The relationship between helminth infections and low haemoglobin levels in Ethiopian children with blood type A

AbstractThe current study was conducted to evaluate the nature of association of ABO blood type with helminth infection and related reduction in haemoglobin concentration. Stool samples were collected from 403 school-age children attending Tikur Wuha Elementary School from February to April 2011. Helminth infection was examined using formol-ether concentration and thick Kato–Katz (two slides per stool specimen) techniques. Haemoglobin level was determined using a HemoCue machine and ABO blood type was determined using the antisera haemagglutination test. Nutritional status was assessed using height and weight measurements. Out of 403 children examined, 169, 120, 96 and 18 had blood type O, A, B and AB, respectively. The prevalences of helminth infections were 46.9% for hookworm, 24.6% forSchistosoma mansoni, 4.2% forAscaris lumbricoides, 1.7% forTrichuris trichiuraand 58.3% for any helminth species. The relative odds of infection with at least one helminth species was significantly higher among children with blood type A (adjusted odds ratio (AOR), 2.10; 95% confidence interval (CI), 1.28–3.45) or blood type B (AOR, 2.08; 95% CI, 1.22–3.56) as compared to children with blood type O. Among children infected with helminths, mean haemoglobin concentration was lower in those with blood type A than those with blood type O (β, −0.36; 95% CI, −0.72 to −0.01). The relative odds of hookworm infection (AOR, 1.78; 95% CI, 1.08–2.92) and related reduction in haemogobin levels (β, −0.45; 95% CI, −0.84 to −0.04) was higher among children with blood type A as compared to those with blood type O. Although the difference was not significant, the relative odds ofS. mansoniorA. lumbricoidesinfections and related reduction in haemoglobin levels was also higher in children with blood type A or B as compared to children with blood type O. In conclusion, children with blood type A are associated with an increased risk of helminth, particularly hookworm, infection and related reduction in haemoglobin level. The mechanisms by which blood type A makes children susceptible to helminth infection and a related reduction in haemoglobin level ought to be investigated.

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ABO blood type and risk of porcine bioprosthetic aortic valve degeneration: SWEDEHEART observational cohort study

BMJ Open ◽

10.1136/bmjopen-2019-029109 ◽

2019 ◽

Vol 9 (5) ◽

pp. e029109 ◽

Cited By ~ 1

Author(s):

Michael Persson ◽

Gustaf Edgren ◽

Magnus Dalén ◽

Natalie Glaser ◽

Martin L Olsson ◽

...

Keyword(s):

Heart Failure ◽

Cohort Study ◽

Aortic Valve ◽

Aortic Valve Replacement ◽

Valve Replacement ◽

Type A ◽

Blood Type ◽

Type B ◽

Structural Valve Deterioration ◽

Abo Blood Type

ObjectiveBlood type A antigen on porcine aortic bioprostheses might initiate an immune reaction leading to an increased frequency of structural valve deterioration in patients with blood type B or O. The aim was to analyse the association between ABO blood type and porcine bioprosthetic aortic valve degeneration.DesignObservational nationwide cohort study.SettingSwedish population-based study.ParticipantsAdult patients (n=3417) who underwent surgical aortic valve replacement and received porcine bioprosthetic aortic valves between 1995 and 2012 from the Swedish Web system for Enhancement and Development of Evidence-based care in Heart disease Evaluated According to Recommended Therapies register. The study database was enriched with information from other national registers.ExposureThe patients were categorised into type A/AB and type B/O blood groups.Primary and secondary outcome measuresPrimary outcome measure was aortic valve reoperation, and secondary outcomes were heart failure and all-cause mortality. We report risk estimates that account for the competing risk of death.ResultsIn total, 3417 patients were identified: 1724 (50.5%) with blood type A/AB and 1693 (49.5%) with blood type B/O. Both groups had similar baseline characteristics. The cumulative incidence of aortic valve reoperation was 3.4% (95% CI 2.5% to 4.4%) and 3.6% (95% CI 2.6% to 4.6%) in the type B/O and the A/AB group, respectively, at 15 years of follow-up (absolute risk difference: −0.2% (95% CI −1.5% to 1.2%)). There was no significantly increased risk for aortic valve reoperation in patients with blood type B/O compared with type A/AB (HR 0.95, 95% CI 0.62 to 1.45). There was no significant difference in absolute or relative risk of heart failure or death between the groups.ConclusionsWe found no significant association between patient blood type and clinical manifestations of structural valve deterioration following porcine aortic valve replacement. Our findings suggest that it is safe to use porcine bioprosthetic valves without consideration of ABO blood type in the recipient.Trial registration numberNCT02276950

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VENOUS THROMBOEMBOLIC DISEASE AND ABO BLOOD TYPE. A COOPERATIVE STUDY

Obstetrical & Gynecological Survey ◽

10.1097/00006254-196909000-00009 ◽

1969 ◽

Vol 24 (9) ◽

pp. 1154-1157

Author(s):

HERSHEL JICK ◽

DENNIS SLONE ◽

BARBRO WESTERHOLM ◽

WILLIAM H. W. INMAN ◽

MARTIN P. VESSEY ◽

...

Keyword(s):

Type A ◽

Thromboembolic Disease ◽

Blood Type ◽

Venous Thromboembolic Disease ◽

Cooperative Study ◽

Venous Thromboembolic ◽

Abo Blood Type

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ABO and RHD blood types distribution of the patients treated in the Federal Center of Cardiovascular Surgery of Krasnoyarsk

Clinical Medicine (Russian Journal) ◽

10.18821/0023-2149-2016-94-5-353-355 ◽

2016 ◽

Vol 94 (5) ◽

pp. 353-355

Author(s):

Aleksnder A. Makovskiy ◽

A. A. Popov ◽

S. D. Gysev ◽

L. I. Barhatova

Keyword(s):

Cardiovascular Surgery ◽

Type A ◽

Blood Type ◽

Transfusion Therapy ◽

Blood Types ◽

The People ◽

Hospital Patients ◽

Abo Blood Type ◽

The Mean ◽

Group B

The knowledge of blood types frequency in hospital patients helps to plan and perform transfusion therapy at blood donor centers. The distribution of patients’ blood by ABO groups and RhD allows to more efficiently organize and use donor blood banks. The risk of a disease is related to genome composition and is inherited with an ABO blood type. Every person should know his (her) ABO blood type and RhD to enable early identification of the first symptoms of an illness. Materials and methods. This work is based on the study of 4831 blood samples from patients treated at the Center of Cardiovascular Surgery in 2013 (2885 (59,7%) men of the mean age 55 years and 1946 (40,3 %) women of the mean age 57 years). Results. Type A blood occurred most frequently (1787 or 37,0% samples) followed by group O (1625 or 33,6% samples). Samples of group B made up 1025 of the total (21,2%), AB blood group was found in 394 samples (8,2%). Conclusion. The blood types distribution of the ABO system in the patients treated at the Center of Cardiovascular Surgery was characterized by the following pattern: A > O > B > AB. Group A was identified in 37,0% of the patients. Its frequency is similar to that in the population of the western part of Russia and Moscow but different from that in the people living in nearby regions. The frequency of RhD system antigens is comparable in all regions of Russia. CcDEe, ccDEe, CcDee, CCDee are considered to be the most widespread phenotypes. The residents of the Krasnoyarsk region and some nearby regions having blood type A apply to the Center of Cardiovascular Surgery with cardiovascular disorders more frequently than those with others ABO blood types.

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Influence of ABO blood group on the natural history of advanced pancreatic adenocarcinoma (PC).

Journal of Clinical Oncology ◽

10.1200/jco.2013.31.4_suppl.307 ◽

2013 ◽

Vol 31 (4_suppl) ◽

pp. 307-307

Author(s):

MinYuen Teo ◽

Mohd Syahizul Nuhairy Mohd Sharial ◽

Jarushka Naidoo ◽

Anuradha Jayaram ◽

Thevaraajan Jayaraman ◽

...

Keyword(s):

Blood Group ◽

Peritoneal Dissemination ◽

Type A ◽

Blood Type ◽

Inclusion Criteria ◽

Entire Cohort ◽

History Of ◽

Abo Blood Type ◽

Advanced Pancreatic Adenocarcinoma ◽

Pro Inflammatory Cytokines

307 Background: An association between blood group (ABO) and PC has been demonstrated at epidemiologic and genomic levels. Variations in ABO type may lead to higher pro-inflammatory cytokines levels with modifications in cellular adhesionand signalling promoting carcinogenesis. This study investigated the influence of ABO on the clinical behaviour of advanced PC in patients (pts) , treated with chemotherapy (ctx). Methods: Pts with confirmed PC were identified from 4 institutional databases. Inclusion criteria were unresectable (UPC) or metastatic disease (MPC), receipt of ctx and availability of ABO data. Clinicopathologic details were collected. 200 random anonymied non-cancer ABO samples were collected as control. Descriptive statistics and survival analyses were performed. Results: Between 2001 and 2012, 222 pts met inclusion criteria. Median age was 63 years (range: 33 – 83) 56% were males. 60% of pts had MPC and 27% received doublet ctx. ABO distribution was: A (40%), AB (5%), B (11%) and O (44%). The incidence of blood type A was higher in PC cohort than control (40 vs 30%, p=.03) but identical between UPC and MPC (41 vs 40%, p=.84). Overall survival between type A and non A were identical for the entire cohort (5.8 vs 6.6 mos, HR 1.04 95% CI 0.76 – 1.40, p=.82), UPC (7.6 vs 9.5 mos, HR 1.08 95% CI 0.65 – 1.76, p=.77) or MPC (5.4 vs 4.7 mos, HR 0.94 95% CI 0.66 – 1.34, p=.78). For UPC, 56 pts (64%) had radiographic documentation of the pattern of progression. Type A pts had lower propensity for developing distant metastasis (7/21) than non A (23/35), at 33 vs 66%, p=0.03. Amongst pts with MPC, the incidence of hepatic and pulmonary metastases for type A and non A were identical (77 vs 74%, p=.83; 21 vs 18%, p=.81). However, peritoneal dissemination was less common in type A pts (6 vs 23%, p=.01). Conclusions: Consistent with existing epidemiologic data, the incidence of blood type A is significantly higher in pts with PC, although this does not appear to be stage dependent. ABO did not appear to influence OS in this cohort. However, our data suggests that the pattern of disease spreadmay be related to the ABO blood type. ABO-related glycosylated products could be a target for disease modulation in further studies.

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Association Between Plasma Concentration Of Factor VIII Related Antigen, ABO Blood Type And Lewis Blood Type

10.1055/s-0038-1652335 ◽

1981 ◽

Author(s):

K H Orstavik ◽

P Magnus

Keyword(s):

Plasma Concentration ◽

Factor Viii ◽

Type System ◽

Type A ◽

Coagulation Factors ◽

Blood Type ◽

Lower Plasma ◽

Factor Viii Related Antigen ◽

Abo Blood Type ◽

B 52

Individuals with blood type 0 have a lower plasma concentration of factor VIII than individuals with blood type A. Since the Lewis blood type system and the ABO blood type system are related, we looked for a possible association between the plasma concentration of factor VIII and Lewis blood type.Plasma concentration of factor VIII related antigen (FVIIIR:Ag) was determined by the Laurell electroimmunoassay in 333 individuals. These individuals were identical and fraternal twins who had been bled as part of a twin study on coagulation factors. The association between factor VIII and ABO blood type was confirmed since a significantly lower concentration of FVIIIR:Ag was found in individuals with blood type 0 (77%) than in individuals with blood type A (106%). Lewis blood type had no significant effect on the concentration of FVIIIR:Ag when the whole material was examined. Within individuals with blood type 0, a much lower concentration of FVIIIR:Ag was found in individuals with Lewis blood type Le(a-b-) (52%) compared to individuals with Lewis blood type Le(a-b+) (80%) or Le(a+b-) (88%).The possibility that individuals with blood type 0 and no Lewis antigens have a low plasma concentration of factor VIII may have implications for the detection of carriers of hemophilia A.

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Associations of ABO blood type and galactose-deficient immunoglobulin A1 with adverse outcomes in patients with IgA nephropathy

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfz171 ◽

2019 ◽

Cited By ~ 1

Author(s):

Manliu Wang ◽

Jicheng Lv ◽

Pei Chen ◽

Guizhen Yu ◽

Sufang Shi ◽

...

Keyword(s):

Iga Nephropathy ◽

Cox Regression ◽

Type A ◽

Adverse Outcomes ◽

Blood Type ◽

Blood Group Antigens ◽

Type B ◽

Progression Of Kidney Disease ◽

Abo Blood Type

Abstract Background Both ABO blood group antigens and pathogenic immunoglobulin A1 (IgA1) in patients with IgA nephropathy (IgAN) are influenced by modifications of N-acetylgalactosamine and galactose. The purpose of this study was to assess whether ABO blood type is associated with galactose-deficient IgA1 (Gd-IgA1) in the progression of kidney disease in patients with IgAN. Methods We enrolled 1313 IgAN patients with a median of 44 months follow-up and measured the plasma Gd-IgA1 levels. Multivariate Cox regression models were used to estimate the association between all variables and adverse outcomes. Using the propensity score matching method, 718 IgAN patients with blood type either A or B were selected, and their data were used to assess the association of blood type and Gd-IgA1/serum complement 3 (sC3) with outcomes. Results We found that the risk of adverse outcomes was significantly higher in patients with blood type A than in those with type B (hazard ratio = 1.82, 95% confidence interval 1.23–2.71; P = 0.003) after multivariate adjustment. The Gd-IgA1 levels showed trends similar to the multivariate-adjusted event-free curves for the blood types. However, this higher risk of adverse outcomes in type A than in type B patients was no longer significant after the addition of Gd-IgA1/sC3 to the model. Conclusions IgAN patients with blood type A had a higher risk of adverse outcomes than those with type B, and this risk was associated with Gd-IgA1/sC3. Thus, the ABO blood type may provide a reference for the prognostic factors for individuals with IgAN.

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ABO Blood Type A Is Associated With Increased Risk of ARDS in Whites Following Both Major Trauma and Severe Sepsis

CHEST Journal ◽

10.1378/chest.13-1962 ◽

2014 ◽

Vol 145 (4) ◽

pp. 753-761 ◽

Cited By ~ 31

Author(s):

John P. Reilly ◽

Nuala J. Meyer ◽

Michael G.S. Shashaty ◽

Rui Feng ◽

Paul N. Lanken ◽

...

Keyword(s):

Severe Sepsis ◽

Major Trauma ◽

Type A ◽

Blood Type ◽

Increased Risk ◽

Abo Blood Type

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Difference in Therapeutic Effects between Roxadustat and Daprodustat, HIF-Ph Inhibitors, Depending on the Blood Type in Hemodialysis (HD) Patients

Blood ◽

10.1182/blood-2021-150206 ◽

2021 ◽

Vol 138 (Supplement 1) ◽

pp. 4147-4147

Author(s):

Satoshi Funakoshi

Keyword(s):

Response Rate ◽

Conflicts Of Interest ◽

Type A ◽

High Response Rate ◽

High Response ◽

Blood Type ◽

Therapeutic Effects ◽

Blood Group Antigens ◽

Abo Blood Type ◽

Figure Type

Abstract Human blood group antigens are glycoproteins and glycolipids expressed on the surface of red blood cells and a variety of human tissues. This study aimed to determine if there is an association between ABO blood type and the efficacy of HIF-PH inhibitors. Roxadustat and daprodustat are potent inhibitors of HIF-PH and capable of stimulating erythropoiesis in patients on patients with impaired renal function. These two compounds are reported to act mechanistically similar but display differences in their effects on cells, and the differences may affect their efficacy in the treatment of renal anemia in HD patients. In this study we compared the response rate by blood type between roxadustat and daprodustat, respectively. Sixty-eight HD patients treated with roxadustat (20-100mg, 3/week) and ninety-five treated with daprodustat (1-12mg, daily) were recruited in our observational study. We defined >1.5g/dL increase in hemoglobin as effective, and <1.5g/dL decrease as ineffective. As shown in the figure, type A had a significantly high response rate at 47% in HD patients treated with roxadustat. On the other hand, type O had a significantly high response rate at 55% in those who were treated with daprodustat. We found the association in the effectiveness of roxadustat on the treatment for anemia in HD patients in type A, while the effectiveness was higher in type O treated with daprodustat. The results suggest that the therapeutic effect of HIF-PH inhibitors may differ depending on the blood type. Figure 1 Figure 1. Disclosures No relevant conflicts of interest to declare.

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Parasitic helminth infections in humans modulate Trefoil Factor levels in a manner dependent on the species of parasite and age of the host

PLoS Neglected Tropical Diseases ◽

10.1371/journal.pntd.0009550 ◽

2021 ◽

Vol 15 (10) ◽

pp. e0009550

Author(s):

Babatunde Adewale ◽

Jonathan R. Heintz ◽

Christopher F. Pastore ◽

Heather L. Rossi ◽

Li-Yin Hung ◽

...

Keyword(s):

Helminth Infection ◽

Serum Levels ◽

Dependent Manner ◽

Hookworm Infection ◽

Trefoil Factor ◽

Interleukin 33 ◽

Helminth Infections ◽

Tnf Α ◽

Cytokine Levels ◽

And Control

Helminth infections, including hookworms and Schistosomes, can cause severe disability and death. Infection management and control would benefit from identification of biomarkers for early detection and prognosis. While animal models suggest that Trefoil Factor Family proteins (TFF2 and TFF3) and interleukin-33 (IL-33) -driven type 2 immune responses are critical mediators of tissue repair and worm clearance in the context of hookworm infection, very little is known about how they are modulated in the context of human helminth infection. We measured TFF2, TFF3, and IL-33 levels in serum from patients in Brazil infected with Hookworm and/or Schistosomes, and compared them to endemic and non-endemic controls. TFF2 was specifically elevated by Hookworm infection in females, not Schistosoma or co-infection. This elevation was correlated with age, but not worm burden. TFF3 was elevated by Schistosoma infection and found to be generally higher in females. IL-33 was not significantly altered by infection. To determine if this might apply more broadly to other species or regions, we measured TFFs and cytokine levels (IFNγ, TNFα, IL-33, IL-13, IL-1β, IL-17A, IL-22, and IL-10) in both the serum and urine of Nigerian school children infected with S. haematobium. We found that serum levels of TFF2 and 3 were reduced by infection, likely in an age dependent manner. In the serum, only IL-10 and IL-13 were significantly increased, while in urine IFN-γ, TNF-α, IL-13, IL-1β, IL-22, and IL-10 were significantly increased in by infection. Taken together, these data support a role for TFF proteins in human helminth infection.

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