Chemo-enzymatic approaches for the creation of novel chiral building blocks and reagents for pharmaceutical applications

2002 ◽  
Vol 19-20 ◽  
pp. 55-66 ◽  
Author(s):  
Kurt Laumen ◽  
Matthias Kittelmann ◽  
Oreste Ghisalba
Keyword(s):  
Building Blocks ◽  
Pharmaceutical Applications ◽  
The Creation

Studying Palestinian-Israeli Relations at the Vanderbilt Television News Archive (VTNA)

2000 ◽  
Vol 34 (1) ◽  
pp. 38-40
Author(s):  
Deborah L. Wheeler
Keyword(s):  
Mass Media ◽  
Collective Identity ◽  
Television News ◽  
Building Blocks ◽  
Media Culture ◽  
The Past ◽  
Shared Identity ◽  
P 16 ◽  
The Creation ◽  
Words And Images

For the Past Five Decades, media texts, broadcast over television air waves, have created a shared identity among viewing audiences. John B. Thompson notes that if culture is understood as “the ways in which meaningful expressions of various kinds are produced, constructed and received by individuals”, then mass media can be understood as central to the creation and maintenance of culture (pp. 122-23). The words and images that construct a media culture are the very building blocks of collective identity. As Michael Schudson observes, “news is part of the background through which and with which people think” (p. 16).

scholarly journals Same but Different: Chaos and TV Drama Narratives

2021 ◽  
Author(s):  
◽  
Alison McLachlan
Keyword(s):  
Building Blocks ◽  
Narrative Form ◽  
Critical Examination ◽  
Narrative Strategies ◽  
Fundamental Level ◽  
The Creation ◽  
Basic Level ◽  
Mathematics And Science ◽  
The Way

<p>Complexity is a term that is now commonly used when discussing TV serial dramas and the way that, in recent years, creators and producers of this narrative form have embraced innovative and challenging strategies to tell their stories. As a result, it is also often argued that all TV serial dramas are strikingly different from one another; one of the few things that contemporary TV serial dramas have in common is their employment of complex narrative strategies. However, in this thesis, I argue that—while serial dramas are different from one another in many ways—they are also all the same at a fundamental level.  In order to examine the fundamental narrative components that all serial dramas employ, I use chaos as a framework. Chaos is a branch of mathematics and science which examines systems that display unpredictable behaviour that is actually determined by deep structures of order and stability. At its most basic level, chaos corresponds with the way in which serial dramas are both complex and simple at the same time; beneath the complexity of serial dramas are fundamental building blocks that are used to generate innovative, challenging and unpredictable narratives.  I apply the findings from my critical examination of chaos and TV drama narratives to the creation of my own TV projects, which employ the inherent structures and patterns of TV drama narratives in a way that produces innovative and complex stories. In doing so, I intend to highlight the potential of serial dramas to be endlessly creative yet consistently the same.</p>

Nanoparticle assembly: from fundamentals to applications: concluding remarks

2016 ◽  
Vol 186 ◽  
pp. 529-537 ◽  
Author(s):  
Oleg Gang
Keyword(s):  
Dynamic Behavior ◽  
Self Assembly ◽  
Building Blocks ◽  
Nanoparticle Assembly ◽  
New Materials ◽  
Practical Applications ◽  
Current Trends ◽  
Novel Approaches ◽  
The Creation

Nanoparticles, due to their broadly tunable functions, are major building blocks for generating new materials. However, building such materials for practical applications by self-assembly is quite challenging. Following the Faraday Discussion on “Nanoparticle Assembly: from Fundamentals to Applications” we discuss here the current trends in the field of self-assembly, including: understanding the unique interplay of molecular and nanoscale effects, a development of novel approaches for the creation of targeted nanoparticle architectures, advances in controlling dynamic behavior of systems and enabling new functions through specifically formed structures.

Creating Successful Portals with a Design Framework

2009 ◽  
Vol 1 (4) ◽  
pp. 63-75 ◽  
Author(s):  
Joe Lamantia
Keyword(s):  
Building Block ◽  
Large Scale ◽  
Building Blocks ◽  
Design Principles ◽  
Design Framework ◽  
Block System ◽  
Business Information ◽  
Social Settings ◽  
The Creation ◽  
Over Time

Portal designers and managers face the difficulties of creating effective information architectures for portals, dashboards, and tile-based platforms for delivering business information and functionality using only flat portlets. This article introduces the idea of a system of standardized building blocks that can simplifies portal design and management, and effectively support growth in content, functionality, and users over time. In enterprise and other large scale social settings, using standardized components allows for the creation of a library of tiles that can be shared across communities of users. It then outlines the design principles underlying the building block system, and the simple guidelines for combining blocks together to create any type of tile-based environment.

Creating Successful Portals with a Design Framework

2011 ◽  
pp. 246-256
Author(s):  
Joe Lamantia
Keyword(s):  
Building Block ◽  
Large Scale ◽  
Building Blocks ◽  
Design Principles ◽  
Design Framework ◽  
Block System ◽  
Social Settings ◽  
The Creation ◽  
Over Time

Portal practitioners face the difficulties of creating effective information architectures for portals, dashboards, and tile-based information environments using only flat portlets. This article introduces the idea of a system of standardized building blocks that can effectively support growth in content, functionality, and users over time. In enterprise and other large scale social settings, using standardized components allows for the creation of a library of tiles that can be shared across communities of users. It then outlines the design principles underlying the building block system, and the simple guidelines for combining blocks together to create any type of tile-based environment.

5-Iodo-1H-1,2,3-triazoles as Versatile Building Blocks

Synthesis ◽  
2020 ◽  
Vol 52 (13) ◽  
pp. 1874-1896 ◽  
Author(s):  
Irina A. Balova ◽  
Natalia A. Danilkina ◽  
Anastasia I. Govdi
Keyword(s):  
Bond Formation ◽  
Cross Coupling ◽  
Building Blocks ◽  
Terminal Alkynes ◽  
Direct Arylation ◽  
Halogen Exchange ◽  
The Creation ◽  
Radiolabeled Compounds ◽  
Synthetic Approaches ◽  
Synthetic Application

Copper-catalyzed azide–alkyne cycloaddition is a useful tool for the synthesis of both 1,2,3-triazoles and 5-iodo-1H-1,2,3-triazoles starting from either terminal alkynes or iodoalkynes. 5-Iodotriazoles have been recognized as very useful building blocks for the synthesis of diverse 1,4,5-trisubstituted 1,2,3-triazoles. Synthetic application of 5-iodo-1,2,3-triazoles through the creation of a new C–C, C–heteroatom, or C–D(T) bond along with the application areas of both iodotriazoles and products of their modification including radiolabeled compounds are discussed.1 Introduction2 Synthetic Approaches to 5-Iodo-1H-1,2,3-triazoles3 5-Iodotriazoles in C–C Bond Formation3.1 Intermolecular C–C Cross-Coupling3.2 Intramolecular Cross-Coupling: Direct Arylation and C–I/C–I Homocoupling­3.3 Other Transformations4 5-Iodotriazoles in Radiolabeling, Halogen Exchange, and Heterocoupling Reactions5 Summary

scholarly journals Self-assembly of “patchy” nanoparticles: a versatile approach to functional hierarchical materials

2015 ◽  
Vol 6 (7) ◽  
pp. 3663-3673 ◽  
Author(s):  
David J. Lunn ◽  
John R. Finnegan ◽  
Ian Manners
Keyword(s):  
Self Assembly ◽  
Building Blocks ◽  
Solution Phase ◽  
Hierarchical Materials ◽  
The Creation ◽  
Patchy Nanoparticles ◽  
Multicompartment Micelles

The solution-phase self-assembly or “polymerization” of discrete colloidal building blocks, such as “patchy” nanoparticles and multicompartment micelles, is attracting growing attention with respect to the creation of complex hierarchical materials.

Synthesis of a Scaffold for the Creation of Non-Peptide Libraries

1995 ◽  
Vol 60 (12) ◽  
pp. 2147-2155 ◽  
Author(s):  
Alexander Kasal ◽  
Ladislav Kohout ◽  
Michal Lebl
Keyword(s):  
Functional Groups ◽  
Acid Derivative ◽  
Building Blocks ◽  
Peptide Libraries ◽  
The Creation ◽  
Cholanic Acid

5β-Cholanic acid derivative XVII was prepared as a skeleton for the creation of non-peptide libraries. In positions 3, 7 and 12, different functional groups were designed in order to provide for the attachment of various building blocks linked to them.

scholarly journals Train of Language, Train of Thought: Notes on an Exophonic Anomaly

2021 ◽  
Vol 26 (1) ◽  
pp. 235-248
Author(s):  
Øyvind Rangøy
Keyword(s):  
Native Language ◽  
Building Blocks ◽  
Poetic Language ◽  
Literary Value ◽  
Change Perception ◽  
The World ◽  
The Creation ◽  
Train Of Thought ◽  
The Ideal

The creation of poetry with literary value in a non-native language often invites questions about how this is possible to achieve. This question, however, can be turned around: is there something in being an exophonic poet that, rather than being an obstacle, could make the development and maturing of a poetic language possible? Adam Zagajewski writes that ardor, not irony, can be primary building blocks, and about the ideal of being ‘in between’. Ben Lerner writes about the sources of Hatred of Poetry and sees poetry as a potential that can never be completely realised. Being between languages causes the reality of language as one of many possibilities to be always present. The result can be construed as a poetic of time and light, but also of a reconciliation at depth warranted by the poetic ethos. Language becomes aware of itself, its autonomy and inherent lack of objectivity, and this becomes less naive and prone to cliches, but this awareness need not spiral into self-dissolving irony. Rather, it may seek to reconcile the possible ways of seeing the world into a new sense of sincerity. It inspires creative and playful use of language, gives heightened awareness of possible metaphors even where the sense of the transferred image is absent within the framework of one language. This has the potential to change perception of language and reality in a way that makes poetry almost possible.

scholarly journals Coupling biocatalysis with high-energy flow reactions for the synthesis of carbamates and β-amino acid derivatives

2021 ◽  
Vol 17 ◽  
pp. 379-384
Author(s):  
Alexander Leslie ◽  
Thomas S Moody ◽  
Megan Smyth ◽  
Scott Wharry ◽  
Marcus Baumann
Keyword(s):  
Amino Acid ◽  
Energy Flow ◽  
Building Blocks ◽  
High Energy ◽  
High Yield ◽  
Addition Reactions ◽  
Flow Process ◽  
The Creation ◽  
Immobilized Calb ◽  
Yield And Purity

A continuous flow process is presented that couples a Curtius rearrangement step with a biocatalytic impurity tagging strategy to produce a series of valuable Cbz-carbamate products. Immobilized CALB was exploited as a robust hydrolase to transform residual benzyl alcohol into easily separable benzyl butyrate. The resulting telescoped flow process was effectively applied across a series of acid substrates rendering the desired carbamate structures in high yield and purity. The derivatization of these products via complementary flow-based Michael addition reactions furthermore demonstrated the creation of β-amino acid species. This strategy thus highlights the applicability of this work towards the creation of important chemical building blocks for the pharmaceutical and speciality chemical industries.

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