguing investment in research should be a clear policy priority.

scholarly journals SUITABLE? THE RHETORICAL AND LIFE COURSE IMPLICATIONS OF SERENA WILLIAMS AND THE CATSUIT

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S537-S537
Author(s):  
Brianne M Stanback
Keyword(s):  
New York ◽  
Los Angeles ◽  
Life Course ◽  
New York Times ◽  
Life Course Perspective ◽  
Power Structures ◽  
Los Angeles Times ◽  
Race And Class ◽  
Sports Illustrated ◽  
The Life Course

Abstract Rhetorical inquires have shown connections between representation and power, workplace fashion and development of ethos, and the rhetoric of glamour through women’s fashion and dress. One element absent from that conversation is how the life course, which typically differs for women because of existing power structures advantaging men, may impact the experience of women as they age, their choice of dress, and the rhetorical implications of those decisions. To explore dress and rhetoric from a life course perspective, this project traces the evolution of Serena Williams’ work apparel across her professional tennis career to the catsuit worn at the 2018 French Open, which is the focus of the project. Press reports on the 2018 catsuit by Nike, New York Times, Sports Illustrated, Business Insider, BBC Sport, Washington Post, and Los Angeles Times, interviews given by Williams, and the television documentary, Becoming Serena, will be analyzed for their treatment of Williams’ work attire and the life course. Responses to the catsuit emphasize attitudes about gender, race, and class, either discounting or ignoring the life course implications such as motherhood and changes in health status. Despite professional success, responses about the catsuit may reflect that Williams faces the same jeopardies, and invisibility, common to many women as they age, and the rhetorical perspective provides new methodological and pedagogical possibilities for instruction in aging.

scholarly journals Development of Violence Across the Lifespan: A Preliminary Model

2021 ◽  
Author(s):  
◽  
Janneke Van't Klooster
Keyword(s):  
Life Course ◽  
Life Course Perspective ◽  
Development Model ◽  
Rehabilitation Unit ◽  
Preliminary Model ◽  
Holistic Understanding ◽  
Pathways Model ◽  
The Life Course ◽  
Adult Rehabilitation ◽  
Age Range

<p>Violence has serious implications for both the victim and the wider community. The current adult rehabilitation programmes accept violent offenders ranged from 20 years and older. This age range could have serious rehabilitation consequences, as a twenty year olds violence and violence related goals may differ substantially to a 70 year old. For this reason an understanding of the development of violence and violence related goals can aide rehabilitation and punitive policies. A review of recent research highlights there are many methodological and empirical gaps in the development of violence whereby the current research aimed to assuage this issue. The current research used grounded theory to develop a model on the development of violence over the life-course. For this research twelve men currently incarcerated at Rimutaka Prison in a violence rehabilitation unit were interviewed. This method developed two models. The “Influences on violence development” model outlines how environment and personal choices had an impact on the development of violence. The “development of violence” model outlines the increasing severity and frequency of violence over time, and the increasing complexity of violence related goals. This model is nested within the influences on violence development model. Comparing the current models to Loeber et al's (1993) pathways model, and Sampson and Laub's life-course perspective on offending, has found support for both models. Thus this model's theoretical value lies within its ability to draw together other areas of research and provide a holistic understanding of both how and why violence develops. One implication of these models is the understanding of the varying influences of environment on violence, upon both different individuals and different ages. This implies that rehabilitation should perhaps follow a more individual based focus. There are many limitations to the research, the most salient one being lack of saturation in the model and low sample size.</p>

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