Maternal caffeine intake during pregnancy and risk of pregnancy loss: a categorical and dose–response meta-analysis of prospective studies

AbstractObjectiveTo assess the association between maternal caffeine intake and risk of pregnancy loss using a systematic review and meta-analysis.DesignCategorical and dose–response meta-analysis of prospective studies.SettingRelevant articles were identified by searching MEDLINE and SCOPUS databases through 30 January 2015. Two authors independently extracted information from eligible studies. Random-effects models were used to derive the summary relative risks (RR) and corresponding 95 % CI for specific categories of caffeine consumption and for a continuous association using generalized least-squares trend estimation.SubjectsA total of 130 456 participants and 3429 cases in fourteen included studies.ResultsCompared with the reference category with no or very low caffeine intake, the RR (95 % CI) of pregnancy loss was 1·02 (0·85, 1·24;I2=28·3 %) for low intake (50–149 mg/d), 1·16 (0·94, 1·41;I2=49·6 %) for moderate intake (150–349 mg/d), 1·40 (1·16, 1·68;I2=18·6 %) for high intake (350–699 mg/d) and 1·72 (1·40, 2·13;I2=0·0 %) for very high intake (≥700 mg/d). In the dose–response analysis, each 100 mg/d increment in maternal caffeine intake (~1 cup of coffee) was associated with 7 % (95 % CI 3 %, 12 %) higher risk of pregnancy loss. Our results may have been affected by publication bias, but the association remained significant for the subset of larger studies. Furthermore, adjustment for smoking and pregnancy symptoms may have been incomplete, potentially resulting in residual confounding.ConclusionsAlbeit inconclusive, higher maternal caffeine intake was associated with a higher risk of pregnancy loss and adherence to guidelines to avoid high caffeine intake during pregnancy appears prudent.

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Abdominal obesity and risk of CVD: a dose–response meta-analysis of thirty-one prospective studies

British Journal Of Nutrition ◽

10.1017/s0007114521000064 ◽

2021 ◽

pp. 1-11

Author(s):

Ran Xue ◽

Qianwen Li ◽

Yaping Geng ◽

Hao Wang ◽

Fudi Wang ◽

...

Keyword(s):

Abdominal Obesity ◽

Dose Response ◽

Prospective Studies ◽

Meta Analysis ◽

Response Analysis ◽

Random Effects Models ◽

Relative Risks ◽

Increased Risk ◽

Unit Increase ◽

The Relationship

Abstract This meta-analysis aimed to study the relationship between abdominal obesity and the risk of CVD by waist circumference (WC), waist:hip ratio (WHR) and waist:height ratio (WHtR). We systematically searched PubMed, Embase and Web of Science. Prospective studies that estimated cardiovascular events by WC, WHR and WHtR were included in this study. Pooled relative risks with 95 % CI were calculated using random effects models. A total of thirty-one studies were included in the meta-analysis, including 669 560 participants and 25 214 cases. Compared the highest with the lowest category of WC, WHR and WHtR, the summary risk ratios were 1·43 (95 % CI, 1·30, 1·56, P < 0·001), 1·43 (95 % CI, 1·33, 1·54, P < 0·001) and 1·57 (95 % CI, 1·37, 1·79, P < 0·001), respectively. The linear dose–response analysis revealed that the risk of CVD increased by 3·4 % for each 10 cm increase of WC, and by 3·5 and 6·0 % for each 0·1 unit increase of WHR and WHtR in women, respectively. In men, the risk of CVD increased by 4·0 % for each 10 cm increase of WC, and by 4·0 and 8·6 % for each 0·1 unit increase of WHR and WHtR, respectively. Collectively, abdominal obesity is associated with an increased risk of CVD. WC, WHR and WHtR are good indicators for the prediction of CVD.

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Caffeine, Type of Coffee, and Risk of Ovarian Cancer: A Dose–Response Meta-Analysis of Prospective Studies

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2019-00637 ◽

2019 ◽

Vol 104 (11) ◽

pp. 5349-5359 ◽

Cited By ~ 8

Author(s):

Asma Salari-Moghaddam ◽

Alireza Milajerdi ◽

Pamela J Surkan ◽

Bagher Larijani ◽

Ahmad Esmaillzadeh

Keyword(s):

Ovarian Cancer ◽

Cohort Studies ◽

Dose Response ◽

Prospective Studies ◽

Meta Analysis ◽

Coffee Consumption ◽

Outcome Variable ◽

Caffeine Intake ◽

Ovarian Cancer Risk ◽

Different Types

Abstract Context Prospective studies on caffeine and different types of coffee intake in relation to the risk of ovarian cancer have shown conflicting results. Objective The aim of the present study was to perform a dose–response meta-analysis of cohort studies on the association between dietary caffeine intake, different types of coffee consumption, and the risk of ovarian cancer. Data sources PubMed/Medline, ISI Web of Science, Scopus, and EMBASE were searched to identify relevant studies reported until October 2018. Study selection Prospective cohort studies that had considered caffeine or different types of coffee as the exposure variable and ovarian cancer as the main outcome variable or as one of the outcome variables were included in our systematic review and meta-analysis. Two of us independently screened 9344 publications. A total of 14 cohort studies were included in the meta-analysis. Data extraction Two of us independently extracted the data. Any disagreements were resolved in consultation with the principal investigator. Results Combining 13 effect sizes, we found no substantial association between coffee consumption and risk of ovarian cancer [risk ratio (RR), 1.08; 95% CI, 0.89 to 1.33]. Also, one additional cup daily of coffee consumption was marginally associated with an increased risk of ovarian cancer (RR, 1.02; 95% CI, 0.99 to 1.05; P = 0.21; I2 = 0.0%; Pheterogeneity = 0.68). No statistically significant association was observed between caffeine intake or caffeinated or decaffeinated coffee consumption and the risk of ovarian cancer. Conclusions We found no statistically significant association between caffeine intake or different types of coffee and the risk of ovarian cancer.

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Does Caffeine Consumption Increase the Risk of New-Onset Atrial Fibrillation?

Cardiology ◽

10.1159/000489843 ◽

2018 ◽

Vol 140 (2) ◽

pp. 106-114 ◽

Cited By ~ 6

Author(s):

Ramy Abdelfattah ◽

Haroon Kamran ◽

Jason Lazar ◽

John Kassotis

Keyword(s):

Atrial Fibrillation ◽

Lower Incidence ◽

Meta Analysis ◽

Coffee Consumption ◽

Caffeine Intake ◽

Response Analysis ◽

Daily Consumption ◽

Caffeine Consumption ◽

Significant Difference ◽

The Relationship

Objective: Caffeine has been considered a trigger for atrial fibrillation (AF). We conducted a meta-analysis including a dose-response analysis to assess the relationship between caffeine consumed and incidence of AF. Methods: Data from selected studies represented 176,675 subjects (AF in 9,987 [5.7%]). Caffeine content varied widely, ranging from 40 to 180 mg per cup of coffee. For purposes of the calculations in this study, we assumed 140 mg of caffeine in a standard 12-oz cup of coffee. Results: No significant difference was found in AF incidence when the subjects consuming less than 2 cups of coffee per day were compared to subjects with higher consumption, 1.068 (0.937–1.216). The risk of AF was higher among subjects consuming less than 2 cups of coffee daily when compared to higher daily consumption subjects. A lower incidence of AF was found among people consuming more than 436 mg daily. Conclusion: The incidence of AF is not increased by coffee consumption. In fact, we found a lower incidence of AF when caffeine consumption exceeded 436 mg/day. Therefore, based on available evidence there is no association between caffeine intake and AF risk.

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High admission blood glucose is an independent risk factor of poor prognosis in COVID-19: A systematic review and dose-response meta-analysis

10.1101/2020.09.25.20200774 ◽

2020 ◽

Author(s):

Gilbert Lazarus ◽

Jessica Audrey ◽

Vincent Kharisma Wangsaputra ◽

Alice Tamara ◽

Dicky L. Tahapary

Keyword(s):

Blood Glucose ◽

Random Effects ◽

Dose Response ◽

Poor Prognosis ◽

Prognostic Value ◽

Meta Analysis ◽

Generalized Least Squares ◽

Response Analysis ◽

Non Linear ◽

Quality Evidence

Aims To investigate the prognostic value of admission blood glucose (BG) in predicting COVID-19 outcomes, including poor composite outcomes (mortality/severity), mortality, and severity. Materials and methods Eligible studies evaluating the prognostic value of fasting BG (FBG) and random BG (RBG) levels in predicting COVID-19 outcomes were included and assessed for risk of bias with the Quality in Prognosis Studies tool. Random-effects high-vs-low meta-analysis followed by dose-response analysis using generalized least squares model in a two-stage random-effects meta-analysis were conducted. Potential non-linear association was explored using restricted cubic splines and pooled using restricted maximum likelihood model in a multivariate meta-analysis. Results The search yielded 35 studies involving a total of 14,502 patients. We discovered independent association between admission FBG and poor prognosis in COVID-19 patients. Furthermore, we demonstrated non-linear relationship between admission FBG and severity (Pnon-linearity<0.001), where each 1 mmol/L increase augmented the risk of COVID-19 severity by 33% (risk ratio 1.33 [95% CI: 1.26-1.40]). Albeit exhibiting similar trends, study scarcity limited the strength of evidence on the independent prognostic value of admission RBG. GRADE assessment yielded high-quality evidence for the association between admission FBG and COVID-19 severity, and moderate-quality evidence for its association with mortality and poor outcomes, while the other assessments yielded very low-to-low quality. Conclusion High level of FBG at admission was independently associated with poor prognosis in COVID-19 patients. Further researches to confirm the observed prognostic value of admission RBG and to ascertain the estimated dose-response risk between admission FBG and on COVID-19 severity are required.

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Fish consumption and CHD mortality: an updated meta-analysis of seventeen cohort studies

Public Health Nutrition ◽

10.1017/s1368980011002254 ◽

2011 ◽

Vol 15 (4) ◽

pp. 725-737 ◽

Cited By ~ 166

Author(s):

Jusheng Zheng ◽

Tao Huang ◽

Yinghua Yu ◽

Xiaojie Hu ◽

Bin Yang ◽

...

Keyword(s):

Dose Response ◽

Fish Consumption ◽

Meta Analysis ◽

Dietary Assessment ◽

Generalized Least Squares ◽

Fish Intake ◽

Response Analysis ◽

Least Squares Regression ◽

Restricted Cubic Splines ◽

High Fish

AbstractObjectiveResults of studies on fish consumption and CHD mortality are inconsistent. The present updated meta-analysis was conducted to investigate the up-to-date pooling effects.DesignA random-effects model was used to pool the risk estimates. Generalized least-squares regression and restricted cubic splines were used to assess the possible dose–response relationship. Subgroup analyses were conducted to examine the sources of heterogeneity.SettingPubMed and ISI Web of Science databases up to September 2010 were searched and secondary referencing qualified for inclusion in the study.SubjectsSeventeen cohorts with 315 812 participants and average follow-up period of 15·9 years were identified.ResultsCompared with the lowest fish intake (<1 serving/month or 1–3 servings/month), the pooled relative risk (RR) of fish intake on CHD mortality was 0·84 (95 % CI 0·75, 0·95) for low fish intake (1 serving/week), 0·79 (95 % CI 0·67, 0·92) for moderate fish intake (2–4 servings/week) and 0·83 (95 % CI 0·68, 1·01) for high fish intake (>5 servings/week). The dose–response analysis indicated that every 15 g/d increment of fish intake decreased the risk of CHD mortality by 6 % (RR = 0·94; 95 % CI 0·90, 0·98). The method of dietary assessment, gender and energy adjustment affected the results remarkably.ConclusionsOur results indicate that either low (1 serving/week) or moderate fish consumption (2–4 servings/week) has a significantly beneficial effect on the prevention of CHD mortality. High fish consumption (>5 servings/week) possesses only a marginally protective effect on CHD mortality, possibly due to the limited studies included in this group.

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Parity and risk of maternal cardiovascular disease: A dose–response meta-analysis of cohort studies

European Journal of Preventive Cardiology ◽

10.1177/2047487318818265 ◽

2018 ◽

Vol 26 (6) ◽

pp. 592-602 ◽

Cited By ~ 12

Author(s):

Wenzhen Li ◽

Wenyu Ruan ◽

Zuxun Lu ◽

Dongming Wang

Keyword(s):

Cardiovascular Disease ◽

Cohort Studies ◽

Dose Response ◽

Disease Risk ◽

Meta Analysis ◽

Cardiovascular Disease Risk ◽

Response Analysis ◽

Significant Heterogeneity ◽

Random Effects Models ◽

Incident Cases

Background Parity has been reported to play an important role in the development of cardiovascular disease; however, the results are still controversial. We aimed to conduct a meta-analysis of cohort studies to assess quantitatively the association between parity and cardiovascular disease risk. Methods PubMed and Web of Science databases were searched to 1 June 2018, supplemented by manual searches of the bibliographies of retrieved articles. And multivariate-adjusted relative risks were pooled by using random-effects models. Restricted cubic spline analysis with four knots was used to explore the relationship of parity and the risk of cardiovascular disease. Results Ten cohort studies involving 150,512 incident cases of cardiovascular disease among 3,089,929 participants were included in the meta-analysis. A significant association between parity and cardiovascular disease risk was observed while comparing parity with nulliparity, with a summarised relative risk of 1.14 (95% confidence interval (CI) 1.09–1.18; I2 = 62.0%, P = 0.002). In the dose–response analysis, we observed a potential non-linear J-shaped dose–response relationship between the number of parity and cardiovascular disease risk, the summary risk estimates for an increase of one live birth was 1.04 (95% CI 1.02–1.05), with significant heterogeneity ( I2 = 89.6%). In addition, the similar J-shaped associations between parturition number and cardiovascular disease, ischaemic heart disease or stroke risk were also observed. Conclusions Our findings suggest that ever parity is related to cardiovascular disease risk and there is an association between the number of pregnancies and the risk of cardiovascular disease. Since the number of included studies was limited, further studies are warranted to confirm our findings.

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Sugar-sweetened beverages and risk of hypertension and CVD: a dose–response meta-analysis

British Journal Of Nutrition ◽

10.1017/s0007114514004383 ◽

2015 ◽

Vol 113 (5) ◽

pp. 709-717 ◽

Cited By ~ 111

Author(s):

Bo Xi ◽

Yubei Huang ◽

Kathleen Heather Reilly ◽

Shuangshuang Li ◽

Ruolong Zheng ◽

...

Keyword(s):

Dose Response ◽

Prospective Studies ◽

Fixed Effects ◽

Meta Analysis ◽

Response Analysis ◽

Sugar Sweetened Beverages ◽

Prospective Cohort Studies ◽

Sweetened Beverages ◽

Relative Risks ◽

Incident Cases

A number of prospective cohort studies have investigated the associations between consumption of sugar-sweetened beverages (SSB) and the risk of hypertension, CHD and stroke, but revealed mixed results. In the present study, we aimed to perform a dose–response meta-analysis of these prospective studies to clarify these associations. A systematic literature search was conducted using the PubMed and Embase databases up to 5 May 2014. Random- or fixed-effects models were used to calculate the pooled relative risks (RR) with 95 % CI for the highest compared with the lowest category of SSB consumption, and to conduct a dose–response analysis. A total of six prospective studies (240 726 participants and 80 411 incident cases of hypertension) from four publications on hypertension were identified. A total of four prospective studies (194 664 participants and 7396 incident cases of CHD) from four publications on CHD were identified. A total of four prospective studies (259 176 participants and 10 011 incident cases of stroke) from four publications on stroke were identified. The summary RR for incident hypertension was 1·08 (95 % CI 1·04, 1·12) for every additional one serving/d increase in SSB consumption. The summary RR for incident CHD was 1·17 (95 % CI 1·10, 1·24) for every serving/d increase in SSB consumption. There was no significant association between SSB consumption and total stroke (summary RR 1·06, 95 % CI 0·97, 1·15) for every serving/d increase in SSB consumption. The present meta-analysis suggested that a higher consumption of SSB was associated with a higher risk of hypertension and CHD, but not with a higher risk of stroke.

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Parkinson's Disease Risk and Alcohol Intake: A Systematic Review and Dose-Response Meta-Analysis of Prospective Studies

Frontiers in Nutrition ◽

10.3389/fnut.2021.709846 ◽

2021 ◽

Vol 8 ◽

Author(s):

Chuan Shao ◽

Xiaoya Wang ◽

Pan Wang ◽

Hui Tang ◽

Jiaquan He ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Dose Response ◽

Prospective Studies ◽

Alcohol Intake ◽

Meta Analysis ◽

Alcohol Exposure ◽

Geographic Area ◽

Alcoholic Beverages ◽

Response Analysis

Background: The association between Parkinson's disease (PD) risk and alcohol intake is a controversial topic.Objectives: To systematically assess the association between PD risk and alcohol intake.Methods: PubMed and Embase databases were searched for eligible studies with prospective design on PD risk and alcohol intake. A meta-analysis with a random-effects model and dose-response analysis was performed. Relative risk ratios (RRs) with 95% CIs were calculated.Results: Eleven prospective studies were included. Overall, a higher intake of alcohol was inversely associated with PD risk (RR: 0.81, 95% CI: 0.70–0.95, I2 = 73.7%). Significant differences existed between the specific types of alcoholic beverages and geographic area. Specifically, a significant association existed for beer (RR: 0.78, 95% CI: 0.65–0.94, I2 = 0.0%) and studies conducted in Asia (RR: 0.66, 95% CI: 0.55–0.80, I2 = 37.3%). Dose-response analysis indicated a nonlinear relationship between PD risk and alcohol exposure. No evidence for publication bias was detected.Conclusions: In summary, our meta-analysis suggests that alcohol consumption was associated with a decreased risk of PD, with a nearly U-shaped association. Future studies are warranted to clarify the question of a specific type of alcoholic beverage-dependent association, geographic area effect, and possible threshold effects regarding both the adverse and beneficial effects of alcohol.

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Carotenoid Intake and Circulating Carotenoids Are Inversely Associated with the Risk of Bladder Cancer: A Dose-Response Meta-analysis

Advances in Nutrition ◽

10.1093/advances/nmz120 ◽

2019 ◽

Vol 11 (3) ◽

pp. 630-643 ◽

Cited By ~ 3

Author(s):

Shenghui Wu ◽

Yanning Liu ◽

Joel E Michalek ◽

Ruben A Mesa ◽

Dorothy Long Parma ◽

...

Keyword(s):

Bladder Cancer ◽

Random Effects ◽

Dose Response ◽

Meta Analysis ◽

Epidemiologic Studies ◽

Cochrane Library ◽

Response Analysis ◽

Random Effects Models ◽

The Cochrane Library ◽

Β Carotene

ABSTRACT Some evidence indicates that carotenoids may reduce the risk of bladder cancer (BC), but the association is unclear. We conducted a systematic review and meta-analysis of case-control and cohort studies investigating the relation between carotenoid intake or circulating carotenoid concentrations and BC risk in men and women. All relevant epidemiologic studies were identified by a search of PubMed and Scopus databases, and the Cochrane Library from inception to April 2019 with no restrictions. A random-effects model was used to calculate pooled RRs and their 95% CIs across studies for high compared with low categories of intake or circulating concentrations. We also performed a dose-response meta-analysis using the Greenland and Longnecker method and random-effects models. A total of 22 studies involving 516,740 adults were included in the meta-analysis. The pooled RRs of BC for the highest compared with the lowest category of carotenoid intake and circulating carotenoid concentrations were 0.88 (95% CI: 0.76, 1.03) and 0.36 (95% CI: 0.12, 1.07), respectively. The pooled RR of BC for the highest compared with lowest circulating lutein and zeaxanthin concentrations was 0.53 (95% CI: 0.33, 0.84). Dose-response analysis showed that BC risk decreased by 42% for every 1 mg increase in daily dietary β-cryptoxanthin intake (RR: 0.58; 95% CI: 0.36, 0.94); by 76% for every 1 μmol/L increase in circulating concentration of α-carotene (RR: 0.24; 95% CI: 0.08, 0.67); by 27% for every 1 μmol/L increase in circulating concentration of β-carotene (RR: 0.73; 95% CI: 0.57, 0.94); and by 56% for every 1 μmol/L increase in circulating concentrations of lutein and zeaxanthin (RR: 0.44; 95% CI: 0.28, 0.67). Dietary β-cryptoxanthin intake and circulating concentrations of α-carotene, β-carotene, and lutein and zeaxanthin were inversely associated with BC risk. The protocol was registered at PROSPERO as CRD42019133240.

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