scholarly journals Immune evasion proteins gpUS2 and gpUS11 of human cytomegalovirus incompletely protect infected cells from CD8 T cell recognition

Virology ◽  
2009 ◽  
Vol 391 (1) ◽  
pp. 5-19 ◽  
Author(s):  
K. Besold ◽  
M. Wills ◽  
B. Plachter
Keyword(s):  
T Cell ◽  
Human Cytomegalovirus ◽  
Immune Evasion ◽  
Cd8 T Cell ◽  
Cell Recognition ◽  
T Cell Recognition ◽  
Infected Cells

scholarly journals CD8+ T-cell recognition of human cytomegalovirus latency-associated determinant pUL138

2010 ◽  
Vol 91 (8) ◽  
pp. 2040-2048 ◽  
Author(s):  
Siok-Keen Tey ◽  
Felicia Goodrum ◽  
Rajiv Khanna
Keyword(s):  
T Cells ◽  
T Cell ◽  
Human Cytomegalovirus ◽  
Cell Response ◽  
Hcmv Infection ◽  
Mononuclear Cells ◽  
T Cell Response ◽  
Cell Recognition ◽  
T Cell Recognition ◽  
Infected Cells

Recent studies have shown that long-term persistence of human cytomegalovirus (HCMV) in mononuclear cells of myeloid lineage is dependent on the UL138 open reading frame, which promotes latent infection. Although T-cell recognition of protein antigens from all stages of lytic HCMV infection is well established, it is not clear whether proteins expressed during latent HCMV infection can also be recognized. This study conducted an analysis of T-cell response towards proteins associated with HCMV latency. Ex vivo analysis of T cells from healthy virus carriers revealed a dominant CD8+ T-cell response to the latency-associated pUL138 protein, which recognized a non-canonical 13 aa epitope in association with HLA-B*3501. These pUL138-specific T cells displayed a range of memory phenotypes that were in general less differentiated than that previously described in T cells specific for HCMV lytic antigens. Antigen-presentation assays revealed that endogenous pUL138 could be presented efficiently by HCMV-infected cells. However, T-cell recognition of pUL138 was dependent on newly synthesized protein, with little presentation from stable, long-lived protein. These data demonstrate that T cells targeting latency-associated protein products exist, although HCMV may limit the presentation of latent proteins, thereby restricting T-cell recognition of latently infected cells.

scholarly journals Two Salmonella OmpC Kb-Restricted Epitopes for CD8+-T-Cell Recognition

2004 ◽  
Vol 72 (5) ◽  
pp. 3059-3062 ◽  
Author(s):  
Alberto Diaz-Quiñonez ◽  
Natalia Martin-Orozco ◽  
Armando Isibasi ◽  
Vianney Ortiz-Navarrete
Keyword(s):  
T Cell ◽  
Cytotoxic T Lymphocytes ◽  
Cd8 T Cell ◽  
Cell Recognition ◽  
Gram Negative ◽  
T Cell Recognition ◽  
Histocompatibility Complex ◽  
Infected Cells ◽  
Bacterial Porins ◽  
Ompc Porin

ABSTRACT We report the identification of two peptides from Salmonella OmpC porin that can bind to major histocompatibility complex class I Kb molecules and are targets of cytotoxic T lymphocytes from Salmonella-infected mice. These peptides are conserved in gram-negative bacterial porins and are the first Salmonella porin-specific epitopes described for possible CD8+-T-cell elimination of infected cells.

scholarly journals Cooperation between Epstein-Barr Virus Immune Evasion Proteins Spreads Protection from CD8+ T Cell Recognition across All Three Phases of the Lytic Cycle

2014 ◽  
Vol 10 (8) ◽  
pp. e1004322 ◽  
Author(s):  
Laura L. Quinn ◽  
Jianmin Zuo ◽  
Rachel J. M. Abbott ◽  
Claire Shannon-Lowe ◽  
Rosemary J. Tierney ◽  
...  
Keyword(s):  
T Cell ◽  
Immune Evasion ◽  
Epstein Barr Virus ◽  
Cd8 T Cell ◽  
Lytic Cycle ◽  
Cell Recognition ◽  
T Cell Recognition ◽  
Barr Virus ◽  
Epstein Barr ◽  
Three Phases

The role of the human cytomegalovirus UL111A gene in down-regulating CD4+ T-cell recognition of latently infected cells: implications for virus elimination during latency

Blood ◽  
2009 ◽  
Vol 114 (19) ◽  
pp. 4128-4137 ◽  
Author(s):  
Allen K. L. Cheung ◽  
David J. Gottlieb ◽  
Bodo Plachter ◽  
Sandra Pepperl-Klindworth ◽  
Selmir Avdic ◽  
...  
Keyword(s):  
T Cell ◽  
Human Cytomegalovirus ◽  
Latent Infection ◽  
Interleukin 10 ◽  
Cd4 T Cell ◽  
Cell Recognition ◽  
T Cell Recognition ◽  
Latently Infected ◽  
Infected Cells

AbstractThe capacity of human cytomegalovirus (HCMV) to establish and maintain a latent infection from which it can later reactivate ensures its widespread distribution in the population, but the mechanisms enabling maintenance of latency in the face of a robust immune system are poorly understood. We examined the role of the HCMV UL111A gene, which encodes homologs of the immunosuppressive cytokine interleukin-10 in the context of latent infection of myeloid progenitor cells. A UL111A deletion virus was able to establish, maintain, and reactivate from experimental latency in a manner comparable with parental virus, but major histocompatibility complex class II levels increased significantly on the surfaces of cells infected with the deletion virus. Importantly, there was an increase in both allogeneic and autologous peripheral blood mononuclear cells and CD4+ T-cell responses to UL111A deletion virus-infected myeloid progenitors, indicating that loss of the capacity to express viral interleukin-10 during latency results in latently infected cells becoming more readily recognizable by a critical arm of the immune response. The detection of a viral gene that suppresses CD4+ T-cell recognition of latently infected cells identifies an immune evasion strategy that probably enhances the capacity of HCMV to persist in a latent state within the human host.

Immunomodulation and RNA interference alter Hepatitis B Virus‐specific CD8 T cell recognition of infected HepG2‐NTCP

Hepatology ◽  
2021 ◽  
Author(s):  
Adrian Kuipery ◽  
Juan Diego Sanchez Vasquez ◽  
Aman Mehrotra ◽  
Jordan J. Feld ◽  
Harry L. A. Janssen ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Rna Interference ◽  
T Cell ◽  
Hepatitis B ◽  
Cd8 T Cell ◽  
Cell Recognition ◽  
T Cell Recognition ◽  
B Virus

PS-079-HDV co-infection modifies the immunoproteasome profile of HBV infected hepatocytes leading to increased CD8 T-cell recognition: Implication for immunotherapy

2019 ◽  
Vol 70 (1) ◽  
pp. e51
Author(s):  
Christine Y.L. Tham ◽  
Janine Kah ◽  
Anthony Tan ◽  
Alessandro Loglio ◽  
Camille Sureau ◽  
...  
Keyword(s):  
T Cell ◽  
Cd8 T Cell ◽  
Cell Recognition ◽  
T Cell Recognition

scholarly journals HIV Controllers Exhibit Effective CD8+ T Cell Recognition of HIV-1-Infected Non-activated CD4+ T Cells

Cell Reports ◽  
2019 ◽  
Vol 27 (1) ◽  
pp. 142-153.e4 ◽  
Author(s):  
Blandine Monel ◽  
Annmarie McKeon ◽  
Pedro Lamothe-Molina ◽  
Priya Jani ◽  
Julie Boucau ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cd4 T Cells ◽  
Cd8 T Cell ◽  
Cell Recognition ◽  
T Cell Recognition ◽  
Hiv Controllers ◽  
Hiv 1

scholarly journals Phylodynamic Analysis and Implication of HCV Genotype 4 Variability on Antiviral Drug Response and T-Cell Recognition

Viruses ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 1363
Author(s):  
Giuseppina Maria Elena Colomba ◽  
Noemi Urone ◽  
Vito di Marco ◽  
Donatella Ferraro
Keyword(s):  
T Cell ◽  
Genetic Variability ◽  
Risk Groups ◽  
Cd8 T Cell ◽  
Antiviral Drugs ◽  
T Cell Response ◽  
Cell Recognition ◽  
Genotype 4 ◽  
Hcv Genotype ◽  
T Cell Recognition

Therapies for HCV care could change the prevalence and the geographic distribution of genotypes due to differences in Sustained Virologic Response (SVR). In this scenario, uncommon genotypes/subtypes, such as genotype 4, could spread from high-risk groups, replacing genotypes eradicated by antiviral drugs. Genotype eradication is also strongly influenced by the CD8+ T cell response. In this study, the genetic variability in HCV genotype 4 strains obtained from a cohort of 67 patients naïve to DAA therapy was evaluated. We found that the presence of resistance-associated substitutions (RAS) was able to affect drug responses. Next, using a prediction tool, viral mutations were identified by their ability, or lack thereof, to reduce the binding affinity with HLA, which affects T cell recognition. The Bayesian coalescent analysis suggested two different circulation clusters, one in risk groups (IDUs and MSM) and the other due to migration flows, dated to 1940 and 1915, respectively. Most of the RAS overlapped with HLA and a lack of binding mutations was observed in 96% of strains. This study describes the introduction of HCV genotype 4 in a region of the Mediterranean basin and evaluates how HCV genotype 4’s genetic variability could affect the response of antiviral drugs and CD8+ T cell recognition.

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