Body adiposity and bone parameters of male rats from mothers fed diet containing flaxseed flour during lactation

2015 ◽  
Vol 7 (3) ◽  
pp. 314-319 ◽  
Author(s):  
C. A. S. da Costa ◽  
P. C. A. da Silva ◽  
D. C. Ribeiro ◽  
A. D. D. Pereira ◽  
A. d. S. d. Santos ◽  
...  
Keyword(s):  
Body Mass ◽  
Density Lipoprotein ◽  
Male Rats ◽  
Skeletal Structure ◽  
Male Rat ◽  
Postnatal Life ◽  
Lactation Period ◽  
Body Adiposity ◽  
Maximal Load ◽  
Flaxseed Flour

Obesity and osteoporosis may have their origins in early postnatal life. This study was designed to evaluate whether flaxseed flour use during lactation period bears effect on body adiposity and skeletal structure of male rat pups at weaning. At birth, male Wistar rats were randomly assigned to control and experimental (FF) groups, whose dams were treated with control or flaxseed flour diet, respectively, during lactation. At 21 days of age, pups were weaned to assess body mass, length and composition by dual-energy X-ray absorptiometry. The animals were then sacrificed to carry out analysis of serum profile, intra-abdominal adipocyte morphology and femur characteristics. Differences were considered significant when P<0.05. The FF group displayed the following characteristics (P<0.05): higher body mass, length, bone mineral content, bone area and concentrations of osteoprotegerin, osteocalcin and high-density lipoprotein cholesterol; higher levels of stearic, α-linolenic, eicosapentaenoic and docosapentaenoic acids and lower levels of arachidonic acid and cholesterol; smaller adipocyte area; and higher mass, epiphysis distance, diaphysis width, maximal load, break load, resilience and stiffness of femur. Flaxseed flour intake during lactation period promoted adipocyte hypertrophy down-regulation and contributed to pup bone quality at weaning.

Body composition in male rats subjected to early weaning and treated with diet containing flour or flaxseed oil after 21 days until 60 days

2015 ◽  
Vol 6 (6) ◽  
pp. 553-557 ◽  
Author(s):  
B. Ferolla da Camara Boueri ◽  
C. Ribeiro Pessanha ◽  
L. Rodrigues da Costa ◽  
M. R. Ferreira ◽  
H. Saldanha Melo ◽  
...  
Keyword(s):  
Body Composition ◽  
Body Mass ◽  
Control Diet ◽  
Flaxseed Oil ◽  
Male Rats ◽  
Bone Area ◽  
Early Weaning ◽  
Mineral Density ◽  
X Ray ◽  
Flaxseed Flour

The aim of this study was analyzed if the flour or flaxseed oil treatment contributes to body composition in male rats subjected to early weaning. Pups were weaned for separation from mother at 14 (early weaning, EW) and 21 days (control, C). At 21 days, part of the pups was evaluated (C21 v. EW21). After 21 days, control (C60) was fed with control diet. EW was divided in control (EWC60); flaxseed flour (EWFF60); flaxseed oil (EWFO60) diets until 60 days. Body mass, length and body composition by dual-energy X-ray absorptiometry were determined. EW21 (v. C21) and EWC60 (v. C60 and EWFF60) showed lower (P<0.05) mass, length and body composition. EWFO60 (v. C60 and EWFF60) showed lower (P<0.05) body mass and length, body and trunk lean mass, bone mineral density and content and bone area. Flaxseed flour, in comparison with flaxseed oil, contributes to recovery of body composition after early weaning.

scholarly journals Flaxseed flour diet during lactation until 180 days results in an increase in body adiposity in adult male rats

2017 ◽  
Vol 39 ◽  
pp. 245-249 ◽  
Author(s):  
Maíra Duque Coutinho de Abreu ◽  
Letícia Rozeno Pessoa ◽  
Luanna Rodrigues da Costa ◽  
Mauricio Alves Chagas ◽  
Carlos Alberto Soares da Costa ◽  
...  
Keyword(s):  
Adult Male ◽  
Male Rats ◽  
Body Adiposity ◽  
Flaxseed Flour

GONADOTROPHINS, TESTOSTERONE AND SPERMATOGENESIS IN NEONATALLY IRRADIATED MALE RATS: EVIDENCE FOR A ROLE OF THE SERTOLI CELL IN FOLLICLE-STIMULATING HORMONE FEEDBACK

1977 ◽  
Vol 75 (2) ◽  
pp. 209-219 ◽  
Author(s):  
F. H. DE JONG ◽  
R. M. SHARPE
Keyword(s):  
Sertoli Cell ◽  
Sertoli Cells ◽  
Age Groups ◽  
Male Rats ◽  
Male Rat ◽  
Postnatal Life ◽  
Spermatogenic Cells ◽  
Normal Numbers ◽  
Testicular Cell

Peripheral concentrations of FSH in the male rat seem to be regulated in part by a protein hormone, inhibin, which originates from the testes. In an attempt to ascertain which type of testicular cell secretes inhibin, groups of male rats were irradiated prenatally or on days 4, 6 or 8 of postnatal life, and killed at 21, 51 or 81 days of age together with castrated and intact controls. The concentrations of FSH and LH in the pituitary gland, and FSH, LH and testosterone in the plasma were estimated for each animal, and the numbers of each class of intratubular cell in the testes were calculated. Rats irradiated neonatally had fewer Sertoli cells than controls at all ages studied, while the numbers of Sertoli cells in rats irradiated prenatally were higher than those in controls on day 21. The number of spermatogenic cells was usually decreased in rats irradiated postnatally. In the rats irradiated prenatally normal numbers of spermatogenic cells were found at day 51. Numbers of spermatogenic cells were significantly correlated with the number of Sertoli cells at the ages of 51 and 81 days. The concentration of FSH in the plasma usually increased in the postnatally irradiated animals on days 21 and 51, but not on day 81; prenatal irradiation did not result in altered levels of FSH at any age. Peripheral levels of LH and testosterone were not affected by irradiation. The concentration of FSH in the plasma was negatively correlated with the number of Sertoli cells in all age groups, whereas significant correlations between the level of FSH and the number of spermatogenic cells were only found at days 51 and 81. It is concluded from these data that the Sertoli cell is the most likely source of inhibin.

scholarly journals Decreasing serum homocysteine and hypocholesterolemic effects of bovine lactoferrin in male rat fed with high-cholesterol diet

2018 ◽  
Vol 10 (4) ◽  
pp. 203-208 ◽  
Author(s):  
Samira Nozari ◽  
Nazila Fathi Maroufi ◽  
Mohammad Nouri ◽  
Mirhamid Paytakhti Oskouei ◽  
Javad Shiralizade ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Male Rats ◽  
Male Rat ◽  
High Cholesterol Diet ◽  
Bovine Lactoferrin ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Serum Homocysteine

Introduction: Lipid metabolism disorder or hyperlipidemia is known as a risk factor for cardiovascular disease, the increase in serum homocysteine and leptin are associated with atherosclerotic disease. The purpose of the present study was to examine the effects of bovine lactoferrin (bLF) on serum homocysteine (Hcy), apolipoproteinA-I (ApoA-I) and B (ApoB), leptin and lipid profile changes in high-cholesterol-diet (HCD) fed rats. Methods: The Healthy Adult Sprague-Dawley (SD) male rats were randomly assigned into three experimental groups. Each group consisted of eleven male rats including control group, HCD rats and hypercholesterolemic rats, which were treated with bLF (HCD+bLF). bLF was given by gavage (200 mg/kg/d). After 4 weeks of feeding and overnight fasting, total blood samples were collected. Results: The results showed the elevated level of Hcy, leptin, total cholesterol, low density lipoprotein cholesterol (LDL-C), ApoB and decrease in ApoA-I in non-treated HCD group compared to the control rats. Administration of bLF significantly ameliorated the Hcy and leptin levels with decrease in LDL-C and total cholesterol in rats fed with a high-cholesterol diet. bLF also tended to increase low serum concentration of ApoA-I and high density lipoprotein cholesterol (HDL-C) in HCD rats. Meanwhile, upon bLF-treated rats, there was a significant decrease in ApoB in HCD group. Conclusion: The findings indicated that bLF can improve the alteration of serum Hcy, leptin, apolipproteins and lipid changes in male rats fed with high-cholesterol diet. So, bLF can counteract with HCD elicited hyper-homocysteinemia and hyper-leptinemia, suggesting it to have the useful therapeutic potential in patients with atherosclerosis and lipid disorder.

Effects of diet containing flaxseed flour (Linum usitatissimum) on body adiposity and bone health in young male rats

2016 ◽  
Vol 7 (2) ◽  
pp. 698-703 ◽  
Author(s):  
Carlos Alberto Soares da Costa ◽  
Paula Cristina Alves da Silva ◽  
Danielle Cavalcante Ribeiro ◽  
Aline D'Avila Pereira ◽  
Aline de Sousa dos Santos ◽  
...  
Keyword(s):  
Bone Health ◽  
Linum Usitatissimum ◽  
Young Male ◽  
Male Rats ◽  
Body Adiposity ◽  
Flaxseed Flour

This study evaluated the effects of flaxseed flour on body adiposity and bone health in rats fed a flaxseed flour diet during lactation until 90 days.

scholarly journals Body Adiposity of Young Male Rats Fed a Diet Containing Flaxseed Flour during Lactation or in Post-Weaning Period

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Costa Carlos Alberto Soares da ◽  
Abreu Maíra Duque Coutinho de ◽  
Pessoa Letícia Rozeno ◽  
Boueri Bianca Ferolla da Camara ◽  
Pessanha Carolina Ribeiro ◽  
...  
Keyword(s):  
Young Male ◽  
Male Rats ◽  
Body Adiposity ◽  
Flaxseed Flour

Cardioprotective Effects of Diet with Different Grains on Lipid Profiles and Antioxidative System in Obesity-Induced Rats

2012 ◽  
Vol 82 (2) ◽  
pp. 85-93 ◽  
Author(s):  
Y. Kim ◽  
H. Shin ◽  
S. Lee
Keyword(s):  
Aortic Wall ◽  
Plasma Lipids ◽  
Antioxidant Activities ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
Thiobarbituric Acid ◽  
Lipid Profiles ◽  
Dietary Lipids ◽  
Male Rats

In the present study, the nutritional quality of four grains including adlay (AD), buckwheat (BW), glutinous barley (GB), and white rice (WR) were evaluated in terms of plasma lipid parameters, gut transit time, and thickness of the aortic wall in rats. The rats were then raised for 4 weeks on the high-fat diet based on the American Institute of Nutrition-93 (AIN-93 G) diets containing 1 % cholesterol and 20 % dietary lipids. Forty male rats were divided into 4 groups and raised for 4 weeks with a diet containing one of the following grains: WR, AD, BW, or WB. The level of thiobarbituric acid-reactive substances (TBARS) in liver was shown to be higher in rats by the order of those fed WR, AD, GB, and BW. This indicates that other grains decreased oxidative stress in vivo more than WR. The superoxide dismutase, glutathione, glutathione peroxidase, and glutathione reductase levels in the AD, BW, and GB groups were significantly higher than those in the WR group (p < 0.05). Plasma lipid profiles differed significantly according to grain combination, and decreased aortic wall thickness was consistent with the finding of decreased plasma low-density lipoprotein cholesterol (LDL-C) (p < 0.05) and increased high-density lipoprotein (HDL-C) in rats fed AD, BW, and GB (p < 0.001). The antioxidant and hypolipidemic capacities of grains are quite high, especially those of adlay, buckwheat, and glutinous barley. In conclusion, this study has demonstrated that the whole grains had a cardioprotective effect. This effect was related to several mechanisms that corresponded to lowering plasma lipids, decreasing TBARS, and increasing antioxidant activities.

Effect of Turmeric and Ginger on Lipid Profile in Male Rats Exposed to Oxidative Stress

2019 ◽  
Vol 10 (01) ◽  
Author(s):  
Eman A. Al-Rekabi ◽  
Dheyaa K. Alomer ◽  
Rana Talib Al-Muswie ◽  
Khalid G. Al-Fartosi
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Drinking Water ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Male Rats ◽  
Control Group ◽  
Very Low Density Lipoprotein ◽  
Low Density

The present study aimed to investigate the effect of turmeric and ginger on lipid profile of male rats exposed to oxidative stress induced by hydrogen peroxide H2O2 at a concentration of 1% given with consumed drinking water to male rats. Methods: 200 mg/kg from turmeric and ginger were used, and the animals were treatment for 30 days. Results: the results showed a significant increase in cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipoprotein (VLDL), whereas it explained a significant decrease in high density lipoprotein (HDL) of male rats exposed to oxidative stress when compared with control group. the results showed a significant decrease in cholesterol, triglycerides, (LDL), (VLDL), whereas it explained a significant increase in (HDL) of rats treated with turmeric and ginger at dose 200 mg/kg when compared with male rats exposed to oxidative stress.

scholarly journals Programming Effect of the Parental Obesity on the Skeletal System of Offspring at Weaning Day

Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 424
Author(s):  
Radoslaw Piotr Radzki ◽  
Marek Bienko ◽  
Dariusz Wolski ◽  
Monika Ostapiuk ◽  
Pawel Polak ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Mineral ◽  
High Energy ◽  
Diet Group ◽  
Male Rats ◽  
Bending Test ◽  
Male Rat ◽  
Skeletal System ◽  
Mineral Density ◽  
Trabecular Thickness

Our study aimed to verify the hypothesis of the existence of a programming effect of parental obesity on the growth, development and mineralization of the skeletal system in female and male rat offspring on the day of weaning. The study began with the induction of obesity in female and male rats of the parental generation, using a high-energy diet (group F). Females and males of the control group received the standard diet (group S). After 90 days of dietary-induced obesity, the diet in group F was changed into the standard. Rats from groups F and S were mated to obtain offspring which stayed with their mothers until 21 days of age. Tibia was tested using dual-energy X-ray absorptiometry (DXA), peripheral quantitative computed tomography (pQCT), micro-computed tomography (µCT) and mechanical strength using the three-point bending test. Biochemical analysis of blood serum bone metabolism markers was performed. DXA analysis showed higher tibia bone mineral content (BMC) and area. pQCT measurements of cortical and trabecular tissue documented the increase of the volumetric bone mineral density and BMC of both bone compartments in offspring from the F group, while µCT of the trabecular tissue showed an increase in trabecular thickness and a decrease of its separation. Parental obesity, hence, exerts a programming influence on the development of the skeletal system of the offspring on the day of the weaning, which was reflected in the intensification of mineralization and increased bone strength.

Sign in / Sign up

Export Citation Format

Share Document