Drug Delivery of Anticancer Drugs from Injectable 3D Porous Silk Scaffold for Prevention of Gastric Cancer Growth and Recurrence

2020 ◽  
Vol 6 (11) ◽  
pp. 6195-6206
Author(s):  
Ankit Gangrade ◽  
Biman B. Mandal
2017 ◽  
Vol 5 (9) ◽  
pp. 1734-1741 ◽  
Author(s):  
S. Karthik ◽  
Avijit Jana ◽  
M. Selvakumar ◽  
Yarra Venkatesh ◽  
Amrita Paul ◽  
...  

Highly sensitive hypoxia (H2O2)-activated photoresponsive polymeric nanoparticles for cocktail delivery of anticancer drugs doxorubicin (Dox) and chlorambucil (Cbl) were developed.


2016 ◽  
Vol 7 (5) ◽  
pp. 3017-3024 ◽  
Author(s):  
Guocan Yu ◽  
Dan Wu ◽  
Yang Li ◽  
Zhihua Zhang ◽  
Li Shao ◽  
...  

Here we integrate diagnostic and therapeutic agents into a mitochondria-targeting [2]rotaxane, which can be utilized as a drug delivery platform to conjugate anticancer drugs to prepare prodrugs for efficient targeted drug delivery.


Nanomaterials ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1697
Author(s):  
Hidenori Ando ◽  
Takashi Mochizuki ◽  
Amr S. Abu Lila ◽  
Shunsuke Akagi ◽  
Kenji Tajima ◽  
...  

Natural materials such as bacterial cellulose are gaining interest for their use as drug-delivery vehicles. Herein, the utility of nanofibrillated bacterial cellulose (NFBC), which is produced by culturing a cellulose-producing bacterium (Gluconacetobacter intermedius NEDO-01) in a medium supplemented with carboxymethylcellulose (CMC) that is referred to as CM-NFBC, is described. Recently, we demonstrated that intraperitoneal administration of paclitaxel (PTX)-containing CM-NFBC efficiently suppressed tumor growth in a peritoneally disseminated cancer xenograft model. In this study, to confirm the applicability of NFBC in cancer therapy, a chemotherapeutic agent, doxorubicin (DXR), embedded into CM-NFBC, was examined for its efficiency to treat a peritoneally disseminated gastric cancer via intraperitoneal administration. DXR was efficiently embedded into CM-NFBC (DXR/CM-NFBC). In an in vitro release experiment, 79.5% of DXR was released linearly into the peritoneal wash fluid over a period of 24 h. In the peritoneally disseminated gastric cancer xenograft model, intraperitoneal administration of DXR/CM-NFBC induced superior tumor growth inhibition (TGI = 85.5%) by day 35 post-tumor inoculation, compared to free DXR (TGI = 62.4%). In addition, compared with free DXR, the severe side effects that cause body weight loss were lessened via treatment with DXR/CM-NFBC. These results support the feasibility of CM-NFBC as a drug-delivery vehicle for various anticancer agents. This approach may lead to improved therapeutic outcomes for the treatment of intraperitoneally disseminated cancers.


Author(s):  
Yong-Sheng Teng ◽  
Wan-Yan Chen ◽  
Zong-Bao Yan ◽  
Yi-Pin Lv ◽  
Yu-Gang Liu ◽  
...  

Small ◽  
2019 ◽  
Vol 15 (5) ◽  
pp. 1970028
Author(s):  
Caoyun Ju ◽  
Yajing Wen ◽  
Luping Zhang ◽  
Qianqian Wang ◽  
Lingjing Xue ◽  
...  

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