scholarly journals THE IMPACT OF AGE AND COMPLETION OF A MODERATE DISTANCE RUNNING RACE ON CARDIAC FUNCTION: RESULTS FROM P.E.A.C.H. (PROFILING THE EFFECTS OF AGING ON EXERCISE-INDUCED CHANGES IN CARDIAC MECHANICS)

2016 ◽  
Vol 67 (13) ◽  
pp. 1637
Author(s):  
Jonathan H. Kim ◽  
Yi-An Ko ◽  
Mosaab Awad ◽  
Jeff Hedley ◽  
James Macnamara ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Cardiac Mechanics ◽  
Distance Running ◽  
Exercise Induced ◽  
Effects Of Aging ◽  
Induced Changes ◽  
The Impact

EXERCISE-INDUCED CHANGES IN CARDIAC FUNCTION OF HYPERTENSIVE AND NORMOTENSIVE FEMALE RATS.

2004 ◽  
Vol 22 (Suppl. 1) ◽  
pp. S150
Author(s):  
J M Potenza ◽  
A M Amanso ◽  
S L Amaral ◽  
C RO Carvalho ◽  
L C Michelini ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Female Rats ◽  
Exercise Induced ◽  
Induced Changes

Abstract 2817: The Impact of Exercise-Induced Changes in Intraventricular Dyssynchrony on the Functional Improvement in Patients with Non-Ischemic Cardiomyopathy

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Soo-Jin Kang ◽  
Hong-Seok Lim ◽  
Un-Jung Choi ◽  
Byung-Joo Choi ◽  
So-Yeon Choi ◽  
...  
Keyword(s):  
Ischemic Cardiomyopathy ◽  
Doppler Imaging ◽  
Functional Improvement ◽  
Peak Exercise ◽  
Lv Function ◽  
Functional Changes ◽  
Exercise Induced ◽  
Induced Changes ◽  
The Impact

Background: We studied whether dynamic changes in LV asynchrony may affect the functional improvement of LV in medically treated patients with non-ischemic cardiomyopathy (CMP). Methods: Supine bicycle exercise was performed in 41 patients (age 51±12 years, EF 33±8%). Using tissue Doppler imaging, the average of peak systolic velocities of 6 basal LV segments were obtained at rest (V b ) and peak exercise (V p ). ΔV was calculated by [V p -V b ], reflecting the contractile reserve. Dyssynchrony index (SD 4 ) was defined as the standard deviation of the time to peak systolic velocities at 4 basal & mid segments of septum and lateral wall on apical 4 chamber view. ΔSD 4 was calculated as [peak exercise SD 4 - resting SD 4 ]. Follow-up echocardiography was done in 35 patients after medication for 11.2±4.2 months. Functional changes of LV was assessed by ΔEF FU and %change of ESV (ΔESV FU ). Results: Baseline SD 4 was 24±17 ms. During exercise, SD 4 increased in 24 patients (ΔSD 4 =+14±12 ms), whereas decreased in 17 patients (ΔSD 4 =-17±14 ms). ΔSD 4 correlated with ΔV (r=-0.36, p=0.021) and exercise-induced increase in MR (ΔJet/LA area (%); r=0.31, p=0.05 and ΔPISA radius at 40cm/s of aliasing v; r=0.46, p=0.003). ΔV and ΔPISA were related to the follow-up change of LV function. Especially, ΔSD 4 independently correlated with ΔEF FU (β= -0.82, p<0.001) and also with ΔESV FU (β= 0.40, p=0.021)(Fig ). However, baseline SD 4 didn’t affect ΔEF FU . On ROC curve analysis, sensitivity and specificity of ΔSD 4 <4.0 ms were 82% and 78% for predicting ΔEF FU >+5% and 70% and 63% for predicting ΔESV FU <-15%. Conclusion : Exercise-induced changes in dyssynchrony (ΔSD 4 ) can predict the functional improvement in non-ischemic CMP.

scholarly journals A Noninvasive Radiographic Technique for Evaluation of Exercise-Induced Changes in Cardiac Function

1983 ◽  
Vol 2 (2) ◽  
pp. 318-326 ◽  
Author(s):  
Robert E. Dinsmore ◽  
Harry Phillips ◽  
Charles A. Boucher ◽  
Robert D. Okada ◽  
Fred Kushner ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Radiographic Technique ◽  
Exercise Induced ◽  
Induced Changes

Drug Induced Changes in Cell Organelles

1968 ◽  
Vol 26 ◽  
pp. 110-111
Author(s):  
Sarah A. Luse
Keyword(s):  
Clinical Medicine ◽  
Cell Organelles ◽  
Riboflavin Deficiency ◽  
Drug Induced ◽  
New Era ◽  
Health And Disease ◽  
In The Beginning ◽  
Cellular Pathology ◽  
Induced Changes ◽  
The Impact

In the mid-nineteenth century Virchow revolutionized pathology by introduction of the concept of “cellular pathology”. Today, a century later, this term has increasing significance in health and disease. We now are in the beginning of a new era in pathology, one which might well be termed “organelle pathology” or “subcellular pathology”. The impact of lysosomal diseases on clinical medicine exemplifies this role of pathology of organelles in elucidation of disease today.Another aspect of cell organelles of prime importance is their pathologic alteration by drugs, toxins, hormones and malnutrition. The sensitivity of cell organelles to minute alterations in their environment offers an accurate evaluation of the site of action of drugs in the study of both function and toxicity. Examples of mitochondrial lesions include the effect of DDD on the adrenal cortex, riboflavin deficiency on liver cells, elevated blood ammonia on the neuron and some 8-aminoquinolines on myocardium.

Effect of Glycosaminoglycans on Thrombin- and Atroxin-Induced Fibrin Assembly and Structure

1989 ◽  
Vol 62 (04) ◽  
pp. 1057-1061 ◽  
Author(s):  
Marcus E Carr ◽  
Patrick L Powers
Keyword(s):  
Chondroitin Sulfate ◽  
Fiber Diameter ◽  
Lag Phase ◽  
Low Molecular Weight ◽  
Fibrin Gels ◽  
Fiber Size ◽  
Induced Changes ◽  
The Impact ◽  
Fiber Radius ◽  
Turbidity Increase

SummaryThis study was performed to quantitate the impact of several glycosaminoglycans (GAG) on fibrin assembly and structure. Gel formation was monitored as the increase in optical density at 633 nm subsequent to thrombin (2 NIH u/ml) or atroxin (0.10 mg/ml) addition to solutions of buffered fibrinogen (1 mg/ml) or plasma. Gel absorbance was measured as a function of wavelength (400 to 800 nm) and gel fiber diameter and mass/length ratio (μ) were calculated. Chondroitin sulfate A (CSA)shortened the lag phase, enhanced the maximal rate of turbidity increase, and increased the final gel turbidity of fibrin gels formed by thrombin or atroxin. CSA (16 mg/ml) increased fiber μ from 1.3 to 3.1 × 1013 dalton/cm and fiber radius from 6.0 to 8.6 × 10-6 cm in thrombin-induced gels. μ increased from 0.7 to 2.7 × 1013 dalton/cm and fiber radius from 4 to 7.8 × 10-6 cm for atroxin-induced gels. Above 16 mg/ml, CSA caused fibrinogen precipitation in purified solutions but not in plasma. CSA inhibited thrombin-induced plasma clotting of plasma but effects in atroxin-mediated plasma gels paralleled those seen in purified solutions. Chondroitin sulfate B (CSB)-induced changes in fibrin were similar but slightly less dramatic than those seen with CSA. μ increased from 0.9 to 2.0 × 1013 dalton/cm for thrombin-induced fibrin gels and from 0.8 to 2.3 × 1013 dalton/cm for atroxininduced gels. Low molecular weight heparin (Mr = 5100) slowed fibrin assembly and reduced fiber size by 50% in thrombininduced gels. Changes in μ of atroxin-induced gels were much less pronounced (<20%). This study documents pronounced GAGinduced changes in fibrin structure which vary with GAG species and may mediate significant physiologic functions.

scholarly journals Exogenous application of growth stimulators improves the condition of maize exposed to soil drought

2021 ◽  
Vol 43 (4) ◽  
Author(s):  
Agnieszka Ostrowska ◽  
Maciej T. Grzesiak ◽  
Tomasz Hura
Keyword(s):  
Plant Growth ◽  
Developmental Stages ◽  
Aminolevulinic Acid ◽  
Stem Elongation ◽  
Development Stage ◽  
Photochemical Activity ◽  
Soil Drought ◽  
Beneficial Effects ◽  
Induced Changes ◽  
The Impact

AbstractSoil drought is a major problem in plant cultivation. This is particularly true for thermophilic plants, such as maize, which grow in areas often affected by precipitation shortage. The problem may be alleviated using plant growth and development stimulators. Therefore, the aim of the study was to analyze the effects of 5-aminolevulinic acid (5-ALA), zearalenone (ZEN), triacontanol (TRIA) and silicon (Si) on water management and photosynthetic activity of maize under soil drought. The experiments covered three developmental stages: three leaves, stem elongation and heading. The impact of these substances applied during drought stress depended on the plant development stage. 5-ALA affected chlorophyll levels, gas exchange and photochemical activity of PSII. Similar effects were observed for ZEN, which additionally induced stem elongation and limited dehydration. Beneficial effects of TRIA were visible at the stage of three leaves and involved leaf hydration and plant growth. A silicon preparation applied at the same developmental stage triggered similar effects and additionally induced changes in chlorophyll levels. All the stimulators significantly affected transpiration intensity at the heading stage.

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