Beneficial Effects of Tactile Stimulation on Early Development

1999 ◽  
Vol 27 (4) ◽  
pp. 255-257 ◽  
Author(s):  
Rick Caulfield
Keyword(s):  
Early Development ◽  
Tactile Stimulation ◽  
Beneficial Effects

Selection and Use of Age Resistors in Rubber Compounds

1934 ◽  
Vol 7 (4) ◽  
pp. 663-687
Author(s):  
Richard A. Crawford
Keyword(s):  
Surface Treatment ◽  
Early Development ◽  
Reducing Agents ◽  
Adhesive Properties ◽  
Temperature Changes ◽  
Rubber Industry ◽  
Beneficial Effects ◽  
Organic Bases ◽  
Rapid Deterioration ◽  
Rubber Compounds

Abstract THE early development of the rubber industry was handicapped by two serious defects in rubber articles. They were not stable to temperature changes, and they deteriorated rapidly with age. Although the process of vulcanization corrected the first difficulty, rapid deterioration with age was common until the discovery of certain organic accelerators, such as p-aminodimethylaniline, the aldehydeamines, and mercaptobenzothiazole. Prior to these discoveries a number of materials had been patented for the purpose of improving the age-resisting properties of rubber, but many of them were of little merit and most of the others possessed some accelerating value, a fact which was not appreciated at the time. Typical of the more useful early patents for age-resisting materials are American patents by Murphy in 1870 (15), Moore in 1901 (14), and Martin in 1922 (12), and the German and English patents of the Ostwalds in 1908 and 1910 (19, 20). Murphy patented phenol, cresol, and cresylic acid, either added to the uncured stock or as dipping solutions for vulcanized articles for the purpose of improving their resistance to aging. Moore used reducing agents, including hydroquinone, pyrogallol, and p-aminophenol hydrochloride, to preserve the adhesive properties of rubber cements. Martin suggested aniline and other organic bases as a surface treatment for vulcanized articles. The Ostwalds also recognized the beneficial effects of aniline on rubber and stated that it could be added at any convenient stage of manufacture. (It is interesting to note that these inventors considered that addition of aniline to uncured stock or dipping the cured article in aniline were equivalent, and they, therefore, evidently did not recognize the accelerating effect of aniline.)

scholarly journals Effects of Simultaneously Applied Short-Term Transcutaneous Electrical Nerve Stimulation and Tactile Stimulation on Memory and Affective Behaviour of Patients with Probable Alzheimer’s Disease

1995 ◽  
Vol 8 (1) ◽  
pp. 3-13 ◽  
Author(s):  
E. Scherder ◽  
A. Bouma ◽  
L. Steen
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Nerve Stimulation ◽  
Tactile Stimulation ◽  
Short Term ◽  
Simultaneous Application ◽  
Electrical Nerve Stimulation ◽  
Beneficial Effects ◽  
Positive Results

In previous studies beneficial effects of peripheral electrical or tactile nerve stimulation were observed on memory and affective behaviour in patients with probable Alzheimer's disease. In the present study, it was investigated whether electrical and tactile stimulation applied simultaneously to Alzheimer patients would exceed the effects which were observed following treatment by each type of stimulation separately. Our data reveal that the simultaneous application of the two types of stimulation had a beneficial effect on non-verbal and verbal long-term recognition memory. In addition, patients who were treated participated more in activities of daily living, and were more interested in social contacts. In spite of these positive results, comparisons with those of previous studies suggest that a combination of electrical and tactile stimulation does not yield more effects than application of each type of stimulation separately.

Mutually Responsive Orientation Between Mothers and Their Young Children: A Context for the Early Development of Conscience

2002 ◽  
Vol 11 (6) ◽  
pp. 191-195 ◽  
Author(s):  
Grazyna Kochanska
Keyword(s):  
Young Children ◽  
Early Development ◽  
Parental Influence ◽  
Parent Child Relationship ◽  
Cognitive Measures ◽  
Beneficial Effects ◽  
Child Relationship ◽  
Early School ◽  
Early Parent ◽  
Parent Child

Some parent–child dyads establish a mutually responsive orientation (MRO), a relationship that is close, mutually binding, cooperative, and affectively positive. Such relationships have two main characteristics—mutual responsiveness and shared positive affect—and they foster the development of conscience in young children. Children growing up with parents who are responsive to their needs and whose interactions are infused with happy emotions adopt a willing, responsive stance toward parental influence and become eager to embrace parental values and standards for behavior. The concurrent and longitudinal beneficial effects of MRO for early development of conscience have been replicated across studies, for a broad range of developmental periods from infancy through early school age, and using a wide variety of behavioral, emotional, and cognitive measures of conscience in the laboratory, at home, and in school. These findings highlight the importance of the early parent–child relationship for subsequent moral development.

Individual differences, social attention, and the history of the social motivation hypotheses of autism

2019 ◽  
Vol 42 ◽  
Author(s):  
Peter C. Mundy
Keyword(s):  
Individual Differences ◽  
Early Development ◽  
Emotional Development ◽  
Social Motivation ◽  
Social Attention ◽  
Social Emotional Development ◽  
Social Emotional ◽  
Precise Understanding ◽  
The Social ◽  
History Of

Abstract The stereotype of people with autism as unresponsive or uninterested in other people was prominent in the 1980s. However, this view of autism has steadily given way to recognition of important individual differences in the social-emotional development of affected people and a more precise understanding of the possible role social motivation has in their early development.

Classical social reward signatures in infants with later ASD

2019 ◽  
Vol 42 ◽  
Author(s):  
Teodora Gliga ◽  
Mayada Elsabbagh
Keyword(s):  
Early Development ◽  
Social Motivation ◽  
Self Report ◽  
Social Reward ◽  
Socially Motivated

Abstract Autistic individuals can be socially motivated. We disagree with the idea that self-report is sufficient to understand their social drive. Instead, we underscore evidence for typical non-verbal signatures of social reward during the early development of autistic individuals. Instead of focusing on whether or not social motivation is typical, research should investigate the factors that modulate social drives.

Early Development of Drug-Induced Hepatic Necrosis

1971 ◽  
Vol 29 ◽  
pp. 576-577
Author(s):  
F. G. Zaki ◽  
E. Detzi ◽  
C. H. Keysser
Keyword(s):  
Early Development ◽  
Hepatic Necrosis ◽  
Screening Tests ◽  
Dense Matrix ◽  
Sprague Dawley ◽  
Electron Microscopic ◽  
Drug Induced ◽  
Hepatocellular Damage ◽  
Sprague Dawley Rats ◽  
Microscopic Studies

This study represents the first in a series of investigations carried out to elucidate the mechanism(s) of early hepatocellular damage induced by drugs and other related compounds. During screening tests of CNS-active compounds in rats, it has been found that daily oral administration of one of these compounds at a dose level of 40 mg. per kg. of body weight induced diffuse massive hepatic necrosis within 7 weeks in Charles River Sprague Dawley rats of both sexes. Partial hepatectomy enhanced the development of this peculiar type of necrosis (3 weeks instead of 7) while treatment with phenobarbital prior to the administration of the drug delayed the appearance of necrosis but did not reduce its severity.Electron microscopic studies revealed that early development of this liver injury (2 days after the administration of the drug) appeared in the form of small dark osmiophilic vesicles located around the bile canaliculi of all hepatocytes (Fig. 1). These structures differed from the regular microbodies or the pericanalicular multivesicular bodies. They first appeared regularly rounded with electron dense matrix bound with a single membrane. After one week on the drug, these vesicles appeared vacuolated and resembled autophagosomes which soon developed whorls of concentric lamellae or cisterns characteristic of lysosomes (Fig. 2). These lysosomes were found, later on, scattered all over the hepatocytes.

The early development of antenna and antennal sensilla in the noctuid moth, Agrotis segetum (Insecta: Lepidoptera)

1990 ◽  
Vol 48 (3) ◽  
pp. 502-503
Author(s):  
Eric Hallberg ◽  
Lina Hansén
Keyword(s):  
Cell Death ◽  
Stem Cell ◽  
Early Development ◽  
Larval Stage ◽  
Pupal Stage ◽  
Agrotis Segetum ◽  
Antennal Sensilla ◽  
Noctuid Moth ◽  
Standard Procedures

The antennal rudiments in lepidopterous insects are present as disks during the larval stage. The tubular double-walled antennal disk is present beneath the larval antenna, and its inner layer gives rise to the adult antenna during the pupal stage. The sensilla develop from a cluster of cells that are derived from one stem cell, which gives rise to both sensory and enveloping cells. During the morphogenesis of the sensillum these cells undergo major transformations, including cell death. In the moth Agrotis segetum the pupal stage lasts about 14 days (temperature, 25°C). The antennae, clearly seen from the exterior, were dissected and fixed according to standard procedures (3 % glutaraldehyde in 0.15 M cacaodylate buffer, followed by 1 % osmiumtetroxide in the same buffer). Pupae from day 1 to day 8, of both sexes were studied.

Live Confocal Analysis of Fertilization and Early Development

2001 ◽  
Vol 7 (S2) ◽  
pp. 1012-1013
Author(s):  
Uyen Tram ◽  
William Sullivan
Keyword(s):  
Drosophila Melanogaster ◽  
Embryonic Development ◽  
Real Time ◽  
Early Development ◽  
Fluorescent Probes ◽  
Primary Defect ◽  
Fluorescent Analysis ◽  
Dynamic Event ◽  
Enormous Amount ◽  
Fluorescent Studies

Embryonic development is a dynamic event and is best studied in live animals in real time. Much of our knowledge of the early events of embryogenesis, however, comes from immunofluourescent analysis of fixed embryos. While these studies provide an enormous amount of information about the organization of different structures during development, they can give only a static glimpse of a very dynamic event. More recently real-time fluorescent studies of living embryos have become much more routine and have given new insights to how different structures and organelles (chromosomes, centrosomes, cytoskeleton, etc.) are coordinately regulated. This is in large part due to the development of commercially available fluorescent probes, GFP technology, and newly developed sensitive fluorescent microscopes. For example, live confocal fluorescent analysis proved essential in determining the primary defect in mutations that disrupt early nuclear divisions in Drosophila melanogaster. For organisms in which GPF transgenics is not available, fluorescent probes that label DNA, microtubules, and actin are available for microinjection.

Nuclear receptors in disease: the oestrogen receptors

2004 ◽  
Vol 40 ◽  
pp. 157-167 ◽  
Author(s):  
Maria Nilsson ◽  
Karin Dahlman-Wright ◽  
Jan-Åke Gustafsson
Keyword(s):  
Nuclear Receptors ◽  
Target Genes ◽  
Receptor Subtype ◽  
Target Tissue ◽  
Oestrogen Receptors ◽  
Nucleotide Polymorphisms ◽  
Cell Type ◽  
Single Nucleotide ◽  
Beneficial Effects ◽  
The Family

For several decades, it has been known that oestrogens are essential for human health. The discovery that there are two oestrogen receptors (ERs), ERalpha and ERbeta, has facilitated our understanding of how the hormone exerts its physiological effects. The ERs belong to the family of ligand-activated nuclear receptors, which act by modulating the expression of target genes. Studies of ER-knockout (ERKO) mice have been instrumental in defining the relevance of a given receptor subtype in a certain tissue. Phenotypes displayed by ERKO mice suggest diseases in which dysfunctional ERs might be involved in aetiology and pathology. Association between single-nucleotide polymorphisms (SNPs) in ER genes and disease have been demonstrated in several cases. Selective ER modulators (SERMs), which are selective with regard to their effects in a certain cell type, already exist. Since oestrogen has effects in many tissues, the goal with a SERM is to provide beneficial effects in one target tissue while avoiding side effects in others. Refined SERMs will, in the future, provide improved therapeutic strategies for existing and novel indications.

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