OC-0059 Clinical characteristics and risk factors for local failure in cervix cancer patients after MR IGABT

2021 ◽  
Vol 158 ◽  
pp. S45
Author(s):  
M. Schmid ◽  
U. Mahantshetty ◽  
C. Kirisits ◽  
K. Tanderup ◽  
C. Haie-Meder ◽  
...  
Author(s):  
Junnan Liang ◽  
Guannan Jin ◽  
Tongtong Liu ◽  
Jingyuan Wen ◽  
Ganxun Li ◽  
...  

Author(s):  
Kazuki Ishikawa ◽  
Tsuneo Yamashiro ◽  
Takuro Ariga ◽  
Takafumi Toita ◽  
Wataru Kudaka ◽  
...  

Abstract Purpose Fractures are known to shorten life expectancy and worsen the quality of life. The risk of fractures after radiation therapy in cervical cancer patients is known to be multifactorial. In this study, we examined risk factors for fractures in cervical cancer patients, especially by evaluating bone densities and DVH parameters for fractured bones. Materials and Methods For 42 patients, clinical characteristics, pretreatment CT bone densities, and radiation dose were compared between patients with and without fractures. Results Posttreatment fractures occurred in 25 bones among ten patients. Pretreatment CT bone densities were significantly lower in patients with fractures (P < 0.05–0.01 across sites, except for the ilium and the ischium). Although DVH parameters were also significantly associated with fractures in univariate analysis, only CT densities were significantly associated with fractures in multivariate analysis. Conclusion Pretreatment CT densities of spinal and pelvic bones, which may reflect osteoporosis, have a significant impact on the risk for posttreatment fractures.


2021 ◽  
Author(s):  
Yan Huang ◽  
Zhenhong Hu ◽  
Dong Hu ◽  
Zhou Quan ◽  
Xiaoyang Zhou ◽  
...  

2021 ◽  
Vol 11 ◽  
Author(s):  
Kashif Asghar ◽  
Muhammad Abu Bakar ◽  
Muhammad Junaid Akram ◽  
Asim Farooq ◽  
Kashif Siddique ◽  
...  

BackgroundCancer patients are considered as highly vulnerable individuals in the current COVID-19 pandemic. We studied the clinical characteristics of survivor and non-survivor COVID-19-infected cancer patients in Pakistan.Patients and MethodsWe did a retrospective study of 70 cancer patients with PCR-confirmed COVID-19 infection from Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore and Peshawar, Pakistan between April 13 and July 09, 2020. These patients were discharged from the hospital or had died by July 09, 2020. Clinical, pathological and radiological characteristics were compared between survivors and non-survivors by fisher’s exact test and chi-square test. Univariable and multivariable logistic regression models were performed to explore the risk factors of mortality.ResultsSeventy cancer patients with SARS-CoV-2 infection were enrolled and the majority were males 38 (54.3%). 57 (81.4%) had solid tumors and 13 (18.6%) had hematological malignancies. Dyspnea (44 cases) was the most common symptom (62.9%). Complications were reported in 51 (72.9%) patients during the course of disease. 19 (27.1%) patients were admitted to an intensive care unit (ICU). A significant increase in the C-reactive protein level and neutrophil count was observed in the deceased patients as compared to the surviving patients. D-dimer values of ≥0.2 mg/L were significantly associated with mortality (P=0.01). We identified two independent risk factors associated with death, ICU admission (P=0.007) and D-dimer (P=0.003).ConclusionPakistani cancer patients with COVID-19 infection reported poor prognosis. Intensive surveillance of clinicopathological characteristics of cancer patients infected with COVID-19 especially D-dimer values may play a pivotal role in the outcome of the disease.


2016 ◽  
Vol 65 (6) ◽  
pp. 792-796 ◽  
Author(s):  
Ozlem Yersal ◽  
Erdogan Malatyali ◽  
Hatice Ertabaklar ◽  
Esin Oktay ◽  
Sabri Barutca ◽  
...  

2020 ◽  
Vol 9 (6) ◽  
pp. 3957-3965
Author(s):  
Chen Zhang ◽  
Fangyan Gao ◽  
Shidai Jin ◽  
Wen Gao ◽  
Shuangjing Chen ◽  
...  

2020 ◽  
Author(s):  
Chengyuan Qian ◽  
Hong Liu ◽  
Yan Feng ◽  
Shenglan Meng ◽  
Dong Wang ◽  
...  

AbstractBackgroundLung cancer as a second primary malignancy is increasingly common, but the clinical characteristics of second primary non-small cell lung cancer after cervix cancer (CC-NSCLC) in comparison with first primary non-small cell lung cancer (NSCLC1) is unknown.MethodsThe Surveillance, Epidemiology and EndResults (SEER) cancer registry between 1998 and 2010 was used to conduct a large population-based cohort analysis. Demographic and clinical characteristics as well as prognostic data were systematically analyzed. We further compared overall survival (OS) in the two cohorts. Risk factors of secondary primary lung cancer in cervical cancer patients were also analyzed.Results557 (3.52%) had developed second primary lung cancer after cervix cancer and 451 were eligible for inclusion in the final analyses. In comparison to NSCLC1, patients with CC-NSCLC had a higher rate of squamous cell carcinoma (SCC) (36.59% vs. 19.07%, p<0.01). Median OS was longer for CC-NSCLC than for NSCLC1 before propensity score matching (PSM) (16 vs. 13months) but there was no significant difference after PSM. High-risk factors in cervical cancer to developing CC-NSCLC include: 50-79years old, black race (OR 1.417; 95%CI 1.095-1.834; p<0.05)and history of radiotherapy (OR 1.392; 95%CI 1.053-1.841; p<0.05).Conclusion50-79years old, black race and history of radiotherapy were independent risk factors of second primary lung cancer in cervical cancer patient. CC-NSCLC patients had distinctive clinical characteristics and a better prognosis compared with NSCLC1 patients.


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