[3] ADHERENCE TO RESTRICTED-CALORIE, MEDITERRANEAN DIET IMPROVES ENDOTHELIAL DYSFUNCTION AND OXIDATIVE STRESS IN PATIENTS WITH THE METABOLIC SYNDROME

The metabolic syndrome (MetS) is a precursor of diabetes. Physical activity (PA) improves endothelial dysfunction and may benefit patients with MetS. Aims. To evaluate the effect of a physical activity (PA) program on markers of endothelial dysfunction and oxidative stress in adolescents with (MetS). Methods. We carried out a cohort study of 38 adolescents with and without MetS (18 females and 20 males). All participants completed a 3-month PA program. All variables of the MetS as well as markers of endothelial dysfunction and oxidative stress tests were evaluated. Results. Females with and without MetS showed significant differences for almost all components of the MetS, whereas males were significantly different in half of the components. After the PA program, components of the MetS were not different from baseline values except for HDL-C levels. Some baseline endothelial dysfunction markers were significantly different among adolescents with and without MetS; however, after the PA program, most of these markers significantly improved in subjects with and without MetS. Conclusion. PA improves the markers of endothelial dysfunction in adolescents with MetS although other changes in the components of the MetS were not observed. Perhaps the benefits of PA on all components of MetS would appear after a PA program with a longer duration.

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Weight loss is associated with improved endothelial dysfunction via NOX2-generated oxidative stress down-regulation in patients with the metabolic syndrome

Internal and Emergency Medicine ◽

10.1007/s11739-011-0591-x ◽

2011 ◽

Vol 7 (3) ◽

pp. 219-227 ◽

Cited By ~ 31

Author(s):

Francesco Angelico ◽

Lorenzo Loffredo ◽

Pasquale Pignatelli ◽

Teresa Augelletti ◽

Roberto Carnevale ◽

...

Keyword(s):

Oxidative Stress ◽

Metabolic Syndrome ◽

Weight Loss ◽

Endothelial Dysfunction ◽

Down Regulation ◽

The Metabolic Syndrome

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Correlation of Ferritin and Transferrin Serum with hsCRP and F2-Isoprostane in Metabolic Syndrome

The Indonesian Biomedical Journal ◽

10.18585/inabj.v2i3.127 ◽

2010 ◽

Vol 2 (3) ◽

pp. 131

Author(s):

Waode Nurfina ◽

Irawan Yusuf ◽

Mansyur Arif

Keyword(s):

Oxidative Stress ◽

Metabolic Syndrome ◽

Iron Status ◽

High Sensitivity ◽

C Reactive Protein ◽

Reactive Protein ◽

The Metabolic Syndrome ◽

Metabolic Conditions ◽

Inflammatory State ◽

And Oxidative Stress

BACKGROUND: The low inflammatory state that accompanies the Metabolic Syndrome (MetS) associates with the overexpression of oxidative stress. Ferritin and Transferrin serum are often used to measure iron status and their concentrations are altered in several metabolic conditions. We hypothesized that concentration of Ferritin and Transferrin serum increase in Metabolic Syndrome (MetS) and correlate with the inflammation and oxidative stress.METHODS: We studied 65 male MetS patients, aged 43.26±7.16 years. Iron metabolism was measured by concentration of Ferritin and Transferrin serums, while inflammatory and oxidative stress by high sensitivity C-reactive Protein (hsCRP) and F2-Isoprostane.RESULTS: Concentration of Ferritin 315.70±188.63 ng/L and Transferrin 2.36±0.31 g/L increased along with increasing components of MetS. Concentration of Ferritin serum had a positive correlation with hsCRP (r=0.220) and F2-Isoprostane (r=0.023).CONCLUSION: Serum concentration of Ferritin increased in the MetS and correlates with hsCRP and F2-Isoprostane.KEYWORDS: metabolic syndrome, ferritin, transferrin, hsCRP, F2-isoprostane

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222 DAILY TREATMENT WITH SILDENAFIL REVERSES ENDOTHELIAL DYSFUNCTION AND OXIDATIVE STRESS IN AN ANIMAL MODEL OF METABOLIC SYNDROME

European Urology Supplements ◽

10.1016/s1569-9056(07)60221-8 ◽

2007 ◽

Vol 6 (2) ◽

pp. 78 ◽

Cited By ~ 1

Author(s):

D. Behr-Roussel ◽

A. Oudot ◽

S. Caisey ◽

O. Le Coz ◽

C. Wayman ◽

...

Keyword(s):

Oxidative Stress ◽

Metabolic Syndrome ◽

Animal Model ◽

Endothelial Dysfunction ◽

Daily Treatment ◽

And Oxidative Stress

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Effect ofBifidobacterium lactisHN019 on inflammatory markers and oxidative stress in subjects with and without the metabolic syndrome

British Journal Of Nutrition ◽

10.1017/s0007114518001861 ◽

2018 ◽

Vol 120 (6) ◽

pp. 645-652 ◽

Cited By ~ 5

Author(s):

Luciana J. Bernini ◽

Andréa N. Colado Simão ◽

Cínthia H. B. de Souza ◽

Daniela F. Alfieri ◽

Liliane G. Segura ◽

...

Keyword(s):

Oxidative Stress ◽

Metabolic Syndrome ◽

Inflammatory Markers ◽

Healthy Subjects ◽

Antioxidant Defenses ◽

Beneficial Effects ◽

The Metabolic Syndrome ◽

Inflammatory State ◽

Baseline Values ◽

And Oxidative Stress

AbstractBeneficial effects of probiotics have been reported on body weight, lipid and carbohydrate metabolism, inflammatory state and oxidative stress in healthy subjects and in many metabolic and inflammatory diseases. The aim of this study was to evaluate the effects ofBifidobacterium lactisHN019 on inflammatory state and nitro-oxidative stress in patients with and without the metabolic syndrome (MetS). The usual diets of the thirty-three subjects were supplemented with probiotic milk for 90 d. Inflammatory markers and oxidative measurements were performed. In relation to the baseline values, subjects in both groups showed a decrease in homocysteine (P=0·02 andP=0·03, respectively), hydroperoxides (P=0·02 andP=0·01, respectively) and IL-6 levels (P=0·02). Increases in adiponectin (P=0·04) and nitric oxide metabolites (NOx,P=0·001) levels were only seen in the group with the MetS in relation to the baseline values, whereas only the individuals without the MetS had increases in total radical-trapping antioxidant parameter levels (P=0·002). In conclusion,B. lactisHN019 have several beneficial effects on inflammatory and oxidative biomarkers in healthy subjects and the MetS patients. Patients with the MetS showed a specific improvement in adiponectin and NOx levels, whereas a specific favourable effect was shown in the antioxidant defenses in healthy subjects. If the results obtained in the present study are confirmed, supplementation of fermented milk with probiotics in healthy subjects and patients with the MetS must be further discussed.

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