A comparison of the effects of soya isoflavonoids and fish oil on cell proliferation, apoptosis and the expression of oestrogen receptors α and β in the mammary gland and colon of the rat

Isoflavonoids and fish oil may be protective against colorectal cancer, but the evidence in relation to breast cancer risk is ambiguous. In the present study, we have investigated the impact of soya-derived isoflavonoids andn-3 fatty acids from fish oil, both individually and in combination, on apoptosis, cell proliferation and oestrogen receptor (ER) expression in the colon and mammary gland of the rat. Female rats were fed diets high inn-3 fatty acids (80 g/kg diet) or soya protein (765 mg/kg diet isoflavones) for 2 weeks, and then killed before the removal of the colon and mammary glands. Cell proliferation and apoptosis were quantified morphologically in whole crypts and terminal end buds. The expressions ofERαandERβwere measured in colon tissue scrapes and the mammary gland. Fish oil significantly increased apoptosis and decreased mitosis in both tissues, an effect associated with a decrease in the expressions ofERα andERβ. Soya had no effect on apoptosis in either tissue, but reduced mitosis in the colon (P < 0·001) while increasing it in the mammary gland (P = 0·001). The changes in proliferation were associated with contrasting changes in theERexpression such that fish oil significantly decreased bothERβandERα, while soya increasedERαand decreasedERβ. The results may provide a novel mechanism by whichn-3 fatty acids could reduce cancer risk, but the interpretation of the results in relation to soya consumption and breast cancer risk requires further investigation.

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The impact of having a sister diagnosed with breast cancer on cancer-related distress and breast cancer risk perception

Cancer ◽

10.1002/cncr.27924 ◽

2013 ◽

Vol 119 (9) ◽

pp. 1722-1728 ◽

Cited By ~ 14

Author(s):

Kelly A. Metcalfe ◽

May-Lynn Quan ◽

Andrea Eisen ◽

Tulin Cil ◽

Ping Sun ◽

...

Keyword(s):

Breast Cancer ◽

Risk Perception ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Cancer Risk Perception ◽

The Impact

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Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

Journal of Visualized Experiments ◽

10.3791/2260 ◽

2010 ◽

Cited By ~ 19

Author(s):

Sonia de Assis ◽

Anni Warri ◽

M. Idalia Cruz ◽

Leena Hilakivi-Clarke

Keyword(s):

Breast Cancer ◽

Mammary Gland ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Mammary Gland Morphology

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From the Table to the Tumor: The Role of Mediterranean and Western Dietary Patterns in Shifting Microbial-Mediated Signaling to Impact Breast Cancer Risk

Nutrients ◽

10.3390/nu11112565 ◽

2019 ◽

Vol 11 (11) ◽

pp. 2565 ◽

Cited By ~ 8

Author(s):

Tiffany M. Newman ◽

Mara Z. Vitolins ◽

Katherine L. Cook

Keyword(s):

Breast Cancer ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Mediterranean Diet ◽

Dietary Patterns ◽

Gut Microbiome ◽

Western Diet ◽

Diet Pattern ◽

The Mediterranean ◽

The Impact

Diet is a modifiable component of lifestyle that could influence breast cancer development. The Mediterranean dietary pattern is considered one of the healthiest of all dietary patterns. Adherence to the Mediterranean diet protects against diabetes, cardiovascular disease, and cancer. Reported consumption of a Mediterranean diet pattern was associated with lower breast cancer risk for women with all subtypes of breast cancer, and a Western diet pattern was associated with greater risk. In this review, we contrast the available epidemiological breast cancer data, comparing the impact of consuming a Mediterranean diet to the Western diet. Furthermore, we will review the preclinical data highlighting the anticancer molecular mechanism of Mediterranean diet consumption in both cancer prevention and therapeutic outcomes. Diet composition is a major constituent shaping the gut microbiome. Distinct patterns of gut microbiota composition are associated with the habitual consumption of animal fats, high-fiber diets, and vegetable-based diets. We will review the impact of Mediterranean diet on the gut microbiome and inflammation. Outside of the gut, we recently demonstrated that Mediterranean diet consumption led to distinct microbiota shifts in the mammary gland tissue, suggesting possible anticancer effects by diet on breast-specific microbiome. Taken together, these data support the anti-breast-cancer impact of Mediterranean diet consumption.

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The impact of Zinc Finger 365 Polymorphisms and haplotypes on breast cancer risk in an Iranian population

The Breast ◽

10.1016/s0960-9776(19)30174-2 ◽

2019 ◽

Vol 44 ◽

pp. S39

Author(s):

F. Homaei Shandiz ◽

F. Afzaljavan ◽

L. Hosseinzadeh ◽

A. Moezzi ◽

A. Pasdar

Keyword(s):

Breast Cancer ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Zinc Finger ◽

Iranian Population ◽

The Impact

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Modifiable Lifestyle Factors: Opportunities for (Hereditary) Breast Cancer Prevention - a Narrative Review

Breast Care ◽

10.1159/000488995 ◽

2018 ◽

Vol 13 (2) ◽

pp. 108-113 ◽

Cited By ~ 9

Author(s):

Jacqueline Lammert ◽

Sabine Grill ◽

Marion Kiechle

Keyword(s):

Breast Cancer ◽

Risk Factors ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Cancer Prevention ◽

Healthy Lifestyle ◽

Absolute Risk ◽

Lifestyle Factors ◽

Breast Cancer Prevention ◽

The Impact

Increasing rates of obesity, lack of physical activity, sedentary behavior, and frequent alcohol consumption are major lifestyle-related risk factors for breast cancer. In fact, it has been estimated that about one-third of breast cancer cases are attributable to factors women can change. Most research has focused on examining the impact of one single exposure on breast cancer risk while adjusting for other risk modifiers. Capitalizing on big data, major efforts have been made to evaluate the combined impact of well-established lifestyle factors on overall breast cancer risk. At the individual level, data indicate that even simple behavior modifications could have a considerable impact on breast cancer prevention. Moreover, there is emerging new evidence that adopting a healthy lifestyle may be particularly relevant for women with hereditary susceptibility to breast cancer. On the absolute risk scale, studies suggest that the presence of certain risk factors, such as excessive body weight, had a substantially higher impact on breast cancer risk if women had a hereditary predisposition to cancer. The existing body of knowledge gives the medical professionals guidance as to which factors to focus on when counseling patients. However, well-designed randomized controlled trials utilizing objective methods are crucial to providing concrete recommendations.

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The Impact of CASP8 rs10931936 and rs1045485 Polymorphisms as well as the Haplotypes on Breast Cancer Risk: A Case-Control Study

Clinical Breast Cancer ◽

10.1016/j.clbc.2019.02.011 ◽

2019 ◽

Vol 19 (5) ◽

pp. e563-e577 ◽

Cited By ~ 2

Author(s):

Elham Vahednia ◽

Fatemeh Homaei Shandiz ◽

Matineh Barati Bagherabad ◽

Atefeh Moezzi ◽

Fahimeh Afzaljavan ◽

...

Keyword(s):

Breast Cancer ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Case Control Study ◽

Case Control ◽

The Impact ◽

Control Study

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Association of serum phospholipid fatty acids with breast cancer risk among postmenopausal cigarette smokers

Cancer Causes & Control ◽

10.1007/s10552-009-9314-2 ◽

2009 ◽

Vol 20 (4) ◽

pp. 497-504 ◽

Cited By ~ 19

Author(s):

Yumie Takata ◽

Irena B. King ◽

Marian L. Neuhouser ◽

Steve Schaffer ◽

Matt Barnett ◽

...

Keyword(s):

Breast Cancer ◽

Fatty Acids ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Phospholipid Fatty Acids ◽

Serum Phospholipid ◽

Cigarette Smokers

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Mammary Gland Mass and Breast Cancer Risk

Epidemiology ◽

10.1097/00001648-199211000-00011 ◽

1992 ◽

Vol 3 (6) ◽

pp. 523-526 ◽

Cited By ~ 72

Author(s):

Dimitrios Trichopoulos ◽

Ruth D. Lipman

Keyword(s):

Breast Cancer ◽

Mammary Gland ◽

Breast Cancer Risk ◽

Cancer Risk

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The impact of exogenous estrogen exposure on the characteristics of estrogen receptor (ER) positive, early-stage breast cancer (EBC).

Journal of Clinical Oncology ◽

10.1200/jco.2020.38.15_suppl.e12606 ◽

2020 ◽

Vol 38 (15_suppl) ◽

pp. e12606-e12606

Author(s):

Orly Yariv ◽

Rinat Yerushalmi ◽

Assaf Moore ◽

Tzippy Shohat ◽

Ofer Rotem ◽

...

Keyword(s):

Breast Cancer ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Hormone Replacement ◽

Luminal Breast Cancer ◽

Fertility Treatments ◽

Estrogen Exposure ◽

Exogenous Estrogen ◽

Er Positive ◽

The Impact

e12606 Background: Oral contraceptives (OC) and hormone replacement therapy (HRT) are well-established risk factors for ER positive breast cancer. Infertility is associated with an increased breast cancer risk and there is conflicting data on the influence of fertility treatments on breast cancer risk. The impact of exogenous estrogen exposure on breast cancer characteristics is not well described. Methods: A single center retrospective cohort study comprising all women with ER positive, human epidermal growth factor receptor 2 (HER2) negative, EBC whose tumors were sent to OncotypeDX analysis treated in our institute between 2005 and 2012. Data on exogenous estrogen exposure were collected including: OC and HRT use and prior fertility treatments. The impact of these exposures was assessed on pre-specified histopathological features including: tumor size, nodal status, ER and progesterone receptor (PR) staining, grade, Oncotype recurrence score (RS), ki67, lymphovascular and perineural invasion. Results: A total of 620 women were included, 79% were postmenopausal. Prior exposure to OC, HRT and fertility treatments was documented in 19% (103), 30% (136) and 11% (62), respectively. OC use was associated with smaller (≤1cm) tumors (30% vs. 20%, p = 0.023) and were less likely to have grade 3 disease (10% vs. 19%, p = 0.049). No other associations were found between exogenous estrogen exposures and tumor characteristics (Table). Conclusions: Use of OC may be associated with breast cancer with a distinct features compared to women with luminal breast cancer without history of OC use. Large scale studies are needed to better characterize these findings. [Table: see text]

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