scholarly journals Relationship between anthropometric/metabolic parameters and bone mineral density in younger adults

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Roberta Hack-Mendes ◽  
Lorraine Brennan
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Metabolic Parameters ◽  
Whole Body ◽  
Mineral Density ◽  
Age Related ◽  
Gender And Age ◽  
Males And Females ◽  
The Mean ◽  
The Relationship

AbstractIntroductionOsteoporosis is characterized by low bone mineral density (BMD) and increased susceptibility to low trauma fractures(1).The relationship between osteoporosis risk and general metabolic health parameters is poorly understood. The aim of this study was to investigate the relationship between anthropometric and metabolic parameters with BMD in Adults.Materials and MethodsA total of 214 (100 male and 114 female) healthy adults were recruited. The mean age was 32 ± 10 years for males and 31 ± 11 years for females. BMD was assessed by whole body dual energy X ray- absorptiometry (Dexa scan). Dexa scores were reported as total bone mineral density, T-score and Z-score. Anthropotemetric measures included body weight, height, waist circumference. Basal metabolic rate (BMR) was assessed by indirect calorimetry. Tertiles of BMD were obtained for males and females. Assessment of parameters across BMD tertiles was performed in males and females separately using ANOVA. Relationships between parameters was assessed using Spearman correlation analysis controlling for gender and age where appropriate.ResultsBMI, Weight and BMR increased significantly across the tertiles for both genders. The mean weight, BMI and BMR were significantly increased in the males at the highest tertile of BMD. Positive correlations (adjusted for gender and age) were observed between weight, BMI, BMR and BMD (R2 = 0.404; p = 0.001, R2 = 0.348, p = 0.001; R2 = 0.363; p = 0.001, respectively).ConclusionsOverall, the results confirm the relationships between BMD and BMI and weight in a healthy cohort. Furthermore, it highlights a relationship between BMR and BMD. Targeting improvement in body composition and BMR may be a strategy for the age-related decline in BMD.

scholarly journals Assessment of Total and Regional Bone Mineral Density Using Bioelectrical Impedance Vector Analysis in Elderly Population

2021 ◽  
Author(s):  
Hsueh-Kuan Lu ◽  
Chung-Liang Lai ◽  
Li-Wen Lee ◽  
Lee-Ping Chu ◽  
Kuen-Chang Hsieh
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Bioelectrical Impedance ◽  
The Elderly ◽  
Whole Body ◽  
Mineral Density ◽  
Femur Neck ◽  
Impedance Vector ◽  
The Relationship ◽  
Different Levels

Abstract This study aimed to investigate the relationship between bone mineral density (BMD) and height-adjusted resistance (R/H), reactance (Xc/H) and phase angle (PhA). A total of 61 male and 64 female subjects aged over 60 years were recruited from middle Taiwan. The R and Xc were measured using Bodystat Quadscan 4000 at a frequency of 50 kHz. BMD at the whole body, L2-L4 spine, and dual femur neck (DFN), denoted as BMDTotal, BMDL2-L4, and BMDDFN, were calculated using a Hologic DXA scanner. The R-Xc graph was used to assess vector shift among different levels of BMD. BMD was positively correlated with Xc/H and negatively correlated with R/H (p<0.001). The General Linear Model (GLM) regression results were as follows: BMDTotal = 1.473 – 0.002 R/H + 0.007 Xc/H, r = 0.684; BMDL2-L4 = 1.526 – 0.002 R/H + 0.012 Xc/H, r = 0.655; BMDDFN = 1.304 – 0.002 R/H + Xc/H, r = 0.680; p<0.0001. Distribution of vector in the R-Xc graph was significantly different for different levels of BMDTotal, BMDL2-L4 and BMDDFN. R/H and Xc/H were correlated with BMD in the elderly. The linear combination of R/H and Xc/H can effectively predict the BMD of the whole body, spine and proximal femur, indicating that BIVA may be used in clinical and home-use monitoring tool for screening BMD in the elderly in the future.

scholarly journals Exploring the Relationships Among the Inflammatory Potential of the Diet, Bone Mineral Density, and Injury Incidence in Collegiate Athletes (P23-006-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Kiley Field ◽  
John Gieng ◽  
Giselle Pignotti ◽  
Sofia Apsey
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Bone Health ◽  
Collegiate Athletes ◽  
Whole Body ◽  
Research Centre ◽  
Injury Incidence ◽  
Mineral Density ◽  
The Relationship ◽  
Prior Injury

Abstract Objectives The relationship between the inflammatory potential of the diet, estimated by the Dietary Inflammatory Index (DII) score, and bone health has been studied in older populations and suggests that the diet can influence bone mineral density (BMD) and fracture risk. These relationships have yet to be explored in other potentially vulnerable populations, such as athletes, where risk of injuries may be more common due to high physical stresses and over-use. The aims of this study were 1) to examine the correlation between DII scores, and BMD in collegiate athletes, and 2) to assess the relationship between DII score and self-reported prior injury incidence. Methods Healthy collegiate athletes (n = 43) were recruited for this study: football, n = 12; men's soccer, n = 2; women's soccer, n = 13; women's swimming, n = 12; and women's basketball, n = 4. For each athlete, three 24-hour dietary intakes were collected using a standardized multiple-pass interview methodology (Nutrition Data System for Research) and this data was used to calculate individual DII scores. Body composition, including whole-body sub-total BMD, was measured using dual-energy X-ray absorptiometry. A modified overuse injury questionnaire (Oslo Sports Trauma Research Centre) was used to assess incidence of injuries in the prior 12 months. Results The participants (n = 14 male, n = 29 female) had a mean age of 19.4 ± 1.1 yrs and BMI of 25.8 ± 4.1 kg/m2. Mean DII score was −0.43 ± 0.17 points (range: −3.94 to 4.34). Mean BMD was 1.251 ± 0.169 g/cm2. Overall, DII score and BMD was not correlated (P = 0.47). Furthermore, DII scores of athletes that reported no prior injury did not differ from those who reported 1 or more injuries. Conclusions Unlike research in postmenopausal women, it appears that bone health of young healthy athletes is less vulnerable to the influence of diets with higher inflammatory potential. Moreover, the lack of difference in DII score among athletes reporting various levels of prior injury suggests that the inflammatory potential of the diet is a poor predictor of injury risk in collegiate athletes. Funding Sources N/A.

scholarly journals Assessment of total and regional bone mineral density using bioelectrical impedance vector analysis in elderly population

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hsueh-Kuan Lu ◽  
Chung-Liang Lai ◽  
Li-Wen Lee ◽  
Lee-Ping Chu ◽  
Kuen-Chang Hsieh
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Bioelectrical Impedance ◽  
The Elderly ◽  
Whole Body ◽  
Mineral Density ◽  
Femur Neck ◽  
Impedance Vector ◽  
The Relationship ◽  
Different Levels

AbstractThis study aimed to investigate the relationship between bone mineral density (BMD) and height-adjusted resistance (R/H), reactance (Xc/H) and phase angle (PhA). A total of 61 male and 64 female subjects aged over 60 years were recruited from middle Taiwan. The R and Xc were measured using Bodystat Quadscan 4000 at a frequency of 50 kHz. BMD at the whole body, L2–L4 spine, and dual femur neck (DFN), denoted as BMDTotal, BMDL2–L4, and BMDDFN, were calculated using a Hologic DXA scanner. The R-Xc graph was used to assess vector shift among different levels of BMD. BMD was positively correlated with Xc/H and negatively correlated with R/H (p < 0.001). The General Linear Model (GLM) regression results were as follows: BMDTotal = 1.473–0.002 R/H + 0.007 Xc/H, r = 0.684; BMDL2–L4 = 1.526–0.002 R/H + 0.012 Xc/H, r = 0.655; BMDDFN = 1.304–0.002 R/H + Xc/H, r = 0.680; p < 0.0001. Distribution of vector in the R-Xc graph was significantly different for different levels of BMDTotal, BMDL2–L4 and BMDDFN. R/H and Xc/H were correlated with BMD in the elderly. The linear combination of R/H and Xc/H can effectively predict the BMD of the whole body, spine and proximal femur, indicating that BIVA may be used in clinical and home-use monitoring tool for screening BMD in the elderly in the future.

scholarly journals Disparity in bone mineral density of males and females with age

2020 ◽  
Vol 8 (3) ◽  
pp. 429-438
Author(s):  
Nusrat Aziz
Keyword(s):  
Bone Mineral Density ◽  
Bone Mass ◽  
Bone Mineral ◽  
Financial Burden ◽  
Lifestyle Changes ◽  
Control Group ◽  
Age Group ◽  
Mineral Density ◽  
Age Related ◽  
Males And Females

Decline in bone mass with aging leads to osteoporosis and fragility fractures. It has profound effect on the morbidity and health quality of the elderly, creating financial burden on the society. Usually, age related loss in bone mass goes undiagnosed until a fragility fracture occurs. It was observed that the bone mineral density (BMD) was found to be lesser in females compared to males in all age groups. There were significant BMD differences between males and females from age 41 yrs and above, BMD declined with age in both males and females. The maximum decline was observed in age group of 41 yrs -50 yrs compared to the control group of 20 yrs-30 yrs. The decrease in BMD was highly noticeable in females, with osteoporosis from age group 51 yrs-60 yrs. It coincides with peri-menopausal and early after menopause period. In males osteoporosis was not observed until the age of 80yrs, though osteopenia have been observed from 41 yrs onwards. There is a paramount need of awareness about detrimental effects of aging on BMD in order to bring about necessary lifestyle changes and follow therapeutic measures. This enables us to attain higher peak bone mass and maintain higher bone densities.

scholarly journals Bone Mineral Density in Cystic Fibrosis Patients with the CFTR I1234V Mutation in a Large Kindred Family Is Associated with Pancreatic Sufficiency

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Atqah Abdul Wahab ◽  
M. Hammoudeh ◽  
Mona Allangawi ◽  
Fawziya Al-Khalaf ◽  
Prem Chandra
Keyword(s):  
Bone Mineral Density ◽  
Cystic Fibrosis ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Whole Body ◽  
Mineral Density ◽  
Total Hip ◽  
Radiographic Absorptiometry ◽  
The Mean ◽  
Total Body

Objectives. To study bone mineral density (BMD) in cystic fibrosis (CF) children and adults with the CFTR I1234V mutation associated with pancreatic sufficiency.Methods. Lumbar spine, total hip, and whole-body mineral density were measured by dual-energy radiographic absorptiometry (DEXA) scan.Zscore was used for those less than 21 years andTscore was used for those 21 years or older.Results. Twenty-one CF patients were younger than 21 years and 5 CF patients were 21 years or older. Mean age was 17.29 ± 4.95 years, ranging from 10 to 33 years. The mean BMDZscores for patients younger than 21 years were −0.69 ± 0.96 (lumbar spine = L1–L4), −0.48 ± 0.92 (total hip), and −0.38 ± 0.86 (total body). The meanTscores for patients 21 years or older were 0.14 ± 0.7 (L1–L4), 0.38 ± 1 (total hip), and 0.52 ± 1.03 (total body). BMD reduction less than −1 was found in 7 (26.9%) CF patients. Vitamin D deficiency in 20 CF patients (76.9%) tended to be lower in CF patients with low BMD. BMD was significantly correlated with FEV1; however, no significant association was observed withP. aeruginosacolonization.Conclusion. BMD reduction does occur in patients with mild CFTR mutation associated with pancreatic sufficiency.

Potent effect of recombinant growth hormone on bone mineral density and body composition in adults with panhypopituitarism

1992 ◽  
Vol 126 (5) ◽  
pp. 387-393 ◽  
Author(s):  
Marie Degerblad ◽  
Nabil Elgindy ◽  
Kerstin Hall ◽  
Hans-Erik Sjöberg ◽  
Marja Thorén
Keyword(s):  
Bone Mineral Density ◽  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Bone Mineral ◽  
Hormone Deficiency ◽  
Whole Body ◽  
Mineral Density ◽  
Hormone Substitution ◽  
Recombinant Growth Hormone ◽  
The Mean

Six patients (21–50 years) with growth hormone deficiency and panhypopituitarism were given recombinant growth hormone, somatropin, 0.04–0.1 U·kg·body wt−1·day−1, for 12 months. All patients reported improved well-being with increased working capacity. Bone mineral density, as measured by single photon absorptiometry at two sites on the forearm, showed increased values in 5/6 patients after 12 months when measured at the most distal site (predominantly trabecular bone) and in 4/6 at the more proximal site (predominantly cortical bone). Five patients continued therapy for an additional year and after 18 months a significant increase in bone mineral density was seen at both the distal and proximal sites. The mean annual increase in bone mineral density was 12.0±0.6 (sem)% and 3.8±1.3% at the distal and proximal sites, respectively. In a growth hormone deficient control group without growth hormone therapy, the corresponding values were −2.4±0.6% and −1.9±0.4%, respectively. Lean body mass, estimated anthropometrically, increased significantly after 12 months and total body potassium, measured by whole body counting technique, increased in 4/6 patients. During growth hormone treatment, the IGF-1 values were above the mean values for age and 50% of the values were above the mean + 2 SD. B-glucose, P-insulin, serum IGF-2, procollagen-III peptide and phosphate increased and urea, creatinine and IGF-binding protein-1 decreased during treatment. The beneficial effects of growth hormone substitution, especially on bone mineral density, indicate that growth hormone substitution should be considered in all patients with hypopituitarism and growth hormone deficiency, irrespective of age.

scholarly journals Assessing the Association between Leptin and Bone Mineral Density in HIV-Infected Men

2012 ◽  
Vol 2012 ◽  
pp. 1-5
Author(s):  
Madhu N. Rao ◽  
Morris Schambelan ◽  
Viva W. Tai ◽  
Donald I. Abrams ◽  
Hootan Khatami ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Density ◽  
Bone Mineral ◽  
Fat Distribution ◽  
Whole Body ◽  
Inverse Association ◽  
Mineral Density ◽  
Cross Sectional ◽  
Increased Risk ◽  
The Relationship

HIV-infected individuals are at risk for decreased bone mineral density (BMD). The known risk factors for bone loss do not fully explain the increased risk in this population. There is emerging evidence that leptin, a hormone secreted by adipocytes, plays an important role in bone metabolism. Several studies have assessed the relationship between leptin and bone density in healthy adults, but there are few such studies in HIV-infected individuals. Furthermore, HIV infected individuals on antiretroviral therapy are at increased risk for altered fat distribution, which may impact the relationship between leptin and BMD. In a cross-sectional analysis of data in 107 HIV-infected men, we determined whether serum leptin levels were associated with whole-body BMD and bone mineral content measured by dual-energy X-ray absorptiometry (DEXA), after adjusting for confounders including body fat distribution. We found an inverse association between leptin and bone density in those with peripheral lipoatrophy, defined objectively as <3 kg appendicular fat by DEXA, but no such relationship was seen in those with >3 kg appendicular fat. This result suggests that fat distribution may modify the relationship between leptin and bone density.

Review of the Literature Examining the Association of Serum Uric Acid with Osteoporosis and Mechanistic Insights into Its Effect on Bone Metabolism

2019 ◽  
Vol 19 (3) ◽  
pp. 259-273 ◽  
Author(s):  
Neelam Kaushal ◽  
Divya Vohora ◽  
Rajinder K Jalali ◽  
Sujeet Jha
Keyword(s):  
Risk Factors ◽  
Bone Mineral Density ◽  
Uric Acid ◽  
Bone Metabolism ◽  
Serum Uric Acid ◽  
Bone Mineral ◽  
Molecular Mechanisms ◽  
Association Studies ◽  
Mineral Density ◽  
Age Related

Background And Objective:Osteoporosis is a common bone disorder that increases susceptibility to fragility bone fractures. The clinical and public health repercussions of osteoporosis are huge due to the morbidity, mortality, and cost of medical care linked with fragility fractures. Clinical assessment of osteoporotic risk factors can help to identify candidates at an early stage that will benefit from medical intervention and potentially lowering the morbidity and mortality seen with fractures and complications. Given this, research is ongoing to evaluate the association of osteoporosis with some novel or less well-studied risk factors/bio-markers such as uric acid (UA).Discussion:Uric acid’s antioxidant activity has been proposed to be one of the factors responsible for increasing longevity and lowering rates of age-related cancers during primate evolution, the level of which increased markedly due to loss of uricase enzyme activity (mutational silencing). Accumulated evidence shows that oxidative stress is the fundamental mechanism of age-related bone loss and acts via enhancing osteoclastic activity and increasing bone resorption. Antioxidant substances such as ascorbic acid scavenge free radicals are positively related to bone health. Thus, it is hypothesized that uric acid holds bone-protective potential owing to its potent antioxidative property. Several correlation studies have been conducted globally to investigate the relationship between serum uric acid with bone mineral density and osteoporosis. Few pre-clinical studies have tried to investigate the interaction between uric acid and bone mineral density and reported important role played via Runt-related transcription factor 2 (RUNX2)/core-binding factor subunit alpha-1 (CBF-alpha-1), Wingless-related integration site (Wnt)-3a/β-catenin signaling pathway and 11β Hydroxysteroid Dehydrogenase type 1.Conclusion:In this review, the authors provided a comprehensive summary of the literature related to association studies reported in humans as well work done until date to understand the potential cellular and molecular mechanisms that interplay between uric acid and bone metabolism.

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