scholarly journals Aggressive behaviour in childhood and adolescence: the role of smoking during pregnancy, evidence from four twin cohorts in the EU-ACTION consortium

2018 ◽  
Vol 49 (4) ◽  
pp. 646-654 ◽  
Author(s):  
Margherita Malanchini ◽  
Emily Smith-Woolley ◽  
Ziada Ayorech ◽  
Kaili Rimfeld ◽  
Eva Krapohl ◽  
...  
Keyword(s):  
Aggressive Behaviour ◽  
Meta Analysis ◽  
Independent Effect ◽  
Childhood And Adolescence ◽  
Perinatal Factors ◽  
Smoking During Pregnancy ◽  
Level Data ◽  
Item Level ◽  
Socio Demographic Factors ◽  
The Eu

AbstractBackgroundMaternal smoking during pregnancy (MSDP) has been linked to offspring's externalizing problems. It has been argued that socio-demographic factors (e.g. maternal age and education), co-occurring environmental risk factors, or pleiotropic genetic effects may account for the association between MSDP and later outcomes. This study provides a comprehensive investigation of the association between MSDP and a single harmonized component of externalizing: aggressive behaviour, measured throughout childhood and adolescence.MethodsData came from four prospective twin cohorts – Twins Early Development Study, Netherlands Twin Register, Childhood and Adolescent Twin Study of Sweden, and FinnTwin12 study – who collaborate in the EU-ACTION consortium. Data from 30 708 unrelated individuals were analysed. Based on item level data, a harmonized measure of aggression was created at ages 9–10; 12; 14–15 and 16–18.ResultsMSDP predicted aggression in childhood and adolescence. A meta-analysis across the four samples found the independent effect of MSDP to be 0.4% (r = 0.066), this remained consistent when analyses were performed separately by sex. All other perinatal factors combined explained 1.1% of the variance in aggression across all ages and samples (r = 0.112). Paternal smoking and aggressive parenting strategies did not account for the MSDP-aggression association, consistent with the hypothesis of a small direct link between MSDP and aggression.ConclusionsPerinatal factors, including MSDP, account for a small portion of the variance in aggression in childhood and adolescence. Later experiences may play a greater role in shaping adolescents’ aggressive behaviour.

Challenges and Opportunities for Neuroimaging in Young Patients with Traumatic Brain Injury: a Coordinated Effort towards Advancing Discovery from the ENIGMA Pediatric Moderate/Severe TBI Group

2019 ◽  
Author(s):  
Emily L. Dennis ◽  
Karen Caeyenberghs ◽  
Robert F. Asarnow ◽  
Talin Babikian ◽  
Brenda Bartnik-Olson ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Meta Analysis ◽  
Young Patients ◽  
Future Research ◽  
Childhood And Adolescence ◽  
Developmental Issues ◽  
Challenges And Opportunities ◽  
Severe Tbi ◽  
Advance Research

Traumatic brain injury (TBI) is a major cause of death and disability in children in both developed and developing nations. Children and adolescents suffer from TBI at a higher rate than the general population; however, research in this population lags behind research in adults. This may be due, in part, to the smaller number of investigators engaged in research with this population and may also be related to changes in safety laws and clinical practice that have altered length of hospital stays, treatment, and access to this population. Specific developmental issues also warrant attention in studies of children, and the ever-changing context of childhood and adolescence may require larger sample sizes than are commonly available to adequately address remaining questions related to TBI. The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Pediatric Moderate-Severe TBI (msTBI) group aims to advance research in this area through global collaborative meta-analysis. In this paper we discuss important challenges in pediatric TBI research and opportunities that we believe the ENIGMA Pediatric msTBI group can provide to address them. We conclude with recommendations for future research in this field of study.

scholarly journals Exposure to Gestational Diabetes Is a Stronger Predictor of Dysmetabolic Traits in Children Than Size at Birth

2018 ◽  
Vol 104 (5) ◽  
pp. 1766-1776 ◽  
Author(s):  
Freja Bach Kampmann ◽  
Anne Cathrine Baun Thuesen ◽  
Line Hjort ◽  
Sjurdur Frodi Olsen ◽  
Sara Monteiro Pires ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
Birth Cohort ◽  
Gestational Age ◽  
Metabolic Profile ◽  
Large For Gestational Age ◽  
Independent Effect ◽  
Birth Cohort Study ◽  
Childhood And Adolescence ◽  
Size At Birth ◽  
Cardiometabolic Traits

Abstract Context and Objective Being born small or large for gestational age and intrauterine exposure to gestational diabetes (GDM) increase the risk of type 2 diabetes in the offspring. However, the potential combined deleterious effects of size at birth and GDM exposure remains unknown. We examined the independent effect of size at birth and the influence of GDM exposure in utero on cardiometabolic traits, body composition, and puberty status in children. Design, Participants, and Methods The present study was a longitudinal birth cohort study. We used clinical data from 490 offspring of mothers with GDM and 527 control offspring aged 9 to 16 years, born singleton at term from the Danish National Birth Cohort with available birthweight data. Results We found no evidence of a U-shaped association between size at birth (expressed as birthweight, sex, and gestational age adjusted z-score) and cardiometabolic traits. Body size in childhood and adolescence reflected the size at birth but was not reflected in any metabolic outcome. No synergistic adverse effect of being born small or large for gestational age and exposure to GDM was shown. However, GDM was associated with an adverse metabolic profile and earlier onset of female puberty in childhood and adolescence independently of size at birth. Conclusion In childhood and adolescence, we found GDM was a stronger predictor of dysmetabolic traits than size at birth. The combination of being born small or large and exposed to GDM does not exacerbate the metabolic profile in the offspring.

Maternal smoking during pregnancy and the risk of strabismus in offspring: a meta‐analysis

2018 ◽  
Vol 97 (4) ◽  
pp. 353-363 ◽  
Author(s):  
Yudi Yang ◽  
Chao Wang ◽  
Yong Gan ◽  
Heng Jiang ◽  
Wenning Fu ◽  
...  
Keyword(s):  
Maternal Smoking ◽  
Meta Analysis ◽  
Smoking During Pregnancy ◽  
Maternal Smoking During Pregnancy

A Meta-Analysis of Latinx Acculturation and Intimate Partner Violence

2018 ◽  
Vol 21 (4) ◽  
pp. 844-854 ◽  
Author(s):  
Miriam J. Alvarez ◽  
Sandra Oviedo Ramirez ◽  
Gabriel Frietze ◽  
Craig Field ◽  
Michael A. Zárate
Keyword(s):  
Intimate Partner Violence ◽  
Partner Violence ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Male Partner ◽  
Intimate Partner ◽  
Health Concern ◽  
Independent Effect ◽  
Subgroup Analyses ◽  
The Relationship

Objective: Intimate partner violence (IPV) is a serious public health concern that affects many Latinx couples. The present study conducted a systematic review and meta-analysis to quantitatively assess acculturation as a predictor of IPV among Latinxs and subgroup analyses to evaluate the effect size by gender and type of acculturation measure. Method: The meta-analysis implemented the preferred reporting items for systematic reviews and meta-analyses guidelines to retrieve studies assessing the relationship between acculturation and intimate partner victimization among foreign-born and U.S.-born Latinx adults. A fixed effects model (FEM) and a random effects model (REM) were employed. Additional subgroup analyses examined the strength of the relationship by gender and type of acculturation measure. Results: The meta-analysis included 27 independent effect sizes across 21 studies. An REM yielded a weighted average correlation of .11 (95% confidence interval [.02, .20]). The strength of the correlation differed by scale and ranged from −.003 to .47. For both men and women, higher acculturation was associated with increased IPV. Conclusions: Our results yielded three important findings: (1) the overall effect of acculturation on IPV is relatively small, (2) acculturation differentially influences male-to-female and female-to-male partner violence, and (3) the strength of the correlation between acculturation and IPV differs by scale. This body of work provides evidence for the effect of acculturation on IPV, with potential implications for interventions targeting Latinxs.

scholarly journals European myriad of approaches to parasitic commercial practices

2017 ◽  
Vol 8 (2) ◽  
pp. 167 ◽  
Author(s):  
Radka MacGregor Pelikánová
Keyword(s):  
Quantitative Research ◽  
Meta Analysis ◽  
Value Added ◽  
Unfair Competition ◽  
Member States ◽  
Secondary Sources ◽  
Eu Member States ◽  
Unfair Commercial Practices Directive ◽  
The Impact ◽  
The Eu

Research background: The Post-Lisbon EU aims at smart, sustainable, and inclusive growth on the single internal market, as indicated by the Europe 2020. The interplay of the competition and consumer protection on such a market is subject to harmonization. The Unfair Commercial Practices Directive has been made in order to achieve a full harmonization in this respect in 2007. However, EU member states share different social, political, legal and economic traditions and their approaches to unfair competition, in particular if committed via parasitic commercial practices, are dramatically diverse. In such a context, is it feasible, effective and efficient to install a full harmonization?Purpose of the article: The primary purpose of this article is to describe and assess ap-proaches to unfair competition, in particular if committed via parasitic commercial practices, by the EU law and EU member states law. The secondary purpose is to study and evaluate possibilities for the feasible, effective and efficient harmonization, or their lack. Methods: The cross-disciplinary and multi-jurisdictional nature of this article, and its dual purposes, implies the use of Meta-Analysis, of the critical comparison of laws and the impact of their application, to the holistic perception of historical and national contexts, and to case studies. The primary and secondary sources are explored and the yield knowledge and data are confronted with the status quo. The dominating qualitative research and data are complemented by the quantitative research and data.Findings & Value added: The EU opted for an ambitious challenge to install via the Unfair Commercial Practices Directive a full harmonization of the regime against unfair commercial practices, including parasitic ones. The exploration pursuant to the duo of purposes suggests that the challenge is perhaps too ambitious and that the EU underestimated the dramatic diversity of approaches to unfair commercial practices, especially parasitic ones.

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