scholarly journals 4292 Epigenetic Age and Depressive Symptoms in African American Women with Cardiometabolic Conditions

2020 ◽  
Vol 4 (s1) ◽  
pp. 108-108
Author(s):  
Nicole B Perez ◽  
Allison Vorderstrasse ◽  
Gary Yu ◽  
Jacquelyn Taylor
Keyword(s):  
African American ◽  
Depressive Symptoms ◽  
African American Women ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Life Quality ◽  
American Women ◽  
Epigenetic Age ◽  
Clinical Phenotyping ◽  
The Relationship

OBJECTIVES/GOALS: To examine the relationship between epigenetic age acceleration (EAA) and depressive symptoms in a cohort of African American women (AAW) with cardiometabolic conditions (CMC) including hypertension, diabetes, obesity; and to explore clinical phenotypes of depressive symptoms in this population. METHODS/STUDY POPULATION: This secondary analysis utilized genomic and longitudinal clinical data from AAW in the InterGEN cohort (n = 250). EWAS data was used to estimate EAA based on the Horvath method, which incorporates the DNA methylation statuses at 353 specific CpG sites and regresses this epigenetic age on chronological age to determine EAA. Pearson’s correlations and linear regression will be used to examine the relationship between EAA and depressive symptoms and a linear mixed model will investigate this relationship over four time points during a two-year period. Clinical phenotyping of depressive symptoms will be explored using a cluster analysis. RESULTS/ANTICIPATED RESULTS: Analysis is underway and will be complete by the time of presentation. We hypothesize that higher EAA will associate with higher depressive symptoms and poorer trajectories over time. We expect that this relationship may be meditated by the presence of CMCs. Exploratory analysis of clinical phenotyping is expected to provide descriptive evidence with respect to specific depressive symptoms or clusters which are most associated with EAA and CMCs. These results will address several gaps. To our knowledge, this is the first study to examine the relationship of EAA and depressive symptoms considering the role of CMC, in a historically understudied population with disproportionate risk. DISCUSSION/SIGNIFICANCE OF IMPACT: Depression limits life quality and quantity and is highly comorbid in CMC. AAW have high risk of comorbidity, and this study furthers knowledge of depression and aging with a clinically accessible marker and aids recognition of a heterogenous phenotype in an undertreated population.

Effect of Psychosocial Factors on Eating Behaviors and BMI Among African American Women

2017 ◽  
Vol 27 (8) ◽  
pp. 917-935 ◽  
Author(s):  
Stephanie Pickett ◽  
Thomas P. McCoy
Keyword(s):  
African American ◽  
Depressive Symptoms ◽  
African American Women ◽  
Perceived Stress ◽  
Eating Behaviors ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
American Women ◽  
Relationship Of ◽  
The Relationship

Psychosocial stress and negative emotions have been associated with the consumption of highly palatable foods and excess weight. Few studies have examined these variable relationships among young African American women. The purpose of this cross-sectional study was to examine the relationship of perceived stress, depressive symptoms, eating behaviors, and body mass index (BMI) among 191 African American women who were 18 to 40 years old. Multivariate analysis indicated that depressive symptoms had a greater impact on highly palatable eating behaviors compared with perceived stress. This study extends understanding of depressive symptoms on eating behaviors among young African American women.

scholarly journals Genital Chlamydia trachomatis Seroprevalence and Uterine Fibroid Development: Cohort Study of Young African-American Women

2021 ◽  
Vol 10 (1) ◽  
pp. 10
Author(s):  
Kristen Moore ◽  
Donna Baird
Keyword(s):  
African American ◽  
Chlamydia Trachomatis ◽  
African American Women ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Cox Proportional Hazards ◽  
Current Evidence ◽  
Inverse Association ◽  
American Women ◽  
Tract Infections

Few studies have investigated the 1930s hypothesis that reproductive tract infections are risk factors for fibroid development. In our 2017 cross-sectional analysis from the Study of Environment, Lifestyle, and Fibroids (2010–2018), a large Detroit community-based cohort of 23–35 year-old African-American women with ultrasound fibroid screening, we found an inverse association between seropositivity for genital Chlamydia trachomatis (gCT) infection and fibroids. With prospective data from the cohort (standardized ultrasounds every 20 months over 5 years), we examined gCT’s associations with fibroid incidence (among 1158 women fibroid-free at baseline) and growth. We computed adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for incidence by gCT serostatus using Cox proportional hazards models. GCT’s influence on growth was assessed by estimating the difference between fibroid size change for seropositive vs. seronegative between successive ultrasounds (1254 growth measures) using a linear mixed model. Growth was scaled to change over 18 months. GCT seropositivity was not associated with fibroid incidence (aHR, 1.0 95% CI: 0.79, 1.29) or growth (4.4%, 95% CI: −5.02, 14.64). The current evidence based on both biomarker gCT data, which can capture the common undiagnosed infections, and prospective ultrasound data for fibroids suggests that Chlamydia is unlikely to increase fibroid risk.

African American Women and Depression: Promoting the Need for Culturally Competent Treatment

2018 ◽  
Author(s):  
Bernice Kennedy ◽  
Chalice Jenkins ◽  
Keyword(s):  
Mental Health ◽  
African American ◽  
Depressive Symptoms ◽  
African American Women ◽  
Mental Health Problems ◽  
American Woman ◽  
Stressful Events ◽  
Mental Illnesses ◽  
Diagnostic Process ◽  
American Women

Abstract Depression is gradually increasing in African American women. These women are experiencing role changes and additional life stressors. Depressed African American women may perceive themselves as being devalued by society with fewer support systems to buffer stressful events. Depressive symptoms may develop into clinical depression and a further decrease in the quality of life for the African American woman. The assumption that all women share similar experiences does not allow for differences to emerge regarding the diagnostic process, measuring tools, and successful treatment strategies for various cultures. The authors developed a Multifaceted Model of Depression in African American Women for improving treatment of African American women with depression and future research needs. Cultural background plays a vital role in how the symptoms of mental illnesses are developed, reported, interpreted, and how women are treated. African Americans who subscribed to the Strong Black Women Archetype (SBWA) are naturally strong, resilient, self-contained, and self-sacrificing. This self-reliance prevents them from reaching out for social support. This, in turn, can contribute to depressive symptoms with negative health outcomes. The African American women are more apt to have less access to routine medical care where early diagnosis and interventions can be done, so their mental health problems (e.g., depression, stress, etc.) are often more developed, complicated, and their social supports more depleted when they do access treatment. When African American women do have access to mental health care, they receive poor quality care compared to Whites.

scholarly journals HIV Prevention Programming for Older African American Women: The Impact of a Faith-Based and Behavioral Science Partnership on Depressive Symptoms

2020 ◽  
Vol 30 (2) ◽  
pp. 287-294
Author(s):  
Megan T. Ebor ◽  
Aurora P. Jackson
Keyword(s):  
African American ◽  
Depressive Symptoms ◽  
Hiv Prevention ◽  
African American Women ◽  
Psychological Wellbeing ◽  
American Women ◽  
Faith Based ◽  
Older African American Women ◽  
The One ◽  
The Impact

Objective: The current study sought to test the effect of an HIV prevention interven­tion on depressive symptoms in a sample of older African American women.Design, Setting and Participants: A pretest-posttest randomized control group design was conducted in a mega-church in Los Angeles with a sample of 62 older African American women, aged ≥50 years, 29 of whom were randomly assigned to the experimental condition and 33 to the comparison/control condition.Measures: A measure of psychological wellbeing (CES-D) was utilized to test the effect of the four-session group interven­tion vs the one-session informational group intervention on change in depressive symp­toms from pretest to posttest. Demographic characteristics included: measures of age in years; relationship and employment statuses (coded 1 for yes, 0 for no); and educational attainment.Results: Participation in the study was as­sociated with a significant improvement in the women’s psychological wellbeing from baseline to time 2; ie, decreased depres­sive symptoms. This change was greater for women in the four-session experimental group than for those in the one-session comparison group, due in part to a margin­ally significant interaction between time and experimental conditions.Conclusions: This study demonstrates the utility of faith-based/behavioral-scientist partnerships in HIV programming. Findings contribute to the evidence on interventions that might reduce depressive symptoms and HIV risk among older African American women. Ethn Dis. 2020;30(2):287-294; doi:10.18865/ed.30.2.287

scholarly journals Discriminatory Experiences and Depressive Symptoms among African American Women: Do Skin Tone and Mastery Matter?

Sex Roles ◽  
2009 ◽  
Vol 62 (1-2) ◽  
pp. 48-59 ◽  
Author(s):  
Verna M. Keith ◽  
Karen D. Lincoln ◽  
Robert Joseph Taylor ◽  
James S. Jackson
Keyword(s):  
African American ◽  
Depressive Symptoms ◽  
African American Women ◽  
Skin Tone ◽  
American Women

scholarly journals Psychosocial and Sociocultural Correlates of Depressive Symptoms Among Diverse African American Women

2012 ◽  
Vol 104 (11-12) ◽  
pp. 493-504 ◽  
Author(s):  
Kisha B. Holden ◽  
Stephanie P. Hall ◽  
Maryam Robinson ◽  
Sharra Triplett ◽  
Dolapo Babalola ◽  
...  
Keyword(s):  
African American ◽  
Depressive Symptoms ◽  
African American Women ◽  
American Women
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