CRISPR/Cas Multiplexed Biosensing: A Challenge or an Insurmountable Obstacle?

2019 ◽  
Vol 37 (8) ◽  
pp. 792-795 ◽  
Author(s):  
Yi Li ◽  
Linyang Liu ◽  
Guozhen Liu
Keyword(s):  
Insurmountable Obstacle ◽  
Multiplexed Biosensing

The “Unspeakable Blessing”: Street Children, Reform Rhetoric, and Misery in Early Industrial Capitalism

1983 ◽  
Vol 12 (3) ◽  
pp. 303-330 ◽  
Author(s):  
Bruce Bellingham
Keyword(s):  
New York ◽  
Annual Report ◽  
Street Children ◽  
Industrial Capitalism ◽  
The Poor ◽  
Insurmountable Obstacle ◽  
The City ◽  
The Way

… surely there would be men enough, willing and glad to contribute to the regeneration of the poor outcasts of the city. It is no longer an experiment since the Children's Aid has removed of this class, in thirteen years, eleven thousand two hundred and seventy two! Who would not rejoice to aid in such an enterprise…? Money only is wanting. Shall that be an insurmountable obstacle in the way of accomplishing such an unspeakable blessing? New York Children's Aid Society, 1866 Annual Report

USTAVNI IDENTITET I VIDOVDANSKI USTAV

2021 ◽  
Author(s):  
Vladan Petrov ◽  
Keyword(s):  
State Sovereignty ◽  
Political Crisis ◽  
The Core ◽  
Liberal Democratic ◽  
National Question ◽  
Insurmountable Obstacle ◽  
Constitutional Identity

With this paper the author completes his analysis of the reference historical constitutions and its influence on the constitutional identity of modern Serbia. Reffering to the effects of constitutional identity "outside" (preservation of state sovereignty) and "inside" (the "core" of the constitution), the author analyzes the functional failures and substantive controversies of the Vidovdan Constitution. Inconsistent normative solutions of this constitution, a deep socio-political crisis and an unresolved national question in the newly created state were an insurmountable obstacle to building the national constitutional identity. However, the symbolism of the date of adoption of the Constitution and the fact that, at least formally, it was the last classical constitution of the liberal-democratic type until the 1990s and the entry into force of the 1990 Serbian Constitution, make the Vidovdan Constitution a reference text for studying the constitutional identity of modern Serbia.

Examining of communication barriers of foreign students at the medical university of Karaganda

2020 ◽  
Vol 44 (3) ◽  
pp. 61-65
Author(s):  
R. Singh ◽  
◽  
M. Ospanova ◽  
Keyword(s):  
Foreign Students ◽  
Self Esteem ◽  
Communication Barriers ◽  
Individual Experience ◽  
Negative Experiences ◽  
Communication Links ◽  
Inferiority Complex ◽  
Insurmountable Obstacle ◽  
Medical University

The article is devoted to the analysis of interethnic barriers of communication in the student sphere. It was studied how emotions prevent students from interacting with each other. The essence and classification of barriers are considered. The barrier is lived by a person as an insurmountable obstacle. As a result, he is not able to create and maintain communication links, during attempts he experiences strong negative experiences. This leads to low self-esteem, lack of ambition, dissatisfaction with yourself and your life, anxiety, guilt and the emergence of an inferiority complex. In psychology, the problem of communication barriers is given enough attention. Experts believe that the emergence of difficulties in communication contributes to individual experience. It affects the perception of information coming from the interlocutor, and does not allow you to look at the situation objectively. For most people, this process occurs unconsciously, so communication often becomes unproductive. Psychological causes are the result of personal aspects. These include differences in types of temperament, antipathy, secrecy, tightness, distrust.

A Not-So-Special Relationship America and Britain

2019 ◽  
pp. 153-172
Author(s):  
Edoardo Campanella ◽  
Marta Dassù
Keyword(s):  
United States ◽  
The United States ◽  
Special Relationship ◽  
The European Union ◽  
Free Markets ◽  
National Myth ◽  
Absolute Strength ◽  
Insurmountable Obstacle ◽  
The Difference ◽  
Power And Influence

The Brexiteers presented a revived partnership with the United States as the cornerstone of Britain’s new Anglosphere-centered diplomacy. Without the United States, any Anglosphere project would lose meaning, and the future of Britain outside the European Union would be grim. But this chapter argues that the focus on the “special relationship” was based on a delusional national myth. Historically, the specialness, which discounted an enormous gap in terms of power and influence between the two countries, has been more keenly felt in London than in Washington. Since 1945, America’s absolute strength and Britain’s relative weakness has always determined a highly unbalanced relationship. In the eyes of Dean Acheson—Secretary of State in the Truman Administration—British rhetoric surrounding the “special” connection between the two countries reflected nothing more than the UK’s unwillingness to accept its post-imperial status: that of a simple transatlantic intermediary and Anglo-Saxon balancer in European affairs. It has been observed that, from 1945 onwards, the “special relationship” rapidly assumed the character of a “special dependancy”, with Britain being very much the junior partner. Currently, the difference in terms of power and influence between the two countries is as great as in the past—if not even greater, given Britain’s diminished influence in European affairs. On top of that, bridging the policy inconsistencies between “America First” (based on unilateralism and protectionism) and “Global Britain” (based on multilateralism and free markets) might represent an insurmountable obstacle.

scholarly journals The challenge of clinical adoption—the insurmountable obstacle that will stop machine learning?

BJR|Open ◽  
2019 ◽  
Vol 1 (1) ◽  
pp. 20180017
Author(s):  
Jonathan Taylor ◽  
John Fenner
Keyword(s):  
Machine Learning ◽  
Clinical Practice ◽  
Health Economics ◽  
Clinical Environment ◽  
New Approach ◽  
Representative Data ◽  
Potential Benefits ◽  
Insurmountable Obstacle ◽  
Learning Software ◽  
Clinical Adoption

Machine learning promises much in the field of radiology, both in terms of software that can directly analyse patient data and algorithms that can automatically perform other processes in the reporting pipeline. However, clinical practice remains largely untouched by such technology. This article highlights what we consider to be the major obstacles to widespread clinical adoption of machine learning software, namely: representative data and evidence, regulations, health economics, heterogeneity of the clinical environment and support and promotion. We argue that these issues are currently so substantial that machine learning will struggle to find acceptance beyond the narrow group of applications where the potential benefits are readily evident. In order that machine learning can fulfil its potential in radiology, a radical new approach is needed, where significant resources are directed at reducing impediments to translation rather than always being focused solely on development of the technology itself.

Kripke's Nonnativity Argument

1997 ◽  
Vol 27 (4) ◽  
pp. 467-488 ◽  
Author(s):  
José L. Zalabardo
Keyword(s):  
Crucial Role ◽  
Private Language ◽  
Linguistic Expression ◽  
Information Theoretic ◽  
Insurmountable Obstacle

In Wittgenstein on Rules and Private Language, Kripke presented an argument to the effect that there can be no facts as to what someone means by a linguistic expression. In this argument, a central role is played by the contention that meaning is a normative notion. Some of the most popular accounts of what meaning facts consist in are rejected on the grounds that they fail to accommodate the normative character of meaning. This aspect of Kripke's dialectic plays a crucial role in his rejection of dispositional accounts of meaning, and it is rightly perceived as undermining, if successful, currently fashionable information theoretic accounts of semantic notions. Assessments of its success vary widely. Whereas for some writers the normative character of meaning constitutes an insurmountable obstacle for dispositional accounts, advocates of the information theoretic program have generally failed to acknowledge that their proposals are invalidated by this aspect of the notion.

scholarly journals Advanced Electrochemical Scaffolds for Multiplexed Biosensing of Cancer Reporters in Complex Clinical Samples

2017 ◽  
Vol 27 ◽  
pp. 17-20
Author(s):  
Rebeca M. Torrente-Rodríguez ◽  
Susana Campuzano ◽  
Víctor Ruiz-Valdepeñas Montiel ◽  
Unai Eletxigerra ◽  
Josu Martinez-Perdiguero ◽  
...  
Keyword(s):  
Clinical Samples ◽  
Multiplexed Biosensing

Pemex business plan draws scepticism in Mexico

2019 ◽  
Keyword(s):  
Federal Government ◽  
Oil Prices ◽  
Business Plan ◽  
Content Type ◽  
Public Finances ◽  
Rating Agencies ◽  
Insurmountable Obstacle ◽  
Oil Sector ◽  
The Government ◽  
Substantial Drop

Significance It has proven a disappointment, failing to explain how ambitious targets will be met, while confirming the reversal of the oil sector liberalisation enacted by the Pena Nieto administration, which had been showing some promising results. Impacts The government cannot mount a massive rescue of Pemex without endangering its own finances. Any substantial drop in global oil prices could present an insurmountable obstacle for Pemex, and a significant blow to public finances. A downgrade of Pemex’s debt could push rating agencies to do the same with the bonds of the federal government.

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