scholarly journals Dietary alanyl-glutamine improves growth performance of weaned piglets through maintaining intestinal morphology and digestion–absorption function

animal ◽  
2019 ◽  
Vol 13 (9) ◽  
pp. 1826-1833 ◽  
Author(s):  
T.D. Zou ◽  
C.X. Deng ◽  
Z.R. Wang ◽  
Y.L. Ye ◽  
J.M. You
Keyword(s):  
Growth Performance ◽  
Intestinal Morphology ◽  
Weaned Piglets ◽  
Absorption Function

Effects of graded levels of xylo-oligosaccharides on growth performance, serum parameters, intestinal morphology and intestinal barrier function in weaned piglets

2021 ◽  
Author(s):  
Yuxia Chen ◽  
Yining Xie ◽  
Ruqing Zhong ◽  
Hui Han ◽  
Lei Liu ◽  
...  
Keyword(s):  
Growth Performance ◽  
Intestinal Barrier ◽  
Intestinal Morphology ◽  
Intestinal Barrier Function ◽  
Weaned Piglets ◽  
Villus Height ◽  
Expression Levels ◽  
Small Intestinal ◽  
Dietary Treatments ◽  
Mrna Expression Levels

Abstract The objective of this study was to investigate the effects of xylo-oligosaccharides (XOS) supplementation on growth performance, serum parameters, small intestinal morphology, intestinal mucosal integrity, and immune function in weaned piglets. A total of 240 weaned piglets with an average body weight (BW) of 8.82 ± 0.05 kg (28 d of age) were assigned randomly to 4 dietary treatments in a 28-d trial, including a control diet (CON), 3 diets with XOS supplementation at the concentration of 100, 500 and 1000 mg/kg (XOS100, XOS500, and XOS1000). There were 4 replicates per treatment with 15 pigs per pen. From d 1 to 14, there were no differences (P > 0.05) in average daily gain (ADG), average daily feed intake (ADFI), and gain to feed ratio (G:F) during the different treatments. The different doses of XOS showed a quadratic effect on BW on d 28, ADG and G:F d 1-28 of piglets (P < 0.05). From d 15 to 28, ADG of pigs fed the XOS500 diet was higher (P < 0.05) than pigs fed the CON diet. During the overall period (d 1 to 28), pigs fed the XOS500 diet had a higher BW, ADG and G:F than pigs fed the CON diet (P < 0.05). In addition, compared with the CON group, the XOS500 group had significantly higher serum total antioxidant capacity (T-AOC), total superoxide dismutase (T-SOD) and catalase (CAT) levels and lower malondialdehyde (MDA) levels on d 14 and 28 (P < 0.05). The serum immunoglobulin G (IgG) concentration in the XOS500 group was also significantly higher compared with the CON group on d 14 and 28 (P <0.05). However, serum immunoglobulin A (IgA) and immunoglobulin M (IgM) were not affected by the dietary treatments. Supplementation of XOS500 to the feed significantly increased the villus height (VH) and villus height to crypt depth ratio (VH:CD) in the jejunum and ileum in comparison with the CON and XOS1000 group. Moreover, the XOS500 group significantly elevated the expression levels of Occludin and zonula occludens protein-1 (ZO-1) in the ileum compared to the CON group. The ileal interleukin (IL)-1β, IL-8 and interferon (IFN)-γ mRNA expression levels in the XOS100 and XOS500 group were markedly lower than in the CON group. In contrast, the ileal IL-10 mRNA expression levels were remarkably higher in the XOS500 than CON group. In conclusion, xylo-oligosaccharides have a beneficial effect on growth performance by improving serum antioxidant defense system, serum IgG, small intestinal structure and intestinal barrier function in weaned piglets.

Dietary xylo-oligosaccharide improves intestinal functions in weaned piglets

2019 ◽  
Vol 10 (5) ◽  
pp. 2701-2709 ◽  
Author(s):  
Jie Yin ◽  
Fengna Li ◽  
Xiangfeng Kong ◽  
Chaoyue Wen ◽  
Qiuping Guo ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Growth Performance ◽  
Tight Junctions ◽  
Intestinal Morphology ◽  
Weaned Piglets ◽  
Intestinal Functions

This study aimed at investigating the effects of dietary xylo-oligosaccharide (XOS) on intestinal functions (i.e., intestinal morphology, tight junctions, gut microbiota and metabolism) and growth performance in weaned piglets.

scholarly journals Dietary chitosan-Cu chelate affects growth performance and small intestinal morphology and apoptosis in weaned piglets.

2017 ◽  
Vol 62 (No. 1) ◽  
pp. 15-21
Author(s):  
X. Yue ◽  
L. Hu ◽  
X. Fu ◽  
M. Lv ◽  
X. Han
Keyword(s):  
Epithelial Cell ◽  
Growth Performance ◽  
Cell Apoptosis ◽  
Intestinal Morphology ◽  
Weaned Piglets ◽  
Villus Height ◽  
Crypt Depth ◽  
Epithelial Cell Apoptosis ◽  
Diarrhea Incidence ◽  
Small Intestinal

The effects of dietary chitosan-copper chelate (CS-Cu) on growth performance, diarrhea, intestinal morphology and epithelial cell apoptosis in weaned piglets was investigated. One hundred and sixty Duroc × Landrace × Yorkshire weanling barrows with an average body weight of 7.75 kg were randomly assigned to one of the following dietary treatments: (1) control, (2) 100 mg Cu/kg diet from CuSO<sub>4</sub>, (3) 100 mg Cu/kg diet from CuSO<sub>4</sub> mixed with chitosan (CuSO<sub>4</sub>+CS), (4) 100 mg Cu/kg diet from CS-Cu. The feeding trial lasted for 30 days. The results showed that the pigs receiving a diet containing CS-Cu had higher average daily gain and lower diarrhea incidence than the pigs receiving dietary CuSO<sub>4</sub> and CuSO<sub>4</sub>+CS. Villus height and the ratio of villus height/crypt depth in duodenum, jejunum, and ileum were higher and crypt depth was lower in CS-Cu treated pigs than in pigs fed dietary CuSO<sub>4 </sub>or CuSO<sub>4</sub>+CS. An apparent decrease of ileal epithelial cell apoptosis in pigs fed CS-Cu diet was found. The activities of antioxidant enzymes were higher in pigs fed dietary CS-Cu than in those fed other diets. The results indicated that dietary CS-Cu showed better biological and physiological function in improving small intestinal morphology and reducing diarrhea incidence.

scholarly journals Effects of vitamin B6 on the growth performance, intestinal morphology, and gene expression in weaned piglets that are fed a low-protein diet1

2020 ◽  
Vol 98 (2) ◽  
Author(s):  
Lanmei Yin ◽  
Jun Li ◽  
Huiru Wang ◽  
Zhenfeng Yi ◽  
Lei Wang ◽  
...  
Keyword(s):  
Growth Performance ◽  
Mrna Expression ◽  
Inflammatory Cytokines ◽  
Vitamin B6 ◽  
Animal Health ◽  
Dietary Supplementation ◽  
Experimental Period ◽  
Intestinal Morphology ◽  
Weaned Piglets ◽  
Cox 2

Abstract Vitamin B6 (VB6), which is an essential functional substance for biosome, plays an irreplaceable role in animal health. However, there are few studies that focus on the correlation between VB6 and intestinal health in weaned piglets. This study was conducted to investigate the effects of VB6 on the growth performance, intestinal morphology, and inflammatory cytokines and amino acid (AA) transporters mRNA expression in weaned piglets that are fed a low crude-protein (CP, 18%) diet. Eighteen crossbred piglets with initial body weights of 7.03 ± 0.17 kg (means ± SEM), weaned at 21-d age, were randomly assigned three diets with 0, 4, and 7 mg/kg VB6 supplementation, respectively. The experimental period lasted 14 days. Our results showed that there were no significant differences in growth performance, diarrhea rate, and biochemical parameters among the three treatments. In the jejunum, dietary VB6 supplementation did not affect the morphology and positive Ki67 counts. Dietary supplementation with 4 mg/kg VB6 decreased the mRNA expression of COX-2, IL-10, and TGF-β (P &lt; 0.05). Dietary supplementation with 7 mg/kg VB6 increased the mRNA expression of SLC7A1, SLC7A6, SLC16A14, and SLC38A5 (P &lt; 0.05) and 4 or 7 mg/kg VB6 decreased SLC36A1 mRNA expression (P &lt; 0.05). In the ileum, VB6 supplementation did not affect positive Ki67 counts but significantly decreased villus area (P &lt; 0.05) and tended to decrease villus height (P = 0.093). Dietary supplementation with 4 mg/kg VB6 had significantly increased the mRNA expression of IL-1β, TNF-α, COX-2, IL-10, and TGF-β (P &lt; 0.05). Dietary supplementation with 4 or 7 mg/kg VB6 had significantly decreased SLC6A20, SLC7A1, SLC7A6, SLC16A14, and SLC38A5 mRNA expression (P &lt; 0.05). These findings suggest that dietary supplementation of VB6 mainly down-regulated inflammatory cytokines and up-regulated AA transporters mRNA expression in jejunum, while up-regulated (4 mg/kg) inflammatory cytokines and down-regulated AA transporters mRNA expression in ileum, which may provide a reference for the intestinal development of weaned piglets that are fed a low-CP diet.

scholarly journals PSVI-40 Effects of dietary glucan on intestinal morphology, immunity response, barrier function and antioxidant capacity in weaning pigs

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 212-213
Author(s):  
xia xiong ◽  
Lvliang Wu ◽  
Yirui Shao ◽  
Jian zou ◽  
Yulong Yin
Keyword(s):  
Antioxidant Capacity ◽  
Growth Performance ◽  
Mrna Expression ◽  
Dietary Supplementation ◽  
Basal Diet ◽  
Intestinal Morphology ◽  
Control Group ◽  
Gut Health ◽  
Weaned Piglets ◽  
Weaning Piglets

Abstract Glucan has been studied as a potential alternative to antibiotics for animals in recent years. The aim of this study was to evaluate the effect of dietary glucan on growth performance and gut health of weaning piglets, which is a water-soluble extracellular ꞵ-glucan produced by Agrobacterium sp. ZX09. A total of 108 weaned piglets (21 d of age; 6.05 ± 0.36 kg) were randomly assigned (6 pens/diet; 18 piglets/pen) to 3 dietary treatments consisting of a basal diet (control group) or the basal diet supplemented with 20 ppm olaquindox or 200 ppm glucan for 14 days, respectively. The results showed that piglets fed with glucan had greater (P &lt; 0.05) body weight and average daily gain than piglets in control group. Piglets fed with glucan or antibiotic had greater villus height to crypt depth ratio on duodenum compared with control group (P &lt; 0.05). The mRNA expression of Claudin-1 on duodenum or ileum was higher (P &lt; 0.05) in glucan group than that on the other groups. The mRNA expression of TLR4, MYD88 and NFκB on jejunum were lower (P &lt; 0.05) in glucan or antibiotic group than those in control group. Dietary supplementation with glucan tended to increase the IL-10 and SIgA concentration on ileum (0.05 &lt; P &lt; 0.1). Dietary supplementation with glucan tended to increase the total antioxidant capacity on jejunum (P = 0.093). In conclusion, 200 ppm glucan or 20 ppm olaquindox can improve the growth performance of weaning piglets. The glucan may can accelerate the growth of weaned piglets by improving gut health. This research will provide guidance for the olaquindox alternative on growing piglets.

scholarly journals The use of an alternative feed additive, containing benzoic acid, thymol, eugenol, and piperine, improved growth performance, nutrient and energy digestibility, and gut health in weaned piglets

2020 ◽  
Vol 98 (5) ◽  
Author(s):  
Cláudio D Silva Júnior ◽  
Cláudia C S Martins ◽  
Francine T F Dias ◽  
Natália Y Sitanaka ◽  
Letícia B Ferracioli ◽  
...  
Keyword(s):  
Benzoic Acid ◽  
Growth Performance ◽  
Phase 1 ◽  
Intestinal Morphology ◽  
Feed Additive ◽  
Growth Promoter ◽  
Gut Health ◽  
Weaned Piglets ◽  
Alternative Feed ◽  
Cecum Content

Abstract This research evaluated a feed additive (benzoic acid, eugenol, thymol, and piperine), associated or not with colistin, in weaned piglets feeding. The parameters evaluated were growth performance, apparent total tract digestibility (ATTD) of nutrients, diarrhea incidence, intestinal morphology, relative weights of digestive organs, microbial diversity, and the percentages of operational taxonomic units of microorganisms in the cecum content of pigs. One-hundred and eight crossbred piglets (5.3 ± 0.5 kg) were used in a three-phase feeding program (21 to 35, 36 to 50, 51 to 65 d of age) and fed a control diet with no inclusion of growth promoter feed additive, a diet with 40 ppm of colistin, a diet with 0.3% of alternative additive, and a diet with 0.3% of alternative additive and 40 ppm of colistin. The diets were based on corn, soybean meal, dairy products, and spray-dried blood plasma and formulated to provide 3.40, 3.38, and 3.20 Mcal of ME/kg and 14.5, 13.3, and 10.9 g/kg of digestible lysine, in phases 1, 2, and 3, respectively. The piglets were housed three per pen, with nine replicates per diet, in a complete randomized block design based on initial BW. The data were submitted to ANOVA and means were separated by Tukey test (5%), using SAS. Pigs fed diets with the alternative feed additive had greater (P &lt; 0.05) ADG (114.3 vs. 91.8 g) and ADFI (190.1 vs. 163.3 g) in phase 1 than pigs fed diets without the product. The alternative additive improved (P &lt; 0.05) ATTD of crude protein (CP) in phase 1 (71.0% vs. 68.6%), gross energy in phases 1 (77.4% vs. 75.2%) and 3 (79.0% vs. 77.1%), and dry matter in phase 3 (79.1% vs. 77.1%). The antibiotic inclusion in the diets increased (P &lt; 0.05) ATTD of CP in phase 1 (71.5% vs. 68.2%). The alternative feed additive tended (P = 0.06) to increase (46%) normal feces frequency, decreased (P &lt; 0.05) goblet cells count (104.3 vs. 118.1) in the jejunum, and decreased (P &lt; 0.05) small intestine (4.60% vs. 4.93%) and colon (1.41% vs. 1.65%) relative weights, compared with pigs not fed with the alternative additive. There was a tendency (P = 0.09) for a lower concentration of Escherichia–Shigella (1.46% vs. 3.5%) and lower (P &lt; 0.05) percentage of Campylobacter (0.52% vs. 10.21%) in the cecum content of piglets fed diets containing essential oils and benzoic acid compared with pigs fed diets without the alternative feed additive. The alternative feed additive was effective in improving growth performance, diets digestibility, and gut health in piglets soon after weaning.

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