The Cardiovascular System, Coronary Artery Disease, and Calcium: A Hypothesis

2000 ◽  
pp. 1109-1120
Author(s):  
Stephen Seely
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cardiovascular System ◽  
Artery Disease

The dynamics of cardiovascular system parts synchronization in patients with coronary artery disease under the impact of metoprolol intake

2007 ◽  
Vol 40 (1) ◽  
pp. S74
Author(s):  
A.R. Kiselev ◽  
V.I. Gridnev ◽  
O.M. Posnenkova ◽  
V.I. Ponomarenko ◽  
A.S. Karavaev ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cardiovascular System ◽  
Artery Disease ◽  
The Impact

scholarly journals The use of psychometric methods for the diagnosis of anxiety and depressive disorders in patients with a general somatic profile

2019 ◽  
Vol 100 (4) ◽  
pp. 565-570
Author(s):  
I V Dubatova ◽  
V G Voyakina ◽  
S V Lepyavka ◽  
A V Safronenko ◽  
I A Demidov
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Artery ◽  
Arterial Hypertension ◽  
Cardiovascular System ◽  
Depressive Disorders ◽  
Depression Scale ◽  
Anxiety And Depression ◽  
Artery Disease

Aim. To identify and compare the level of anxiety and depression in therapeutic patients with somatic pathology, establish the structure of the gender distribution of anxiety and depressive disorders. Methods. The study involved 126 people: 74 (58.73%) women and 52 (41.27%) men aged 21–59 years. 59 patients had diseases of the respiratory system (chronic bronchitis in the acute stage with an asthmatic component), 67 patients with cardiovascular diseases (40 subjects with coronary heart disease, 27 subjects with arterial hypertension). In 11 patients with coronary artery disease and 13 patients with hypertension, type I thyrotoxicosis was diagnosed. Clinical psychopathological, psychometric, psychological and statistical methods were used in the study. Psychometric tests were used: the Depression Scale of the Center for Epidemiological Research; Hospital Anxiety and Depression Scale and Taylor Anxiety Disorder Scale adapted by T.A. Nemchinova and V.G. Norakidze, adapted standardized multivariate questionnaire for personality research. Results. According to the severity of anxiety and depressive disorders, patients were divided into the groups: group 1 with severe level, group 2 with a moderate (subclinical) level, and group 3 with mild (not exceeding the norm) anxiety and depressive disorders. Severe and moderate disorders are most characteristic for the pathology of cardiovascular system. In coronary artery disease and arterial hypertension, abnormal (severe and moderate) anxiety and depressive disorders were observed in 24/29 (82.76%) and 20/22 (90.9%) patients, respectively. In patients with abnormal anxiety and depressive disorders, the number of women prevailed over men in the subgroup with hypertension (80% versus 20%, p=0.025) as well as in combination of hypertension with type 1 thyrotoxicosis (85.7% versus 14.3%, р=0.029). Conclusion. In patients, severe and moderate anxiety and depressive disorders are associated with the development of the pathology of cardiovascular system: coronary heart disease and arterial hypertension.

scholarly journals Działania wspierające zatrudnienie osób z chorobami przewlekłymi

2021 ◽  
Vol 601 (10) ◽  
pp. 12-16
Author(s):  
Joanna Bugajska ◽  
◽  
Elżbieta Łastowiecka-Moras
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Everyday Life ◽  
Cardiovascular System ◽  
Chronic Diseases ◽  
Working Conditions ◽  
Healthy Lifestyle ◽  
Work Activity ◽  
Occupational Factors ◽  
Artery Disease

Chronic diseases are progressively limiting the functioning of persons suffering from them in everyday life, including work activity. They have a great impact on the ability to perform work, and thus the earnings. The etiology of chronic diseases is multifactorial. Occupational factors and lifestyle play an important role in their formation. Influencing these factors is one of the most important measures supporting the employment of people suffering from chronic diseases. The article discusses the main activities in promoting a healthy lifestyle and adjusting working conditions to the needs of people with osteoarthritis, selected diseases of the cardiovascular system (coronary artery disease and hypertension), and diabetes.

Precordial Vibrations

2014 ◽  
pp. 201-220
Author(s):  
Mikko Paukkunen ◽  
Matti Linnavuo
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cardiovascular Diseases ◽  
Physical Examination ◽  
Cardiovascular System ◽  
Three Dimensional ◽  
Cost Effective ◽  
Cost Effective Method ◽  
Dimensional Measurements ◽  
Artery Disease

In the era of medicine, the heart and cardiovascular system has become one of the standard observation targets. Palpation and auscultation in the precordial area is performed as part of the regular physical examination to detect possible cardiovascular and pulmonary problems. However, due to the large number of people suffering from cardiovascular problems, labor-intensive methods such as auscultation might be inefficient in preventive cardiovascular condition screening. Seismocardiography (SCG) could have the potential to be a part of the solution to this problem. SCG is one of many modalities of cardiac-induced vibration measurements, and it has been shown to be of use in detecting coronary artery disease and assessing myocardial contractility. Lately, due to advances in sensor technologies, the SCG measurement is being developed by introducing three-dimensional measurements. Three-dimensional approach is considered to yield more information about the cardiovascular system than any single uniaxial approach. In conclusion, SCG seems to have the potential to offer a complementary view to cardiovascular function and a cost-effective method for screening of cardiovascular diseases. SCG is explored in this chapter.

scholarly journals Adenosine and Its Receptors: An Expected Tool for the Diagnosis and Treatment of Coronary Artery and Ischemic Heart Diseases

2020 ◽  
Vol 21 (15) ◽  
pp. 5321
Author(s):  
Marine Gaudry ◽  
Donato Vairo ◽  
Marion Marlinge ◽  
Melanie Gaubert ◽  
Claire Guiol ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cardiovascular System ◽  
Heart Diseases ◽  
Receptor Subtypes ◽  
Receptor Ligands ◽  
A2a Receptor ◽  
Innovative Therapies ◽  
Artery Disease ◽  
G Protein Coupled

Adenosine is an endogenous nucleoside which strongly impacts the cardiovascular system. Adenosine is released mostly by endothelial cells and myocytes during ischemia or hypoxia and greatly regulates the cardiovascular system via four specific G-protein-coupled receptors named A1R, A2AR, A2BR, and A3R. Among them, A2 subtypes are strongly expressed in coronary tissues, and their activation increases coronary blood flow via the production of cAMP in smooth muscle cells. A2A receptor modulators are an opportunity for intense research by the pharmaceutical industry to develop new cardiovascular therapies. Most innovative therapies are mediated by the modulation of adenosine release and/or the activation of the A2A receptor subtypes. This review aims to focus on the specific exploration of the adenosine plasma level and its relationship with the A2A receptor, which seems a promising biomarker for a diagnostic and/or a therapeutic tool for the screening and management of coronary artery disease. Finally, a recent class of selective adenosine receptor ligands has emerged, and A2A receptor agonists/antagonists are useful tools to improve the management of patients suffering from coronary artery disease.

scholarly journals Fractal structure of cardiovascular system

2021 ◽  
Vol 1 ◽  
pp. 3-6
Author(s):  
Plamen Gatzov
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cardiovascular System ◽  
Fractal Structure ◽  
Vascular System ◽  
Ischemic Myocardium ◽  
Entire System ◽  
Current Review ◽  
Mathematical Equations ◽  
Artery Disease

The structure of different systems, aiming to supply a volume of definite tissue with a specific fluid, which is for example the blood in the vascular system, obeys on similar lows, which can be expressed by mathematical equations. Those systems have fractal structure, that means every small part of the system repeats the structure of entire system. Knowing those dependencies permits calculation of one particular parameter of cardiovascular system, for example, the amount of myocardium on the basis of diameter of coronary artery supplying it. This approach is extremely applicable to the patients with coronary artery disease, where the amount of ischemic myocardium is of paramount importance for the patient`s fate. The aim of the current review is to present the main interdependencies between anatomical and physiological parameters of cardiovascular system.

Elevated level of circulatory sTLT1 induces inflammation through SYK/MEK/ERK signalling in coronary artery disease

2019 ◽  
Vol 133 (22) ◽  
pp. 2283-2299
Author(s):  
Apabrita Ayan Das ◽  
Devasmita Chakravarty ◽  
Debmalya Bhunia ◽  
Surajit Ghosh ◽  
Prakash C. Mandal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Chronic Inflammation ◽  
Ex Vivo ◽  
Human Subjects ◽  
Critical Role ◽  
Atherosclerotic Cardiovascular Disease ◽  
Tnf Α ◽  
Artery Disease

Abstract The role of inflammation in all phases of atherosclerotic process is well established and soluble TREM-like transcript 1 (sTLT1) is reported to be associated with chronic inflammation. Yet, no information is available about the involvement of sTLT1 in atherosclerotic cardiovascular disease. Present study was undertaken to determine the pathophysiological significance of sTLT1 in atherosclerosis by employing an observational study on human subjects (n=117) followed by experiments in human macrophages and atherosclerotic apolipoprotein E (apoE)−/− mice. Plasma level of sTLT1 was found to be significantly (P<0.05) higher in clinical (2342 ± 184 pg/ml) and subclinical cases (1773 ± 118 pg/ml) than healthy controls (461 ± 57 pg/ml). Moreover, statistical analyses further indicated that sTLT1 was not only associated with common risk factors for Coronary Artery Disease (CAD) in both clinical and subclinical groups but also strongly correlated with disease severity. Ex vivo studies on macrophages showed that sTLT1 interacts with Fcɣ receptor I (FcɣRI) to activate spleen tyrosine kinase (SYK)-mediated downstream MAP kinase signalling cascade to activate nuclear factor-κ B (NF-kB). Activation of NF-kB induces secretion of tumour necrosis factor-α (TNF-α) from macrophage cells that plays pivotal role in governing the persistence of chronic inflammation. Atherosclerotic apoE−/− mice also showed high levels of sTLT1 and TNF-α in nearly occluded aortic stage indicating the contribution of sTLT1 in inflammation. Our results clearly demonstrate that sTLT1 is clinically related to the risk factors of CAD. We also showed that binding of sTLT1 with macrophage membrane receptor, FcɣR1 initiates inflammatory signals in macrophages suggesting its critical role in thrombus development and atherosclerosis.

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