The effects of breed, breeding system and other factors on lamb mortality: 2. Factors influencing the incidence of delayed birth, dystokia, congenital defects and miscellaneous causes of early death

1983 ◽  
Vol 100 (3) ◽  
pp. 553-561 ◽  
Author(s):  
Carol Woolliams ◽  
G. Wiener ◽  
N. S. M. Macleod
Keyword(s):  
Birth Weight ◽  
Causes Of Death ◽  
Early Death ◽  
Inbred Lines ◽  
Inbreeding Coefficient ◽  
Congenital Defects ◽  
Significant Extent ◽  
Skeletal Defects ◽  
Brain Haemorrhage ◽  
Birth Type

SUMMARYThe incidence of a number of causes of death of lambs around the time of birth was examined in relation to breed, inbreeding, birth weight, birth type, sex of lamb, week of birth and parity. Data were from a grazing flock on an upland farm over a 6-year period. The breeds were the Scottish Blackface, Cheviot, and Welsh Mountain and the crosses among them. Each breed and cross was maintained at five levels of inbreeding ranging from zero to 59% inbreeding coefficient.The incidence of delayed birth varied significantly among the breeds and crosses with the Welsh having the lowest incidence. Compared with the pure breeds the crosses showed a lower incidence of both delayed birth and preparturient deaths, but significantly only for the latter.Dystokia was classified according to whether it arose from the relative dimensions of lamb and dam or from malpresentation. For both types the heaviest lambs had the highest incidence but the association with birth weight was much stronger for dystokia involving dimensions. Breed variation was not significant, but cross-breds had the highest frequency for the dimensions category and the lowest for malpresentation. Singles were at greater risk than twins as were lambs born to a first parity.Congenital defects as a cause of death were divided into six categories. Only skeletal defects varied significantly among breeds and the incidence increased with inbreeding, but crosses of inbred lines did not have the lowest frequency. For congenital defects overall and for hydrocephalus and hydronephrosis in particular, line crosses (noninbred) had the lowest incidence and 25% inbred lambs the highest, the frequency declining with further inbreeding. None of the other factors considered affected variation in the incidence of any of these defects to a significant extent.Liver rupture and brain haemorrhage were most frequent in heavy lambs, singles and lambs born to a first parity dam.

The effects of breed, breeding system and other factors on lamb mortality: 1. Causes of death and effects on the incidence of losses

1983 ◽  
Vol 100 (3) ◽  
pp. 539-551 ◽  
Author(s):  
G. Wiener ◽  
Carol Woolliams ◽  
N. S. M. Macleod
Keyword(s):  
Birth Weight ◽  
Mortality Rate ◽  
Breeding System ◽  
Causes Of Death ◽  
Inbred Lines ◽  
Congenital Defects ◽  
Post Mortem ◽  
Size Type ◽  
Upland Grassland ◽  
Better Than

SUMMARYThe incidence of lamb mortality from birth to 8 months of age has been studied over a 6-year period in an upland, grassland flock of sheep comprising the Scottish Blackface, Cheviot and Welsh Mountain breeds and the crosses among these breeds. Each breed and cross-bred type was maintained at varying levels of inbreeding. Approximately half the lambs which died were stillborn or dead on the day of birth, nearly 40% died thereafter but before weaning and about 10% after weaning.Post-mortem examinations on 586 of the 632 lambs which died from among the 2453 born attributed death on average to two causes per lamb. Approximately 11% of the causes were stillbirths or delayed births; 11% were cases of dystokia; congenital defects of various types accounted for about 10% of the causes; 25% made reference to weakly lamb, exposure or starvation; 14% to infectious diseases and 16% to noninfectious diseases. The extent to which causes of death occur together is examined.Breeds differed in mortality rate with the Welsh the lowest and Cheviot the highest. Cross-breds were better than the average of the pure breeds but this advantage emerged only in the period between 3 days and. 6 weeks of age. Inbreeding, both of dam and of lamb, increased mortality. Lambs from dams which were crosses of inbred lines had the best survival. Litter size, type of rearing, parity of dam, sex of lamb and birth weight also had significant effects on mortality rate.

The effects of breed, breeding system and other factors on lamb mortality: 3. Factors influencing the incidence of weakly lambs as a cause of death

1983 ◽  
Vol 100 (3) ◽  
pp. 563-570 ◽  
Author(s):  
Carol Woolliams ◽  
G. Wiener ◽  
N. S. M. Macleod
Keyword(s):  
Birth Weight ◽  
Cause Of Death ◽  
Breeding System ◽  
Causes Of Death ◽  
Inbred Lines ◽  
Factors Influencing ◽  
Line Cross ◽  
Low Incidence

SUMMARYThe incidence of lamb mortality from weakness at birth, underdevelopment, exposure and starvation was examined over 6 years in an upland flock and analysed in relation to breed, breeding system and other factors. These causes accounted for more than a quarter of the deaths and contributed to many more.The frequency of death due to these causes was greater in lambs light at birth. The incidence of these causes of death differed significantly between the breeds, Scottish Blackface, Cheviot and Welsh Mountain and their crosses, but for the separate categories breed variation was significant only for the incidence of death by starvation, which was also less frequent in cross-breds than purebreds. Mortality from several of these causes was increased by inbreeding (25–59%), but decreased by crossing inbred lines. Lambs born to line-cross or other non-inbred dams had a relatively low incidence of these various causes of death. For underdeveloped lambs variation due to maternal inbreeding was significant. When classes were adjusted for difference in birth weight, breed variation in mortality was greatly enhanced but variation due to inbreeding much reduced.Slightly more twins than single-born lambs died from these causes and triplets fared worst, but such variation was significant only for death from exposure. Mortality from these causes varied significantly with parity of dam, being highest in the first, and mortality in males was slightly but not significantly higher than in females.

scholarly journals Energy Supplementation during the Last Third of Gestation Improves Mother–Young Bonding in Goats

Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 287
Author(s):  
Juan M. Vázquez-García ◽  
Gregorio Álvarez-Fuentes ◽  
Héctor O. Orozco-Gregorio ◽  
Juan C. García-López ◽  
Milagros González-Hernández ◽  
...  
Keyword(s):  
Heart Rate ◽  
Birth Weight ◽  
Respiratory Rate ◽  
Rectal Temperature ◽  
First Feeding ◽  
Labor Duration ◽  
Daily Energy ◽  
Energy Supplementation ◽  
Birth Body Weight ◽  
Birth Type

We tested whether maternal energy supplementation during the last third of gestation improves birth weight, neonatal wellbeing, and mother–young bonding. Thirty-six pregnant French Alpine goats were randomly allocated among three nutritional treatments for the last third of pregnancy: (i) Control, fed alfalfa (T-0; n = 12); (ii) alfalfa + 150 g/head daily energy concentrate (T-150; n = 12); (iii) alfalfa + 300 g/head daily energy concentrate (T-300; n = 12). At birth, we collected progeny data on birth weight, birth type, sex, rectal temperature, heart rate, respiratory rate, time to standing, time to udder connection, and time to first feeding. For the dams, we collected data on the duration of labor, time to clean the progeny, and time to allow first suckling. At birth, body weight, rectal temperature, heart rate, and the respiratory rate did not differ among treatments (p > 0.05). In the dams, labor duration was not affected by the treatments (p > 0.05). The T-150 dams were faster to clean the newborn and allow first suckling (p < 0.05). The T-150 progeny were faster to stand and the T-300 progeny were faster to connect to the udder (p < 0.05). We conclude that energy supplementation of the dam during the last third of gestation does not affect the birth weight of the progeny, but enhances the mother–young bonding.

Role of Discoidin Domain Receptor 2 in Craniofacial Bone Regeneration

2021 ◽  
pp. 002203452110074
Author(s):  
A. Binrayes ◽  
C. Ge ◽  
F.F. Mohamed ◽  
R.T. Franceschi
Keyword(s):  
Bone Regeneration ◽  
Healing Process ◽  
Congenital Defects ◽  
Calvarial Bone ◽  
Discoidin Domain Receptor ◽  
Skeletal Defects ◽  
Discoidin Domain Receptor 2 ◽  
Collagen Receptor ◽  
Deficient Mice

Bone loss caused by trauma, neoplasia, congenital defects, or periodontal disease is a major cause of disability and human suffering. Skeletal progenitor cell–extracellular matrix interactions are critical for bone regeneration. Discoidin domain receptor 2 (DDR2), an understudied collagen receptor, plays an important role in skeletal development. Ddr2 loss-of-function mutations in humans and mice cause severe craniofacial and skeletal defects, including altered cranial shape, dwarfing, reduced trabecular and cortical bone, alveolar bone/periodontal defects, and altered dentition. However, the role of this collagen receptor in craniofacial regeneration has not been examined. To address this, calvarial subcritical-size defects were generated in wild-type (WT) and Ddr2-deficient mice. The complete bridging seen in WT controls at 4 wk postsurgery was not observed in Ddr2-deficient mice even after 12 wk. Quantitation of defect bone area by micro–computed tomography also revealed a 50% reduction in new bone volume in Ddr2-deficient mice. Ddr2 expression during calvarial bone regeneration was measured using Ddr2-LacZ knock-in mice. Expression was restricted to periosteal surfaces of uninjured calvarial bone and, after injury, was detected in select regions of the defect site by 3 d postsurgery and expanded during the healing process. The impaired bone healing associated with Ddr2 deficiency may be related to reduced osteoprogenitor or osteoblast cell proliferation and differentiation since knockdown/knockout of Ddr2 in a mesenchymal cell line and primary calvarial osteoblast cultures reduced osteoblast differentiation while Ddr2 overexpression was stimulatory. In conclusion, Ddr2 is required for cranial bone regeneration and may be a novel target for therapy.

Comparison of Phototherapy Results in Small-for-Gestational-Age and Appropriate-for-Gestational-Age Infants Weighing Less Than 2,000 Grams

PEDIATRICS ◽  
1985 ◽  
Vol 75 (2) ◽  
pp. 413-441
Author(s):  
Joan E. Hodgman ◽  
Paul Y. K. Wu ◽  
Nathaniel B. White ◽  
Dolores A. Bryla
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Congenital Defects ◽  
Intrauterine Growth ◽  
Appropriate For Gestational Age ◽  
Study Population ◽  
Similar Weight ◽  
Gestational Age At Birth ◽  
Evaluation Techniques

The infant who is small for gestational age (SGA) is more mature at birth than similar weight infants who are appropriate for gestational age (AGA). Whether the SGA infant behaves as does the larger gestationally equivalent infant, or whether there are specific changes related to intrauterine growth retardation is a matter of some interest in the understanding of the special needs of these infants. The National Institute of Child Health and Human Development (NICHD) phototherapy study provided a large newborn population for whom birth weight, gestational age at birth, and, thereby, intrauterine growth were carefully assessed. Infants who weighed 2,000 g or more at birth were included in the study only when they became jaundiced, whereas infants who weighed less than 2,000 g at birth were routinely entered into the study. Consequently, this report will be limited to the lowbirth-weight population selected by birth weight. Too few SGA babies were present in the groups with greater birth weight to allow meaningful comparisons. PATIENT SELECTIQN All infants whose birth weight was less than 2,000 g were entered into the study at 24 ± 12 hours. Those excluded from the study were: (1) infants who died before 24 hours, (2) infants with serious congenital defects, and (3) infants whose mothers refused consent for study. The study population consisted of 922 infants surviving at 24 hours. Gestational age was calculated from the first day of the last menstrual period obtained from maternal history and also by the evaluation techniques of Dubowitz.25 Intrauterine growth was determined by plotting birth weight and gestational age on the Denver Intrauterine Growth Curves8; infants below the 10th percentile were considered SGA.

scholarly journals Pengaruh Zat Besi (Tablet Fe) Terhadap Berat Badan Lahir Pada Ibu Bersalin Normal

2020 ◽  
Vol 10 (1) ◽  
pp. 470-475
Author(s):  
Zulliati Zulliati ◽  
Nita Hestiyana
Keyword(s):  
Systematic Review ◽  
Birth Weight ◽  
Controlled Trial ◽  
Congenital Defects ◽  
Attractive Alternative ◽  
Scientific Article ◽  
Viet Nam ◽  
Anemia In Pregnancy ◽  
Infant Birth ◽  
In Pregnancy

 Latar Belakang: Anemia dalam kehamilan mempengaruhi lebih dari 500 juta wanita dalam masa kehamilan, yang nantinya dapat dikaitkan dengan gangguan pada ibu dan bayi. Suplementasi zat besi selama masa kehamilan diberikan secara terus menerus adalah alternatif yang menarik. Anemia sering terjadi akibat defisiensi zat besi dikarenakan pada ibu hamil terjadi peningkatan kebutuhan zat besi dua kali lipat akibat peningkatan volume darah tanpa ekspansi volume plasma, untuk memenuhi kebutuhan ibu (mencegah kehilangan darah pada saat melahirkan) dan pertumbuhan janin.Tujuan: Artikel ilmiah ini mencoba menelaah berdasarka studi literature hasil penelitian mengenai penggunaan tablet zat besi terhadap peningkatan berat badan lahir bayi.  Metode: Studi ini merupakan tinjauan literatur yang dilakukan dari tiga jurnal penelitian yang dilakukan di Viet Nam dan Spayol dan systematic review dari beberapa Randomized Controlled Trial yang dilakukan di cluster dan communityHasil: Beberapa penelitian menyebutkan terdapat korelasi yang erat antara anemia pada saat kehamilan dengan kematian janin, abortus, cacat bawaan, berat bayi lahir rendah, cadangan zat besi yang berkurang pada anak atau anak lahir dalam keadaan anemia gizi.Kesimpulan: Pemberian zat besi selama kehamilan selama ini diyakini  dapat mengatasi anemia dalam kehamilan untuk menghindari persalinan prematur dan perdarahan pada saat persalinan,Kata kunci :Berat badan lahir, zat besi ABSTRACT Background: Anemia in pregnancy affects more than 500 million women during pregnancy, which can later be associated with disorders of the mother and baby. Iron supplementation during pregnancy is given continuously is an attractive alternative. Anemia often occurs due to iron deficiency because in pregnant women there is a doubling of iron demand due to increased blood volume without plasma volume expansion, to meet the needs of the mother (preventing blood loss during childbirth) and fetal growth.Purpose: This scientific article tries to examine the literature based on the results of research on the use of iron tablets to increase infant birth weight.Methods: This study is a literature review conducted from three research journals conducted in Viet Nam and Spain and a systematic review of several Randomized Control Trials conducted in clusters and communities.Results: Several studies suggest that there is a close correlation between anemia during pregnancy and fetal death. , abortion, congenital defects, low birth weight, reduced iron reserves in children or children born in a state of nutritional anemia.Conclusion: The administration of iron during pregnancy is believed to be able to overcome anemia in pregnancy to avoid premature labor and bleeding during labor, Keywords: Birth weight, iron

scholarly journals IDENTITY COEFFICIENTS IN FINITE POPULATIONS. I. EVOLUTION OF IDENTITY COEFFICIENTS IN A RANDOM MATING DIPLOID DIOECIOUS POPULATION

Genetics ◽  
1977 ◽  
Vol 86 (3) ◽  
pp. 697-713
Author(s):  
C Chevalet ◽  
M Gillois ◽  
R F Nassar
Keyword(s):  
Genetic Variability ◽  
Population Size ◽  
Effective Population Size ◽  
Random Mating ◽  
Matrix Multiplication ◽  
Inbred Lines ◽  
Inbreeding Coefficient ◽  
Effective Population ◽  
The Mean ◽  
Over Time

ABSTRACT Properties of identity relation between genes are discussed, and a derivation of recurrent equations of identity coefficients in a random mating, diploid dioecious population is presented. Computations are run by repeated matrix multiplication. Results show that for effective population size (Ne) larger than 16 and no mutation, a given identity coefficient at any time t can be expressed approximately as a function of (1—f), (1—f)3 and (1—f)6, where f is the mean inbreeding coefficient at time t. Tables are presented, for small Ne values and extreme sex ratios, showing the pattern of change in the identity coefficients over time. The pattern of evolution of identity coefficients is also presented and discussed with respect to N eu, where u is the mutation rate. Applications of these results to the evolution of genetic variability within and between inbred lines are discussed.

Factors governing the shape of the growth curve of body weight and the age at slaughter of Suffolk × Welsh lambs

1966 ◽  
Vol 8 (3) ◽  
pp. 435-444 ◽  
Author(s):  
J. S. Broadbent ◽  
J. H. Watson
Keyword(s):  
Body Weight ◽  
Birth Weight ◽  
Growth Curve ◽  
Compensatory Growth ◽  
Marked Effect ◽  
Growth Curves ◽  
Live Weight ◽  
Linear Component ◽  
Slaughter Weight ◽  
Birth Type

Curves of growth in live-weight, from birth to 16 weeks of age, of 362 Suffolk × Welsh lambs were analysed for the effect of sex, birth type, sire and test centre environment and related to variation in age at slaughter.The relative pre-natal disadvantages of twin lambs resulted in their curves of growth differing from those of single-born animals, particularly in males. Test centre environment exerted a marked effect in such cases. At one centre, male twins showed marked compensatory growth.Differences in growth existed between the 14 sire progeny groups. As the linear component of the growth curves decreased, the quadratic values became increasingly negative. Deceleration of growth was most marked in slowest growing progeny groups and this was accentuated by a poor test centre environment.These factors combined to influence age at slaughter, which was also related to birth weight of the lamb. Lambs at the best test centre reached slaughter weight 10 and 16 days earlier than lambs at the two remaining centres. Sires produced differences in age at slaughter of 10 to 14 days, within centres.

scholarly journals Clinical diagnoses vs. autopsy findings in early deceased septic patients in the intensive care: a retrospective cohort study

2020 ◽  
Author(s):  
Rob G. H. Driessen ◽  
Bartholomeus G. H. Latten ◽  
Dennis C. J. J. Bergmans ◽  
Riquette P. M. G. Hulsewe ◽  
Johanna W. M. Holtkamp ◽  
...  
Keyword(s):  
Intensive Care ◽  
Clinical Diagnosis ◽  
Causes Of Death ◽  
Early Death ◽  
Class I ◽  
Icu Patients ◽  
Icu Admission ◽  
Clinical Diagnoses ◽  
Important Diagnostic Tool ◽  
Record Review

AbstractEarly death in sepsis occurs frequently; however, specific causes are largely unknown. An autopsy can contribute to ascertain causes of death. The objective of the study was to determine discrepancies in clinical diagnosis and postmortem findings in septic intensive care unit (ICU) patients deceased within 48 h after ICU admission. All septic ICU patients who deceased within 48 h after ICU admission were identified and included. Four intensivists determined the clinical cause of death by medical record review. An autopsy was performed within 24 h of death. Clinical diagnosis and postmortem findings were compared and classified as autopsy-identified missed clinical diagnoses and autopsy-refuted diagnoses. Class I and II missed major diagnoses using the Goldman criteria were scored. Between 2012 and 2017, 1107 septic patients were admitted to ICU. Of these, 344 patients (31%) died, of which 97 patients (28%) deceased within 48 h. In 32 (33%) early deceased patients, an autopsy was agreed. There were 26 autopsy-identified missed clinical diagnoses found, mostly myocardial infarction (n = 4) and pneumonia (n = 4). In four patients (13%), a class I discrepancy was found. In fourteen patients (42%), a class II discrepancy was found. In conclusion, an autopsy is an important diagnostic tool that can identify definite causes of death. These diagnoses deviate from diagnoses established during admission in early deceased sepsis patients.

Congenital Defects of Squirrel Monkeys (Saimiri sciureus)

1981 ◽  
Vol 18 (1) ◽  
pp. 29-36 ◽  
Author(s):  
H. F. Stills ◽  
B. C. Bullock
Keyword(s):  
Congenital Anomalies ◽  
Cleft Lip ◽  
Left Kidney ◽  
Squirrel Monkeys ◽  
Saimiri Sciureus ◽  
Congenital Defects ◽  
Skeletal Defects ◽  
High Incidence ◽  
Primary Palate ◽  
Ultimobranchial Gland

Nine congenital defects were seen in six animals during necropsies of 27 aborted or stillborn and 25 neonatal squirrel monkeys ( Saimiri sciureus) during a two-year period. The defects were left diaphragmatic hypoplasia with herniation; right renal aplasia in conjunction with a right cleft lip and primary palate; supernumerary left kidney; skeletal defects, hydrocephalus, and thyroid anomalies consistent with the campomelic syndrome; atresia ani; and ultimobranchial gland remnants. The high incidence of congenital anomalies (4.9% of births and 11.5% of nonsurviving births) is consistent with a previous report of congenital defects in squirrel monkeys.

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