scholarly journals Assessment of the acute and sub-acute toxicity of the ethanolic extract of the aerial parts of Crassocephalum rabens (Asteraceae) in rats

2021 ◽  
Author(s):  
Pang-Kuei Hsu ◽  
Yueh-Ting Tsai ◽  
Yu-Cheng Lin ◽  
Chen-Meng Kuan
Keyword(s):  
Acute Toxicity ◽  
Ethanolic Extract ◽  
Aerial Parts

scholarly journals Bioactivity of microencapsulated soursop seeds extract on Plutella xylostella

2016 ◽  
Vol 46 (5) ◽  
pp. 771-775 ◽  
Author(s):  
Ismael Barros Gomes ◽  
Roseane Cristina Predes Trindade ◽  
Antônio Euzébio Goulart Sant'Ana ◽  
Eurico Eduardo Pinto de Lemos ◽  
Irinaldo Diniz Basílio Júnior
Keyword(s):  
Acute Toxicity ◽  
Plutella Xylostella ◽  
Larval Stage ◽  
Diamondback Moth ◽  
Ethanolic Extract ◽  
Spray Dryer ◽  
Annona Muricata ◽  
Ultrapure Water ◽  
Arabic Gum ◽  
Chronic Effects

ABSTRACT: The aim of this study was to evaluate the bioactivity of microencapsulated extract from the soursop seeds, Annona muricata L. ( Annonaceae ), on diamondback moth, Plutella xylostela L. (Lepidoptera: Plutellidae ). Microencapsulation was performed in a Mini Spray Dryer model B-290 using 50mL of ethanolic and hexanic extracts plus 150mL of ethanol and 150mL of ultrapure water, mixed with aerosil (first polymer) or arabic gum (second polymer). It was possible to microencapsulate the ethanolic extract of soursop seeds only by using the polymer arabic gum at 20%. The microencapsulated extract caused significant acute toxicity (LC50=258mg L-1) and chronic effects, especially reduction of larval viability and increased larval stage. We concluded that the microencapsulation of the ethanolic extract of soursop seeds can be a viable alternative for controlling diamondback moth with possible gains for the environment.

Acute toxicity test for the ethanolic extract of the white oyster mushroom

2020 ◽  
pp. 41-43
Author(s):  
S.B. Rahimah ◽  
Y. Kharisma ◽  
M.K. Dewi ◽  
J. Hartati ◽  
W. Maharani
Keyword(s):  
Acute Toxicity ◽  
Toxicity Test ◽  
Ethanolic Extract ◽  
Oyster Mushroom ◽  
Acute Toxicity Test

scholarly journals In vitro Assessment of Antiplasmodial Activity and Acute Oral Toxicity of Dissotis rotundifolia Extracts and Fractions on Plasmodium falciparum Strains

2020 ◽  
pp. 8-19
Author(s):  
Rock Djehoue ◽  
Rafiou Adamou ◽  
Abdou Madjid O. Amoussa ◽  
Adande A. Medjigbodo ◽  
Anatole Laleye ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Acute Toxicity ◽  
Ethanolic Extract ◽  
Antiplasmodial Activity ◽  
Oral Toxicity ◽  
Aqueous Fraction ◽  
Vector Borne Diseases ◽  
Natural Substances ◽  
Study Laboratory

Aim: Dissotis rotundifolia were selected after an ethnopharmacological survey conducted on plants used traditionally for malaria treatment in South Benin, with the aim of discovering new natural active extracts against malaria parasites. Place and Duration of Study: Laboratory of Biochemistry and Bioactive Natural Substances, University of Abomey-Calavi (Benin)/ Laboratory of Infectious Vector Borne Diseases, Regional Institute of Public Health (Benin)/ Laboratoire d’Histologie, de Cytogénétique et d’Embryologie, Faculté des Sciences de la Santé (Benin). The study was conduct from October 2018 to June 2019 in Benin. Methodology: The antiplasmodial activity of the plant extracts was evaluated using the parasite lactate dehydrogenase (pLDH) immunodetection assay. The extract with the best antiplasmodial activity were used on Wistar rats for acute toxicity. Results: Ethanolic extract of Dissotis rotundifolia showed promising activity (Isolate: IC50 = 22.58 ± 1.12 µg/mL; 3D7: IC50 = 6.81 ± 0.85 µg/mL) on Plasmodium falciparum compared to the aqueous extract (Isolate: IC50 > 100 µg/mL; 3D7: IC50> 100 µg/mL). The aqueous fraction of D. rotundifolia exhibit highly potent activity against P. falciparum strain (Isolate: IC50 > 100 µg/mL μg/mL; 3D7: IC50 = 4.05 ± 0.72 μg/mL). Haemolytic effect of actives extracts and fractions is less than 5%. Ethanolic extract of D. rotundifolia revealed no obvious acute toxicity in rat up to the highest dose administered (2000 mg/kg). Conclusion: This study justifies traditional uses of D. rotundifolia against malaria. A bioguided fractionation of these extracts would identify molecules responsible for their antiplasmodial activity. Moreover, these results could lead to the design of improved traditional medicines in the basis of this plant.

scholarly journals Ketoksikan Akut dari Ekstrak Etanolik Daun Jarak Pagar (Jatropa curcas) pada Mencit Jantan Galur Balb/C

2014 ◽  
Vol 15 (1) ◽  
pp. 52
Author(s):  
Hanif Nasiatul Baroroh ◽  
Eka Prasasti Nur Rachmani
Keyword(s):  
Acute Toxicity ◽  
Ethanolic Extract ◽  
Negative Control ◽  
Male Mice ◽  
Animal Test ◽  
Group I ◽  
Liver And Kidney ◽  
Single Dosage ◽  
Histopathology Examination ◽  
Lung And Kidney

The acute toxicity of Jatropa curcas leaves on Balb/C male mice was studied in rats. This research aimed to determine acute toxicity, evaluate spectrum of toxic effect and mechanism that caused the death of animal test after administration of ethanolic extract of J. curcas leaves, single dosage orally on 24 hours observation. The research used male mice, which are divided into 5 groups. Group I was negative control with CMC-Na. Group II, III, IV, and V were given extract with dose of 1400 mg/kgBW, 2240 mg/kgBW, 3584 mg/kgBW and 5734 mg/kgBW, respectively. Evaluation of the toxic symptoms and death of animal test was done for 24 hours. If the animal test was died before 24 hours then it underwent surgery to take the heart, liver, lung, and kidney. In the end of the evaluation, all mice were killed to take the vital organs for histopathologic examination. No mortality was observed during study. The test resulted LD50 of ethanolic extract from J. curcas leaves using Balb/C male mice was 5734 mg/kg of BW. It was categorized as practically not toxic. Administration of the extract did not cause alterations of animal behaviours. Histopathology examination shows inflammation in lung, liver, and kidney after administration of the extract.

scholarly journals An Ethanolic Extract of Boehmeria caudata Aerial Parts Displays Anti-inflammatory and Anti-tumor Activities

2020 ◽  
Vol 7 (01) ◽  
pp. e17-e25 ◽  
Author(s):  
Paula Pereira de Paiva ◽  
Fabiana Regina Nonato ◽  
Ana Lúcia Tasca Gois Ruiz ◽  
Ilza Maria de Oliveira Sousa ◽  
Rafael Rosolen Teixeira Zafred ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Ethanolic Extract ◽  
Experimental Models ◽  
New Drugs ◽  
Antiproliferative Effects ◽  
Aerial Parts ◽  
Anti Inflammatory ◽  
Inflammatory Action ◽  
Effective Source

AbstractThe tumor microenvironment presents several therapeutic targets, with inflammation being one of them. In search of new drugs, plants have shown to be an effective source of potent anti-inflammatory and anticancer agents. This study aimed to evaluate the antitumoral and inflammatory activities of Boehmeria caudata aerial parts extract. Bioguided in vitro antiproliferative screening showed that phenanthroquinolizidine obtained from the aerial B. caudata ethanolic extract had a straight relationship with activity. Moreover, the orally administered ethanolic extract reduced Ehrlich solid tumor growth and displayed an anti-inflammatory effect in both evaluated experimental models (carrageenan-induced paw edema and croton oil-induced ear edema). These results suggest that the antitumor activity of the ethanolic extract could be explained by antiproliferative effects associated with anti-inflammatory action.

Anti-inflammatory and analgesic properties of water–ethanolic extract from Pothomorphe umbellata (Piperaceae) aerial parts

2005 ◽  
Vol 99 (2) ◽  
pp. 215-220 ◽  
Author(s):  
Fabio F. Perazzo ◽  
Gustavo H.B. Souza ◽  
Walter Lopes ◽  
Luis G.V. Cardoso ◽  
Jose C.T. Carvalho ◽  
...  
Keyword(s):  
Ethanolic Extract ◽  
Aerial Parts ◽  
Anti Inflammatory

scholarly journals Effects of ethanolic extract of Waltheria indica aerial parts on some liver and kidney function indices in albino rats

2018 ◽  
Vol 17 (19) ◽  
pp. 626-632 ◽  
Author(s):  
J. L. Hamidu ◽  
J. O. Ayo ◽  
A. B. Adelaiye ◽  
M. S. Abubakar
Keyword(s):  
Kidney Function ◽  
Ethanolic Extract ◽  
Albino Rats ◽  
Aerial Parts ◽  
Liver And Kidney

scholarly journals Phytochemical Identification, Acute, and Sub-Acute Oral Toxicity Studies of the Foliar Extract of Withania frutescens

Molecules ◽  
2020 ◽  
Vol 25 (19) ◽  
pp. 4528 ◽  
Author(s):  
Abdelfattah EL Moussaoui ◽  
Mohammed Bourhia ◽  
Fatima Zahra Jawhari ◽  
Hamza Mechchate ◽  
Meryem Slighoua ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Clinical Symptoms ◽  
Ethanolic Extract ◽  
Control Group ◽  
Phytochemical Analysis ◽  
Oral Toxicity ◽  
Phytochemical Composition ◽  
Subacute Toxicity ◽  
Repeated Doses

Withania frutescens (W. frutescens) is a medicinal plant widely used to treat several diseases. This work aims to study phytochemical composition as well as acute and subacute toxicity of W. frutescens hydroethanolic extract in mice. The phytochemical composition of W. frutescens extract was performed using gas chromatographic analysis. Acute toxicity was studied in vivo with oral administration of single doses 400 mg/kg, 1000 mg/kg, and 2000 mg/kg for 14 days. Subacute toxicity was studied with the administration of repeated doses of 400 mg/kg/day and 2000 mg/kg/day for 28 days. Phytochemical analysis of W. frutescens hydro-ethanolic extract confirmed the presence of interesting chemical compounds. Acute toxicity results showed no toxic symptoms in mice treated with an increasing dose up to a maximum of 2000 mg/kg. Alongside acute toxicity, subacute data showed no clinical symptoms nor biochemical or histological alteration in mice treated with an increasing dose up to a maximum of 2000 mg/kg compared to the control group (p < 0.05). This study shows no toxic effects in animals treated with W. frutescens extract, and, therefore, this plant can be considered safe in animals up to 2000 mg/kg under both acute and subacute toxicity conditions.

scholarly journals Acute and sub-acute toxicity of aqueous extract of aerial parts of Caralluma dalzielii N. E. Brown in mice and rats

Heliyon ◽  
2019 ◽  
Vol 5 (1) ◽  
pp. e01179 ◽  
Author(s):  
Chinenye Jane Ugwah-Oguejiofor ◽  
Charles Ogbonna Okoli ◽  
Michael Oguejiofor Ugwah ◽  
Millicent Ladi Umaru ◽  
Chiedozie Smart Ogbulie ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Aqueous Extract ◽  
Aerial Parts
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