Can Wolbachia modulate the fecundity costs of Plasmodium in mosquitoes?

Parasitology ◽  
2017 ◽  
Vol 145 (6) ◽  
pp. 775-782 ◽  
Author(s):  
F Zélé ◽  
J Denoyelle ◽  
O Duron ◽  
A Rivero

AbstractVertically transmitted parasites (VTPs) such as Wolbachia are expected not only to minimize the damage they inflict on their hosts, but also to protect their hosts against the damaging effects of coinfecting parasites. By modifying the fitness costs of the infection, VTPs can therefore play an important role in the evolution and epidemiology of infectious diseases.Using a natural system, we explore the effects of a Wolbachia–Plasmodium co-infection on mosquito fecundity. While Plasmodium is known to frequently express its virulence by partially castrating its mosquito vectors, the effects of Wolbachia infections on mosquito fecundity are, in contrast, highly variable. Here, we show that Plasmodium drastically decreases the fecundity of mosquitoes by ca. 20%, and we provide the first evidence that this decrease is independent of the parasite's burden. Wolbachia, on the other hand, increases fecundity by roughly 10%, but does not alter the tolerance (fecundity–burden relationship) of mosquitoes to Plasmodium infection.Although Wolbachia-infected mosquitoes fare overall better than uninfected ones, Wolbachia does not confer a sufficiently high reproductive boost to mosquitoes to compensate for the reproductive losses inflicted by Plasmodium. We discuss the potential mechanisms and implications underlying the conflicting effects of these two parasites on mosquito reproduction.

Author(s):  
A. V. Crewe

We have become accustomed to differentiating between the scanning microscope and the conventional transmission microscope according to the resolving power which the two instruments offer. The conventional microscope is capable of a point resolution of a few angstroms and line resolutions of periodic objects of about 1Å. On the other hand, the scanning microscope, in its normal form, is not ordinarily capable of a point resolution better than 100Å. Upon examining reasons for the 100Å limitation, it becomes clear that this is based more on tradition than reason, and in particular, it is a condition imposed upon the microscope by adherence to thermal sources of electrons.


During the last few years of his life Prof. Simon Newcomb was keenly interested in the problem of periodicities, and devised a new method for their investigation. This method is explained, and to some extent applied, in a paper entitled "A Search for Fluctuations in the Sun's Thermal Radiation through their Influence on Terrestrial Temperature." The importance of the question justifies a critical examination of the relationship of the older methods to that of Newcomb, and though I do not agree with his contention that his process gives us more than can be obtained from Fourier's analysis, it has the advantage of great simplicity in its numerical work, and should prove useful in a certain, though I am afraid, very limited field. Let f ( t ) represent a function of a variable which we may take to be the time, and let the average value of the function be zero. Newcomb examines the sum of the series f ( t 1 ) f ( t 1 + τ) + f ( t 2 ) f ( t 2 + τ) + f ( t 3 ) f ( t 3 + τ) + ..., where t 1 , t 2 , etc., are definite values of the variable which are taken to lie at equal distances from each other. If the function be periodic so as to repeat itself after an interval τ, the products are all squares and each term is positive. If, on the other hand, the periodic time be 2τ, each product will be negative and the sum itself therefore negative. It is easy to see that if τ be varied continuously the sum of the series passes through maxima and minima, and the maxima will indicated the periodic time, or any of its multiples.


2012 ◽  
Vol 16 (01) ◽  
pp. 114-121 ◽  
Author(s):  
Tapan K. Saha ◽  
Yutaka Yoshikawa ◽  
Hirouki Yasui ◽  
Hiromu Sakurai

We prepared [meso-tetrakis(4-carboxylatophenyl)porphyrinato]oxovanadium(IV) tetrasodium, ([VO(tcpp)]Na4), and investigated its in vitro insulin-mimetic activity and in vivo metallokinetic feature in healthy rats. The results were compared with those of previously proposed insulin-mimetic oxovanadium(IV)porphyrin complexes and oxovanadium(IV) sulphate. The in vitro insulin-mimetic activity and bioavailability of [VO(tcpp)]Na4 were considerably better than those of [meso-tetrakis (1-methylpyridinium-4-yl)porphyrinato]oxovanadium(IV)(4+) tetraperchlorate ([VO(tmpyp)](ClO4)4) and oxovanadium(IV) sulphate. On the other hand, [VO(tcpp)]Na4 and [meso-tetrakis(4-sulfonatophenyl) porphyrinato]oxidovanadate(IV)(4-)([VO(tpps)]) showed very similar in vitro insulin-mimetic activity and in vivo metallokinetic feature in healthy rats. In particular, the order of in vitro insulin-mimetic activity of the complexes was determined to be: [VO(tcpp)]Na4 ≈ [VO(tpps)] > ([VO(tmpyp)](ClO4)4 > oxovanadium(IV) sulphate.


De Jure ◽  
2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Daniel Haman ◽  
◽  
◽  

The difference between intent (dolus) and negligence (culpa) was rarely emphasized in codified medieval laws and regulations. When compared to the legal statements related to intent, negligence was mentioned even more rarely. However, there are some laws that distinguished between the two concepts in terms of some specific crimes, such as arson. This paper draws attention to three medieval Slavic legal documents – the Zakon Sudnyj LJudem (ZSLJ), the Vinodol Law and the Statute of Senj. They are compared with reference to regulations regarding arson, with the focus being on arson as a crime committed intentionally or out of negligence. The ZSLJ as the oldest known Slavic law in the world shows some similarities with other medieval Slavic legal codes, especially in the field of criminal law, since most of the ZSLJ’s articles are related to criminal law. On the other hand, the Vinodol Law is the oldest preserved Croatian law and it is among the oldest Slavic codes in the world. It was written in 1288 in the Croatian Glagolitic script and in the Croatian Chakavian dialect. The third document – the Statute of Senj – regulated legal matters in the Croatian littoral town of Senj. It was written in 1388 – exactly a century after the Vinodol Law was proclaimed. When comparing the Vinodol Law and the Statute of Senj with the Zakon Sudnyj LJudem, there are clear differences and similarities, particularly in the field of criminal law. Within the framework of criminal offenses, the act of arson is important for making a distinction between intent and negligence. While the ZSLJ regulates different levels of guilt, the Vinodol Law makes no difference between dolus and culpa. On the other hand, the Statute of Senj strictly refers to negligence as a punishable crime. Even though the ZSLJ is almost half a millennium older than the Statute of Senj and around 400 years older than the Vinodol Law, this paper proves that the ZSLJ defines the guilt and the punishment for arson much better than the other two laws.


2009 ◽  
Vol 1 (1) ◽  
pp. 1
Author(s):  
Rohmawati Kusumaningtias

AbstractAt the time of financial crisis, one of the influential institutions in society is banking. Banking sector provide soft loans to create productive employment for the community. On the other hand, customers also need the liquidity from bank-ing. These stakeholders' needs can be met by looking at the performance of bank-ing. This study aims to determine differences in the performance of sharia banking and conventional banking during economic crisis. This study uses t-test to analyze the data. From the research, it was found that in general, the performance of conventional banking is better than sharia banking in the economic crisis.


2020 ◽  
Vol 1 (2) ◽  
pp. 107-123
Author(s):  
Farid Pribadi

This article discusses the symbiotic relationship of mutualism between mass media andterrorism. Whether we realize it or not, acts of terrorism in the homeland are still interestingand economically valuable news material in front of the mass media. On the other hand, onthe part of terrorists, the news about terrorist acts actually becomes a strategic campaignarea to show their existence. The research uses a qualitative approach to narrative analysismethod. The results of the study are www.okezone.com and www.tribunnews.com placingthe terror terror events in Medan Mapolrestabes as interesting and economically valuablenews material. The style of the news flow is arranged with a choice of tense, dramatic andsensational nuances of words. In addition, the display of photo and video illustrationsshortly after the explosion also aims to display as if the news of the explosion event is true,not engineering, objective and valid. The combination technique of choice of words, storyline, placement techniques and the size of photos and videos all aim to make the emotions ofthe reader participate dissolved in a tense situation as the situation at the scene of theexplosion. The practice of compiling this kind of news flow is called, as Jean Baudrillard'spractice of simulation. The practice of simulation through the practice of compiling newslines and the touch of visual image technology will eventually create conditions ofhyperreality. Namely the conditions between reality will be mixed with the pseudo so it isdifficult to distinguish which is original and fake. Next, the airing of a list of victims ofunknown origin will actually give birth, as Pierre Bourdie calls it symbolic violence. That is,the practice of violent symbols aimed no longer at the physical target but rather consciousthoughts. Symbolic violence in the appearance of the victim list really has the potential tocreate traumatic feelings towards the families of the victims.


2019 ◽  
Vol 30 (1) ◽  
Author(s):  
Tautvydas Vėželis

This article examines the problem of overcoming nihilism in Heidegger’s dialogue with Jünger. It is suggested that nihilism is manifested in various forms and is the deep logic of the whole history of European civilization. One of the main aims of this paper is to outline the relationship of nihilism and Nothing in Heidegger’s dispute with Jünger, viewing how Heidegger distinguishes his approach from Jünger’s point of view. Heidegger, on the one hand, treats nihilism as consummation of the Western metaphysical tradition, on the other hand, identifies Nothing itself as the shadow of Being, which cannot be overcome in the traditional dialectical thinking manner.


2016 ◽  
Vol 11 (10) ◽  
pp. 3828-3833
Author(s):  
Anar Amil Namazov ◽  
Vagif Maharram Abbasov ◽  
Tarana Aslan Mammadova ◽  
Khayyam Rahim Valiyev ◽  
Khayala Hamlet Kasamanli

In this research, the influence of amino- and hydroxyethyl imidazolines of petroleum acids on the antistatic property and lubricity of diesel fuel has been studied. The researches illustrated that when the boiling point of petroleum acid fractions increases, the influence of imidazolines on the antistatic property and lubricity of diesel fuel decreases. Besides, it has been known that, the influence of aminoethyl imidazolines of petroleum acids on the antistatic property and lubricity of diesel fuel is better than the influence of hydroxyethyl imidazolines, On the other hand, it has been revealed that, when imidazolines of petroleum acids are added to the diesel fuel, the antistatic effect increases over time.


1979 ◽  
Vol 25 (2) ◽  
pp. 180-203 ◽  
Author(s):  
B. C. Johanson

I Corinthians xiv. 20–25 has long posed severalcruces interpretationisfor commentators. The basic problems concern the relationship of the assertions made about tongues and prophecy in υ. 22 to the quotation of Isa. xxviii. 11–12 in υ. 21 and to the illustrations concerning tongues and prophecy in υυ. 23–5. As to the quotation, J. Ruef remarks that most commentators admit to the difficulty of seeing how it substantiates Paul's conclusion that tongues are meant as a sign for the unbeliever. Concerning the illustrations, both J. Héring and J. P. M. Sweet note that in the light of the assertions we would expect them to be the reverse of what they are. While tongues are asserted to be meant as a sign for unbelievers and prophecy for believers, the illustrations depict the negative effect of tongues upon unbelievers and the positive effect of prophecy not on believers but upon unbelievers. The second assertion (υ. 22b) in particular contradicts the second illustration (υυ. 24–5) in that it clearly states that ‘prophecy is meant as a signnot for unbelieversbut for believers’. This is so if σημεĩον is taken in a positive sense. If, on the other hand, it is taken in a negative sense, the logical relation of this second illustration to the second assertion becomes ambiguous.


2021 ◽  
Vol 24 (2) ◽  
pp. 231-246
Author(s):  
Jonathan Jacobs

Abstract This study addresses the views of two Byzantine commentators regarding Targum Onqelos: R. Samuel Roshano of the twelfth century and R. Meyuhas ben Elijah of the thirteenth. R. Samuel explicitly refers to the translation forty-six times; R. Meyuhas makes explicit reference to it 104 times. But there are differences between the two commentators in their relation to the Targum: R. Samuel never mentions the name Onqelos, while R. Meyuhas does so explicitly; R. Samuel systematically cites the text of the Targum, while in most cases in R. Meyuhas’ commentary, there is no accurate citation. The qualitative difference is in their respective relationships with the Targum: all of R. Samuel’s references to it signal his agreement; R. Meyuhas, on the other hand, while frequently agreeing with Onqelos, also brings the Targum as one of two possible alternatives and sometimes openly challenges its interpretation.


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