Sleep apnoea and ischaemic stroke: current knowledge and future directions

Colorectal cancer (CRC) is one of the most common cancers worldwide. In developed countries, its mortality remains high, yet the prevalence has established owing to effective screening programs; however due to the westernization of lifestyle, the incidences in many other countries have increased. Although the treatment of CRC has improved in the last few years, the side effects of these approaches cannot be neglected. Recently, members of the family of free fatty acid receptors (FFARs) have become attractive pharmacological targets in many diseases, including asthma; studies also point to their role in carcinogenesis. Here, we discuss current knowledge and future directions in FFAR research related to CRC. Contradictory results of FFARs modulation may derive from the pleiotropic effects of FFAR ligands, receptor distribution and different signal transduction. Hence, we indicate directions of further studies to fully use the potential of FFARs in CRC.

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Alcohol Consumption and Risk of Uterine Fibroids

Current Molecular Medicine ◽

10.2174/1566524019666191014170912 ◽

2020 ◽

Vol 20 (4) ◽

pp. 247-258 ◽

Cited By ~ 1

Author(s):

Hajra Takala ◽

Qiwei Yang ◽

Ahmed M. Abd El Razek ◽

Mohamed Ali ◽

Ayman Al-Hendy

Keyword(s):

Alcohol Consumption ◽

Animal Studies ◽

Molecular Mechanisms ◽

Legal Status ◽

Current Knowledge ◽

Uterine Fibroids ◽

Future Directions ◽

Working Adults ◽

The Us ◽

Alcohol Related Problems

Lifestyle factors, such as alcohol intake, have placed a substantial burden on public health. Alcohol consumption is increasing globally due to several factors including easy accessibility of this addictive substance besides its legal status and social acceptability. In the US, alcohol is the third leading preventable cause of death (after tobacco, poor diet and physical inactivity) with an estimated 88,000 people dying from alcohol-related causes annually, representing 1 in 10 deaths among working adults. Furthermore, the economic burden of excess drinking costs the US around $249 billion ($191.1 billion related to binge drinking). Although men likely drink more than women do, women are at much higher risk for alcohol-related problems. Alcohol use is also considered to be one of the most common non-communicable diseases, which affects reproductive health. This review article summarizes the current knowledge about alcohol-related pathogenesis of uterine fibroids (UFs) and highlights the molecular mechanisms that contribute to the development of UFs in response to alcohol consumption. Additionally, the effect of alcohol on the levels of various factors that are involved in UFs pathogenesis, such as steroid hormones, growth factors and cytokines, are summarized in this review. Animal studies of deleterious alcohol effect and future directions are discussed as well.

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Current Knowledge and Future Directions for Improving Subsoiling Quality and Reducing Energy Consumption in Conservation Fields

Agriculture ◽

10.3390/agriculture11070575 ◽

2021 ◽

Vol 11 (7) ◽

pp. 575

Author(s):

Shangyi Lou ◽

Jin He ◽

Hongwen Li ◽

Qingjie Wang ◽

Caiyun Lu ◽

...

Keyword(s):

Energy Consumption ◽

Cover Crops ◽

Current Knowledge ◽

High Energy ◽

Field Application ◽

Research Progress ◽

Monitoring And Control ◽

Future Directions ◽

Tillage Depth ◽

And Control

Subsoiling has been acknowledged worldwide to break compacted hardpan, improve soil permeability and water storage capacity, and promote topsoil deepening and root growth. However, there exist certain factors which limit the wide in-field application of subsoiling machines. Of these factors, the main two are poor subsoiling quality and high energy consumption, especially the undesired tillage depth obtained in the field with cover crops. Based on the analysis of global adoption and benefits of subsoiling technology, and application status of subsoiling machines, this article reviewed the research methods, technical characteristics, and developing trends in five key aspects, including subsoiling shovel design, anti-drag technologies, technologies of tillage depth detection and control, and research on soil mechanical interaction. Combined with the research progress and application requirements of subsoiling machines across the globe, current problems and technical difficulties were analyzed and summarized. Aiming to solve these problems, improve subsoiling quality, and reduce energy consumption, this article proposed future directions for the development of subsoiling machines, including optimizing the soil model in computer simulation, strengthening research on the subsoiling mechanism and comprehensive effect, developing new tillage depth monitoring and control systems, and improving wear-resisting properties of subsoiling shovels.

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Fusarium basal rot: profile of an increasingly important disease in Allium spp.

Tropical Plant Pathology ◽

10.1007/s40858-021-00421-9 ◽

2021 ◽

Author(s):

Dung Le ◽

Kris Audenaert ◽

Geert Haesaert

Keyword(s):

Disease Management ◽

Cultural Practices ◽

Current Knowledge ◽

Management Strategies ◽

Future Directions ◽

Basal Rot ◽

Major Constraint ◽

Fusarium Basal Rot ◽

Chemical Pesticides ◽

Important Disease

AbstractFusarium basal rot (FBR) is a soil-borne disease that affects Allium species worldwide. Although FBR has long been recognized as a major constraint to the production of economically important Allium species, information that could support disease management remains scattered. In this review, the current knowledge on the causal agents, symptomology and epidemiology, impact, and management strategies of FBR is synthesized. We highlight that FPR is associated with different complexes of several Fusarium species, of which Fusarium oxysporum and F. proliferatum are the most prevalent. These pathogenic complexes vary in composition and virulence, depending on sites and hosts, which can be challenging for disease management. Research to improve disease management using chemical pesticides, resistance cultivars, biocontrol agents, and cultural practices has achieved both promising results and limitations. Finally, research needs and future directions are proposed for the development of effective FBR management strategies.

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The Fourth IOCDC

CNS Spectrums ◽

10.1017/s1092852900024950 ◽

2000 ◽

Vol 5 (S4) ◽

pp. 4-4

Author(s):

Eric Hollander ◽

Joseph Zohar ◽

Donatella Marazziti

Keyword(s):

Obsessive Compulsive Disorder ◽

Brain Stimulation ◽

Current Knowledge ◽

Active Role ◽

Cortical Inhibition ◽

Obsessive Compulsive ◽

Future Directions ◽

Compulsive Disorder ◽

Ablative Surgery

The Fourth International Obsessive Compulsive Disorder Conference (IOCDC) was held February 10–12, 2000, on the beautiful island of St. Thomas. The IOCDC is an annual meeting which brings together the world's leading experts in obsessive-compulsive disorder (OCD) and related disorders in a small workshop setting to present recent research advances, discuss gaps in our current knowledge, and plan or international approaches that address these knowledge gaps. The IOCDC meetings have been held on islands on both sides of the Atlantic—Capri, Guadeloupe, Madeira, and now St. Thomas.The International Organizing Committee consists of Eric Hollander, MD (USA), Joseph Zohar, MD (Israel), and Donatella Marazziti, MD (Italy). The proceedings are generously supported by an unrestricted educational grant from Solvay Pharmaceuticals Inc. and Solvay Pharmaceuticals, and we would like to acknowledge the very important contributions of Chantal Vekens and Mary Blangiardo of Solvay. Also, an mportant part of the success of these meetings stems from the very active role of the chairpersons and cochairpersons of the workshops who lead the discussions, who synthesize the future directions and prepare the manuscripts that result from these discussions that appear in this academic supplement.The meeting led off with a state-of-the-art plenary address by Mark George, MD (USA), describing how new methods of brain stimulation are improving research and therapy in OCD and promise to revolutionize neuropsychiatric research and herapy over the next decade. He describes how transcranial magnetic stimulation (TMS) is used to test the circuits in OCD and test electrophysiologic evaluations of cortical inhibition n OCD. Newer techniques that are less invasive than ablative surgery and appear promising in OCD therapy include vagus nerve stimulation and deep brain stimulation.

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Sleep Disorders in Adults with Down Syndrome

Journal of Clinical Medicine ◽

10.3390/jcm10143012 ◽

2021 ◽

Vol 10 (14) ◽

pp. 3012

Author(s):

Sandra Giménez ◽

Miren Altuna ◽

Esther Blessing ◽

Ricardo M. Osorio ◽

Juan Fortea

Keyword(s):

Quality Of Life ◽

Mental Health ◽

Down Syndrome ◽

Sleep Disorders ◽

Negative Impact ◽

Current Knowledge ◽

Sleep Disruption ◽

Physical And Mental Health ◽

Future Directions

Sleep disorders, despite being very frequent in adults with Down syndrome (DS), are often overlooked due to a lack of awareness by families and physicians and the absence of specific clinical sleep guidelines. Untreated sleep disorders have a negative impact on physical and mental health, behavior, and cognitive performance. Growing evidence suggests that sleep disruption may also accelerate the progression to symptomatic Alzheimer’s disease (AD) in this population. It is therefore imperative to have a better understanding of the sleep disorders associated with DS in order to treat them, and in doing so, improve cognition and quality of life, and prevent related comorbidities. This paper reviews the current knowledge of the main sleep disorders in adults with DS, including evaluation and management. It highlights the existing gaps in knowledge and discusses future directions to achieve earlier diagnosis and better treatment of sleep disorders most frequently found in this population.

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