Interlocking Directorates and the Corporate Revolution

1983 ◽  
Vol 7 (2) ◽  
pp. 143-164 ◽  
Author(s):  
William G. Roy

Many social scientistshave documented that the American corporate capitalist class is highly organized and cohesive, both in terms of formal structural characteristics (Domhoff, 1967; Useem, 1979; Scott, 1979) and informal social patterns (Baltzell, 1964; Domhoff, 1974; Mills, 1956). One of the major structural features integrating corporate capitalists is interlocking directorates, which have been shown to form a single, continuous, cohesive network (Sonquist and Koenig, 1975; Allen, 1974; Mariolis, 1975; Mizruchi, 1982; Pennings, 1980; Scott, 1979; Fennema and Schijf, 1978).

Molecules ◽  
2019 ◽  
Vol 24 (11) ◽  
pp. 2125 ◽  
Author(s):  
Kazuma Murakami ◽  
Kazuhiro Irie

Aggregation of amyloid β42 (Aβ42) is one of the hallmarks of Alzheimer’s disease (AD). There are numerous naturally occurring products that suppress the aggregation of Aβ42, but the underlying mechanisms remain to be elucidated. Based on NMR and MS spectroscopic analysis, we propose three structural characteristics found in natural products required for the suppressive activity against Aβ42 aggregation (i.e., oligomerization by targeting specific amino acid residues on this protein). These characteristics include (1) catechol-type flavonoids that can form Michael adducts with the side chains of Lys16 and 28 in monomeric Aβ42 through flavonoid autoxidation; (2) non-catechol-type flavonoids with planarity due to α,β-unsaturated carbonyl groups that can interact with the intermolecular β-sheet region in Aβ42 aggregates, especially aromatic rings such as those of Phe19 and 20; and (3) carboxy acid derivatives with triterpenoid or anthraquinoid that can generate a salt bridge with basic amino acid residues such as Lys16 and 28 in the Aβ42 dimer or trimer. Here, we summarize the recent body of knowledge concerning amyloidogenic inhibitors, particularly in functional food components and Kampo medicine, and discuss their application in the treatment and prevention of AD.


2018 ◽  
Vol 927 ◽  
pp. 13-19 ◽  
Author(s):  
Tatyana A. Krylova ◽  
Konstantin V. Ivanov ◽  
Vladimir E. Ovcharenko

An interrelation between structural features, microhardness and wear resistance was studied in the coatings obtained by non-vacuum relativistic electron beam cladding of chromium and titanium carbides powder mixture on low carbon steel. Five coatings differing in the amount of the entered energy were investigated using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), indentation tests and wear resistance measurements. It was found that the concentration of alloying elements both in solid solution and eutectic as well as the volume fraction of eutectic are the main structural characteristics which defines the microhardness of the coatings. The distribution of TiC phase plays a key role in the resistance to wear.


1981 ◽  
Vol 44 (336) ◽  
pp. 417-423 ◽  
Author(s):  
M. Cathelineau ◽  
J. Leroy

AbstractHydrothermal uranium veins, associated with the Hercynian leucogranites show important variations in their mineralogical, chemical and structural features in relation to the host rock lithology. These are described with particular reference to the Chardon deposit, Vendée where the veins cut granite, basic lithologies, and shales. The following features are described: 1Changes in the thickness of veins near to contact zones, particularly those between granites and basic lithologies, lamprophyres, and shales.2Changes in the gangue mineral assemblage with the preferential development of carbonate in veins cutting basic lithologies, and of silica in veins which cut granite.3Paragenetic zoning in the veins in passing from granites to their metamorphic aureoles.Comparisons between deposits of Vendée, Limousin, and Erzgebirge allow the following generalizations to be made: 1Open faults and subsequent mineralization are concentrated at boundaries between competent and more plastic lithologies.2Mineralizing fluids cause wall-rock alteration characterized by the removal of Si from granite and of Ca, Mg, Fe from metamorphic and basic rocks.3The chemical and structural characteristics of wallrocks are important controls on the mineralization but in acid lithologies the main controls on the pitchblende vein formation are the structural characteristics of the wallrock.


mSphere ◽  
2017 ◽  
Vol 2 (5) ◽  
Author(s):  
Rebecca Rabi ◽  
Lynne Turnbull ◽  
Cynthia B. Whitchurch ◽  
Milena Awad ◽  
Dena Lyras

ABSTRACT Clostridium sordellii is a significant pathogen with mortality rates approaching 100%. It is the bacterial spore that is critical in initiating infection and disease. An understanding of spore structures as well as spore morphology across a range of strains may lead to a better understanding of C. sordellii infection and disease. However, the structural characteristics of the C. sordellii spores are limited. In this work, we have addressed this lack of detail and characterized the C. sordellii spore morphology. The use of traditional and advanced microscopy techniques has provided detailed new observations of C. sordellii spore structural features, which serve as a reference point for structural studies of spores from other bacterial species. Clostridium sordellii is an often-lethal bacterium causing human and animal disease. Crucial to the infectious cycle of C. sordellii is its ability to produce spores, which can germinate into toxin-producing vegetative bacteria under favorable conditions. However, structural details of the C. sordellii spore are lacking. Here, we used a range of electron microscopy techniques together with superresolution optical microscopy to characterize the C. sordellii spore morphology with an emphasis on the exosporium. The C. sordellii spore is made up of multiple layers with the exosporium presenting as a smooth balloon-like structure that is open at the spore poles. Focusing on the outer spore layers, we compared the morphologies of C. sordellii spores derived from different strains and determined that there is some variation between the spores, most notably with spores of some strains having tubular appendages. Since Clostridium difficile is a close relative of C. sordellii, their spores were compared by electron microscopy and their exosporia were found to be distinctly different from each other. This study therefore provides new structural details of the C. sordellii spore and offers insights into the physical structure of the exosporium across clostridial species. IMPORTANCE Clostridium sordellii is a significant pathogen with mortality rates approaching 100%. It is the bacterial spore that is critical in initiating infection and disease. An understanding of spore structures as well as spore morphology across a range of strains may lead to a better understanding of C. sordellii infection and disease. However, the structural characteristics of the C. sordellii spores are limited. In this work, we have addressed this lack of detail and characterized the C. sordellii spore morphology. The use of traditional and advanced microscopy techniques has provided detailed new observations of C. sordellii spore structural features, which serve as a reference point for structural studies of spores from other bacterial species.


2010 ◽  
Vol 113-116 ◽  
pp. 1693-1696
Author(s):  
Ming Hui Guo ◽  
Xin Guan ◽  
Li Zhu ◽  
Jian Li

Trees are complicated and important organisms in forest ecosystem. They are both carbon stocks and carbon source. In order to give full play to the role of wood carbon sequestration, this paper discussed the relationship of wood structural features and wood carbon sequestration at micro-level. It shows that wood carbon sequestration can be synthetically reflected by vessel, tracheid/xylon, wood rays, intercellular canal, xylem parenchyma and so on. The rate of cell wall and wood carbon sequestration is the relationship of direct proportional function. Micro-structural characteristics of wood can reflect wood carbon sequestration of forest ecosystems, as well as have a practical guide to enhance carbon storage of wood.


2012 ◽  
Vol 65 (2) ◽  
pp. 138 ◽  
Author(s):  
Li-Tao Fan ◽  
Ying Li ◽  
Di Wu ◽  
Zhi-Ru Li ◽  
Chia-Chung Sun

A series of M2+(H5Aza222)–M′– (M = Be, Mg, Ca; M′ = Li, Na, K) alkalides that contain alkaline earth metal cations complexed by the H5Aza222– cage have been investigated using the CAM-B3LYP method. These alkaline earth-based alkalides not only present unusual structural features but also exhibit extraordinarily large static first hyperpolarizabilities (β0) up to 1.98 × 105 au. By comparing the β0 values among alkalides with various complexants, the Aza222 cage is found to be preferable to the previously investigated calix[4]pyrrole and n6adamanzane (n = 2, 3) complexants in enhancing the first hyperpolarizabilities of alkalides. In addition, the relationships between the β0 values of M2+(H5Aza222)–M′– and the atomic number of the M′– anion, the atomic number of the M2+ cation, and the M–M′ distance are explored.


Author(s):  
Osman Burak Okan ◽  
Deniz Turgut ◽  
Canan Atilgan ◽  
Ali Rana Atilgan ◽  
Rahmi Ozisik

AbstractA direct way to spot structural features that are universally shared among proteins is to find proper analogues from simpler condensed matter systems. In most cases, sphere-packing arguments provide a straightforward route for structural comparison, as they successfully characterize a wide array of materials such as close packed crystals, dense liquids, and structural glasses. In the current study, the feasibility of creating ensembles of artificial structures that can automatically reproduce a large number of geometrical and topological descriptors of globular proteins is investigated. Towards this aim, a simple cubic (SC) arrangement is shown to provide the best background lattice after a careful analysis of the residue packing trends from 210 proteins. It is shown that a minimalistic set of ground rules imposed on this lattice is sufficient to generate structures that can mimic real proteins. In the proposed method, 210 such structures are generated by randomly removing residues (beads) from clusters that have a SC lattice arrangement until a predetermined residue concentration is achieved. All generated structures are checked for residue connectivity such that a path exists between any two residues. Two additional sets are prepared from the initial structures via random relaxation and a reverse Monte Carlo simulated annealing (RMC-SA) algorithm, which targets the average radial distribution function (RDF) of 210 globular proteins. The initial and relaxed structures are compared to real proteins via RDF, bond orientational order parameters, and several descriptors of network topology. Based on these features, results indicate that the structures generated with 40% occupancy via the proposed method closely resemble real residue networks. The broad correspondence established this way indicates a non-superficial link between the residue networks and the defect laden cubic crystalline order. The presented approach of identifying a minimalistic set of operations performed on a target lattice such that each resulting cluster possess structural characteristics largely indistinguishable from that of a coarse-grained globular protein opens up new venues in structural characterization, native state recognition, and rational design of proteins.


Author(s):  
V.V. Detinkina ◽  
Yu.V. x Yu.V. Zheleznova ◽  
I.Yu. Rusanova

The high density of ergonyms in the urban onomasticon, as well as their social orientation, has contributed to the constant scientific interest in these linguistic units. The article presents the results of studying ergonyms with an anthroponymic element of commercial enterprises and service companies located in the city of Izhevsk. The authors analyze the typological characteristics of ergonyms, their structural features. The problems of compatibility between business name and company sector is under consideration as well. When selecting material for research, the method of continuous sampling was used. The main method used to study is the method of scientific description, which involves direct observation, systematization, classification and interpretation. Based on the results of the description of the constituents of the four groups, a conclusion is made about the high typological variation of units and their structural diversity. Graphic ways to display a business name are characterized by the use of the Cyrillic and Latin alphabets including letters, punctuation marks and different symbols.


BioResources ◽  
2020 ◽  
Vol 15 (2) ◽  
pp. 4362-4372
Author(s):  
Na Li ◽  
Chao Cao ◽  
Lupeng Shao ◽  
Chao Wang ◽  
Yu Liu ◽  
...  

Achieving mild and efficient extraction of high purity lignin from corncob acid hydrolysis residue is essential for efficient lignin application. In this study, enzymatic/mild acidolysis lignin (EMAL) and deep eutectic solvent (DES)-lignin were extracted from corncob acid hydrolysis residue. The structural features of the two lignin fractions were investigated by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), gel permeation chromatography (GPC), and 31P-nuclear magnetic resonance (31P-NMR). The highest DES-lignin yield of 58.8 wt% was achieved at 120 °C with a choline chloride-to-lactic acid (ChCl-to-Lac) molar ratio of 1:10 and a reaction time of 12 h. The FTIR analysis indicated a higher amount of guaiacyl units in EMAL than DES-lignin. Furthermore, condensation and fragmentation occurred simultaneously under DES pretreatment, but the fragmentation reaction was dominant. The structural characteristics investigated will allow for more effective lignin usage.


2019 ◽  
Vol 16 (3) ◽  
pp. 353-363 ◽  
Author(s):  
Che Puteh Osman ◽  
Nor Hadiani Ismail ◽  
Aty Widyawaruyanti ◽  
Syahrul Imran ◽  
Lidya Tumewu ◽  
...  

Background: A phytochemical study on medicinal plants used for the treatment of fever and malaria in Africa yielded metabolites with potential antiplasmodial activity, many of which are Anthraquinones (AQ). AQs have similar sub-structure as naphthoquinones and xanthones, which were previously reported as novel antiplasmodial agents. </P><P> Objective: The present study aimed to investigate the structural requirements of 9,10- anthraquinones with hydroxy, methoxy and methyl substituents to exert strong antiplasmodial activity and to investigate their possible mode of action. </P><P> Methods: Thirty-one AQs were synthesized through Friedel-Crafts reaction and assayed for antiplasmodial activity in vitro against Plasmodium falciparum (3D7). The selected compounds were tested for toxicity and probed for their mode of action against β-hematin dimerization through HRP2 and lipid catalyses. The most active compounds were subjected to a docking study using AutoDock 4.2. </P><P> Results: The active AQs have similar common structural characteristics. However, it is difficult to establish a structure-activity relationship as certain compounds are active despite the absence of the structural features exhibited by other active AQs. They have either ortho- or meta-arranged substituents and one free hydroxyl and/or carbonyl groups. When C-6 is substituted with a methyl group, the activity of AQs generally increased. 1,3-DihydroxyAQ (15) showed good antiplasmodial activity with an IC50 value of 1.08 &#181;M, and when C-6 was substituted with a methyl group, 1,3- dihydroxy-6-methylAQ (24) showed stronger antiplasmodial activity with an IC50 value of 0.02 &#181;M, with better selectivity index. Compounds 15 and 24 showed strong HRP2 activity and mild toxicity against hepatocyte cells. Molecular docking studies showed that the hydroxyl groups at the ortho (23) and meta (24) positions are able to form hydrogen bonds with heme, of 3.49 Å and 3.02 Å, respectively. </P><P> Conclusion: The activity of 1,3-dihydroxy-6-methylAQ (24) could be due to their inhibition against the free heme dimerization by inhibiting the HRP2 protein. It was further observed that the anthraquinone moiety of compound 24 bind in parallel to the heme ring through hydrophobic interactions, thus preventing crystallization of heme into hemozoin.


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