Transcriptome-wide analysis reveals core set of transcriptional key regulators of sensome and inflammation in retinal microglia

Genomics ◽  
2021 ◽  
Author(s):  
Madhu Sudhana Saddala ◽  
Xu Yang ◽  
Shibo Tang ◽  
Hu Huang
Keyword(s):  
Core Set ◽  
2018 ◽  
Author(s):  
Rajendra K. Bera

It now appears that quantum computers are poised to enter the world of computing and establish its dominance, especially, in the cloud. Turing machines (classical computers) tied to the laws of classical physics will not vanish from our lives but begin to play a subordinate role to quantum computers tied to the enigmatic laws of quantum physics that deal with such non-intuitive phenomena as superposition, entanglement, collapse of the wave function, and teleportation, all occurring in Hilbert space. The aim of this 3-part paper is to introduce the readers to a core set of quantum algorithms based on the postulates of quantum mechanics, and reveal the amazing power of quantum computing.


2019 ◽  
Vol 46 (10) ◽  
pp. 1415-1420 ◽  
Author(s):  
Nataliya Milman ◽  
Eilish McConville ◽  
Joanna C. Robson ◽  
Annelies Boonen ◽  
Peter Tugwell ◽  
...  

Objective.Aspects of antineutrophil cytoplasmic antibodies–associated vasculitis (AAV) prioritized by patients with AAV were described using the International Classification of Function, Disability, and Health (ICF).Methods.Items identified during 14 individual interviews were incorporated into an ICF-based questionnaire administered to participants of 2 vasculitis patient symposia: 36 in the United Kingdom and 63 in the United States.Results.Categories identified as at least “moderately relevant” by ≥ 5% of subjects included 44 body functions, 14 body structures, 35 activities and participation, 31 environmental factors, and 38 personal factors.Conclusion.Identified categories differ from those identified by the current Outcome Measures in Rheumatology (OMERACT) core set and those prioritized by vasculitis experts.


2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Diego F. Leal ◽  
Nicolas L. Harder

AbstractEvidence from 184 countries over the span of 25 years is gathered and analyzed to understand North–North, South–South, and North–South international migration flows. Conceptually, the analysis borrows from network theory and Migration Systems Theory (MST) to develop a model to characterize the structure and evolution of international migration flows. Methodologically, the Stochastic Actor-oriented Model of network dynamics is used to jointly model the three types of flows under analysis. Results show that endogenous network effects at the monadic, dyadic, and triadic levels of analysis are relevant to understand the emergence and evolution of migration flows. The findings also show that a core set of non-network covariates, suggested by MST as key drivers of migration flows, does not always explain migration dynamics in the systems under analysis in a consistent fashion; thus, suggesting the existence of important levels of heterogeneity inherent to these three types of flows. Finally, evidence related to the role of political instability and countries’ care deficits is also discussed as part of the analysis. Overall, the results highlight the importance of analyzing flows across the globe beyond typically studied migratory corridors (e.g., North–South flows) or regions (e.g., Europe).


2021 ◽  
Vol 38 ◽  
Author(s):  
Xin Li ◽  
Zi-Wei Yu ◽  
Hui-Yao Li ◽  
Yue Yuan ◽  
Xin-Yuan Gao ◽  
...  

Abstract Microglia, the main immune cell of the central nervous system (CNS), categorized into M1-like phenotype and M2-like phenotype, play important roles in phagocytosis, cell migration, antigen presentation, and cytokine production. As a part of CNS, retinal microglial cells (RMC) play an important role in retinal diseases. Diabetic retinopathy (DR) is one of the most common complications of diabetes. Recent studies have demonstrated that DR is not only a microvascular disease but also retinal neurodegeneration. RMC was regarded as a central role in neurodegeneration and neuroinflammation. Therefore, in this review, we will discuss RMC polarization and its possible regulatory factors in early DR, which will provide new targets and insights for early intervention of DR.


2020 ◽  
Vol 71 (1) ◽  
pp. 435-460 ◽  
Author(s):  
Melvin J. Oliver ◽  
Jill M. Farrant ◽  
Henk W.M. Hilhorst ◽  
Sagadevan Mundree ◽  
Brett Williams ◽  
...  

Desiccation of plants is often lethal but is tolerated by the majority of seeds and by vegetative tissues of only a small number of land plants. Desiccation tolerance is an ancient trait, lost from vegetative tissues following the appearance of tracheids but reappearing in several lineages when selection pressures favored its evolution. Cells of all desiccation-tolerant plants and seeds must possess a core set of mechanisms to protect them from desiccation- and rehydration-induced damage. This review explores how desiccation generates cell damage and how tolerant cells assuage the complex array of mechanical, structural, metabolic, and chemical stresses and survive.Likewise, the stress of rehydration requires appropriate mitigating cellular responses. We also explore what comparative genomics, both structural and responsive, have added to our understanding of cellular protection mechanisms induced by desiccation, and how vegetative desiccation tolerance circumvents destructive, stress-induced cell senescence.


2021 ◽  
Author(s):  
Joanna K. Polko ◽  
Kevin C. Potter ◽  
Christian A. Burr ◽  
G. Eric Schaller ◽  
Joseph J. Kieber

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