Superior effect of broccoli methanolic extract on control of oxidative damage of sperm cryopreservation and reproductive performance in rats: A comparison with vitamin C and E antioxidant

Vitamin C is one of the nutrients that act as antioxidants and effectively overcome free radicals that can damage cells or tissues, including protecting the lens from oxidative damage caused by radiation. Vitamin C is widely found in fruits, and vegetables, one of them in chili. Vitamin C in chili has a function as a good antioxidant for the body (able to increase the immune system absorbed by calcium in the body. This study aims to determine the levels of vitamin C contained in some types of chili using UV-Vis spectrophotometry method and conduct a preliminary test. The highest levels of vitamin C obtained by using spectrophotometric method at 200 nm wavelength were on red curly pepper (50 g/100 g) and followed by chili jablay orange-red (38 g/100 g), green cayenne (29 g/100 g), red pepper large (22 g/100 g), and large green chili (9 g/100 g). While based on preliminary test it was found that all chilies contain saponins, as well as only large red pepper (sample 1) and red curly pepper (sample 4) containing flavonoids Keywords: capsicum, chilly, spectrophotometry

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Variegate porphyria induces plasma and neutrophil oxidative stress: effects of dietary supplementation with vitamins E and C

British Journal Of Nutrition ◽

10.1017/s0007114509991413 ◽

2009 ◽

Vol 103 (1) ◽

pp. 69-76 ◽

Cited By ~ 8

Author(s):

Miguel D. Ferrer ◽

Pedro Tauler ◽

Antoni Sureda ◽

Clara Palacín ◽

Josep A. Tur ◽

...

Keyword(s):

Vitamin E ◽

Vitamin C ◽

Oxidative Damage ◽

Antioxidant Activities ◽

Dietary Supplementation ◽

Antioxidant Defenses ◽

Ros Production ◽

Double Blind ◽

Variegate Porphyria ◽

Vitamins E And C

Our aim was to analyse the influence of variegate porphyria (VP) on the antioxidant defenses and markers of oxidative damage and inflammation in plasma and neutrophils and the effects of dietary supplementation with vitamins E and C on these parameters in plasma, neutrophils and erythrocytes. Twelve women affected by VP and twelve pair-matched healthy control women participated in a double-blind crossover study. Each participant took 50 mg/d of vitamin E and 150 mg/d of vitamin C, or a placebo, for 6 months, by consuming an almond-based beverage as the vehicle. Women affected by VP presented higher C-reactive protein and malondialdehyde (MDA) circulating levels. Plasma antioxidant defenses were not different between porphyric and control women. Neutrophils from VP women presented decreased catalase (CAT) and glutathione reductase (GR) activities together with increased protein carbonyl levels. Reactive oxygen species (ROS) production from stimulated neutrophils was also higher in porphyric women than their controls. Dietary supplementation was effective in increasing α-tocopherol levels in neutrophils and in reducing MDA levels in plasma. Erythrocyte CAT and GR activities were enhanced by the enriched beverage only in the control subjects. In conclusion, women affected by VP present a situation of inflammation, plasma oxidative damage and neutrophils more primed to the oxidative burst, with decreased antioxidant activities and increased ROS production capabilities and protein oxidative damage. Dietary supplementation with vitamin E (50 mg/d) and vitamin C (150 mg/d) for 6 months decreased plasma oxidative damage and enhanced the erythrocyte activities of CAT and GR.

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In vivo changes in antioxidant systems and protective role of melatonin and a combination of vitamin C and vitamin E on oxidative damage in erythrocytes induced by chlorpyrifos-ethyl in rats

Archives of Toxicology ◽

10.1007/s002040100219 ◽

2001 ◽

Vol 75 (2) ◽

pp. 88-96 ◽

Cited By ~ 183

Author(s):

Fatih Gultekin ◽

Namik Delibas ◽

Sulhattin Yasar ◽

Ibrahim Kilinc

Keyword(s):

Vitamin E ◽

Vitamin C ◽

Oxidative Damage ◽

Protective Role ◽

Antioxidant Systems ◽

Chlorpyrifos Ethyl

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Vitamin C and the Lens: New Insights into Delaying the Onset of Cataract

Nutrients ◽

10.3390/nu12103142 ◽

2020 ◽

Vol 12 (10) ◽

pp. 3142

Author(s):

Julie C Lim ◽

Mariana Caballero Arredondo ◽

Andrea J. Braakhuis ◽

Paul J. Donaldson

Keyword(s):

Quality Of Life ◽

Risk Factors ◽

Vitamin C ◽

Oxidative Damage ◽

Cataract Surgery ◽

Future Studies ◽

The World ◽

Diabetic Population ◽

Lens Physiology

Cataracts or clouding of the lens is the leading cause of blindness in the world. Age and diabetes are major risk factors, and with an increasing aging and diabetic population, the burden of cataracts will grow. Cataract surgery is an effective way to restore vision; however, alternatives to cataract surgery are required to reduce the looming cataract epidemic. Since it is well established that oxidative damage plays a major role in the etiology of cataracts, antioxidants have been promoted as therapies to delay and/or prevent cataracts. However, many antioxidant interventions including vitamin C have produced mixed results as anti-cataract therapies. Progress has been made towards our understanding of lens physiology and the mechanisms involved in the delivery and uptake of antioxidants to the lens which may guide future studies aimed at addressing some of the inconsistencies seen in previous animal and human studies. Of interest is the potential for vitamin C based supplements in delaying the onset of cataracts post vitrectomy which occurs in up to 80% of patients within two years. These targeted approaches are required to reduce the burden of cataract on hospitals and improve the quality of life of our aging and diabetic population.

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