scholarly journals Correlation of vitamin D level with its related biochemical parameters and impact of different treatment regimens on their correction

2020 ◽  
Vol 8 (1) ◽  
pp. 86
Author(s):  
Amit Gupta ◽  
Sachin Kumar
Keyword(s):  
Biochemical Parameters ◽  
Inverse Correlation ◽  
Ultraviolet Rays ◽  
P Value ◽  
Significant Inverse Correlation ◽  
Treatment Groups ◽  
Treatment Regimens ◽  
Before And After ◽  
Group A ◽  
Group B

Background: Vit D is a fat-soluble vitamin that is produced when ultraviolet rays from sunlight strike the skin and trigger vit D synthesis. Aims and Objectives of the study were to find out the correlation of vit D level with its related biochemical parameters and impact of two different treatment regimens on their correction. Methods: A total of 107 patients were followed up out of which 89 were vit D deficient and rest were vit D insufficient. Results: Mean age of the patients was 6.11±4.49 and males comprised 66%. Mean BMI of children included in group A, B and C was 19.40±2.69, 19.60±3.18 and 20.95±3.72 kg/m2 respectively. Vit D levels at baseline had a significant inverse correlation with ALP (r=-0.27, p value=0.008).  Before and after comparison of mean serum calcium levels revealed significant improvement in both the treatment groups. Severity of vit D deficiency, at baseline, 9.10, 77.30 and 13.60% of patients had vit D levels of less than 5, 5 to 15 and more than 15 for group A respectively. In group B at baseline, 6.70, 71.10 and 22.20% of patients had vit D levels of less than 5, 5 to 15 and more than 15 respectively.Conclusions: Present study found that 60,000 IU/week and dose of 2000 IU/day for infants or 5000 IU/day for 1 to 18 years of age, along with 500 to 800 mg oral calcium for 6 to 8 weeks can result in correction of vit D deficiency.

scholarly journals Survival and echocardiographic evaluation of dogs with idiopathic dilated cardiomyopathy treated with carvedilol

2010 ◽  
Vol 62 (3) ◽  
pp. 555-563 ◽  
Author(s):  
E.C. Soares ◽  
G.G. Pereira ◽  
L.C. Petrus ◽  
M. Leomil Neto ◽  
F.L. Yamaki ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Ventricular Remodeling ◽  
Left Ventricular ◽  
Idiopathic Dilated Cardiomyopathy ◽  
P Value ◽  
Echocardiographic Evaluation ◽  
Before And After ◽  
Group A ◽  
The Stability ◽  
Group B

Sixty dogs with idiopathic dilated cardiomyopathy were randomly treated with traditional therapy - digitalis, diuretics, angiotensin-converting inhibitors - (group A) or treated with these drugs plus carvedilol (group B). Echocardiographic variables were measured before and after 3, 13, 26, and 52 weeks of treatment or until death. Comparisons between groups and time were performed. No significant differences between groups were found in the most of the echocardiographic variables. The left ventricular end-systolic diameter indexed to body surface area (LVESDi) increased significantly in the group A dogs compared to the group B animals. The survival of groups A and B dogs were not different (P-value=0.1137). In conclusion, the stability of the LVESDi observed in the group treated with carvedilol may represent the beneficial effect over the ventricular remodeling.

scholarly journals Chest Mobility Exercise with Staked Breathing Versus Chest Mobility Exercises with Incentive Spirometery On Chest Expansion with Pleural Effusion Patient: A Comparative Study

2021 ◽  
Vol 9 (4) ◽  
pp. 3949-3953
Author(s):  
Minhaj Tahir ◽  
◽  
Tahzeeb Fatima ◽  
Devendra Trivedi ◽  
Manjit Kumar ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Pleural Effusion ◽  
P Value ◽  
Chest Expansion ◽  
Before And After ◽  
Group A ◽  
Group B ◽  
Pleura Effusion ◽  
Respiratory Conditions ◽  
Incentive Spirometry

Background: Pleural effusion is one of the commonly seen respiratory conditions in India with approximately 1 million people being diagnosed each year. Twenty to forty percent of hospitalized patients with bacterial pneumonia develop pleural effusion. In India unlike western countries, tuberculosis pleura effusion is common. The pleural cavity is involved in approximately 5% of all patients with tuberculosis. Since there was no literature regarding the effectiveness chest mobility exercise with staked breathing or chest mobility exercises with incentive spirometery in pleural effusion. There was a need to find out as to which approach are the best ones to implement. Objective: To compare the efficacy of chest mobility exercise with stacked breathing versus chest mobility exercise with incentive spirometery on chest expansion in patients with pleural effusion. Materials and Method: 20 patients with pleural effusion were selected by easy sampling and randomly assigned into two groups (10 patients each groups). Group A received chest mobility exercises and intensive spirometery and group B received chest mobility exercises and stacked breathing. Both groups were instructed to perform the intervention 3 time per day, 8 to 10 time per session for one week. Chest expansion was measured by thoracic flow cytometry before and after one week of intervention. Result: In group A chest expansion increase from 2.68 to 2.87 which was statistically significant (P value < 0.0023). In Group B the chest expansion increases from 2.94 to 3.09 which was not statistically significant (P value < 0.216). Conclusion: It was concluded from the result that both chest mobility exercises with intensive spirometery and chest mobility exercise with stacked breathing are equally effective in improving the chest expansion in subject with pleural effusion. KEY WORDS: Pleural effusion, Chest mobility exercises, Incentive Spirometry, Stacked breathing, Thoracic flow cytometry.

scholarly journals EFFECTIVENESS OF NEURAL MOBILIZATION AND STRETCHING EXERCISE FOR THE MANAGEMENT OF SCIATICA

2014 ◽  
Vol 3 (2) ◽  
pp. 11-15
Author(s):  
Sidra Zahid ◽  
Ghazala Noor Nizami
Keyword(s):  
Conventional Therapy ◽  
Controlled Trial ◽  
Treatment Options ◽  
Tertiary Care ◽  
P Value ◽  
Below The Knee ◽  
Pain Disability ◽  
Before And After ◽  
Group A ◽  
Group B

OBJECTIVE To find out the effectiveness of neural mobilization and stretching exercise for the management of sciatica BACKGROUND Sciatica is described as pain, radiating to the leg below the knee joint and caused by irritation of the sciatic nerve or nerve trunk. There are many treatment options for the management of sciatica, including stretching exercise and neural mobilization. MATERIAL AND METHODS This study was a Randomized Controlled Trial. 94 patients from physical therapy OPD of tertiary care hospitals, were participated in this study. Hence, 47 patients were randomly allocated into each group A and B. Before and after the nine treatment sessions, both groups were assessed with VAS, SLR ROM and Quebec back pain disability scale. In group A, neural mobilization with conventional therapy (heat and TENS) was applied, while stretching exercise with same conventional therapy was applied to group B. RESULTS It was observed that both treatments were helpful in reducing the symptoms. The analysis showed significant improvement (p-value <0.05) in the SLR to 60.851o±6.86oand Quebec score to 23.617±3.125, after the stretching exercise. Hence, both treatments were equally effective in reducing pain (p-value >0.05). CONCLUSION Stretching exercise is more effective in the improvement of SLR and disability. Furthermore, both techniques are helpful in the management of pain. KEY WORDS Sciatica, Stretching, Neural Mobilization, Straight Leg Raising, Visual Analogue Scale, TENS.

scholarly journals AN EFFECT OF POSTURAL DRAINAGE ON MANAGEMENT OF PNEUMONIA

2020 ◽  
Vol 8 (12) ◽  
pp. 759-761
Author(s):  
Tahzeeb Fatima ◽  
◽  
Minhaj Tahir ◽  
Devendra Trivedi ◽  
◽  
...  
Keyword(s):  
T Test ◽  
P Value ◽  
Age Group ◽  
Physiotherapy Treatment ◽  
Postural Drainage ◽  
Before And After ◽  
Group A ◽  
Group B

Objective:To compare the patients with pneumonia with and without postural drainage and to measure the amount of sputum produced before and after physiotherapy treatment. Material and Method:This study was carried out at Lilamani Hospital, Kanpur. Total 7 patients was placed into two groups i.e. Group A and Group B. Group A included 4 patients, 3 females and 1 male with the age group is between 25-60. While Group B having 3 patients, 1 female and 2 males with the age group is between 26-62 years. Group A was received chest mobilization techniques, two times a day.While Group B received postural drainage in different positions with chest mobilisation twice a day. The amount of sputum before and after the physiotherapy techniques, the p-value was calculated for both groups by t-test and data was analysed through SPSS. Results: In this study, amount of sputum was significantly reduced in Group B as comparison to Group A. Conclusion: Postural drainage techniques with chest mobilisation are much effective. It also helps in reducing the amount of sputum in pneumonia patients.

scholarly journals Comparison of 4% Topical Hydroquinone versus Combination of Oral Tranexamic Acid and 4% Topical Hydroquinone in the Treatment of Epidermal Melasma

2021 ◽  
Vol 15 (10) ◽  
pp. 3406-3409
Author(s):  
Sarah Riaz ◽  
Najia Ahmed ◽  
Ayesha Anwar ◽  
Moizza Tahir ◽  
Farrah Yousaf ◽  
...  
Keyword(s):  
Tranexamic Acid ◽  
Topical Therapy ◽  
Military Hospital ◽  
Ethical Review ◽  
P Value ◽  
Treatment Groups ◽  
Quasi Experimental ◽  
Group A ◽  
Group B ◽  
Better Than

Objective: comparison of efficacy of topical 4% hydroquinone monotherapy with combination of oral tranexamic acid and topical 4% hydroquinone in the treatment of epidermal melasma Study design: Quasi experimental study Study period and place: Dermatology OPD, Pak Emirates Military Hospital Rawalpindi from July 2018 to January 2019. Methodology: Total 80 patients presenting with epidermal melasma were selected from outdoor patient department after applying the inclusion criteria and consent was taken from selected patients. Study was started after getting permission from hospital ethical review board. Two treatment groups were made after dividing patients by using alternate method. Treatment with topical 4% hydroquinone alone was started for group A patients and combination of capsule tranexamic acid (250 mg two times a day) along with topical 4% hydroquinone were started for group B patients for the next 6 months. Evaluation of patients through detailed history, clinical and wood’s light examination before starting therapy and after of 24 weeks of treatment was done for both groups. Efficacy of treatment was assessed via Modified MASI score. Results: Hydroquinone monotherapy was effective in 21 (52.5%) patients among group A while in group B patients, combination treatment i.e. oral tranexamic acid and topical hydroquinone, was effective in 31 (77.5%) patients (p value= 0.01). Conclusion: Effectiveness of Hydroquinone 4% topical therapy combined with oral tranexamic acid for epidermal melasma is better than topical 4% hydroquinone alone. Key words: Epidermal melasma, oral tranexamic acid, topical 4% hydroquinone.

scholarly journals GABAPENTIN

2018 ◽  
Vol 25 (12) ◽  
pp. 1892-1898
Author(s):  
Brig (Retd) Muhammad Boota ◽  
Sohail Nasir ◽  
Imran Hyder
Keyword(s):  
Heart Rate ◽  
Nasotracheal Intubation ◽  
Hemodynamic Response ◽  
Controlled Clinical Trial ◽  
P Value ◽  
Base Line ◽  
Time Intervals ◽  
Treatment Groups ◽  
Group A ◽  
Group B

Introduction: There have been several methods used to prevent or attenuate the adverse hemodynamic changes following endotracheal intubation, but not many studies have been done for the same purpose in patients undergoing nasotracheal intubation. Deepening of anaesthesia, omitting cholinergic premedication, pre-treatment with vasodilators such as nitroglycerine, beta blockers, calcium channel blockers and opioids are few of the different techniques used when trachea is intubated orally or nasally, to blunt significant swings in hemodynamic parameters. We assessed the effectiveness of oral gabapentin to determine changes in hemodynamic response in normotensive patients following nasotracheal intubationwith or without laryngoscopy for elective maxillofacial surgeries. Study Design: Randomized double blind, placebo-controlled clinical trial. Setting: Department of Anesthesia & Intensive Care, Fauji Foundation Hospital Rawalpindi. Period: 18 months after approval from the ethical committee. Material & Methods: Total 130 patients were included in the study. These patients were randomly divided into 2 groups. In Group-A patients were given 800 mg gabapentin and in Group-B patients were given placebo. Heart rate and mean arterial pressures were recorded just before intubation as base line values, and then average readings were taken at 1 minute, 3 minutes, 5 minutes and 10 minutes after intubation. Bradycardia and hypotension were adequately treated with intravenous atropine and vasopressors. Data entry and analysis was done by using SPSS 17. Results: Total 130 patients who underwent elective surgeries were included in the study and divided into 2 groups each group containing 65 patients each. At 1st minute MAP in Group-A (oral gabapentin) and in Group-B (Placebo) was 86.89±4.36 and 98.70±4.39. At 3rd minute MAP in Group-A, in Group-B was 83.40±4.05 and 92.93±4.79. At 5th minute MAP was 82.50±5.00 and 88.03±4.22 and lastly at 10th minute MAP was 79.81±5.37 in Group-A and 83.18±4.77 in Group-B respectively. P-value at 1st, 3rd, 5th and at 10th minutes showed that statistically MAP was different in both treatment groups at the above mentioned time intervals. 1st minute: p-value=0.042, 3rd minute: p-value=0.000, 5th minute: p-value=0.000 and at 10th minute: p-value=0.000. At 1st minute heart rate in Group-A and Group-B was 87.89±1.39 and 93.47±6.88 respectively. At 3rd minute heart rate in Group-A and Group-B was 83.47±5.47 and 89.70±6.76. At 5th minute heart rate was 82.10±5.01 and 84.60±5.91 and lastly at 10th minute heart rate was 78.09±6.79 in Group-A and 77.27±5.34 in Group-B respectively. P -value at 1st, 3rd and 5th minutes showed that statistically heart rate was different in both treatment groups at the above mentioned time intervals. But at 10th minute heart rate was statistically same in both treatment groups. 1st minute: p-value=0.144, 3rd minute: p-value=0.000, 5th minute: p-value=0.011 and at 10th minute: p-value=0.448. Conclusion: According to the results of this study it was observed that oral gabapentin is effective in modifying hemodynamic response to nasotracheal intubation in normotensive patients undergoing elective maxillofacial surgeries. MAP (10th Minute: Group-A vs. Group-B: 0.000) & Heart Rate (10th Minute: Group-A vs. Group-B:0.448)

scholarly journals UJI EFEK AFRODISIAK EKSTRAK BIJI PINANG MUDA (Areca Catechu L) PADA TIKUS JANTAN

2020 ◽  
Vol 8 (1) ◽  
pp. 34-39
Author(s):  
Ave Olivia Rahman ◽  
Erny Kusdiyah ◽  
Herlambang Herlambang ◽  
Aldo Victoria
Keyword(s):  
Wilcoxon Test ◽  
Female Rats ◽  
Male Rats ◽  
P Value ◽  
Betel Nut ◽  
Areca Catechu ◽  
Before And After ◽  
Group A ◽  
Herbal Plants ◽  
Group B

ABSTRACT Background: polyphenols and alkaloids in herbal plants could have aphrodisiac effect.  Betel nut (Areca catechu L) contain polyphenol and alkaloid. Alkaloid of betel nut has aphrodisiac effect, but also has side effect to many organs. Data of aphrodisiac effect of betel nut’s polyphenols is limited. This study aim to determine aphrodisiac effect of extraction of betel nut’s polyphenols in rats Method:  twelve rats, Sprague dawney, aged 2-3 months, weight 150-200 gram were divided into 2 group randomly. Group A were given  the extract with doses 100mg/kgWB and  group B were given extract with doses 200mg/kgWB  daily for 35 days. The aphrodisiacs effect determined by difference of mounting frequency before and after treatment. Male rats were mated with female rats which were in estrous phase and were recorded for 7 days.  Wilcoxon test were used for statistical analysis with p value < 0,05. Result: extract from extractio’s method that was used in this study had 39,8%(w/w) of polyphenols and 0,98% (w/w) of alkaloids. Both groups had decreasing of mounting’s frequency after treatment (p>0,05). Conclusions:  Extract of betel nut from this study had 39,8% (w/w) of polyphenols and had no aphrodisiacs effect in male rats. Keywords: Areca Catechu L, Betel nut, polyohenols, alkaloids, Rats, Aphrodisiac, Mounting.   ABSTRAK Latarbelakang: senyawa polifenol atau alkaloid suatu tanaman dapat mempunyai efek afrodisiak. Biji pinang (Areca catechu L) mempunyai kandungan polifenol dan alkaloid. Alkaloid biji pinang telah diketahui mempunyai efek afrodisiak, akan tetapi juga mempunyai banyak efek samping. Efek afrodisiak polifenol biji pinang belum diketahui. Penelitian ini bertujuan untuk melihat efek afrodisiak ekstrak polifenol biji pinang muda terhadap tikus putih. Metode: dua belas ekor tikus  Sprague dawney berumur 2-3 bulan, berat 150-200 gram dibagi secara random menjadi 2 kelompok yaitu Kelompok A diberikan ekstrak biji pinang dosis 100 mg/ kgBB, dan kelompok B diberikan dosis 200 mg/ kgBB setiap hari selama 35 hari. Efek afrodisiak dilihat dari perbedaan rerata frekuensi tunggangan sebelum dan sesudah perlakuan. Jantan dikawinkan dengan betina fase estrus dan direkam masing-masing selama 7 hari. Uji statistik menggunakan Wilcoxon dengan p<0,05. Hasil: ekstrak hasil ekstraksi yang digunakan pada penelitian ini mempunyai kandungan polifenol 39,8%(b/b) dan alkaloid 0,98% (b/b). Kedua kelompok terdapat penurunan rerata frekuensi  tunggangan setelah perlakuan (p >0,05). Kesimpulan: Ekstrak Biji Pinang Muda pada penelitian ini mempunyai kandungan 39,8% polifenol dan tidak mempunyai efek afrodisiak  pada tikus jantan. Kata kunci:  Areca Catechu L, biji pinang, polifenol, alkaloid, tikus, afrodisiak, tunggangan

Role of Aminophylline Intravesical Instillation on Enhancing Ureteral Dilatation prior to Ureteroscopy

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Ahmed Mohamed Saafan ◽  
Mohamed Ismail Shabayek ◽  
Marwa Mamdouh Mohamed ◽  
Mostafa Mabrouk Bayomi Ali
Keyword(s):  
Intravesical Instillation ◽  
Controlled Study ◽  
P Value ◽  
Pressure Monitor ◽  
Post Operative Pain ◽  
Significant Difference ◽  
Before And After ◽  
Group A ◽  
Ureteral Dilatation ◽  
Group B

Abstract Background Semi-rigid uretroscopy (URS) is a common intervention approach for lower ureteric stones. Ureteral dilatation is frequently needed before URS to enable ureter accessing. Aminophylline is known by its muscle relaxant effect and has been suggested to be effective in ureteral dilation. Objectives To evaluate the effect of intravesical administration of aminophylline on ureteroscopy and to measure intraureteral pressure Methods This prospective randomized controlled study included 50 before and after aminophylline injection. patients with lower ureteral calculi. In group A, the ureter was dilated by intravesical aminophylline whereas in group B balloon dilator was used. Intraureteral pressure was measured using pressure transducer connected to invasive pressure monitor. Results No statistically significant difference was noticed between both groups in operative time, intra operative complication, need for ureteral stenting or stone free rate. However, post-operative pain and haematuria were statistically significantly higher among balloon group compared to aminophylline group. In group A, there was statistically significant decrease in intraureteral pressure after injection of aminophylline (7.80 ± 1.71) compared to before injection (12.2 ± 1.85) with p-value &lt; 0.001. Conclusion Aminophylline is effective in ureteral dilatation when intravesically injected with less frequent post-operative pain and hematuria.

scholarly journals Effectiveness between Salam Leaf Booking Water and Red Ginger Towards Reducing Acid Levels in Patients of Gout Arthritis

2021 ◽  
Vol 2 (1) ◽  
pp. 6-11
Author(s):  
Hartono ◽  
Chicilia Puspita Darmaningrum
Keyword(s):  
Uric Acid ◽  
Sampling Technique ◽  
T Test ◽  
P Value ◽  
Test Analysis ◽  
Before And After ◽  
Group A ◽  
Group B ◽  
Red Ginger ◽  
Boiled Water

Background. The prevalence of Gout Arthritis in the world is 34.2%. Gout Arthritis is characterized by an increase in uric acid levels >7.2 mg/dl in men and >6 mg/dl in women. This disease can be treated pharmacologically and non-pharmacologically, one of which is bay leaf and red ginger. Research purposes. The purpose of this study was to determine the effectiveness of boiled water of bay leaves and red ginger on reducing uric acid levels in patients with gout arthritis. Methods. This research method is a pre-experimental static-group comparison design. The sampling technique used purposive sampling. A sample of 60 respondents was divided into two groups of 30 respondents each, group A intervention boiled bay leaf water for 7 days, group B intervention boiled red ginger water for 7 days. Both groups were observed uric acid levels before and after the procedure using the GCU tool. Result: The results of the paired t-test analysis of group A p = 0.000 and group B p = 0.005 p value <0.05 which means there is a difference between before and after intervention A and intervention B were given. The results of the Independent t-test analysis showed that there was a difference in uric acid levels. after intervention A and intervention B with p = 0.004. The results showed that boiled water of bay leaves was more effective than boiled water of red ginger in reducing uric acid levels. Conclusion. Boiled water of bay leaves is more effective than boiled water of red ginger in reducing uric acid levels in gout arthritis patients

scholarly journals COMPARATIVE STUDY ON THE EFFICACY OF MAITLAND TECHNIQUE (GRADE IV) AND MULLIGAN TECHNIQUE, IN THE TREATMENT OF FROZEN SHOULDER

2013 ◽  
Vol 2 (1) ◽  
pp. 10-14
Author(s):  
Syed Abid Mehdi Kazmi ◽  
Jharna Devi ◽  
Faisal Yamin ◽  
Sunil Kumar
Keyword(s):  
Experimental Study ◽  
Functional Activity ◽  
Frozen Shoulder ◽  
Group Interventions ◽  
Treatment Results ◽  
Treatment Groups ◽  
Before And After ◽  
Group A ◽  
Group B ◽  
Positive Results

OBJECTIVES To compare the effectiveness of Maitland technique (Grade IV) and Mulligan technique for the treatment of frozen shoulders. STUDY DESIGN Experimental Study. STUDY SETTINGS & PARTICIPANTS This study has been conducted at Ziauddin Hospital with 50 volunteers who participated in the study that were equally divided into two groups (pre and post treatment groups). Subjects were randomly assigned to each group. INTERVENTIONS Intervention given to Group A was Maitland Technique (Grade IV) and Group B, Mulligan Technique. OUTCOME MEASURES Functional activity of shoulder is measured by using Shoulder Pain and Disability Index (SPADI) score, Pain is measured by VAS Score, and Range of motion, measured by Goniometer both before and after treatment. RESULTS Both the treatments showed positive results but Mulligan technique was found to be more effective. The total SPADI score was 15.48 before and 11.92 after the Mulligan technique and 15.32 before and 13.16 after the Maitland technique. CONCLUSIONS It is evident that Mulligan technique is more effective for the treatment of frozen shoulder compared to Maitland technique.

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