scholarly journals Dietary predictors of plasma total homocysteine in the Hordaland Homocysteine Study

2007 ◽  
Vol 98 (1) ◽  
pp. 201-210 ◽  
Author(s):  
Svetlana V. Konstantinova ◽  
Stein Emil Vollset ◽  
Paula Berstad ◽  
Per Magne Ueland ◽  
Christian A. Drevon ◽  
...  
Keyword(s):  
Large Population ◽  
Population Based ◽  
B Vitamins ◽  
Processed Meat ◽  
Food Groups ◽  
Thcy Level ◽  
Food Items ◽  
Total Homocysteine ◽  
Dietary Components ◽  
Plasma Total Homocysteine

Established dietary predictors of plasma total homocysteine (tHcy) include folate, riboflavin, and vitamins B6and B12, while information is scarce regarding other dietary components. The aim of this study was to examine the relation between a variety of food groups, food items and nutrients, and plasma tHcy in a large population-based study. The study population included 5812 men and women aged 47–49 and 71–74 years who completed a 169-item FFQ. tHcy was examined across quartiles of dietary components by multiple linear regression analyses adjusting for age, sex, energy intake, various risk factors for elevated tHcy, as well as for dietary and plasma B-vitamins. Among 4578 non-users of vitamin supplements, intake of vegetables, fruits, cereals, eggs, fish and milk, as well as chicken and non-processed meats were inversely associated with tHcy level. The estimated mean difference in tHcy per increasing quartile of intake ranged from − 0·11 (95 % CI − 0·21, − 0·01) μmol/l for milk to − 0·32 (95 % CI − 0·42, − 0·22) μmol/l for vegetables. Positive associations were found for sweets and cakes. Whole-grain bread was significantly inversely related to tHcy only after additional adjustment for dietary and plasma B-vitamins. The nutrients folate, vitamin B6, B12, and riboflavin were inversely related to tHcy. Complex carbohydrates were inversely, and fat positively associated with tHcy, also after adjustment for dietary and plasma B-vitamins. In conclusion, food items rich in B-vitamins and with a low content of fat and sugar were related to lower tHcy levels. Eggs, chicken, non-processed meat, fish and milk were inversely associated with tHcy.

scholarly journals Influence of food groups on plasma total homocysteine for specificMTHFR C677Tgenotypes in Chinese population

2016 ◽  
Vol 61 (2) ◽  
pp. 1600351 ◽  
Author(s):  
Qiang Zeng ◽  
Fan Li ◽  
Tianyuan Xiang ◽  
Weimin Wang ◽  
Cong Ma ◽  
...  
Keyword(s):  
Chinese Population ◽  
Food Groups ◽  
Influence Of Food ◽  
Total Homocysteine ◽  
Plasma Total Homocysteine

scholarly journals Association between plasma total homocysteine level within normal range and bone mineral density in adults

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Zhongxin Zhu ◽  
Changhua Liu ◽  
Xiao’e Li ◽  
Xiaocong Yao
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Recursive Algorithm ◽  
Positive Trend ◽  
Mineral Density ◽  
Normal Range ◽  
Thcy Level ◽  
Plasma Thcy ◽  
Total Homocysteine ◽  
Plasma Total Homocysteine

Abstract Background Growing evidence indicates that homocysteine is a noteworthy marker for general health status. However, research regarding plasma total homocysteine (tHcy) levels and bone mineral density (BMD) is sparse and controversial. Hence, we aimed to investigate the association between plasma tHcy level within normal range and lumbar BMD in adults. Methods In this cross-sectional study, using the National Health and Nutrition Examination Survey database, data on 10748 adults aged between 30 and 85 years were analyzed. The weighted multiple logistic regression analyses were conducted to evaluate the association between plasma tHcy level and lumbar BMD. The fitted smoothing curves were performed to explore potential non-linear relationships. When non-linearity was detected, we further calculated the inflection point using a recursive algorithm and constructed a weighted two-piecewise linear regression model. Results After adjusting for all the covariates, the association between plasma tHcy and lumbar BMD was different in various age groups (adults aged 30–49 years: β = −0.0004, 95% CI −0.0025, 0.0018; adults aged 50–69 years: β = 0.0001, 95% CI −0.0025, 0.0026; adults aged 70–85 years: β = 0.0050, 95% CI 0.0008, 0.0092). In the subgroup analysis stratified by gender, this association also differed based on gender. There was a negative trend in females (aged 30–49 years: β = −0.0022, 95% CI −0.0054, 0.0011; aged 50–69 years: β = −0.0028, 95% CI −0.0062, 0.0007), and a positive trend in males (aged 30–49 years: β = 0.0018, 95% CI −0.0012, 0.0048; aged 50–69 years: β = 0.0027, 95% CI −0.0009, 0.0063) in both 30–49 years group and 50–69 years group. In the 70–85 years group, this association was significantly positive in males (β = 0.0136, 95% CI 0.0068, 0.0204), but was not significantly different in females (β = 0.0007, 95% CI −0.0046, 0.0060). Conclusion The correlation between plasma tHcy level within the normal range and lumbar BMD differs by age and gender.

Relationship between dietary folate intakes, maternal plasma total homocysteine and B-vitamins during pregnancy and fetal growth in Japan

2007 ◽  
Vol 46 (5) ◽  
pp. 300-306 ◽  
Author(s):  
Hidemi Takimoto ◽  
Natsuko Mito ◽  
Keizo Umegaki ◽  
Asako Ishiwaki ◽  
Kaoru Kusama ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Maternal Plasma ◽  
B Vitamins ◽  
Dietary Folate ◽  
Total Homocysteine ◽  
Plasma Total Homocysteine

Plasma Total Homocysteine, B Vitamins, and Risk of Coronary Atherosclerosis

1997 ◽  
Vol 17 (5) ◽  
pp. 989-995 ◽  
Author(s):  
Petra Verhoef ◽  
Frans J. Kok ◽  
Dick A.C.M. Kruyssen ◽  
Evert G. Schouten ◽  
Jacqueline C.M. Witteman ◽  
...  
Keyword(s):  
Coronary Atherosclerosis ◽  
B Vitamins ◽  
Total Homocysteine ◽  
Plasma Total Homocysteine

Vitamin B2, vitamin B12 and total homocysteine status in children and their associations with dietary intake of B-vitamins from different food groups: the Healthy Growth Study

2015 ◽  
Vol 56 (1) ◽  
pp. 321-331 ◽  
Author(s):  
Yannis Manios ◽  
George Moschonis ◽  
Renske Dekkers ◽  
Christina Mavrogianni ◽  
Eva Grammatikaki ◽  
...  
Keyword(s):  
Dietary Intake ◽  
Vitamin B12 ◽  
B Vitamins ◽  
Vitamin B2 ◽  
Food Groups ◽  
Growth Study ◽  
Total Homocysteine ◽  
Healthy Growth

scholarly journals Nutritional risk factors for SARS-CoV-2 infection: a prospective study within the NutriNet-Santé cohort

BMC Medicine ◽  
2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Mélanie Deschasaux-Tanguy ◽  
Bernard Srour ◽  
Laurent Bourhis ◽  
Nathalie Arnault ◽  
Nathalie Druesne-Pecollo ◽  
...  
Keyword(s):  
Vitamin C ◽  
Vitamin K ◽  
Large Population ◽  
Dried Blood Spots ◽  
Population Based ◽  
Fruit And Vegetables ◽  
Nutritional Risk ◽  
Dietary Intakes ◽  
Food Groups ◽  
Vitamin B9

Abstract Background Nutritional factors are essential for the functioning of the immune system and could therefore play a role in COVID-19 but evidence is needed. Our objective was to study the associations between diet and the risk of SARS-CoV-2 infection in a large population-based sample. Methods Our analyses were conducted in the French prospective NutriNet-Santé cohort study (2009–2020). Seroprevalence of anti-SARS-CoV-2 antibodies was assessed by ELISA on dried blood spots. Dietary intakes were derived from repeated 24 h dietary records (at least 6) in the two years preceding the start of the COVID-19 pandemic in France (February 2020). Multi-adjusted logistic regression models were computed. Results A total of 7766 adults (70.3% women, mean age: 60.3 years) were included, among which 311 were positive for anti-SARS-CoV-2 antibodies. Dietary intakes of vitamin C (OR for 1 SD=0.86 (0.75–0.98), P=0.02), vitamin B9 (OR=0.84 (0.72–0.98), P=0.02), vitamin K (OR=0.86 (0.74–0.99), P=0.04), fibers (OR=0.84 (0.72–0.98), P=0.02), and fruit and vegetables (OR=0.85 (0.74–0.97), P=0.02) were associated to a decreased probability of SARS-CoV-2 infection while dietary intakes of calcium (OR=1.16 (1.01–1.35), P=0.04) and dairy products (OR=1.19 (1.06–1.33), P=0.002) associated to increased odds. No association was detected with other food groups or nutrients or with the overall diet quality. Conclusions Higher dietary intakes of fruit and vegetables and, consistently, of vitamin C, folate, vitamin K and fibers were associated with a lower susceptibility to SARS-CoV-2 infection. Beyond its established role in the prevention of non-communicable diseases, diet could therefore also contribute to prevent some infectious diseases such as COVID-19.

scholarly journals The correlation between plasma total homocysteine level and gestational diabetes mellitus in a Chinese Han population

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Mengyao Deng ◽  
Jia Zhou ◽  
Zhao Tang ◽  
Jun Xiang ◽  
Jing Yi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Family History ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Thcy Level ◽  
Plasma Thcy ◽  
History Of ◽  
Total Homocysteine ◽  
Plasma Total Homocysteine

Abstract To assess the correlation between plasma total homocysteine (tHcy) level and gestational diabetes mellitus (GDM) in a Chinese Han population. This case–control study included 350 GDM patients and 346 gestational week-matched normal glucose tolerance (NGT) pregnant women. Plasma tHcy and insulin levels were analyzed by HPLC and ELISA respectively. Logistic regression analysis was used to investigate the correlation between plasma tHcy level and risk of GDM. Women with GDM had a higher plasma tHcy level than NGT women (6.61 ± 1.32 vs. 6.17 ± 1.29 μmol/L, P = 0.001)). The GDM risk was 1.79 (OR = 1.79, 95% CI 1.18–2.72, P = 0.006) times higher in women whose plasma tHcy level was ≥ 7.29 μmol/L compared to women with plasma tHcy level < 5.75 μmol/L. Stratified analysis showed the GDM risk were much higher when HOMA-IR index ≥ 2 (OR = 5.42, 95% CI 2.51–11.74, P < 0.001), age ≥ 30 years (OR = 5.14, 95% CI 2.78–9.52, P < 0.001), or women with a family history of type 2 diabetes mellitus (T2DM) (OR = 4.13, 95% CI 1.78–9.56, P = 0.001). In the Chinese Han population, an elevated plasma tHcy level may increase the overall risk of GDM especially in women with a high HOMA-IR index, increasing age or with family history of T2DM.

scholarly journals Plasma Total Homocysteine and Hemodialysis Access Thrombosis

1999 ◽  
Vol 10 (5) ◽  
pp. 1095-1099
Author(s):  
DOUGLAS SHEMIN ◽  
KATE L. LAPANE ◽  
LINDA BAUSSERMAN ◽  
ELIAS KANAAN ◽  
SEWELL KAHN ◽  
...  
Keyword(s):  
Vascular Access ◽  
Proportional Hazards ◽  
Controlled Trial ◽  
Hemodialysis Access ◽  
Graft Thrombosis ◽  
Thcy Level ◽  
Increased Risk ◽  
Total Homocysteine ◽  
Plasma Total Homocysteine

Abstract. Mild hyperhomocysteinemia, a putative risk factor for atherothrombotic cardiovascular disease morbidity and mortality, may contribute to the excess incidence of atherothrombotic outcomes in the dialysis-dependent end-stage renal disease population. Hemodialysis access (fistula or graft) thrombosis is an unfortunately common and costly morbidity in this patient population. In this study, using a prospective design, the potential relationship between baseline nonfasting, predialysis plasma total homocysteine (tHcy) levels and vascular access-related morbidity was examined in a cohort of 84 hemodialysis patients with a fistula or prosthetic graft as their primary hemodialysis access. Vascular access thrombotic episodes were recorded over a subsequent 18-mo follow-up period. Forty-seven patients (56% of the total) had at least one access thrombosis during the 18-mo follow-up period (median follow-up, 13 mo; rate, 0.6 events per patient-year of follow-up). Proportional hazards modeling revealed that each 1 μM/L increase in the tHcy level was associated with a 4.0% increase in the risk of access thrombosis (95% confidence interval, 1.0 to 6.0%, P = 0.008). This association persisted after adjustment for type of access (fistula versus graft), age, gender, time on dialysis, diabetes, smoking, hypertension, nutritional status, urea reduction ratio, dyslipidemia, and the presence of previous vascular disease. Elevated tHcy levels appear to confer a graded, independent increased risk for hemodialysis access thrombosis. A randomized, controlled trial examining the effect of tHcy-lowering intervention on hemodialysis access thrombosis appears to be justified.

Lowering of Homocysteine Concentrations in Elderly Men and Women

1999 ◽  
Vol 69 (3) ◽  
pp. 187-193 ◽  
Author(s):  
Brönstrup ◽  
Hages ◽  
Pietrzik
Keyword(s):  
Low Dose ◽  
Geometric Mean ◽  
B Vitamins ◽  
Vitamin Supplementation ◽  
Entire Treatment Period ◽  
Men And Women ◽  
Elderly Individuals ◽  
Total Homocysteine ◽  
B Vitamin ◽  
Plasma Total Homocysteine

B-vitamin supplementation has previously been shown to lower the concentration of plasma total homocysteine, a risk factor for cardiovascular disease. Little is known about the homocysteine-lowering effects of low-dose B-vitamins in elderly individuals, who are prone to higher homocysteine levels due to advanced age and a greater frequency of impaired vitamin status. We aimed to identify if and to what extent B-vitamins lower total homocysteine and its subfractions in elderly individuals. Men and women (>= 60 years) received either B-vitamins (400 mug folic acid +1.65 mg pyridoxine +3 mug cyanocobalamin) or a placebo daily for 4 weeks. Subjects in the vitamin group showed a significant decrease in plasma total homocysteine during the first 2 weeks; thereafter, total homocysteine only slightly decreased further resulting in a geometric mean reduction of –16.3% (95% CI: –11.3% to –21.0%) over the entire treatment period. Free homocysteine decreased as well. However, the observed higher ratio of free/total homocysteine after 4 weeks of supplementation suggest a more pronounced reduction in protein-bound homocysteine. Low-dose B-vitamin supplementation is effective in lowering homocysteine in elderly individuals. Further studies are needed to be able to depict the effect of B-vitamin supplementation on different homocysteine subfractions in plasma.

scholarly journals Assessing Food Liking: Comparison of Food Liking Questionnaires and Direct Food Tasting in Two Cultures

Nutrients ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1957 ◽  
Author(s):  
Uracha Wanich ◽  
Dhoungsiri Sayompark ◽  
Lynn Riddell ◽  
Sara Cicerale ◽  
Djin Liem ◽  
...  
Keyword(s):  
Soft Drink ◽  
Large Population ◽  
Correlation Coefficients ◽  
Population Based ◽  
Sensory Testing ◽  
Food Items ◽  
Food Liking ◽  
The Difference ◽  
Hedonic Scale ◽  
Test Retest Reliability

Food liking can be directly measured in specialised sensory testing facilities; however, this method is not feasible for large population samples. The aim of the study was to compare a Food Liking Questionnaire (FLQ) against lab-based sensory testing in two countries. The study was conducted with 70 Australian and Thai participants (35 Australian, 35 Thai, mean (SD) age 19 (3.01) years, 51% men). Participants completed a FLQ (consisting of 73 food items Australia, 89 Thai) and then, after tasting the food, rated their liking of a selection of 10 commercially available food items using a nine-point hedonic scale. Both tasks were completed on the same day and were repeated one week later. The reliability of and a comparison between methods was determined using Intra-Class Correlation Coefficients (ICC), and the difference was assessed using an independent sample t-test. The results indicate that the test-retest reliability of FLQ and the laboratory-based liking assessment range was moderate (0.40–0.59) to excellent (0.75–1.00). There were significant differences for the FLQ and the laboratory-based liking assessment between countries for three food items: soft drink, instant vegetable soup, and broccoli (p < 0.01). However, the data produced from the FLQ reflects the laboratory-based liking assessment. Therefore, it provides representative liking data in large population-based studies including cross-cultural studies.

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