Intensity of Depressive Symptoms and Disorders of Working Memory and Executive Functions in Hyperthyroidism in the Course of Graves’ Disease and Toxic Nodular Goitre

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
K. Jabłkowska ◽  
K. Nowakowska ◽  
G. Adamiak ◽  
A. Borkowska
Keyword(s):  
Working Memory ◽  
Executive Functions ◽  
Wisconsin Card Sorting Test ◽  
Thyroid Diseases ◽  
Control Group ◽  
Depression Symptoms ◽  
Graves Disease ◽  
Nodular Goitre ◽  
Increased Risk ◽  
Toxic Nodular Goitre

Current data show an association between thyroid diseases and cognitive dysfunction and depression. Depression may affect the clinical picture and the course of thyroid diseases, while also certain correlations are seen between depression and an increased risk of the incidence of these diseases.The aim of this study was tracing associations among depression and hyperthyroidism in the course of Graves’ disease and toxic nodular goitre in particular stages of the disease and frontal cognitive function.Eighty persons (63 females and 17 males) with diagnosed hyperthyroidism, their age ranging between 18 and 55 years, were qualified into the study, fifty (50) of them with Graves’ disease and thirty (30) with toxic nodular goitre.Following performed hormonal evaluations, patients with overt or subclinical hyperthyroidism were identified, together with patients in euthyroidism.The control group included thirty-one (31) healthy volunteers, matched with the study group, regarding their age, sex and education.In the evaluation of working memory and executive functions, the Wisconsin Card Sorting Test (WCST) was used, while Beck Depression Inventory (BDI) was applied to determine the degree of depression symptoms.The obtained results showed impairment of WCST performance in patients with Graves’ disease and with toxic nodular goitre. Any significant associations between the degree of depression symptoms and the efficiency of either working memory or executive functions were found.Acknowledgements:This research was supported by grant 502-16-683 Medical University of Lodz.

Executive Function Deficits in Patients after Cerebellar Neurosurgery

2015 ◽  
Vol 22 (1) ◽  
pp. 47-57 ◽  
Author(s):  
Monika Mak ◽  
Ernest Tyburski ◽  
Łukasz Madany ◽  
Andrzej Sokołowski ◽  
Agnieszka Samochowiec
Keyword(s):  
Working Memory ◽  
Executive Functions ◽  
Response Times ◽  
Digit Span ◽  
Wisconsin Card Sorting Test ◽  
Control Group ◽  
Card Sorting ◽  
Mediating Role ◽  
Regulatory Processes ◽  
Perseverative Errors

AbstractThe cerebellum has long been perceived as a structure responsible for the human motor function. According to the contemporary approach, however, it plays a significant role in complex behavior regulatory processes. The aim of this study was to describe executive functions in patients after cerebellar surgery. The study involved 30 patients with cerebellar pathology. The control group comprised 30 neurologically and mentally healthy individuals, matched for sex, age, and number of years of education. Executive functions were measured by the Wisconsin Card Sorting Test (WCST), Stroop Color Word Test (SCWT), Trail Making Test (TMT), and working memory by the Digit Span. Compared to healthy controls, patients made more Errors and Perseverative errors in the WCST, gave more Perseverative responses, and had a lower Number of categories completed. The patients exhibited higher response times in all three parts of the SCWT and TMT A and B. No significant differences between the two groups were reported in their performance of the SCWT and TMT with regard to the measures of absolute or relative interference. The patients had lower score on the backward Digit Span. Patients with cerebellar pathology may exhibit some impairment within problem solving and working memory. Their worse performance on the SCWT and TMT could, in turn, stem from their poor motor–somatosensory control, and not necessarily executive deficits. Our results thus support the hypothesis of the cerebellum’s mediating role in the regulation of the activity of the superordinate cognitive control network in the brain. (JINS, 2016, 22, 47–57)

scholarly journals Smoking and thyroid disorders--a meta-analysis

2002 ◽  
pp. 153-161 ◽  
Author(s):  
P Vestergaard
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
Post Partum ◽  
Statistical Significance ◽  
Hashimoto's Thyroiditis ◽  
Graves Disease ◽  
Thyroid Disorders ◽  
Nodular Goitre ◽  
Graves Ophthalmopathy ◽  
Increased Risk ◽  
Toxic Nodular Goitre

BACKGROUND: Smoking has been associated with Graves' disease, but it remains unclear if the association is present in other thyroid disorders. OUTCOME VARIABLES: Graves' disease, Graves' ophthalmopathy, toxic nodular goitre, non-toxic goitre, post-partum thyroid disease, Hashimoto's thyroiditis, or hypothyroidism. MATERIAL AND METHODS: A search of MEDLINE identified 25 studies on the association between smoking and thyroid diseases. RESULTS: In Graves' disease eight studies were available showing an odds ratio (OR) of 3.30 (95% confidence interval (CI): 2.09-5.22) in current smokers compared with never smokers. In ex-smokers there was no significant excess risk of Graves' disease (OR=1.41, 95% CI: 0.77-2.58). The OR associated with ever smoking in Graves' ophthalmopathy (4.40, 95% CI: 2.88-6.73, six studies) was significantly higher than in Graves' disease (1.90, 95% CI: 1.42-2.55, two-sided P-value <0.01). Ever smoking was not associated with toxic nodular goitre (OR=1.27, 95% CI: 0.69-2.33, three studies), while there was an increased risk of non-toxic goitre in smokers if men were excluded (OR=1.29, 95% CI: 1.01-1.65, eight studies). The risk associated with smoking was significantly lower in men than in women for both Graves' disease and non-toxic goitre. Hashimoto's thyroiditis and post-partum thyroid dysfunction were also associated with smoking while the association with hypothyroidism did not reach statistical significance. CONCLUSIONS: Cessation of smoking seems associated with a lower risk of Graves' disease than current smoking. Smoking increases the risk of Graves' ophthalmopathy beyond the risk associated with Graves' disease alone. Smoking cessation may lead to a decrease in morbidity from Graves' disease, especially in women.

Development of a Program based on Goal Management Training for Adolescents with Executive Dysfunctions Complaints

2021 ◽  
Vol 24 ◽  
Author(s):  
Liana Garcia Nunes ◽  
Alessandra Gotuzo Seabra
Keyword(s):  
Working Memory ◽  
Executive Functions ◽  
Execution Time ◽  
Management Training ◽  
Intellectual Ability ◽  
Control Group ◽  
Goal Management ◽  
Executive Dysfunctions ◽  
Goal Management Training

Abstract This study aimed to develop a program based on Goal Management Training (GMT) and to investigate its effectiveness on executive functions, through formal instruments and an ecological task. Participants were 25 adolescents with complaints of executive dysfunctions. They underwent neuropsychological assessment of working memory, inhibitory control, cognitive flexibility, planning, and intellectual ability. Participants also took part in a cooking activity and were evaluated for errors per action, of omission, activity performance time, recipe consultation. After, they were randomly allocated to an active control group (CG), which underwent psychoeducation sessions, and an experimental group (EG), stimulated through GMT in eight sessions. Then participants underwent another assessment and follow-up after 4 weeks. In post-intervention analyses, results showed an improvement in executive functions in EG, in the working memory measurement and time of the ecological activity (g = 1.78 and .93, respectively), IQ (g = −1.01), reasoning (g = −.89), flexibility (g = −1.21), and inhibition (g = −3.11). In follow-up evaluation, large-size effects were observed on flexibility (g = −2.95), inhibition (g = −5.78) and execution time of the ecological activity (g = .98). Significant interactions between assessment Time x Group revealed EG gains in IQ, scores in reasoning and flexibility. EG also had longer execution time in flexibility and inhibition tests. That is, EG had greater scores and probably was less impulsive in these tests. Furthermore, EG decreased the number of verifications and the time in the ecological task, that is, had a more efficient performance. Results suggest the intervention can be as instrument to promote executive function.

scholarly journals Clinical and neuropsychological assessment of executive function in a sample of children and adolescents with idiopathic epilepsy

2014 ◽  
Vol 72 (12) ◽  
pp. 954-959 ◽  
Author(s):  
Andrea Bandeira de Lima ◽  
Fernanda Moreira ◽  
Marleide da Mota Gomes ◽  
Heber Maia-Filho
Keyword(s):  
Academic Performance ◽  
Executive Function ◽  
Executive Functions ◽  
Children And Adolescents ◽  
Clinical Data ◽  
Wisconsin Card Sorting Test ◽  
Idiopathic Epilepsy ◽  
Control Group ◽  
Seizure Type ◽  
Card Sorting

Objective To compare the executive functions of children and adolescents with idiopathic epilepsy with a control group and to correlate with clinical data, intelligence and academic performance. Method Cross-sectional, descriptive and analytical study. Thirty-one cases and thirty-five controls were evaluated by the WCST (Wisconsin Card Sorting Test).The results were compared with clinical data (seizure type and frequency, disease duration and number of antiepileptic drugs used), IQ (WISC-III) and academic performance (APT). Results Patients with epilepsy had poorer executive function scores. There was no positive linear correlation between test scores and epilepsy variables. There was a positive association between academic performance and some executive function results. Conclusion Children with well controlled idiopathic epilepsy may show deficits in executive functions in spite of clinical variables. Those deficits may influence academic performance.

scholarly journals Mathematics Skills and Executive Functions Following Preterm Birth: A Longitudinal Study of 5-to 7- Year Old Children

2019 ◽  
Author(s):  
Julia Anna Adrian ◽  
Frank Haist ◽  
Natacha Akshoomoff
Keyword(s):  
Working Memory ◽  
Executive Functions ◽  
Processing Speed ◽  
Spatial Working Memory ◽  
Working Memory Capacity ◽  
Full Term ◽  
Healthy Children ◽  
Time Points ◽  
Mathematics Skills ◽  
Increased Risk

Early mathematics skills are an important predictor of later academic, economic and personal success. Children born preterm, about 10% of the US population, have an increased risk of deficits in mathematics. These deficits may be related to lower levels of executive functions and processing speed. We investigated the development of mathematics skills, working memory, inhibitory control and processing speed of healthy children born very preterm (between 25 and 32 weeks gestational age, n=51) and full-term (n=29). Children were tested annually from ages 5 to 7 years. We found persistent lower overall mathematics skills in the preterm group, driven by differences in more informal skills (e.g. counting) at earlier time points, and by differences in more formal skills (e.g. calculation) at later time points. We did not find significant differences between preterm and full-term born children in spatial working memory capacity or processing speed. However, these cognitive measures were significant predictors of mathematics skills in the preterm but not the full-term group, hinting towards the use of different strategies when solving problems.

scholarly journals Polymorphisms of IKZF3 Gene and Autoimmune Thyroid Diseases: Associated with Graves’ Disease but Not with Hashimoto’s Thyroiditis

2018 ◽  
Vol 45 (5) ◽  
pp. 1787-1796 ◽  
Author(s):  
Ling Li ◽  
Xiaolian Ding ◽  
Xuan Wang ◽  
Qiuming Yao ◽  
Xiaoqing Shao ◽  
...  
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
Zinc Finger Protein ◽  
Thyroid Diseases ◽  
Hashimoto's Thyroiditis ◽  
Control Group ◽  
Graves Disease ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Significant Difference ◽  
Proliferation And Differentiation

Background/Aims: The IKZF3 gene encodes a zinc-finger protein that plays an important role in the proliferation and differentiation of B lymphocytes. Autoimmune thyroid diseases (AITDs), mainly include Graves’ disease (GD) and Hashimoto’s thyroiditis (HT), are probably caused by the aberrant proliferation of B cells. The objective of this study was to explore the association between IKZF3 polymorphisms and AITDs. Methods: We examined 915 AITD patients (604 GD and 311 HT) and 814 healthy controls. IKZF3 variants (rs2941522, rs907091, rs1453559, rs12150079 and rs2872507) were tested by PCR-ligase detection reaction. Results: It was manifested that that the minor alleles of the five loci increased susceptibility to GD (p<0.05 for rs2941522, and p<0.01 for rs907091, rs1453559, rs12150079 and rs2872507) but in HT patients, these loci showed no significant difference compared with controls. Similarly, the genotype distributions of GD patients manifested obvious differences in all these loci compared with the control group, whereas no statistical differences were observed between HT patients and controls. Furthermore, bioinformatics tools were used to analyze rs1453559, rs12150079 and rs907091. These variants were believed to be the transcription regulator. Conclusion: It is the first time we reported the association between the IKZF3 polymorphisms and GD, indicating that IKZF3 gene tends to bean important risk factor for the development of GD.

scholarly journals Effects of Selenium Supplementation on Graves’ Disease: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Huijuan Zheng ◽  
Junping Wei ◽  
Liansheng Wang ◽  
Qiuhong Wang ◽  
Jing Zhao ◽  
...  
Keyword(s):  
Systematic Review ◽  
Thyroid Function ◽  
Meta Analysis ◽  
Selenium Supplementation ◽  
Control Group ◽  
Graves Disease ◽  
Cochrane Central Register ◽  
Placebo Administration ◽  
Increased Risk ◽  
Tsh Levels

Low selenium status is associated with increased risk of Graves’ disease (GD). While several trials have discussed the efficacy of selenium supplementation for thyroid function, in GD patients, the effectiveness of selenium intake as adjuvant therapy remains unclear. In this systematic review and meta-analysis, we aimed to determine the efficacy of selenium supplementation on thyroid function in GD patients. Two reviewers searched PubMed, Web of Science, the Cochrane Central Register of Controlled Trials, and four Chinese databases for studies published up to October 31, 2017. RCTs comparing the effect of selenium supplementation on thyroid hyperfunction in GD patients on antithyroid medication to placebo were included. Serum free thyroxine (FT4), free triiodothyronine (FT3), thyrotrophic hormone receptor antibody (TRAb), and thyroid-stimulating hormone (TSH) levels were assessed. Ten trials involving 796 patients were included. Random-effects meta-analyses in weighted mean difference (WMD) were performed for 3, 6, and 9 months of supplementation and compared to placebo administration. Selenium supplementation significantly decreased FT4 (WMD=-0.86 [confidence interval (CI)-1.20 to -0.53]; p=0.756; I2=0.0%) and FT3 (WMD=-0.34 [CI-0.66 to -0.02]; p=0.719; I2=0.0%) levels at 3 months, compared to placebo administration; these findings were consistent at 6 but not 9 months. TSH levels were more elevated in the group of patients taking selenium than in the control group at 3 and 6, but not 9 months. TRAb levels decreased at 6 but not 9 months. At 6 months, patients on selenium supplementation were more likely than controls to show improved thyroid function; however, the effect disappeared at 9 months. Whether these effects correlate with clinically relevant measures remains to be demonstrated.

scholarly journals Association of Sleep Quality on Memory-Related Executive Functions in Middle Age

2017 ◽  
Vol 24 (1) ◽  
pp. 67-76 ◽  
Author(s):  
Brinda K. Rana ◽  
Matthew S. Panizzon ◽  
Carol E. Franz ◽  
Kelly M. Spoon ◽  
Kristen C. Jacobson ◽  
...  
Keyword(s):  
Working Memory ◽  
Executive Function ◽  
Episodic Memory ◽  
Sleep Quality ◽  
Executive Functions ◽  
Later Life ◽  
Set Shifting ◽  
Interference Control ◽  
Visual Spatial ◽  
Increased Risk

AbstractObjectives: Sleep quality affects memory and executive function in older adults, but little is known about its effects in midlife. If it affects cognition in midlife, it may be a modifiable factor for later-life functioning. Methods: We examined the association between sleep quality and cognition in 1220 middle-aged male twins (age 51–60 years) from the Vietnam Era Twin Study of Aging. We interviewed participants with the Pittsburgh Sleep Quality Index and tested them for episodic memory as well as executive functions of inhibitory and interference control, updating in working memory, and set shifting. Interference control was assessed during episodic memory, inhibitory control during working memory, and non-memory conditions and set shifting during working memory and non-memory conditions. Results: After adjusting for covariates and correcting for multiple comparisons, sleep quality was positively associated with updating in working memory, set shifting in the context of working memory, and better visual-spatial (but not verbal) episodic memory, and at trend level, with interference control in the context of episodic memory. Conclusions: Sleep quality was associated with visual-spatial recall and possible resistance to proactive/retroactive interference. It was also associated with updating in working memory and with set shifting, but only when working memory demands were relatively high. Thus, effects of sleep quality on midlife cognition appear to be at the intersection of executive function and memory processes. Subtle deficits in these age-susceptible cognitive functions may indicate increased risk for decline in cognitive abilities later in life that might be reduced by improved midlife sleep quality. (JINS, 2018, 24, 67–76)

STATISTICAL EVALUATION OF SYMPTOMS AND CLINICAL SIGNS IN THE DIAGNOSIS OF HYPERTHYROIDISM

1969 ◽  
Vol 62 (4_Suppla) ◽  
pp. S37-S42
Author(s):  
B.-A. Lamberg ◽  
O. P. Heinonen ◽  
A. Aro ◽  
M. Viherkoski ◽  
P. Knekt
Keyword(s):  
Nervous System ◽  
Statistical Evaluation ◽  
Clinical Signs ◽  
Control Group ◽  
Nodular Goitre ◽  
The Difference ◽  
Hyperthyroid Patients ◽  
Symptoms And Signs ◽  
Toxic Nodular Goitre ◽  
Stimulation Of

ABSTRACT The occurrence of 15 symptoms and 11 clinical signs was studied in 101 hyperthyroid patients and 106 euthyroid subjects. The hyperthyroid group comprised 50 patients with toxic diffuse goitre and 51 with toxic nodular goitre. The control group included 31 subjects with non-toxic goitre. The symptoms and signs were registered in a standardised manner. The difference in the frequency of each symptom and sign between the hyperthyroid and the control group was analysed statistically. The most discriminatory were the symptoms and signs related to excessive production of heat and to stimulation of the nervous system. The results were mostly in agreement with those of the few previously existing reports. Lid signs, however, were in both groups less frequent than in a British material. The need for standardisation in registration of symptoms and signs is emphasized.

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