Effects of 3,3′,4,4′,5-pentachlorobiphenyl (PCB126) on vertebral bone mineralization and on thyroxin and vitamin D levels in Sprague–Dawley rats

2009 ◽  
Vol 187 (2) ◽  
pp. 63-68 ◽  
Author(s):  
Pedro Alvarez-Lloret ◽  
P. Monica Lind ◽  
Ingrid Nyberg ◽  
Jan Örberg ◽  
Alejandro B. Rodríguez-Navarro
Keyword(s):  
Vitamin D ◽  
Bone Mineralization ◽  
Sprague Dawley ◽  
Vertebral Bone ◽  
Sprague Dawley Rats ◽  
Vitamin D Levels

scholarly journals Effect of Nigella sativa against cisplatin induced nephrotoxicity in rats

2018 ◽  
Vol 7 (2) ◽  
Author(s):  
Amnah M.A. Alsuhaibani
Keyword(s):  
Vitamin D ◽  
Seed Treatment ◽  
Mineral Content ◽  
Renal Toxicity ◽  
Nigella Sativa ◽  
Bioactive Components ◽  
Sprague Dawley ◽  
Nigella Sativa Oil ◽  
Sprague Dawley Rats ◽  
Nigella Sativa Seed

In this study, the gross composition and mineral content of Nigella sativa seed powder (NSP) and fatty acid composition of Nigella sativa oil (NSO) were investigated. The ability of NSP, extract (NSE) and NSO in reducing the effects of cisplatin-induced renal toxicity in Sprague-Dawley rats were examined. The obtained results showed that NSP contains high amounts of carbohydrates, protein, and fiber while NSO has higher amounts of linoleicacid, oleic acid, and myristic acid. Rats treated with NSP, NSO, and NSE exhibitedreducedserum levels of urea, creatinine, and potassium, and a significant increase of Na, Na/K, vitamin D, nutritional markers, and antioxidant enzymes compared to the cisplatin-induced renal toxicity group receiving no Nigella sativa seed treatment. This study determined that all powder, oil, and extracts of N. sativa contain potent bioactive components that may aid in treatment against cisplatininduced renal toxicity in rats.

scholarly journals Ameliorative Potential of Riboceine, Vitamin D and Calcium on Amodaiquine‐Induced Reproductive Dysfunctions in Female Sprague‐Dawley Rats

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
SUNDAY OLUWADUROTIMI MOBOLAJI-JOBI ◽  
Ini-ibehe Essien OKOKO ◽  
Leke Jacob MEDUBI ◽  
Abayomi Olugbenga OKANLAWON
Keyword(s):  
Vitamin D ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Effects of Diet-Induced Obesity and Deficient in Vitamin D on Spermatozoa Function and DNA Integrity in Sprague-Dawley Rats

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
O. Merino ◽  
R. Sánchez ◽  
B. M. Gregorio ◽  
F. J. Sampaio ◽  
J. Risopatrón
Keyword(s):  
Vitamin D ◽  
Dna Fragmentation ◽  
High Fat Diet ◽  
Control Diet ◽  
Sperm Function ◽  
Sprague Dawley ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Sprague Dawley Rats ◽  
The Impact

Obesity has adverse effects on male fertility and usually is diagnosed with a prevalence of vitamin D deficiency (VD-). Discussion on the impact of obesity/VD- on sperm function has been limited. This study analyzed the effects of diet-induced obesity/VD- on viability and plasma membrane integrity (PMI), superoxide anion (O2-) level, and DNA fragmentation (DNAfrag) in sperm Sprague-Dawley rats. The males were randomized into four groups and fed for a period of 12 weeks: G1: control diet with vitamin D (C/VD+), G2: control diet without vitamin D (C/VD-), G3: high-fat diet with vitamin D (HF/VD+), and G4: high-fat diet without vitamin D (HF/VD-). Sperm function parameters were analyzed by flow cytometry. PMI percentages and O2- levels were not affected by any of the diets. DNA fragmentation was increasing significantly (p<0.05) in the spermatozoa of animals with diets vitamin D deficient (G2) and diet-induced obesity (G4). Our results allow us to point out that diet-induced obesity and VD- produce greater damage in DNA sperm of rats. The use of nutraceuticals containing vitamin D could be reducing the risk of fragmentation of DNA in spermatozoa.

scholarly journals Comparison of the Pharmacological Effects of Paricalcitol and Doxercalciferol on the Factors Involved in Mineral Homeostasis

2010 ◽  
Vol 2010 ◽  
pp. 1-8 ◽  
Author(s):  
J. Ruth Wu-Wong ◽  
Masaki Nakane ◽  
Gerard D. Gagne ◽  
Kristin A. Brooks ◽  
William T. Noonan
Keyword(s):  
Vitamin D ◽  
Cell Proliferation ◽  
Mrna Expression ◽  
Active Form ◽  
Parathyroid Cell ◽  
Pharmacological Effects ◽  
Sprague Dawley ◽  
Mineral Homeostasis ◽  
Sprague Dawley Rats ◽  
Serum Pth

Vitamin D receptor agonists (VDRAs) directly suppress parathyroid hormone (PTH) mRNA expression. Different VDRAs are known to have differential effects on serum calcium (Ca), which may also affect serum PTH levels since serum Ca regulates PTH secretion mediated by the Ca-sensing receptor (CaSR). In this study, we compared the effects of paricalcitol and doxercalciferol on regulating serum Ca and PTH, and also the expression of PTH, VDR, and CaSR mRNA. The 5/6 nephrectomized (NX) Sprague-Dawley rats on a normal or hyperphosphatemia-inducing diet were treated with vehicle, paricalcitol, or doxercalciferol for two weeks. Both drugs at the tested doses (0.042–0.33 g/kg) suppressed PTH mRNA expression and serum PTH effectively in the 5/6 NX rats, but paricalcitol was less potent in raising serum Ca than doxercalciferol. In pig parathyroid cells, paricalcitol and the active form of doxercalciferol induced VDR translocation from the cytoplasm into the nucleus, suppressed PTH mRNA expression and inhibited cell proliferation in a similar manner, although paricalcitol induced the expression of CaSR mRNA more effectively. The multiple effects of VDRAs on modulating serum Ca, parathyroid cell proliferation, and the expression of CaSR and PTH mRNA reflect the complex involvement of the vitamin D axis in regulating the mineral homeostasis system.

scholarly journals The Impact of Adult Vitamin D Deficiency on Behaviour and Brain Function in Male Sprague-Dawley Rats

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e71593 ◽  
Author(s):  
Jacqueline H. Byrne ◽  
Meggie Voogt ◽  
Karly M. Turner ◽  
Darryl W. Eyles ◽  
John J. McGrath ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Brain Function ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
The Impact

scholarly journals The Effect of Maternal Vitamin D Status on Fetal Growth and Stunting: A Systematic Review

2021 ◽  
Vol 5 (2) ◽  
pp. 204-214
Author(s):  
Nareesa Karmali ◽  
Kanisha Blake ◽  
Brownmagnus Olivers ◽  
Sussan Ekejiuba ◽  
Romuladus Azuine
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Fetal Growth ◽  
Keyword Search ◽  
Bone Mineralization ◽  
Statistical Significance ◽  
Vitamin D Status ◽  
Maternal Vitamin ◽  
Vitamin D Levels ◽  
Maternal Vitamin D Status

Background and Objective: Impaired fetal growth and stunting remain immense public health problems involving maternal nutrition during pregnancy, as linear growth failure in children is the most common form of undernutrition across the world. Although both are preventable through adequate prenatal care and nutrition, impaired fetal growth and stunting continue to be implicated in multiple child health morbidities, physical, and psychological functioning. Recent knowledge and requirements for normal fetal and neonatal development are lacking. This systematic review investigates the effects of maternal vitamin D status on fetal growth and stunting. Methods: We reviewed three widely-used publications databases: the National Institutes of Health’s PubMed, Clarivate Analytics’ Web of Science, and Google Scholar using pre-established inclusion and exclusion criteria and keyword search strategy. Studies from 2010 to 2020 were included if they reported vitamin D levels on pregnant women, indicated growth outcomes and used quantitative measurements. We excluded non-English language studies, studies with ambiguous outcomes, studies that did not specify vitamin D intake, and studies that involved other maternal health complications. The search was implemented using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Results: Out of a total of 2,481 studies reviewed, we identified 8 studies on vitamin D and fetal growth and stunting. Published literature addressing maternal vitamin D status on fetal growth and stunting remains ambiguous. Five studies demonstrated improvements in fetal and humerus z-scores, which are known proxies for fetal growth, in groups with higher vitamin D status. Three studies found no statistical significance between vitamin D levels and fetal growth. Vitamin D status and ethnicity were correlated; vitamin D interacts with calcium levels in pregnant mothers to improve bone mineralization and fetal growth. Conclusion and Implications for Translation: Further studies are needed to understand the relationship between maternal vitamin D, ethnicity, and fetal growth and the long-term effects of maternal vitamin D levels on neonatal, early childhood, and adolescent growth.   Copyright © 2021 Karmali et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY 4.0.

scholarly journals STATUS OF SERUM VITAMIN D IN PRE MENOPAUSAL INDIAN WOMEN

2021 ◽  
Vol 9 (04) ◽  
pp. 255-260
Author(s):  
Manasa D.R Sharma ◽  
Narayana S. ◽  
Suresh Babu S.V
Keyword(s):  
Vitamin D ◽  
Bone Mineralization ◽  
Serum Vitamin ◽  
Premenopausal Women ◽  
Reference Interval ◽  
Cross Sectional Study ◽  
Renal Tubules ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Vitamin D promotes absorption of calcium in the intestine as well as renal tubules and maintains adequate levels of calcium and phosphate in serum to maintain normal bone mineralization and prevents osteoporosis. This vitamin can be produced endogenously when ultraviolet (UV) rays in sunlight hit the skin and promotes its synthesis [1]. Deficiency of this vitamin is common in India, the rate of prevalence range from 40 – 90 percent [2]! Geographically India is partly tropical and subtropical and receives sunlight round the year. More than 30ng/mL was the biological reference interval for vitamin D but it was derived from western population and it is using by the diagnostic laboratories across the country. Because of this scale majority of healthy individuals shows insufficient Vitamin D levels [3]. Objectives: To assess the status of vitamin D in the premenopausal women. To evolve a reference range in Indian sub-population and to correlate the findings with the reference interval established by National institutes of health (NIH), USA. Methodology: A cross sectional study consisting of 127 adult pre-menopausal women (29 – 45 years of age) was conducted. Their total Vitamin D levels were measured by Chemiluminescence immunoassay technique. Result: 26 ± 8.5ng/mL was the biological reference interval (BRI) for Vitamin D, established by NIH but the in-house obtained BRI was 18.2 ± 11.5ng/mL. The obtained BRI was significantly decreased (p <0.001) than NIH established values. Conclusion: 18.2 ± 11.5ng/mL of Serum Vitamin D was observed in the adult premenopausal Indian sub population.

Therapeutic Effect of Vitamin D3 in a Rat Diffuse Axonal Injury Model

2005 ◽  
Vol 33 (1) ◽  
pp. 90-95 ◽  
Author(s):  
UA Malcok ◽  
G Sengul ◽  
HH Kadioglu ◽  
IH Aydin
Keyword(s):  
Vitamin D ◽  
Therapeutic Effect ◽  
Head Trauma ◽  
Axonal Injury ◽  
Diffuse Axonal Injury ◽  
Sprague Dawley ◽  
Post Injury ◽  
Sprague Dawley Rats ◽  
Injury Model ◽  
Impact Acceleration

We investigated the therapeutic effect of vitamin D3 in a rat diffuse axonal injury model. A total of 60 male Sprague-Dawley rats weighing 175 − 200 g were anaesthetized and subjected to head trauma using Marmarou's impact-acceleration model. The rats were then separated into two groups; one group was treated with vitamin D3 and the other with saline for up to 4 days after the head trauma. Rats from both groups were killed 1, 3 or 8 days post-injury. The brains were examined histopathologically and scored according to the level of neuronal, vascular and axonal damage. There were no significant differences between the groups after 1 or 3 days, but evaluation after 8 days revealed a significant improvement in the group treated with vitamin D3. Our data indicate that vitamin D3 has a beneficial effect in diffuse axonal injury and may be useful in the management of this condition.

scholarly journals Relationship Between Vitamin D Deficiency and the Amount of Sun Exposure in Young Women

2021 ◽  
Author(s):  
ŞÜKRİYE TAŞÇI KARAGÖL ◽  
sevil turhan ◽  
Hulya Coskun ◽  
Yusuf Bostan ◽  
Raziye yıldız
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Young Women ◽  
Bone Mineralization ◽  
Sunshine Duration ◽  
Sun Exposure ◽  
Care Hospital ◽  
Monthly Average ◽  
Vitamin D Levels ◽  
The Individual

Abstract Objective: Vitamin D is an essential vitamin for bone mineralization and its deficiency adversely affects many systems, predominantly the musculoskeletal system. A lack of synthesis in the skin is the key step that predominantly causes vitamin D deficiency. Vitamin D synthesis can be affected by numerous factors including geographical region of residence, seasons, monthly average daily global horizontal solar radiation (MADGHSR), monthly average daily sunshine duration (MADSD), ethnic group of the individual. The study aimed to investigate the relationship between vitamin D level and MADSD and MADGHSR values in young women. Methods: The retrospective study included women aged 15-45 years, who presented to Secondary Care Hospital for general health screening. Vitamin D levels were classified according to age groups, months, seasons, MADGHSR and MADSD values. Results: The mean vitamin D level was 17.3±7.3 ng/mL in summer and was 15.9±7.5 ng/mL in winter (p=0.001). Vitamin D deficiency (<20 ng/mL) was detected in 68.1% as opposed to 75.1% of women in summer and winter, respectively (p<0.001). A weak correlation was found between vitamin D level and age (r=0.082, p=0.002), MADGHSR (r=0.062, p=0.006), and MADSD (r=0.075, p=0.001). Conclusion: The individual and environmental factors with the MADGHSR, MADSD have a direct effect on sun exposure. The traditional and religious clothing habits of our participants constituted the most important factor contributing to their low vitamin D levels. We propose that routine vitamin D supplementation at optimal doses will be an appropriate approach in populations similar to the population studied in the present study.

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