Berries modify the postprandial plasma glucose response to sucrose in healthy subjects

2009 ◽  
Vol 103 (8) ◽  
pp. 1094-1097 ◽  
Author(s):  
Riitta Törrönen ◽  
Essi Sarkkinen ◽  
Niina Tapola ◽  
Elina Hautaniemi ◽  
Kyllikki Kilpi ◽  
...  
Keyword(s):  
Plasma Glucose ◽  
Healthy Subjects ◽  
Postprandial Glucose ◽  
Postprandial Blood Glucose ◽  
Glycaemic Response ◽  
Glucose Response ◽  
Postprandial Plasma Glucose ◽  
Increased Risk ◽  
Significant Difference ◽  
Randomised Controlled

Sucrose increases postprandial blood glucose concentrations, and diets with a high glycaemic response may be associated with increased risk of obesity, type 2 diabetes and CVD. Previous studies have suggested that polyphenols may influence carbohydrate digestion and absorption and thereby postprandial glycaemia. Berries are rich sources of various polyphenols and berry products are typically consumed with sucrose. We investigated the glycaemic effect of a berry purée made of bilberries, blackcurrants, cranberries and strawberries, and sweetened with sucrose, in comparison to sucrose with adjustment of available carbohydrates. A total of twelve healthy subjects (eleven women and one man, aged 25–69 years) with normal fasting plasma glucose ingested 150 g of the berry purée with 35 g sucrose or a control sucrose load in a randomised, controlled cross-over design. After consumption of the berry meal, the plasma glucose concentrations were significantly lower at 15 and 30 min (P < 0·05, P < 0·01, respectively) and significantly higher at 150 min (P < 0·05) compared with the control meal. The peak glucose concentration was reached at 45 min after the berry meal and at 30 min after the control meal. The peak increase from the baseline was 1·0 mmol/l smaller (P = 0·002) after ingestion of the berry meal. There was no statistically significant difference in the 3 h area under the glucose response curve. These results show that berries rich in polyphenols decrease the postprandial glucose response of sucrose in healthy subjects. The delayed and attenuated glycaemic response indicates reduced digestion and/or absorption of sucrose from the berry meal.

scholarly journals Impact of protein-rich meals on glycaemic response of rice

2016 ◽  
Vol 115 (7) ◽  
pp. 1194-1201 ◽  
Author(s):  
Rina Quek ◽  
Xinyan Bi ◽  
Christiani Jeyakumar Henry
Keyword(s):  
Insulin Response ◽  
Glucagon Secretion ◽  
Glycaemic Index ◽  
Glycaemic Response ◽  
Glucose Response ◽  
Lower Glucose ◽  
Increased Risk ◽  
To Come ◽  
Randomised Controlled ◽  
Protein Rich

AbstractAsians typically consume carbohydrate-rich and high-glycaemic-index diets that have been associated with an increased risk of developing type 2 diabetes. Rice is rarely eaten alone such that it is of interest to investigate the effects of co-ingesting different protein-rich meals with rice on insulin and glycaemic response. This study had a randomised, controlled, non-blind, cross-over design in which fifteen healthy Chinese male participants were required to come on non-consecutive days. Five rice-based test meals were served: rice alone (control), rice with fish (RWF), rice with egg white (RWE), rice with soya beancurd (taukwa) (RWT) and rice with chicken (RWC). The control meal consisted of 50 g of available carbohydrate, whereas all other test meals contained additional 25 g of protein. RWT was the only meal that showed significantly lower glucose response when compared with the control (P<0·05). RWF and RWE had significantly higher insulin response, but no significant increase was observed in RWT and RWC when compared with the control (P<0·05). RWT and RWF showed significantly higher glucagon secretion as compared with the control (P<0·05). The four test meals studied showed varying effects, with RWT showing the greatest reduction in glycaemic response. Therefore, the ingestion of soya beancurd with rice may have a direct impact on reducing the risk in Asians transiting from being pre-diabetics to diabetics.

scholarly journals Trigonella Foenum-Graecum Seeds Lowers Postprandial Blood Glucose in Overweight and Obese Individuals

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Sathyasurya Daniel Robert ◽  
Aziz Al-Safi Ismail ◽  
Wan Ishak Wan Rosli
Keyword(s):  
Blood Glucose ◽  
Primary Endpoint ◽  
Plasma Glucose ◽  
Response Curve ◽  
Postprandial Blood Glucose ◽  
White Bread ◽  
Glucose Response ◽  
Postprandial Plasma Glucose ◽  
Trigonella Foenum Graecum

This study determined the effects of fenugreek on postprandial plasma glucose (PPG) and satiety among overweight and obese individuals. Fourteen subjects were studied in the morning after overnight fasts on four separate occasions. Glycaemic responses elicited by 50 g carbohydrate portions of white bread and jam with or without 5.5 g of fenugreek and fried rice with or without 5.5 g fenugreek were determined over 2 h. The primary endpoint was the incremental area under the plasma glucose response curve (IAUC). Adding fenugreek to both foods significantly reduced the IAUC compared to the food alone: white bread and jam, 180 ± 22 versus 271 ± 23 mmol × min/L (P= 0.001); fried rice, 176 ± 20 versus 249 ± 25 mmol × min/L (P= 0.001). Fenugreek also significantly reduced the area under the satiety curve for white bread with jam (134 ± 27 versus 232 ± 33 mm × hr,P= 0.01) and fried rice (280 ± 37 versus 379 ± 36 mm × hr,P= 0.01). It is concluded that fenugreek significantly decreased the PPG response and increased satiety among overweight and obese individuals.

scholarly journals Effect of Moringa oleifera Leaf Powder on Postprandial Blood Glucose Response: In Vivo Study on Saharawi People Living in Refugee Camps

Nutrients ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1494 ◽  
Author(s):  
Alessandro Leone ◽  
Simona Bertoli ◽  
Sara Di Lello ◽  
Angela Bassoli ◽  
Stefano Ravasenghi ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Moringa Oleifera ◽  
Postprandial Glucose ◽  
Postprandial Blood Glucose ◽  
Refugee Camps ◽  
Long Term Effects ◽  
Glucose Response ◽  
Leaf Powder

The hypoglycemic effect in humans of Moringa oleifera (MO) leaf powder has, to date, been poorly investigated. We assessed the chemical composition of MO leaf powder produced at Saharawi refugee camps, its in vitro ability to inhibit α-amylase activity, and its sensory acceptability in food. We then evaluated its effect on postprandial glucose response by randomly administering, on 2 different days, a traditional meal supplemented with 20 g of MO leaf powder (MOR20), or not (control meal, CNT), to 17 Saharawi diabetics and 10 healthy subjects. Capillary glycaemia was measured immediately before the meal and then at 30 min intervals for 3 h. In the diabetic subjects the postprandial glucose response peaked earlier with MOR20 compared to CNT and with lower increments at 90, 120, and 150 min. The mean glycemic meal response with MOR20 was lower than with CNT. The healthy subjects showed no differences. Thus, MO leaf powder could be a hypoglycemic herbal drug. However, given the poor taste acceptability of the 20 g MO meal, lower doses should be evaluated. Moreover, the hypoglycemic effects of MO leaf powder should also be demonstrated by trials evaluating its long-term effects on glycaemia.

scholarly journals Glycaemic response to barley porridge varying in dietary fibre content

2011 ◽  
Vol 107 (5) ◽  
pp. 719-724 ◽  
Author(s):  
Pariyarath S. Thondre ◽  
Ke Wang ◽  
Andrew J. Rosenthal ◽  
Christiani J. K. Henry
Keyword(s):  
Blood Glucose ◽  
Dietary Fibre ◽  
Human Subjects ◽  
Glycaemic Index ◽  
Fibre Content ◽  
Postprandial Blood Glucose ◽  
Glycaemic Response ◽  
Glucose Response ◽  
Glucose Levels ◽  
Significant Difference

The interest in barley as a food is increasing worldwide because of its high dietary fibre (DF) content and low glycaemic index (GI). DF in cereals may prove beneficial in improving blood glucose response in the long term. However, a dose-dependent effect of insoluble fibre on reducing postprandial blood glucose levels is yet to be proven. The objective of the present study was to determine the glycaemic response to two barley porridges prepared from whole barley grains varying in fibre content. In two separate non-blind randomised crossover trials, ten human subjects consumed barley porridge with 16 g/100 g and 10 g/100 g fibre content provided in different serving sizes (equivalent to 25 and 50 g available carbohydrate). The glycaemic response to both barley porridges was significantly lower than the reference glucose (P < 0·05). There was no significant difference between the glucose areas under the curve or GI for the two barley porridges. We concluded that irrespective of the difference in total fibre content or serving size of barley porridges, their GI values did not differ significantly.

scholarly journals Effect of dose and modification of viscous properties of oat gum on plasma glucose and insulin following an oral glucose load

1994 ◽  
Vol 72 (5) ◽  
pp. 731-743 ◽  
Author(s):  
Peter J.Wood ◽  
Jan T. Braaten ◽  
Fraser W. Scott ◽  
K. Doreen Riedel ◽  
Mark S. Wolynetz ◽  
...  
Keyword(s):  
Plasma Glucose ◽  
Postprandial Glucose ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glycaemic Response ◽  
Postprandial Plasma Glucose ◽  
Insulin Levels ◽  
Healthy Humans ◽  
Insulin Responses ◽  
The Relationship

An extract from oats known as oat gum (OG) is composed mainly of the polysaccharide (1→3) (1→4)-β-D-glucan, which is highly viscous in aqueous solution. Viscous polysaccharides are known to attenuate postprandial plasma glucose and insulin responses. The purposes of this study were to determine the dose–response to OG and establish quantitatively the effect of viscosity on plasma glucose and insulin levels of healthy humans consuming 50 g glucose. Increasing the dose of OG successively reduced the plasma glucose and insulin responses relative to a control without gum. Reduction of the viscosity of OG by acid hydrolysis reduced or eliminated the capacity to decrease postprandial glucose and insulin levels. The ability of OG to modify glycaemic response was unchanged following agglomeration in the presence of maltodextrin. Agglomerated gum dispersed smoothly in a drink without formation of lumps, and development of maximum viscosity was delayed. These properties improve palatability. There was a highly significant linear relationship between log[viscosity] of the mixtures consumed and the glucose and insulin responses. The relationship shows that 79–96% of the changes in plasma glucose and insulin are attributable to viscosity, and that changes occur at relatively low doses and viscosities.

Postprandial hormone and metabolic responses in simulated shift work

1996 ◽  
Vol 151 (2) ◽  
pp. 259-267 ◽  
Author(s):  
S M Hampton ◽  
L M Morgan ◽  
N Lawrence ◽  
T Anastasiadou ◽  
F Norris ◽  
...  
Keyword(s):  
Phase Shift ◽  
Shift Work ◽  
Plasma Glucose ◽  
Peak Plasma ◽  
Work Conditions ◽  
Postprandial Glucose ◽  
Clock Time ◽  
Postprandial Plasma Glucose ◽  
Significant Difference ◽  
Before And After

Abstract This study was designed to investigate postprandial responses to a mixed meal in simulated shift work conditions. Nine normal healthy subjects (six males and three females) were studied on two occasions at the same clock time (1330 h) after consuming test meals, first in their normal environment and secondly after a 9 h phase advance (body clock time 2230 h). Plasma glucose, insulin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), triacylglycerol (TAG) and non-esterified fatty acids (NEFAs) were determined at intervals for 6 h after each test meal. Postprandial plasma glucose, insulin, GIP and GLP-1 profiles were evaluated by calculating areas under the curve (AUC) for the first 2 h and the last 4 h of the sampling together with total AUC. Significantly higher postprandial glucose responses (total AUC) were observed after the phase shift than before (AUC 0–360 min, 2·01 (1·51–2·19) vs 1·79 (1·56–2·04) mmol/l.min; P<0·02; mean (range)). No significant difference was observed when the first 2 h of each response was compared, but significantly higher glucose levels were observed in the last 4 h of the study after the phase shift than before (AUC 120–360 min, 1·32 (1·08–1·42) vs 1·16 (1·00–1·28) mmol/l.min; P<0·05). Similar results were obtained for insulin (AUC 0—360 min, 81·72 (30·75– 124·97) vs 58·98 (28·03–92·57) pmol/l.min; P<0·01; AUC 120–360 min, 40·73 (16·20–65·25) vs 25·71 (14·25–37·33) pmol/l.min; P<0·02). No differences were observed in postprandial plasma GIP and GLP-1 responses before and after the phase shift. Postprandial circulating lipid levels were affected by phase shifting. Peak plasma TAG levels occurred 5 h postprandially before the phase shift. Postprandial rises in plasma TAG were significantly delayed after the phase shift and TAG levels continued to rise throughout the study. Plasma postprandial NEFA levels fell during the first 3 h both before and after the phase shift. Their rate of return to basal levels was significantly delayed after the phase shift compared with before. This study demonstrates that a simulated phase shift can significantly alter pancreatic B-cell responses and postprandial glucose and lipid metabolism. Journal of Endocrinology (1996) 151, 259–267

scholarly journals Can the Sequence of Food Presentation Influence Postprandial Glycaemia? (P10-072-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Christiani Henry ◽  
Lijuan Sun ◽  
Priya Govindharajulu ◽  
Melvin Khee-Shing Leow
Keyword(s):  
Random Order ◽  
Postprandial Glucose ◽  
Food Presentation ◽  
Chinese Adults ◽  
Glycaemic Response ◽  
Glucose Response ◽  
Randomized Controlled ◽  
Funding Sources ◽  
Postprandial Glycaemia ◽  
Different Order

Abstract Objectives The study was to investigate how a rice-based meal composed of rice, vegetable (green leaf) and meat (breast of chicken) when presented in different order of sequence, impacts on postprandial glycaemia. Methods In a randomized controlled crossover trial, sixteen healthy Chinese adults participated in this study (13 males and 3 females). Subjects consumed in random order 5 experimental meals. The 5 test meal were: (1) vegetables first followed by meat and rice (V-MR), (2) meat first followed by vegetables and rice (M-VR), (3) vegetables first, meat second followed by rice (V-M-R), (4) vegetables, meat and rice together (VMR), (5) rice followed by vegetables and meat (R-VM). Vegetable consumed first followed by meat and rice (V-MR), finally vegetable consumed first, followed by meat and followed by rice (V-M-R). Results In comparison to rice consumed first followed by vegetable and meat (R-VM), the overall postprandial glucose response was significantly lower after the consumption of vegetable first, followed by meat and rice (V-MR) or meat first, followed by vegetable and rice (M-VR) or vegetable followed by meat and followed by rice (V-M-R) or vegetable, meat and rice consumed together (VMR). The insulin iAUC (0–60) was significantly lower after V-M-R than M-VR, VMR and R-VM. V-M-R food sequence intake stimulated higher GLP-1 release than other meal sequence. However, GIP response was lower after V-MR and V-M-R than M-VR and R-MR food sequence. Conclusions Food sequence can considerably influence a meals response to glycaemic, insulinaemic and incretin. V-M-R food sequence intake lowered the glycaemic response significantly with an increased stimulation of GLP1. The order of food presentation has a great potential to alter the glycaemic response of rice-based diets. Our results provide a simple but effective way to reduce postprandial glucose and may help prevent the transition from pre-diabetics to diabetics Funding Sources Singapore Institute for Clinical Sciences, A*STAR, Singapore. Supporting Tables, Images and/or Graphs

GIP and GLP-1 Receptor Antagonism During a Meal in Healthy Individuals

2020 ◽  
Vol 105 (3) ◽  
pp. e725-e738 ◽  
Author(s):  
Lærke S Gasbjerg ◽  
Mads M Helsted ◽  
Bolette Hartmann ◽  
Alexander H Sparre-Ulrich ◽  
Simon Veedfald ◽  
...  
Keyword(s):  
Energy Expenditure ◽  
Receptor Antagonist ◽  
Plasma Glucose ◽  
Area Under The Curve ◽  
Postprandial Glucose ◽  
Gallbladder Motility ◽  
Incretin Hormones ◽  
Gallbladder Ejection Fraction ◽  
Postprandial Plasma Glucose ◽  
Postprandial Glycemia

Abstract Context The actions of both endogenous incretin hormones during a meal have not previously been characterized. Objective Using specific receptor antagonists, we investigated the individual and combined contributions of endogenous glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) to postprandial glucose metabolism, energy expenditure, and gallbladder motility. Design Randomized, double-blinded, placebo-controlled, crossover design. Setting On four separate days, four liquid mixed meal tests (1894 kJ) over 270 minutes (min). Patients or Other Participants Twelve healthy male volunteers. Interventions Infusions of the GIP receptor antagonist GIP(3–30)NH2 (800 pmol/kg/min), the GLP-1 receptor antagonist exendin(9–39)NH2 (0–20 min: 1000 pmol/kg/min; 20–270 min: 450 pmol/kg/min), GIP(3–30)NH2+exendin(9–39)NH2, or placebo/saline. Main Outcome Measure Baseline-subtracted area under the curve (bsAUC) of C-peptide. Results Infusion of GIP(3–30)NH2+exendin(9–39)NH2 significantly increased plasma glucose excursions (bsAUC: 261 ± 142 mmol/L × min) during the liquid mixed meals compared with GIP(3–30)NH2 (180 ± 141 mmol/L × min; P = 0.048), exendin(9–39)NH2 (171 ± 114 mmol/L × min; P = 0.046), and placebo (116 ± 154 mmol/L × min; P = 0.015). Correspondingly, C-peptide:glucose ratios during GIP(3–30)NH2+exendin(9–39)NH2 infusion were significantly lower than during GIP(3–30)NH2 (P = 0.0057), exendin(9–39)NH2 (P = 0.0038), and placebo infusion (P = 0.014). GIP(3–30)NH2 resulted in significantly lower AUCs for glucagon than exendin(9–39)NH2 (P = 0.0417). Gallbladder ejection fraction was higher during GIP(3–30)NH2 compared with placebo (P = 0.004). For all interventions, energy expenditure and respiratory quotient were similar. Conclusions Endogenous GIP and GLP-1 lower postprandial plasma glucose excursions and stimulate insulin secretion but only endogenous GIP affects gallbladder motility. The two incretin hormones potentiate each other’s effects in the control of postprandial glycemia in healthy men.

scholarly journals Randomized, Double-Blinded, Double-Dummy, Active-Controlled, and Multiple-Dose Clinical Study Comparing the Efficacy and Safety of Mulberry Twig (Ramulus Mori, Sangzhi) Alkaloid Tablet and Acarbose in Individuals with Type 2 Diabetes Mellitus

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Mengyi Li ◽  
Xuemin Huang ◽  
Hui Ye ◽  
Yao Chen ◽  
Jing Yu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Clinical Trial ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Efficacy And Safety ◽  
Postprandial Plasma Glucose ◽  
Glucose Levels ◽  
Fasting Plasma ◽  
Significant Difference

Aims. To evaluate the efficacy and safety of mulberry twig alkaloid (SZ-A) tablet compared with acarbose in patients with type 2 diabetes.Methods. This clinical trial enrolled 38 patients who were randomized into two groups (SZ-A: 23; acarbose: 15) and were treated for 24 weeks. Patients and clinical trial staffs were masked to treatment assignment throughout the study. The primary outcome measures were glycated hemoglobin (HbA1c) and 1-hour and 2-hour postprandial and fasting plasma glucose levels from baseline to the end of treatment. Analysis included all patients who completed this study.Results. By the end of this study, HbA1c level in SZ-A group was decreased from baseline significantly (P<0.001). No significant difference was found when compared with acarbose group (P=0.652). Similarly, 1-hour and 2-hour postprandial plasma glucose levels in SZ-A group were decreased from baseline statistically (P<0.05), without any significant differences compared with acarbose group (P=0.748and 0.558, resp.). The fasting plasma glucose levels were not significantly changed in both groups. One of 23 patients in SZ-A group (4.76%) and 5 of 15 patients in acarbose group (33.33%) suffered from gastrointestinal adverse events.Conclusions. Compared with acarbose, SZ-A tablet was effective and safe in glycemic control in patients with type 2 diabetes.

Sign in / Sign up

Export Citation Format

Share Document