Comparison of serum cytokine levels between dogs with multicentric lymphoma and healthy dogs

2016 ◽  
Vol 182 ◽  
pp. 106-114 ◽  
Author(s):  
Jerome Calvalido ◽  
Geoffrey A. Wood ◽  
Anthony J. Mutsaers ◽  
Darren Wood ◽  
William Sears ◽  
...  
Keyword(s):  
Serum Cytokine ◽  
Cytokine Levels ◽  
Healthy Dogs ◽  
Multicentric Lymphoma

An Examination of Generalized Pustular Psoriasis in Pregnancy Based on the Serum Cytokine Levels.

1999 ◽  
Vol 61 (2) ◽  
pp. 144-147
Author(s):  
Miyako KUDO ◽  
Yoshihiro UMEBAYASHI ◽  
Tomoe KOTSUJI ◽  
Fujio OTSUKA
Keyword(s):  
Pustular Psoriasis ◽  
Serum Cytokine ◽  
Cytokine Levels ◽  
Generalized Pustular Psoriasis ◽  
In Pregnancy

scholarly journals Reactive arthritis and undifferentiated peripheral spondyloarthritis share human leucocyte antigen B27 subtypes and serum and synovial fluid cytokine profiles

Rheumatology ◽  
2020 ◽  
Author(s):  
Jyoti Ranjan Parida ◽  
Sandeep Kumar ◽  
Sakir Ahmed ◽  
Smriti Chaurasia ◽  
Ratnadeep Mukherjee ◽  
...  
Keyword(s):  
Statistical Difference ◽  
Human Leucocyte Antigen ◽  
Healthy Controls ◽  
Hla B27 ◽  
Serum Cytokine ◽  
Cytokine Profiles ◽  
Cytokine Levels ◽  
Peripheral Spondyloarthritis ◽  
Multiplex Cytokine ◽  
Age And Sex

Abstract Objectives Peripheral SpA (pSpA) is comprised of ReA, PsA, enteritis-associated arthritis and undifferentiated pSpA (upSpA). ReA and upSpA share T cell oligotypes and metabolomics in serum and SF. We investigated HLA-B27 subtypes and cytokines in serum and SF that were compared between ReA and upSpA. Methods ReA and upSpA were compared in two cohorts. In cohort I (44 ReA and 56 upSpA), HLA-B27 subtyping was carried out. In cohort II (17 ReA and 21 upSpA), serum and SF cytokines were compared using a multiplex cytokine bead assay (27 cytokines). A total of 28 healthy controls with similar age and sex to cohort II were included for comparison of serum cytokine levels. Results In cohort I, HLA-B27 was positive in 81.8% (36/44) of ReA and 85.71% (48/56) of upSpA patients. HLA-B27 typing was successful in 70 patients (30 ReA and 40 uSpA). HLA-B*2705 was the most common, followed by HLA-B*2704 and HLA-B*2707. Frequencies were the same between ReA and upSpA. In cohort II, 14 cytokines were detectable in the serum of patients. The levels of eight cytokines were higher than in the controls. The cytokine levels of ReA and upSpA were similar. Sixteen cytokines were detectable in the SF of patients. There was no statistical difference in the levels between ReA and upSpA. The cytokine profiles in sera and SF were also similar among HLA-B27-positive and negative patients. Conclusion ReA and upSpA have similar HLA-B27 subtype associations and similar cytokine profiles. They should be considered as a single entity during studies as well as clinical management.

Characterizing Circulating Nucleosomes in the Plasma of Dogs with Lymphoma

2021 ◽  
Author(s):  
Christopher Dolan ◽  
Tasha Miller ◽  
Jarvis Jill ◽  
Jason Terrell ◽  
Theresa Kelly ◽  
...  
Keyword(s):  
Fold Increase ◽  
Monitoring Tool ◽  
Treatment Results ◽  
Canine Lymphoma ◽  
Histone Octamer ◽  
Objective Monitoring ◽  
Remission Status ◽  
T Cell Lymphomas ◽  
Healthy Dogs ◽  
Multicentric Lymphoma

Abstract Background: Nucleosomes consist of DNA wrapped around a histone octamer core like beads on a string so that DNA can be condensed as chromatin into chromosomes. Diseases such as cancer or inflammation lead to cell death where chromatin is fragmentated and released as mononucleosomes into the blood. The Nu.QTM H3.1 assay measures total nucleosome concentration in plasma of humans and has been used to detect and identify cancer even at early stages. The objectives of this study were to determine if nucleosome levels could be used to distinguish between healthy dogs and dogs with various stages of lymphoma (LSA) using the Nu.Q™ H3.1 assay. A total of 126 dogs diagnosed with LSA and 134 healthy controls were recruited for this study. Plasma was collected from each dog and stored in K2-EDTA tubes. The LSA patient samples were recruited from TAMU or purchased from various biobanks. All control cases were recruited from TAMU. Samples were also collected longitudinally from 3 dogs undergoing treatment for multicentric lymphoma at TAMU as a pilot study to investigate the pattern of nucleosome concentrations in plasma during treatment. Results: Dogs with LSA had an approximately 7-fold increase in their plasma nucleosome concentrations compared to controls (AUC 87.8%). Nucleosome concentrations increased with cancer stage and dogs with B cell lymphomas had significantly higher nucleosome concentrations than dogs with T cell lymphomas. Nucleosome concentrations from serially monitored patients were elevated at diagnosis and progression with subsequent decreases in nucleosome concentration that corresponded to clinically detectable responses to therapy. Conclusions: The Nu.QTM H3.1 assay was able to reliably detect elevated nucleosome concentrations in the plasma of dogs with LSA. Furthermore, it appears that nucleosomes are useful for differentiating cancer from healthy individuals in canines. Results from serially monitored patients indicate that nucleosomes could be an objective monitoring tool for remission status in canine lymphoma patients.

Modulation of serum cytokine levels by a novel superoxide dismutase mimetic, M40401, in an Escherichia coli model of septic shock: Correlation with preserved circulating catecholamines*

2003 ◽  
Vol 31 (1) ◽  
pp. 237-245 ◽  
Author(s):  
Heather Macarthur ◽  
Daniel M. Couri ◽  
Gerald H. Wilken ◽  
Thomas C. Westfall ◽  
Andrew J. Lechner ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Septic Shock ◽  
Superoxide Dismutase ◽  
Serum Cytokine ◽  
Cytokine Levels

scholarly journals Mercury exposure, serum antinuclear/antinucleolar antibodies, and serum cytokine levels in mining populations in Amazonian Brazil: A cross-sectional study

2010 ◽  
Vol 110 (4) ◽  
pp. 345-354 ◽  
Author(s):  
Renee M. Gardner ◽  
Jennifer F. Nyland ◽  
Ines A. Silva ◽  
Ana Maria Ventura ◽  
Jose Maria de Souza ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Mercury Exposure ◽  
Sectional Study ◽  
Serum Cytokine ◽  
Cross Sectional ◽  
Cytokine Levels ◽  
Amazonian Brazil

Effects of vitamin D3-fortified low-fat yogurt and milk on serum cytokine levels and anti hsp-27 antibody titer in adults with abdominal obesity: A randomized clinical trial

2021 ◽  
pp. 100382
Author(s):  
Fatemeh Najar Sedgh Doust ◽  
Payam Sharifan ◽  
Mahya Razmi ◽  
Mansoureh Sadat Ekhteraei Toussi ◽  
Niloofar Taghizadeh ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Antibody Titer ◽  
Abdominal Obesity ◽  
Vitamin D3 ◽  
Serum Cytokine ◽  
Low Fat ◽  
Hsp 27 ◽  
Cytokine Levels

Pulmonary involvements in systemic juvenile arthritis

2020 ◽  
Author(s):  
Tingyan He ◽  
Jiayun Ling ◽  
Jun Yang
Keyword(s):  
Sinus Thrombosis ◽  
Drug Hypersensitivity ◽  
Systemic Juvenile Idiopathic Arthritis ◽  
Clinical Manifestations ◽  
Cerebral Venous Sinus Thrombosis ◽  
Chronic Inflammatory Disease ◽  
Serum Cytokine ◽  
Radiological Features ◽  
Cytokine Levels ◽  
To Receive

Abstract Background Systemic juvenile idiopathic arthritis (sJIA) is a chronic inflammatory disease of childhood. Pulmonary involvements in sJIA have been recently described. Herein, we assess unusual clinical and radiological features of patients with sJIA, and possible risk factors for pulmonary involvements in sJIA. Methods A total of thirty-nine patients with sJIA were retrospectively enrolled. Data extracted included demographics, medical history, clinical manifestations, laboratory results, serum cytokine levels, radiological findings, management, and prognosis. Results Macrophage activation syndrome (MAS) had been observed at the initial diagnosis or during disease flares in eleven patients (11/39, 28%). Cerebral venous sinus thrombosis was observed in one patient with paroxysmal headache during the MAS phase. Twenty-three patients demonstrated abnormal radiological features on chest Computed Tomography (CT). Only eleven patients had subtle respiratory symptoms with normal oxygen saturation. Eight patients had lung disease (LD) before biologic exposure. sJIA-LD occurred in another six patients after the introduction of tocilizumab. All these patients continued to receive tocilizumab therapy, and sJIA-LD was improved in twelve patients with complete resolution of pulmonary presentations, and partially relieved in two patients. Only one of the two patients with possible anaphylaxis to tocilizumab presented with LD. Severe sJIA-LD was found in two patients with trisomy 21 and Kabuki syndrome, respectively. Conclusions Pulmonary involvements are increasingly observed in children with sJIA. Possible high risks for sJIA-LD include the occurrence of MAS, some inherited diseases, and evidence of drug hypersensitivity. It is still a question of whether IL-1/IL-6 inhibitor exposure increases the risk of sJIA-LD. Vasculitis and thrombosis should be considered in sJIA during the MAS phase, particularly in patients with pulmonary involvements. Trial registration: Not applicable; this was a retrospective study.

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