Effect of iron deficiency onTrichuris suisandAscaris suuminfections in pigs

Parasitology ◽  
2001 ◽  
Vol 122 (5) ◽  
pp. 589-598 ◽  
Author(s):  
S. PEDERSEN ◽  
I. SAEED ◽  
H. FRIIS ◽  
K. F. MICHAELSEN
Keyword(s):  
Iron Deficiency ◽  
Female Worm ◽  
Inverse Correlation ◽  
Iron Group ◽  
Significant Inverse Correlation ◽  
Intestinal Nematode ◽  
Significant Difference ◽  
Group A ◽  
Body Store ◽  
Eosinophil Counts

The objective of this experiment was to detect a possible interaction between iron deficiency and intestinal nematode infections. We report on a 2×2 study where thirty-one 10-week-old pigs fed a low or a normal iron diet were infected with bothTrichuris suis(4500 eggs) andAscaris suum(1200 eggs). No significant difference was detected between diet groups with respect to parasitological parameters forA. suumor the total number of adultT. suisrecovered at necropsy 10 weeks p.i. However, in the low iron groupT. suiswere located more proximally and the worms were increased in length. A higher proportion of pigs with initial faecal egg excretion at 6 weeks p.i. was observed in the low iron group, indicating a shortened pre-patency period. Worm fecundity and total faecal egg excretion were also highest in the low iron group. A significant correlation was found between female worm length and fecundity. The peripheral eosinophil counts were diminished in the low iron host groups. The infected low iron group experienced more severe pathophysiological changes in terms of hypoalbuminaemia and decreases in erythrocyte volumes. A significant inverse correlation existed between iron content in the bone-marrow and liver (body) store. In conclusion, iron deficiency increased the severity ofT. suisinfection in pigs.

Maternal Age And Birth Weight Characteristics of Twins Born to Nulliparous Mothers: A Population Study

Twin Research ◽  
2001 ◽  
Vol 4 (1) ◽  
pp. 1-3
Author(s):  
Isaac Blickstein ◽  
Ran D. Goldman ◽  
Ram Mazkereth
Keyword(s):  
Birth Weight ◽  
Maternal Age ◽  
Very Low Birth Weight ◽  
Age Groups ◽  
Inverse Correlation ◽  
Population Based ◽  
Age Group ◽  
Significant Inverse Correlation ◽  
Twin Birth ◽  
Significant Difference

AbstractIn order to examine birth weight characteristics of twins delivered to nulliparous mothers in relation to maternal age, we used a population-based cohort of Israeli twins delivered between 1993–98 to select all 4793 (37.6%) nulliparas who delivered twins. Maternal age was subdivided as less than 20 years, 20–24, 25–29, 30–34, 35–39, and 40 years or more. We counted the frequencies of each total twin birth weight (twin A+twin B) in each of three categories (less than 3000, 3000–4999, and more than 5000 g) and the frequency of very low birth weight (VLBW, less than 1500 g) neonates in each of the six maternal age categories. There were significantly more nulliparas in the twin population at age groups less 30 years and significantly less at ages 30 years or more. We found a highly significant inverse correlation between the proportion of nulliparas and maternal age group, decreasing from 71.8% at less than 20 years to 18.6% at age 35–39 years (% nulliparas = 85 − 13.7 × age group, Pearson R2 = 0.98). However, this trend changed abruptly to the observed figure of 25.9% nulliparas aged 40 years or more instead of the expected 2.8%. We failed to reveal any significant difference in birth weight characteristics between the maternal age groups (all p > 0.05, all confidence intervals included 1.0). The more than tenfold deviation of the observed from the predicted frequency of nulliparas aged 40 years or more suggests that a different relationship between parity and age occurs at this age group. Maternal age of nulliparas is not associated with different birth weight characteristics of their twins.

Increased B-type natriuretic peptide levels in early-onset versus late-onset preeclampsia

2014 ◽  
Vol 52 (2) ◽  
Author(s):  
Gábor Szabó ◽  
Attila Molvarec ◽  
Bálint Nagy ◽  
János Rigó Jr.
Keyword(s):  
Natriuretic Peptide ◽  
Total Protein ◽  
Early Onset ◽  
Late Onset ◽  
Inverse Correlation ◽  
Significant Inverse Correlation ◽  
Laboratory Findings ◽  
Protein Levels ◽  
Group A ◽  
Early Onset Preeclampsia

AbstractWe compared B-type natriuretic peptide (BNP) levels, clinical and laboratory findings in early-onset preeclampsia (EOP), late-onset preeclampsia (LOP) and healthy pregnant groups.We studied 40 healthy pregnant and 40 preeclamptic patients. Preeclamptics were divided in two groups, the EOP group (n=20) and LOP group (n=20), according to gestational age at the onset of disease. The distinction criterion for early- vs. late-onset was set as week 34 of gestation. The concentration of the BNP levels was measured by a sandwich fluorescence immunoassay. For statistical analysis of the clinical and laboratory findings non-parametric methods were applied.BNP levels were higher in EOP [61.35 (36.95–93.25) pg/mL] and LOP patients [32.4 (19.15–39.2) pg/mL] than in healthy pregnant women [10.05 (6.08–16.03) pg/mL] (both p<0.001). Furthermore, EOPs had significantly higher BNP levels as compared to LOP patients (p<0.001). A BNP cut-off <24.5 pg/mL had a negative-predictive value of 85.1% excluding preeclampsia. There was a significant inverse correlation between plasma BNP levels of EOP patients and sodium (p<0.05) and total protein concentrations (p<0.05). In the EOP group, a significant positive correlation was observed between plasma levels of BNP and hematocrit (p<0.05), serum potassium (p<0.05), urea (p<0.05) and 24-h proteinuria (p<0.05).BNP levels were significantly higher in EOP than in LOP patients. The cut-off value <24.5 pg/mL seems to be a powerful discriminative indicator excluding preeclampsia. The amount of proteinuria and total protein levels correlate with the elevation of the BNP levels. In EOP the extent of proteinuria is higher than in the LOP.

scholarly journals Oxidative stress and anabolic hormones in back pain: Current concept and preliminary analysis in male cohort

2020 ◽  
Author(s):  
Edoardo Vergani ◽  
Carmine Bruno ◽  
Andrea Silvestrini ◽  
Elisabetta Meucci ◽  
Luca Proietti ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Back Pain ◽  
Inverse Correlation ◽  
Medical Problem ◽  
Significant Inverse Correlation ◽  
Anabolic Hormones ◽  
Total Antioxidant ◽  
Male Cohort ◽  
Group A ◽  
Group B

Back Pain (BP) is a common medical problem; anabolic hormones, through the modulation of oxidative stress (OS), could influence fracture risk. We evaluated the prevalence of anabolic hormonal deficiencies and their relationship with OS in males with BP, associated or not to nontraumatic fractures. 49 males with BP, from 36 to 80 years, were divided in two groups according to radiological evidence of nontraumatic fractures; group A (n=25): non-fractured; group B (n=24): fractured. A different prevalence of hormonal deficits was observed: 24% of hypotestosteronemia in A, 0% in B; 16% of GHD in A, 29% in B; Total Antioxidant Capacity (TAC) showed a trend toward higher levels in B. In A, despite lower TAC, a significant inverse correlation was present between TAC and IGF-1. A greater prevalence of GHD in patients with vertebral fractures was seen and, in a subgroup, OS could mediate the deleterious effects of hyposecretory GH state.

scholarly journals Increased Levels of Thrombopoietin and IPF in Patients with Iron Deficiency Anemia

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 5018-5018
Author(s):  
Kazuo Kawasugi ◽  
Tadashi Yamamoto ◽  
Naoki Shirafuji ◽  
Yoko Oka
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Conflicts Of Interest ◽  
Inverse Correlation ◽  
Deficiency Anemia ◽  
Significant Inverse Correlation ◽  
Platelet Counts ◽  
Immature Platelet Fraction ◽  
Healthy Control ◽  
Normal Controls

Abstract Background Thrombocytosis has been reported in about 50% of patients with iron deficiency anemia (IDA). However, the mechanism of the increase in the number of platelets is unknown. To investigate the relationship of endogenous thrombopoietin (TPO) and circulating platelet counts, we measured the plasma levels of TPO, immature platelet fraction (IPF) and erythropoietin ( EPO ) in 25 patients with IDA. Patients and methods Patients with IDA (newly diagnosed) were recruited from February 2013 through March 2014 in Teikyo University School of Medicine. TPO (Immuno-Biological Laboratory, Japan), was determined by an EILSA. IPF was measured on the Sysmex XE2100. EPO (Roch Diagnostic Japan) was determined by an EILSA. Results and Conclusions The number of platelets was increasing in the half patients with IDA in this study. Peripheral blood samples for measuring IPF were obtained from 300 healthy adult controls (160 women and 140 men) and 20 patients with IDA, consisting of 19 women and 6 men with age ranging from 16 to 75 years. The etiology of iron deficiency was gastrointestinal (GI) blood loss, menometrorrhagia, previous GI surgery, and low dietary iron intake. The mean absolute-IPF was significantly higher for IDA patients than for healthy control (8193±571 vs. 4254±193 p＜0.05). The endogenous levels of TPO were significantly elevated in patients with IDA (216.4±41 pg/ ml) as compared with normal controls (116.5±23 pg/ml). Also, The endogenous levels of EPO were significantly elevated in patients with IDA as compared with normal controls. There was a significant inverse correlation between serum Fe levels and platelet counts (r=0.551, p＜0.05). Also, a positive correlation (r=0.311, p＜0.05) between platelet counts and endogenous level of TPO was found. Moreover, there was a significant inverse correlation (r=-0.458, p＜0.05) between Hb and TPO. These results suggest that TPO is active regulator, in thrombopoiesis and megakaryocytopoiesis in patients with IDA. Also, it appears there is relationship between erythropoiesis and TPO. Disclosures No relevant conflicts of interest to declare.

scholarly journals Correlation of vitamin D level with its related biochemical parameters and impact of different treatment regimens on their correction

2020 ◽  
Vol 8 (1) ◽  
pp. 86
Author(s):  
Amit Gupta ◽  
Sachin Kumar
Keyword(s):  
Biochemical Parameters ◽  
Inverse Correlation ◽  
Ultraviolet Rays ◽  
P Value ◽  
Significant Inverse Correlation ◽  
Treatment Groups ◽  
Treatment Regimens ◽  
Before And After ◽  
Group A ◽  
Group B

Background: Vit D is a fat-soluble vitamin that is produced when ultraviolet rays from sunlight strike the skin and trigger vit D synthesis. Aims and Objectives of the study were to find out the correlation of vit D level with its related biochemical parameters and impact of two different treatment regimens on their correction. Methods: A total of 107 patients were followed up out of which 89 were vit D deficient and rest were vit D insufficient. Results: Mean age of the patients was 6.11±4.49 and males comprised 66%. Mean BMI of children included in group A, B and C was 19.40±2.69, 19.60±3.18 and 20.95±3.72 kg/m2 respectively. Vit D levels at baseline had a significant inverse correlation with ALP (r=-0.27, p value=0.008).  Before and after comparison of mean serum calcium levels revealed significant improvement in both the treatment groups. Severity of vit D deficiency, at baseline, 9.10, 77.30 and 13.60% of patients had vit D levels of less than 5, 5 to 15 and more than 15 for group A respectively. In group B at baseline, 6.70, 71.10 and 22.20% of patients had vit D levels of less than 5, 5 to 15 and more than 15 respectively.Conclusions: Present study found that 60,000 IU/week and dose of 2000 IU/day for infants or 5000 IU/day for 1 to 18 years of age, along with 500 to 800 mg oral calcium for 6 to 8 weeks can result in correction of vit D deficiency.

scholarly journals Impact of Iron deficiency on diagnosis of Beta Thalassemia Trait.

2020 ◽  
Vol 27 (04) ◽  
pp. 849-852
Author(s):  
Asma Naseer Cheema ◽  
Rubya Khanum ◽  
Shireen Hamid
Keyword(s):  
Iron Deficiency ◽  
Serum Ferritin ◽  
Total Leukocyte Count ◽  
Beta Thalassemia ◽  
Red Cell ◽  
Iron Deficient ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
Deficient Group

Objectives: We aimed to evaluate the effect of low serum ferritin levels on HbA2 values in BTT patients. Study Design: Cross-sectional study. Setting: Pathology department of University Medical & Dental College Faisalabad. Period: August, 2018 to July, 2019. Materials & Methods: One hundred and thirty seven subjects were included in the study after written informed consent. Those with serum ferritin < 10µg/L were taken as iron deficient. Based on serum ferritin levels, we divided our study participants into two groups (Group A Vs Group B). As ferritin is considered an acute-phase protein, 25/137 participants with leukocytosis were excluded from statistical analysis. We measured serum Ferritin on Cobas 6000 e611 and we assessed the red cell parameters on Sysmex (seven part differential XN 1000). Hb variants were analysed through High performance liquid chromatography (HPLC) based technique of BioRad D10. Results: After excluding 25 subjects with high Total leukocyte count (TLC), we are left with 112 subjects. We observed 26 participants in group A with Iron deficiency and 38 in group B with no Iron deficiency. Mean±SD serum ferritin in iron deficient group was 7.25±1.95 as compared to non-iron deficient group (87.63±7.35). Mean HbA2 value in group A was 4.56±0.04 and in group B it was 5.80±1.06 with significant statistical difference of P=0.0188. We also observed significant difference in the mean values of other Red cell indices (MCV, HCT MCHC, MCH) except for RBC count and RDW. Conclusion: This study shows that ID may reduce HbA2 levels. Overall, it does not essentially preclude the identification of BTT. It is recommended that Iron deficiency should be considered before measuring HbA2 levels in BTT.

scholarly journals FACTORS AFFECTING INTERPRETATION OF TISSUE DIELECTRIC CONSTANT (TDC) IN ASSESSING BREAST CANCER TREATMENT RELATED LYMPHEDEMA (BCRL)

Lymphology ◽  
2019 ◽  
Vol 52 (2) ◽  
Author(s):  
HN Mayrovitz ◽  
E Arzanova ◽  
S Somarriba ◽  
S Eisa
Keyword(s):  
Dielectric Constant ◽  
Inverse Correlation ◽  
Breast Cancer Treatment ◽  
Significant Inverse Correlation ◽  
Factors Affecting ◽  
Indentation Force ◽  
Significant Difference ◽  
Total Body ◽  
Skin Indentation ◽  
Measurement Depth

Tissue dielectric constant (TDC) measurements are increasingly used as quantitative adjunctive tools to detect and assess lymphedema. Various factors affect measured TDC values that may impact clinical interpretations. Our goal was to investigate possible impacts of: 1) anterior vs. medial arm measures, 2) total body water (TBW%) and arm fat percentages (AF%), 3) measurement depth, and 4) skin firmness. In 40 healthy women (24.5±2.5 years), TDC was measured bilaterally on anterior forearm to 0.5, 1.5, 2.5, and 5.0 mm depths using a multiprobe device and on anterior and medial aspects using a compact device. TBW% and AF% were measured at 50KHz and skin firmness measured by skin indentation force (SIF). Results showed: 1) No statistically significant difference in TDC values between anterior and medial arm, 2) a moderate direct correlation between TDC and TBW% (r=0.512, p=0.001), 3) an inverse correlation between TDC and AF% (r= -0.494, p&lt;0.001) with correlations greatest at the deepest depth, and 4) a slight but statistically significant inverse correlation between TDC and SIF (r= -0.354, p=0.001). TDC values with compact vs. multiprobe were within 6% of each other with interarm (dominant/nondominant) ratios not significantly different. The findings provide a framework to help interpret TDC values among divergent conditions.

High Levels of Plasma Protein C in Nephrotic Syndrome

1985 ◽  
Vol 53 (01) ◽  
pp. 005-007 ◽  
Author(s):  
I Pabinger-Fasching ◽  
K Lechner ◽  
H Niessner ◽  
P Schmidt ◽  
E Balzar ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Plasma Protein ◽  
Protein C ◽  
Inverse Correlation ◽  
Elevated Plasma ◽  
Significant Inverse Correlation ◽  
At Iii ◽  
Thrombotic Tendency ◽  
Protein C Activity

SummaryIn patients with severe nephrotic syndrome determinations of plasma protein C : Ag levels (8 patients: 5 adults, 3 children) and protein C activity (3 out of 8 patients) revealed significantly elevated plasma protein C concentrations. Furthermore we observed a significant inverse correlation of protein C : Ag to AT III : Ag levels. No protein C : Ag could be detected in the urine of two patients studied. We conclude from our data, that changes of plasma protein C do not contribute to the high thrombotic tendency in nephrotic syndrome.

DeVega versus ring annuloplasty in severe functional tricuspid insufficiency and their impact on the right ventricle

2019 ◽  
Vol 1 (4) ◽  
pp. 133-139
Author(s):  
Yasser Hamdy ◽  
Mohammed Mahmoud Mostafa ◽  
Ahmed Elminshawy
Keyword(s):  
Right Ventricular ◽  
Tricuspid Valve ◽  
Tricuspid Regurgitation ◽  
Early Postoperative Period ◽  
Tricuspid Valve Repair ◽  
Ring Annuloplasty ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
The Right

Background: Functional tricuspid valve regurgitation secondary to left-sided valve disease is common. DeVega repair is simple, but residual regurgitation with subsequent impairment of the right ventricular function is a concern. This study aims to compare tricuspid valve repair using DeVega vs. ring annuloplasty and their impact on the right ventricle in the early postoperative period and after six months. Methods: This is a prospective cohort study of 51 patients with rheumatic heart disease who underwent tricuspid valve repair for secondary severe tricuspid regurgitation. Patients were divided into two groups: group A; DeVega repair (n=34) and group B; ring annuloplasty repair (n=17). Patients were assessed clinically and by echocardiography before discharge and after six months for the degree of tricuspid regurgitation, right ventricular diameter and tricuspid annular plane systolic excursion (TAPSE). Results: Preoperative echocardiographic assessment showed no difference in left ventricular end-systolic diameter, end-diastolic diameter, ejection fraction and right ventricular diameter, however; group A had significantly better preoperative right ventricular function measured by TAPSE (1.96 ± 0.27 vs1.75 ± 0.31 cm; p=0.02). Group B had significantly longer cardiopulmonary bypass time (127.65 ± 13.56 vs. 111.74 ± 18.74 minutes; p= 0.003) and ischemic time (99.06 ± 11.80 vs. 87.15 ± 16.01 minutes; p= 0.009). Pre-discharge, there was no statistically significant difference in the degree of tricuspid regurgitation, but the right ventricular diameter was significantly lower in group B (2.66 ± 0.41 and 2.40 ± 0.48 cm; p=0.049). After six months of follow up, the degree of tricuspid regurgitation (p= 0.029) and the right ventricular diameter were significantly lower in the ring annuloplasty group (2.56 ± 0.39 and 2.29 ± 0.44 cm; p=0.029). Although there was a statistically significant difference in preoperative TAPSE, this difference disappeared after six months. Conclusion: Both DeVega and ring annuloplasty techniques were effective in the early postoperative period, ring annuloplasty was associated with lesser residual regurgitation and better right ventricular remodeling in severe functional tricuspid regurgitation than DeVega procedure after 6-months of follow up.

Effect of short-term use of oral contraceptive pills on intraocular pressure

2020 ◽  
Vol 35 (3) ◽  
Author(s):  
Tayyaba Gul Malik ◽  
Hina Nadeem ◽  
Eiman Ayesha ◽  
Rabail Alam
Keyword(s):  
Oral Contraceptive ◽  
Childbearing Age ◽  
Short Term ◽  
Oral Contraceptive Pills ◽  
Contraceptive Pills ◽  
Time Period ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
Short Time

Objective: To study the effect of short-term use of oral contraceptive pills on intra-ocular pressures of women of childbearing age.   Methods: It was a comparative observational study, conducted at Arif memorial teaching hospital and Allied hospital Faisalabad for a period of six months. Hundred female subjects were divided into two groups of 50 each. Group A, included females, who had been taking oral contraceptive pills (OCP) for more than 6 months and less than 36 months. Group B, included 50 age-matched controls, who had never used OCP. Ophthalmic and systemic history was taken. Careful Slit lamp examination was performed and intraocular pressures (IOP) were measured using Goldman Applanation tonometer. Fundus examination was done to rule out any posterior segment disease. After collection of data, we analyzed and compared the intra ocular pressures between the two groups by using ANOVA in SPSS version 21.   Results: Average duration of using OCP was 14.9 months. There was no significant difference of Cup to Disc ratios between the two groups (p= 0.109). However, significant difference was noted between the IOP of OCP group and controls. (p=0.000). Conclusion: OCP significantly increase IOP even when used for short time period.

Sign in / Sign up

Export Citation Format

Share Document