Remote-Controlled Drug Release from Graphene Oxide-Capped Mesoporous Silica to Cancer Cells by Photoinduced pH-Jump Activation

Langmuir ◽  
2014 ◽  
Vol 30 (24) ◽  
pp. 7182-7189 ◽  
Author(s):  
Dinggeng He ◽  
Xiaoxiao He ◽  
Kemin Wang ◽  
Zhen Zou ◽  
Xue Yang ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Cancer Cells ◽  
Controlled Drug Release ◽  
Ph Jump

scholarly journals Cancer cell targeting, controlled drug release and intracellular fate of biomimetic membrane-encapsulated drug-loaded nano-graphene oxide nanohybrids

2018 ◽  
Vol 6 (31) ◽  
pp. 5080-5090 ◽  
Author(s):  
Kun Ma ◽  
Duo Fu ◽  
Yajun Liu ◽  
Rui Dai ◽  
Dongli Yu ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Drug Release ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Controlled Drug Release ◽  
Tumor Tissues ◽  
Biomimetic Membrane ◽  
Cancer Cell Targeting ◽  
Nano Graphene ◽  
Intracellular Fate

FA-modified nanohybrids, NGO/DOX@SPC-FA, could deliver DOX to cancer cells and tumor tissues with improved delivery and inhibition efficacy.

Noncovalent assembly of reduced graphene oxide and alkyl-grafted mesoporous silica: an effective drug carrier for near-infrared light-responsive controlled drug release

2015 ◽  
Vol 3 (27) ◽  
pp. 5588-5594 ◽  
Author(s):  
Dinggeng He ◽  
Xuecai Li ◽  
Xiaoxiao He ◽  
Kemin Wang ◽  
Jinlu Tang ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Reduced Graphene Oxide ◽  
Near Infrared ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Effective Drug ◽  
Infrared Light ◽  
Reduced Graphene

A novel NIR-responsive drug release system based on noncovalent assembly of reduced graphene oxide and alkyl-grafted mesoporous silica.

scholarly journals Photo-Responsive Supramolecular Micelles for Controlled Drug Release and Improved Chemotherapy

2020 ◽  
Vol 22 (1) ◽  
pp. 154
Author(s):  
Fasih Bintang Ilhami ◽  
Kai-Chen Peng ◽  
Yi-Shiuan Chang ◽  
Yihalem Abebe Alemayehu ◽  
Hsieh-Chih Tsai ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Release ◽  
Visible Light ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Reactive Oxygen ◽  
Controlled Drug Release ◽  
Grand Challenge ◽  
Supramolecular System ◽  
Oxygen Species

Development of stimuli-responsive supramolecular micelles that enable high levels of well-controlled drug release in cancer cells remains a grand challenge. Here, we encapsulated the antitumor drug doxorubicin (DOX) and pro-photosensitizer 5-aminolevulinic acid (5-ALA) within adenine-functionalized supramolecular micelles (A-PPG), in order to achieve effective drug delivery combined with photo-chemotherapy. The resulting DOX/5-ALA-loaded micelles exhibited excellent light and pH-responsive behavior in aqueous solution and high drug-entrapment stability in serum-rich media. A short duration (1–2 min) of laser irradiation with visible light induced the dissociation of the DOX/5-ALA complexes within the micelles, which disrupted micellular stability and resulted in rapid, immediate release of the physically entrapped drug from the micelles. In addition, in vitro assays of cellular reactive oxygen species generation and cellular internalization confirmed the drug-loaded micelles exhibited significantly enhanced cellular uptake after visible light irradiation, and that the light-triggered disassembly of micellar structures rapidly increased the production of reactive oxygen species within the cells. Importantly, flow cytometric analysis demonstrated that laser irradiation of cancer cells incubated with DOX/5-ALA-loaded A-PPG micelles effectively induced apoptotic cell death via endocytosis. Thus, this newly developed supramolecular system may offer a potential route towards improving the efficacy of synergistic chemotherapeutic approaches for cancer.

scholarly journals AuNP and ssDNA capped mesoporous silica nanoparticles for laser controlled drug release

RSC Advances ◽  
2019 ◽  
Vol 9 (60) ◽  
pp. 34958-34962 ◽  
Author(s):  
Lu Zhou ◽  
Guojie Liu ◽  
Yang Wang ◽  
Jianling Liu ◽  
Yajie Zhang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Release

Gold nanoparticles were linked to the surface of mesoporous silica through a polyA oligonucleotide and infrared stimulation controlled drug release.

scholarly journals Controlled drug release to cancer cells from modular one-photon visible light-responsive micellar system

2016 ◽  
Vol 52 (69) ◽  
pp. 10525-10528 ◽  
Author(s):  
Saemi O. Poelma ◽  
Seung Soo Oh ◽  
Sameh Helmy ◽  
Abigail S. Knight ◽  
G. Leslie Burnett ◽  
...  
Keyword(s):  
Drug Release ◽  
Visible Light ◽  
Small Molecules ◽  
Cancer Cells ◽  
Controlled Drug Release ◽  
Micellar System ◽  
On Demand ◽  
System P

We present a one-photon visible light-responsive micellar system for efficient, on-demand delivery of small molecules.

One-Pot Synthesis of Redox-Responsive Polymers-Coated Mesoporous Silica Nanoparticles and Their Controlled Drug Release

2013 ◽  
Vol 34 (17) ◽  
pp. 1387-1394 ◽  
Author(s):  
Jiao-Tong Sun ◽  
Ji-Gang Piao ◽  
Long-Hai Wang ◽  
Mohsin Javed ◽  
Chun-Yan Hong ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Release ◽  
One Pot ◽  
Responsive Polymers ◽  
One Pot Synthesis ◽  
Redox Responsive

DNA-capped Fe3O4/SiO2 magnetic mesoporous silica nanoparticles for potential controlled drug release and hyperthermia

RSC Advances ◽  
2015 ◽  
Vol 5 (29) ◽  
pp. 22365-22372 ◽  
Author(s):  
Yufang Zhu ◽  
Cuilian Tao
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Potential Temperature ◽  
Controlled Drug Release ◽  
Magnetic Hyperthermia ◽  
Temperature Controlled ◽  
Magnetic Mesoporous Silica

DNA-capped Fe3O4/SiO2 magnetic mesoporous silica (MMS) nanoparticles were developed for potential temperature controlled drug release and magnetic hyperthermia.

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