Target Family-Directed Exploration of Scaffolds with Different SAR Profiles

2011 ◽  
Vol 51 (12) ◽  
pp. 3138-3148 ◽  
Author(s):  
Ye Hu ◽  
Jürgen Bajorath
Keyword(s):  
Target Family

scholarly journals Peran Tenaga Pelaksana Eliminasi dalam Pelaksanaan Program Pemberian Obat Secara Massal (POPM) Filariasis di Kota Pekalongan

2020 ◽  
Vol 19 (1) ◽  
pp. 14-18
Author(s):  
Herlysse Jorghi Jorghi ◽  
Praba Ginandjar ◽  
Nissa Kusariana ◽  
Lintang Dian Saraswati
Keyword(s):  
Family Member ◽  
Drug Administration ◽  
Mass Drug Administration ◽  
Research Method ◽  
Health Workers ◽  
Family Members ◽  
Cross Sectional ◽  
Target Family ◽  
The Given

Latar belakang: Penyakit Filariasis merupakan penyakit yang disebabkan oleh cacing filaria. Kota Pekalonganmerupakan kota dengan endemis filariasis dan telah dilakukan Program Pemberian Obat secara Massal (POPM) sejak tahun 2011 hingga 2015, Namun, hasil Survei Darah Jari (SDJ) menunjukkan nilai Mikrofilaria Rate di Kota  Pekalongan  masih  >  1%.  Penelitian  ini  bertujuan  untuk  menggambarkan  peran  Tenaga  Pelaksana Eliminasi (TPE) filariasis dan hambatan yang ditemui pada pelaksanaan POPM di Kota Pekalongan.Metode: Penelitian ini merupakan penelitian cross sectiona. Jumlah sampel 95 orang petugas TPE dengan menggunakan simple ramdom sampling. Pengumpulan data dengan wawancara menggunakan kuesioner.  Hasil: Hasil penelitian menunjukkan bahwa EP dalam memilih anggota keluarga target yang akan dirawat adalah optimal (63,2%). EP dalam membantu puskesmas menentukan dosis dan pemberian obat-obatan untuk masing-masing keluarga yang dibantu (52,6%). EP dalam merekam keluarga yang dibantu yang minum obat pada kartu sudah optimal (55,8%). EP dalam memantau dan mencatat reaksi perawatan yang mungkin timbul dan melaporkan kepada petugas kesehatan adalah optimal (61,1%).Simpulan: Peran tenaga pelaksana eliminasi TPE di Kota Pekalongan dalam menyeleksi anggota keluarga binaan yang akan diobati, dalam membantu puskesmas menentukan dosis dan pemberian obat pada setiap keluarga binaan, dalam pencatatan keluarga binaan yang meminum obat pada kartu, dan dalam pengawasan dan pencatatan reaksi pengobatan yang mungkin timbul serta pelaporan kepada petugas kesehatan sudah optimalKata kunci: Filariasis, Tenaga Pelaksana EliminasiABSTRACT Title: The role of Elimination Personnel (EP) implementing filariasis MDA in Pekalongan City Background: Filariasis is a disease caused by filarial worms, Pekalongan City has carried out filariasis MDA (Mass Drug Administration) since 2011-2015. However, the results of the Finger Blood Survey (SDJ) showed that the microfilaria rate was > 1%. This study aims to describe the role of Elimination Personnel (EP) and the obstacles faced in implementing filariasis MDA in Pekalongan City.Method: This study used a cross sectional research method. Sampling in this study used simple random side, total 95 respondents. Data obtained by structure interviews using questionnaires.Result: The results showed that EP in selecting the target family members to be treated is optimal (63.2%). EP in helping puskesmas determine the dosage and administration of medicines for each of the assisted families (52.6%). EP in recording the assisted families who drank the medicine on the card was optimal (55.8%). EP in monitoring and recording treatment reactions that may arise and reporting to health workers was optimal (61.1%).Conclusion: The roles of TPE elimination workers of Pekalongan City were optimum, such as selecting family member who will be treated, helping Puskesmas in deciding the dosage and giving the medicine to every treated family, record of treated family who take the medicine in the given card, and in the supervision and record of medical reaction that might happen and reporting it to health workers.Keywords: Filariasis, Elimination Personnel  

scholarly journals Thermodynamic properties of thermonuclear fuel in inertial confinement fusion

2016 ◽  
Vol 34 (3) ◽  
pp. 539-544 ◽  
Author(s):  
V. Brandon ◽  
B. Canaud ◽  
M. Temporal ◽  
R. Ramis
Keyword(s):  
Kinetic Energy ◽  
Inertial Confinement Fusion ◽  
Hot Spot ◽  
Inertial Confinement ◽  
Direct Drive ◽  
Aspect Ratios ◽  
Confinement Fusion ◽  
Thermonuclear Fuel ◽  
Target Family ◽  
Very High

AbstractHot-spot path in the thermodynamic space $({\rm \rho} R,T_{\rm i} )_{{\rm hs}} $ is investigated for direct-drive scaled-target family covering a huge interval of kinetic energy on both sides of kinetic threshold for ignition. Different peak implosion velocities and two initial aspect ratios have been considered. It is shown that hot spot follows almost the same path during deceleration up to stagnation whatever the target is. As attended, after stagnation, a clear distinction is done between non-, marginally-, or fully igniting targets. For the last, ionic temperature can reach very high values when the thermonuclear energy becomes very high.

Abstract 1924: The paraproteins of patients with familial MGUS / multiple myeloma (MM) target family-specific antigens: Experience with paratarg-7 and paratarg-8

2010 ◽  
Author(s):  
Sandra Grass ◽  
Klaus-Dieter Preuss ◽  
Aleksandra Wikowicz ◽  
Stephan Thome ◽  
Dennis D. Weisenburger ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Specific Antigens ◽  
Target Family

Introduction to Preadolescent Depression

2018 ◽  
pp. 3-22
Author(s):  
Laura J. Dietz
Keyword(s):  
Risk Factors ◽  
Peer Relationships ◽  
Formative Period ◽  
Recurrent Depression ◽  
Effective Interventions ◽  
Reduce Risk ◽  
Interpersonal Risk ◽  
Target Family ◽  
Family Based

Chapter 1 of Family-based Interpersonal Psychotherapy for Depressed Preadolescents discusses preadolescent depression. Marked interpersonal impairment has been associated with depression in preadolescents and appears to be one of the mechanisms for recurrent depression in adolescence and adulthood. Depressed preadolescents experience frequent negative interactions and more distant relationships with parents, as well as more problematic and fewer close peer relationships. Preadolescent depression not only interferes with normative social development at a formative period but also results in residual impairments in interpersonal functioning, which may increase their risk for recurrent depression into adolescence and adulthood. Effective interventions for depression in the preadolescent period that target family and interpersonal risk factors may reduce risk for depression recurrence in adolescence.

Target-Family-Oriented Focused Libraries for Kinases-Conceptual Design Aspects and Commercial Availability

ChemBioChem ◽  
2005 ◽  
Vol 6 (3) ◽  
pp. 500-505 ◽  
Author(s):  
Olaf Prien
Keyword(s):  
Conceptual Design ◽  
Target Family

Are Target-Family-Privileged Substructures Truly Privileged?

2006 ◽  
Vol 49 (6) ◽  
pp. 2000-2009 ◽  
Author(s):  
Dora M. Schnur ◽  
Mark A. Hermsmeier ◽  
Andrew J. Tebben
Keyword(s):  
Target Family

The 7TM G-Protein-Coupled Receptor Target Family

ChemInform ◽  
2006 ◽  
Vol 37 (42) ◽  
Author(s):  
Edgar Jacoby ◽  
Rochdi Bouhelal ◽  
Marc Gerspacher ◽  
Klaus Seuwen
Keyword(s):  
G Protein ◽  
G Protein Coupled Receptor ◽  
Target Family ◽  
G Protein Coupled

scholarly journals HTS Promiscuity Analyses for Accelerating Decision Making

2011 ◽  
Vol 16 (7) ◽  
pp. 765-774 ◽  
Author(s):  
Alexander Böcker ◽  
Pierre R. Bonneau ◽  
Paul J. Edwards
Keyword(s):  
Decision Making ◽  
High Throughput ◽  
High Throughput Screening ◽  
Large Scale ◽  
Data Repositories ◽  
Decision Making Processes ◽  
Target Family ◽  
The One

Frequent hitters are compounds that are detected as a “hit” in multiple high-throughput screening (HTS) assays. Such behavior is specific (e.g., target family related) or unspecific (e.g., reactive compounds) or can result from a combination of such behaviors. Detecting such hits while predicting the underlying reason behind their promiscuous behavior is desirable because it provides valuable information not only about the compounds themselves but also about the assay methodology and target classes at hand. This information can also greatly reduce cost and time during HTS hit profiling. The present study exemplifies how to mine large HTS data repositories, such as the one at Boehringer Ingelheim, to identify frequent hitters, gain further insights into the causes of promiscuous behavior, and generate models for predicting promiscuous compounds. Applications of this approach are demonstrated using two recent large-scale HTS assays. The authors believe this analysis and its concrete applications are valuable tools for streamlining and accelerating decision-making processes during the course of hit discovery.

Paraproteins of familial MGUS/multiple myeloma target family-typical antigens: hyperphosphorylation of autoantigens is a consistent finding in familial and sporadic MGUS/MM

Blood ◽  
2011 ◽  
Vol 118 (3) ◽  
pp. 635-637 ◽  
Author(s):  
Sandra Grass ◽  
Klaus-Dieter Preuss ◽  
Stephan Thome ◽  
Dennis D. Weisenburger ◽  
Vinetta Witt ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Monoclonal Gammopathy ◽  
Family Members ◽  
Carrier State ◽  
General Mechanism ◽  
Consistent Finding ◽  
Waldenstrom Macroglobulinemia ◽  
Target Family ◽  
Normal Controls ◽  
Undetermined Significance

Abstract Paratarg-7 (P-7) is a frequent paraprotein target in monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma (MM), and Waldenström macroglobulinemia. Patients with P-7-specific paraproteins carry a hyperphosphorylated paratarg-7 (pP-7). Because pP-7 carrier state is dominantly inherited, we determined the paraprotein targets in 4 families with familial MGUS/MM. No antigenic target was identified for the paraproteins from 2 members of one family. Paraproteins from affected members of 2 other families targeted P-7, and paraproteins from 4 affected members of a fourth family targeted P-8, which is encoded by the ATG13 gene. P-8 was hyperphosphorylated in the affected family members (pP-8) and pP-8 carrier state is inherited in a dominant fashion. Six additional autoantigenic nonfamilial paraprotein targets were also hyperphosphorylated in the respective patients compared with normal controls. We conclude that paraproteins of affected members with familial MGUS/MM share family-typical hyperphosphorylated antigens and hyperphosphorylation of paraprotein targets might be a general mechanism underlying the pathogenesis of MGUS/MM.

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