scholarly journals Population-based seroprevalence of Puumala hantavirus in Finland: smoking as a risk factor

2018 ◽  
Vol 146 (3) ◽  
pp. 367-371 ◽  
Author(s):  
F. Latronico ◽  
S. Mäki ◽  
H. Rissanen ◽  
J. Ollgren ◽  
O. Lyytikäinen ◽  
...  
Keyword(s):  
Adult Population ◽  
Hemorrhagic Fever ◽  
Population Based ◽  
Immunofluorescence Assay ◽  
Smoking Prevention ◽  
Sampling Weights ◽  
Disease Associations ◽  
Guide Intervention ◽  
Cluster Design

AbstractPuumala hantavirus (PUUV) causes hemorrhagic fever with renal syndrome in humans, that is an endemic disease in Finland. We estimated the seroprevalence of PUUV in Finland and explored risk factors and disease associations by using unique survey data with health register linkage. A total of 2000 sera from a nationwide health survey from 2011, representative of the adult population, were screened for PUUV IgG by immunofluorescence assay. We performed statistical analysis adjusting for stratified cluster design and taking into account sampling weights. In total, 254 sera among 2000 tested were PUUV-IgG-positive resulting in a weighted seroprevalence of 12.5%, (95% CI 10.9–14.4), mirroring known age and regional variation in reported incidence. No associations between PUUV-seropositivity and chronic diseases including cardiovascular (including hypertension), pulmonary, kidney disease and cancer were observed. Smoking was significantly associated with seropositivity (adjusted OR 1.54; 95% CI 1.16–2.04). In addition, significant dose-response relations were found for the number of cigarettes smoked daily (OR 1.14; 95% CI 1.12–1.28). The results are important for disease burden assessment and guide intervention strategies, highlighting also the role of smoking prevention.

Mean Dietary Fiber Intake of Romanian Adults Results of a Survey Questionnaire

2017 ◽  
Vol 68 (9) ◽  
pp. 2083-2087
Author(s):  
Monica Tarcea ◽  
Zita Fazakas ◽  
Viktoria Szucs ◽  
Zsolt Kovacs ◽  
Eniko Nemes Nagy ◽  
...  
Keyword(s):  
Dietary Fiber ◽  
Adult Population ◽  
Population Based ◽  
Fiber Intake ◽  
Public Health Programs ◽  
Dietary Fiber Intake ◽  
Dietary Requirements ◽  
Mathematical Formulas ◽  
The Mean

The role of dietary fibers is crucial especially for the prevention of degenerative diseases and cancer. The purpose of this study was to find practical mathematical formulas to calculate the mean dietary fiber intake of Romanian adult population. Based on the intakes of vegetables, fruits and whole cereals we calculated the Mean Dietary Fiber Intake/day/person (MDFI). Our research shows that the national average MDFI was 9.8 g fiber/day/person, meaning 38% of Dietary Requirements, and the rest of 62% representing a fiber gap that we have to take into account. Public health programs actions sustained and developed by the Romanian Dietitians should be taken towards increasing the consumption of fiber-rich products associated with an increased frequency of physical activity, because these actions will be helpful in reducing chronic diseases incidence in Romania.

scholarly journals Strong Gender-Specific Additive Effects of the NYD-SP18 and FTO Variants on BMI Values

2015 ◽  
pp. S419-S426
Author(s):  
J. A. HUBACEK ◽  
D. DLOUHA ◽  
V. LANSKA ◽  
V. ADAMKOVA
Keyword(s):  
Adult Population ◽  
Population Based ◽  
Additive Effect ◽  
Fto Gene ◽  
P Values ◽  
Specific Effects ◽  
Significant Additive Effect ◽  
Gender Specific ◽  
Large Adult

The role of the FTO gene in obesity development is well established in populations around the world. The NYD-SP18 variant has been suggested to have a similar effect on BMI, but the role of this gene in determining BMI has not yet been verified. The objective of our study was to confirm the association between NYD-SP18 rs6971019 SNP and BMI in the Slavic population and to analyze i) the gender-specific effects of NYD-SP18 on BMI and ii) the simultaneous effect of FTO rs17817449 and NYD-SP18 on BMI. We analyzed a sample of a large adult population based on the post-MONICA study (1,191 males and 1,368 females). Individuals were analyzed three times over 9 years. NYD-SP18 rs6971019 SNP is related to BMI in males (2000/1 GG 28.3±3.7 kg/m2 vs. +A 27.5±3.7 kg/m2 P<0.0005; in other examinations P<0.05 and <0.005), but not in females (all P values over 0.48 in all three examinations). Further analysis revealed the significant additive effect (but not the interaction) of FTO and NYD-SP18 SNPs on BMI in males (all P<0.01). These results suggest that association between NYD-SP18 rs6971019 SNP and BMI may be restricted to males. Furthermore, variants within NYD-SP18 and FTO genes revealed a significant additive effect on BMI values in males.

scholarly journals Social factors and the prevalence of social isolation in a population-based adult cohort

2021 ◽  
Author(s):  
Susanne Röhr ◽  
Felix Wittmann ◽  
Christoph Engel ◽  
Cornelia Enzenbach ◽  
A. Veronica Witte ◽  
...  
Keyword(s):  
Socioeconomic Factors ◽  
Social Isolation ◽  
Short Form ◽  
Adult Population ◽  
Population Based ◽  
Life Course Perspective ◽  
Age Group ◽  
Sampling Weights ◽  
Public Health Perspective ◽  
Effective Prevention

Abstract Purpose Social isolation has negative effects on physical and brain health across the lifespan. However, the prevalence of social isolation, specifically with regard to sociodemographic and socioeconomic factors, is not well known. Methods Database was the Leipzig population-based study of adults (LIFE-Adult Study, n = 10,000). The short form of the Lubben Social Network Scale (LSNS-6) was used to assess social isolation (cutoff < 12 points). Sampling weights were applied to account for differences in sampling fractions. Results Data were available for 9392 study participants; 51.6% were women, the mean age was 45.2 years (SD = 17.3). The prevalence of social isolation was 12.3% (95% CI 11.6–13.0) across ages 18–79 years. Social isolation was more prevalent in men (13.8%, 95% CI 12.8–14.8) compared to women (10.9%, 95% CI 10.0–11.8; $$\chi^{2}$$ χ 2 (1) = 18.83, p < .001), and it showed an increase with increasing age from 5.4% (95% CI 4.7–6.0) in the youngest age group (18–39 years) to 21.7% (95% CI 19.5–24.0) in the oldest age group (70–79 years; $$\chi^{2}$$ χ 2 (4) = 389.51, p < .001). Prevalence differed largely with regard to socioeconomic status (SES); showing lower prevalence in high SES (7.2%, 95% CI 6.0–8.4) and higher prevalence in low SES (18.6%, 95% CI 16.9–20.3; $$\chi^{2}$$ χ 2 (2) = 115.78; p < .001). Conclusion More than one in ten individuals in the adult population reported social isolation, and prevalence varied strongly with regard to sociodemographic and socioeconomic factors. Social isolation was particularly frequent in disadvantaged socioeconomic groups. From a public health perspective, effective prevention of and intervention against social isolation should be a desired target as social isolation leads to poor health. Countermeasures should especially take into account the socioeconomic determinants of social isolation, applying a life-course perspective.

Association Between Knowledge and Practice in the Field of Physical Activity and Health: A Population-Based Study

2015 ◽  
Vol 12 (7) ◽  
pp. 1005-1009 ◽  
Author(s):  
Thiago T. Borges ◽  
Pedro C. Hallal ◽  
Inacio Crochemore Mohnsam da Silva ◽  
Grégore Iven Mielke ◽  
Airton J. Rombaldi ◽  
...  
Keyword(s):  
Physical Activity ◽  
Health Knowledge ◽  
Adult Population ◽  
Health Benefits ◽  
Population Based ◽  
Population Based Study ◽  
Minimum Frequency ◽  
Minimum Number ◽  
Knowledge And Practice

Background:The aim of the current study was to evaluate the association between knowledge about physical activity (PA) recommendations (in terms of duration and frequency) and physical activity practice in a population-based sample of adults and adolescents.Methods:Crosssectional survey, conducted in Pelotas, Brazil. Participants (10+ years) were included in the sample and reported their perception about the minimum number of days and duration of PA to achieve health benefits. Those who reported PA practice ≥ 150 min/wk (adults) and ≥ 300 min/wk (adolescents) were considered active.Results:The sample included 1696 adults and 399 adolescents. More than one-third (38.6%) of the adult population reported that < 150 minutes of PA per week would be sufficient to obtain health benefits. Moreover, 76.1% of the adolescents reported that < 300 minutes per week were sufficient to obtain health benefits. Among adolescents, those who were active tended to report that higher amounts of PA were needed to obtain health benefits.Conclusions:Despite global recognition of the role of PA for improving health, knowledge about the minimum frequency and duration for achieving health benefits is still low in Brazil, particularly among adolescents.

scholarly journals DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Monica del C. Gomez-Alonso ◽  
Anja Kretschmer ◽  
Rory Wilson ◽  
Liliane Pfeiffer ◽  
Ville Karhunen ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Lipid Metabolism ◽  
Population Based ◽  
Total Serum ◽  
Resonance Spectroscopy ◽  
Metabolic Disturbances ◽  
Cpg Sites ◽  
Gene Transcripts

Abstract Background The discovery of robust and trans-ethnically replicated DNA methylation markers of metabolic phenotypes, has hinted at a potential role of epigenetic mechanisms in lipid metabolism. However, DNA methylation and the lipid compositions and lipid concentrations of lipoprotein sizes have been scarcely studied. Here, we present an epigenome-wide association study (EWAS) (N = 5414 total) of mostly lipid-related metabolic measures, including a fine profiling of lipoproteins. As lipoproteins are the main players in the different stages of lipid metabolism, examination of epigenetic markers of detailed lipoprotein features might improve the diagnosis, prognosis, and treatment of metabolic disturbances. Results We conducted an EWAS of leukocyte DNA methylation and 226 metabolic measurements determined by nuclear magnetic resonance spectroscopy in the population-based KORA F4 study (N = 1662) and replicated the results in the LOLIPOP, NFBC1966, and YFS cohorts (N = 3752). Follow-up analyses in the discovery cohort included investigations into gene transcripts, metabolic-measure ratios for pathway analysis, and disease endpoints. We identified 161 associations (p value < 4.7 × 10−10), covering 16 CpG sites at 11 loci and 57 metabolic measures. Identified metabolic measures were primarily medium and small lipoproteins, and fatty acids. For apolipoprotein B-containing lipoproteins, the associations mainly involved triglyceride composition and concentrations of cholesterol esters, triglycerides, free cholesterol, and phospholipids. All associations for HDL lipoproteins involved triglyceride measures only. Associated metabolic measure ratios, proxies of enzymatic activity, highlight amino acid, glucose, and lipid pathways as being potentially epigenetically implicated. Five CpG sites in four genes were associated with differential expression of transcripts in blood or adipose tissue. CpG sites in ABCG1 and PHGDH showed associations with metabolic measures, gene transcription, and metabolic measure ratios and were additionally linked to obesity or previous myocardial infarction, extending previously reported observations. Conclusion Our study provides evidence of a link between DNA methylation and the lipid compositions and lipid concentrations of different lipoprotein size subclasses, thus offering in-depth insights into well-known associations of DNA methylation with total serum lipids. The results support detailed profiling of lipid metabolism to improve the molecular understanding of dyslipidemia and related disease mechanisms.

Heart failure in an elderly man: where is that coronary?

2021 ◽  
pp. 1-4
Author(s):  
Charlie J. Sang ◽  
Stephen A. Clarkson ◽  
Elizabeth A. Jackson ◽  
Firas Al Solaiman ◽  
Marc G. Cribbs
Keyword(s):  
Heart Failure ◽  
Coronary Artery ◽  
Pulmonary Artery ◽  
Medical Therapy ◽  
Coronary Arteries ◽  
Right Coronary Artery ◽  
Adult Population ◽  
Anomalous Coronary ◽  
Anomalous Coronary Arteries

Abstract Anomalous coronary arteries from the pulmonary artery are uncommon causes of heart failure in the adult population. This case demonstrates the unusual presentation in a patient with anomalous right coronary artery from the pulmonary artery and discusses the complex pathophysiology of this lesion and the role of guideline-directed medical therapy in the management of these patients.

scholarly journals Systemic Antibiotics and Obesity: Analyses from a Population-Based Cohort

2021 ◽  
Vol 10 (12) ◽  
pp. 2601
Author(s):  
So Young Park ◽  
Morena Ustulin ◽  
SangHyun Park ◽  
Kyung-Do Han ◽  
Joo Young Kim ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Adult Population ◽  
Antibiotic Use ◽  
Population Based ◽  
Obesity Risk ◽  
Gram Negative ◽  
Korean Adult ◽  
Korean National Health Insurance ◽  
Gram Negative Organisms ◽  
Systemic Antibiotics

Background: In this study, we analyzed the association between antibiotic use and obesity and metabolic syndrome (MS) in a Korean adult population. Methods: Subjects using the Korean National Health Insurance Service sample cohort were retrospectively analyzed in 2015. The differences in obesity and metabolic syndrome (MS) status were compared and analyzed according to duration of systemic antibiotic treatment in the previous 10 years (non-users, 1st, 2nd, and 3rd tertile). Results: Subjects who used systemic antibiotics for longer periods were older, satisfied more criteria for MS, and had more comorbidities than non-users (non-users vs. 3rd tertile, p < 0.0001 for all). After adjusting for confounding factors, the risk of obesity was higher in subjects who used systemic antibiotics for longer periods than in non-users (non-users vs. 3rd tertile, OR (odds ratio) (95% CI (confidence interval)); 1.20 (1.12–1.38)). The criteria for MS were more satisfied in the 3rd tertile than in non-users. A higher obesity risk was also found in subjects treated with antibiotics targeting Gram-negative organisms than in those targeting Gram-positive organisms. Conclusion: The risk of obesity was higher in subjects who took systemic antibiotics more frequently. The risk was more prominent when they took antibiotics targeting Gram-negative bacteria.

scholarly journals Role of community pharmacies in a population-based colorectal cancer screening program

2021 ◽  
pp. 106420
Author(s):  
Nuria Vives ◽  
Núria Milà ◽  
Gemma Binefa ◽  
Noemie Travier ◽  
Albert Farre ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Screening ◽  
Colorectal Cancer Screening ◽  
Screening Program ◽  
Population Based ◽  
Community Pharmacies ◽  
Cancer Screening Program
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