Psychomotor retardation in depression, a pilot study

1991 ◽  
Vol 3 (2) ◽  
pp. 22-25
Author(s):  
J.J.M. van Hoof ◽  
L.P. van Bavel ◽  
A.J.M. van den Berg
Keyword(s):  
Depressive Episode ◽  
Major Depressive Episode ◽  
Rating Scale ◽  
Psychiatric Patients ◽  
Depression Scale ◽  
Psychomotor Retardation ◽  
Point Of View ◽  
Major Depressive ◽  
Important Sign ◽  
Depressive Patients

SummarySeveral studies have demonstrated that psychomotor retardation is an important sign of the major depressive episode, both from a diagnostic point of view and as a predictor of treatment outcome. However, it is uncertain to what extent psychomotor retardation is specific for the major depressive episode. A heterogeneous group of psychiatric patients (n=26) was studied using a rating scale developed specifically to assess psychomotor retardation (RRS). The 13 patients suffering from a major depressive episode had a significantly higher RRS score than patients with another diagnosis. Furthermore, in the depressive subjects the severity of the depression (measured by means of Hamilton's depression rating scale) appeared to correlate with the severity of the psychomotor retardation. Cognitive features of psychomotor retardation were mainly responsible for the more severe psychomotor retardation in the depressive patients. Surprisingly. Hamilton's depression scale which was used in this study does not pay much attention to these aspects.

scholarly journals Validation of the Edinburgh postnatal depression scale (EPDS) for screening of major depressive episode among adults from the general population

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Alicia Matijasevich ◽  
Tiago N Munhoz ◽  
Beatriz Franck Tavares ◽  
Ana Paula Pereira Neto Barbosa ◽  
Diego Mello da Silva ◽  
...  
Keyword(s):  
General Population ◽  
Depressive Episode ◽  
Postnatal Depression ◽  
Major Depressive Episode ◽  
Edinburgh Postnatal Depression Scale ◽  
Depression Scale ◽  
Major Depressive

Impairment of endothelial protection by ischemic postconditioning in patients with major depressive disorder

2011 ◽  
Vol 89 (9) ◽  
pp. 647-653 ◽  
Author(s):  
Chuanjun Zhuo ◽  
Ying Wang ◽  
Hongjun Tian ◽  
Xiaohui Wang ◽  
Yuhui Chen ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Depressive Episode ◽  
Major Depressive Episode ◽  
Rating Scale ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Ischemic Postconditioning ◽  
Healthy Controls ◽  
Major Depressive

This study used a model of ischemia–reperfusion injury to the brachial artery endothelium to investigate whether the protective role of ischemic postconditioning (IPostC) is impaired in patients with major depressive episode. Flow-mediated dilation (FMD) was measured before and after ischemia–reperfusion in the absence or presence of IPostC in 24 patients with major depressive disorder and 20 healthy controls. In addition, the severity of the depression, as assessed by the Hamilton Depression Rating Scale (HDRS) and Beck Depression Inventory (BDI) scores, and plasma nitrogen dioxide (NOx) levels were also determined. Ischemia–reperfusion resulted in a significant decrease in FMD in both patients with a major depressive episode and healthy controls. IPostC effectively prevented this decrease in FMD in healthy controls, but not in patients with a major depressive episode. HDRS and BDI scores were markedly increased, but plasma NOx levels decreased, in patients with a major depressive episode compared with those in healthy controls. Correlation analysis showed that HDRS and BDI scores and plasma NOx levels were significantly associated with post-ischemia–reperfusion FMD. These results suggest that endothelial protection by IPostC is impaired in patients with major depressive disorder, which may be related to the decrease in endothelial nitric oxide production and the severity of the depression.

scholarly journals Importance of retardation and fatigue/interest domains for the diagnosis of major depressive episode after stroke: a four months prospective study

2009 ◽  
Vol 31 (3) ◽  
pp. 202-207 ◽  
Author(s):  
Luisa de Marillac Niro Terroni ◽  
Renério Fráguas ◽  
Mara de Lucia ◽  
Gisela Tinone ◽  
Patricia Mattos ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Depressive Episode ◽  
Major Depressive Episode ◽  
Rating Scale ◽  
University Hospital ◽  
Regression Equations ◽  
Stroke Patients ◽  
Major Depressive ◽  
Post Stroke ◽  
Neurology Clinic

OBJECTIVE: Post-stroke major depressive episode is very frequent, but underdiagnosed. Researchers have investigated major depressive episode symptomatology, which may increase its detection. This study was developed to identify the depressive symptoms that better differentiate post-stroke patients with major depressive episode from those without major depressive episode. METHOD: We screened 260 consecutive ischemic stroke patients admitted to the neurology clinic of a university hospital. Seventy-three patients were eligible and prospectively evaluated. We assessed the diagnosis of major depressive episode using the Structured Clinical Interview for DSM-IV and the profile of depressive symptoms using the 31-item version of the Hamilton Depression Rating Scale. For data analysis we used cluster analyses and logistic regression equations. RESULTS: Twenty-one (28.8%) patients had a major depressive episode. The odds ratio of being diagnosed with major depressive episode was 3.86; (95% CI, 1.23-12.04) for an increase of one unit in the cluster composed by the domains of fatigue/interest and retardation, and 2.39 (95% CI, 1.21-4.71) for an increase of one unit in the cluster composed by the domains of cognitive, accessory and anxiety symptoms. The domains of eating/weight and insomnia did not contribute for the major depressive episode diagnosis. CONCLUSION: The domains of retardation and interest/fatigue are the most relevant for the diagnosis of major depressive episode after stroke.

scholarly journals Diagnosis Accuracy of Baptista Depression Scale: Adult and Screening Versions

2021 ◽  
Vol 37 ◽  
Author(s):  
André Pereira Gonçalves ◽  
Makilim Nunes Baptista ◽  
Anna Elisa de Villemor-Amaral ◽  
Lucas de Francisco Carvalho
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Diagnostic Accuracy ◽  
Depressive Episode ◽  
Major Depressive Episode ◽  
Depression Scale ◽  
Major Depressive ◽  
Diagnosis Accuracy

Abstract This study aimed to investigate the diagnostic accuracy of the Baptista Depression Scale adult and screening versions (EBADEP-A and EBADEP-screening) for discrimination of people with a major depressive episode (MDE) or major depressive disorder (MDD) and to compare discriminative capacities. Participants were 187 people, 52 patients, and 135 non-clinical individuals. Results indicated sensitivity equal to 0.92 and specificity equal to 0.88 for EBADEP-A (cut-off = 54), and 0.96 and 0.82, respectively, for EBADEP-screening (cut-off = 17). Findings suggest equivalence between the two versions of EBADEP to discriminate people with MDE or MDD. Results indicate that the two versions can provide a correct diagnostic indicative for MDE and MDD.

scholarly journals Characteristics Associated with Depression Severity in 270 Juveniles in a Major Depressive Episode

2021 ◽  
Vol 11 (4) ◽  
pp. 440
Author(s):  
Giulia Serra ◽  
Maria Elena Iannoni ◽  
Monia Trasolini ◽  
Gino Maglio ◽  
Camilla Frattini ◽  
...  
Keyword(s):  
Depressive Episode ◽  
Major Depressive Episode ◽  
Rating Scale ◽  
Severe Depression ◽  
Psychotic Symptoms ◽  
Depression Severity ◽  
Suicidal Risk ◽  
Major Depressive ◽  
Mood Lability ◽  
Linear Regression Modeling

Introduction: Severe depression is prevalent in young persons and can lead to disability and elevated suicidal risk. Objectives: To identify clinical and demographic factors associated with the severity of depression in juveniles diagnosed with a major mood disorder, as a contribution to improving clinical treatment and reducing risk of suicide. Methods: We analyzed factors associated with depression severity in 270 juveniles (aged 6–18 years) in a major depressive episode, evaluated and treated at the Bambino Gesù Children’s Hospital of Rome. Depressive symptoms were rated with the revised Children’s Depression Rating Scale (CDRS-R) and manic symptoms with the Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS) Mania Rating Scale (K-SADS-MRS). Bivariate comparisons were followed by multivariable linear regression modeling. Results: Depression severity was greater among females than males (55.0 vs. 47.2), with the diagnosis of a major depressive disorder (MDD) vs. bipolar disorder (BD; 53.8 vs. 49.3), and tended to increase with age (slope = 1.14). Some symptoms typical of mania were associated with greater depression severity, including mood lability, hallucinations, delusions, and irritability, whereas less likely symptoms were hyperactivity, pressured speech, grandiosity, high energy, and distractibility. Factors independently and significantly associated with greater depression severity in multivariable linear regression modeling were: MDD vs. BD diagnosis, female sex, higher anxiety ratings, mood lability, and irritability. Conclusions: Severe depression was significantly associated with female sex, the presence of some manic or psychotic symptoms, and with apparent unipolar MDD. Manic/psychotic symptoms should be assessed carefully when evaluating a juvenile depressive episode and considered in treatment planning in an effort to balance risks of antidepressants and the potential value of mood-stabilizing and antimanic agents to decrease the severity of acute episodes and reduce suicidal risk.

A Comparison of the QIDS-C16, QIDS-SR16, and the MADRS in an Adult Outpatient Clinical Sample

CNS Spectrums ◽  
2010 ◽  
Vol 15 (7) ◽  
pp. 458-468 ◽  
Author(s):  
Ira H. Bernstein ◽  
A. John Rush ◽  
Diane Stegman ◽  
Laurie Macleod ◽  
Bradley Witte ◽  
...  
Keyword(s):  
Depressive Episode ◽  
Major Depressive Episode ◽  
Rating Scale ◽  
Depressive Symptomatology ◽  
Clinical Sample ◽  
Classical Test Theory ◽  
Test Theory ◽  
Self Report ◽  
Screening Tools ◽  
Major Depressive

ABSTRACTBackground: This study compared the 16-item Clinician and Self-Report versions of the Quick Inventory of Depressive Symptomatology (QIDS-C16 and QIDS-SR16) and the 10-item Montgomery-Asberg Depression Rating Scale (MADRS) in adult outpatients. The comparison was based on psychometric features and their performance in identifying those in a major depressive episode as defined by the Mini-International Neuropsychiatric Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition.Methods: Of 278 consecutive outpatients, 181 were depressed. Classical test theory, factor analysis, and item response theory were used to evaluate the psychometric features and receiver operating characteristic (ROC) analyses.Results: All three measures were unidimensional. All had acceptable reliability (coefficient α=.87 for MADRS10, .82 for QIDS-C16, and .80 for QIDS-SR16). Test information function was higher for the MADRS (ie, it was most sensitive to individual differences in levels of depression). The MADRS and QIDS-C16 slightly but consistently outperformed the QIDS-SR16 in differentiating between depressed versus non-depressed patients.Conclusion: All three measures have satisfactory psychometric properties and are valid screening tools for a major depressive episode.

Depressive symptoms in chronic schizophrenia patients: any differences between patients with and without a major depressive episode?

2003 ◽  
Vol 18 (3) ◽  
pp. 137-139 ◽  
Author(s):  
Yasuhiro Kaneda
Keyword(s):  
Depressive Symptoms ◽  
Depressive Episode ◽  
Major Depressive Episode ◽  
Depression Scale ◽  
Chronic Schizophrenia ◽  
Depression Score ◽  
Major Depressive

AbstractThe author investigated the differences between schizophrenia patients with and without a major depressive episode (MDE) using the Japanese Calgary Depression Scale for Schizophrenics. The total depression score was correlated with the dosage of antipsychotics in patients without an MDE, but such a correlation was not found in patients with an MDE.

FC10-01 - Pharmacogenetic association between 5HTT/SLC6A4, 5HTR2A and THP2 genes and the response to tianeptine in major depressive episode

2011 ◽  
Vol 26 (S2) ◽  
pp. 1864-1864
Author(s):  
N. Ramoz ◽  
E. Burgess ◽  
Y. Le Strat ◽  
P. Gorwood
Keyword(s):  
Treatment Response ◽  
Depressive Episode ◽  
Serotonin Receptor ◽  
Major Depressive Episode ◽  
Tryptophan Hydroxylase ◽  
Saliva Sample ◽  
Antidepressant Drug ◽  
Depression Scale ◽  
Taqman Assay ◽  
Major Depressive

IntroductionDepression is the most frequent psychiatric disorder. Antidepressant drug treatment response is modulated by genetic factors. Tianeptine molecule does not inhibit serotonin reuptake. Possible targets to this treatment are the serotonin transporter (5HTT/SLC6A4), the serotonin receptor 2A (5HT2A) and, the neuronal-specific enzyme that controls brain serotonin synthesis, the tryptophan hydroxylase-2 (TPH2).ObjectivesWe screened variants of candidate genes 5HTT/SLC6A4, 5HTR2A and THP2 in 3500 outpatients treated with tianeptine for a major depressive episode (MDE) to search for an association to a positive treatment response.AimsThe goal of this work was to study the pharmacogenetic response to tianeptine treatment in MDE.MethodsA total of 3500 outpatients were treated with tianeptine for a MDE. The criteria for a MDE were examined by the clinicians according to the DSM-IV diagnosis and the duration of each symptom was recorded during the inclusion and at 4 to 8 weeks of treatment. The Hospital Anxiety and Depression Scale (HAD) was evaluated at the two visits. DNA was extract from saliva sample and genotyping of single nucleotide polymorphisms (SNPs) was performed by Taqman assay.ResultsAll clinical and genotype data were collected for 1855 tianeptine-treated patients. The SNP rs6354 in SLC6A4 gene was significantly associated with response to tianeptine (p = 0.009; Odds ratio = 1.26; 95% confident interval = 1.06–1.50). Two SNPs in 5HT2A and one in TPH2 were also associated to treatment response (rs7322347 p = 0.03, rs7997012 p = 0.04 and rs7955501 p = 0.04).ConclusionsWe detected a pharmacogenetic association between serotonin genes and the response to tianeptine in major depressive episode.

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