scholarly journals Seven-month kinetics of SARS-CoV-2 antibodies and role of pre-existing antibodies to human coronaviruses

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Natalia Ortega ◽  
Marta Ribes ◽  
Marta Vidal ◽  
Rocío Rubio ◽  
Ruth Aguilar ◽  
...  
Keyword(s):  
Individual Characteristics ◽  
Neutralization Capacity ◽  
Care Workers ◽  
Neutralizing Capacity ◽  
Human Coronaviruses ◽  
The Individual ◽  
Antibody Levels ◽  
The Impact ◽  
Kinetics Of ◽  
Over Time

AbstractUnraveling the long-term kinetics of antibodies to SARS-CoV-2 and the individual characteristics influencing it, including the impact of pre-existing antibodies to human coronaviruses causing common cold (HCoVs), is essential to understand protective immunity to COVID-19 and devise effective surveillance strategies. IgM, IgA and IgG levels against six SARS-CoV-2 antigens and the nucleocapsid antigen of the four HCoV (229E, NL63, OC43 and HKU1) were quantified by Luminex, and antibody neutralization capacity was assessed by flow cytometry, in a cohort of health care workers followed up to 7 months (N = 578). Seroprevalence increases over time from 13.5% (month 0) and 15.6% (month 1) to 16.4% (month 6). Levels of antibodies, including those with neutralizing capacity, are stable over time, except IgG to nucleocapsid antigen and IgM levels that wane. After the peak response, anti-spike antibody levels increase from ~150 days post-symptom onset in all individuals (73% for IgG), in the absence of any evidence of re-exposure. IgG and IgA to HCoV are significantly higher in asymptomatic than symptomatic seropositive individuals. Thus, pre-existing cross-reactive HCoVs antibodies could have a protective effect against SARS-CoV-2 infection and COVID-19 disease.

scholarly journals Seven-month kinetics of SARS-CoV-2 antibodies and protective role of pre-existing antibodies to seasonal human coronaviruses on COVID-19

2021 ◽  
Author(s):  
Natalia Ortega ◽  
Marta Ribes ◽  
Marta Vidal ◽  
Rocío Rubio ◽  
Ruth Aguilar ◽  
...  
Keyword(s):  
Protective Role ◽  
Neutralization Capacity ◽  
Care Workers ◽  
Neutralizing Capacity ◽  
Human Coronaviruses ◽  
Antibody Levels ◽  
The Impact ◽  
Kinetics Of ◽  
Over Time

AbstractUnraveling the long-term kinetics of antibodies to SARS-CoV-2 and its determinants, including the impact of pre-existing antibodies to human coronaviruses causing common cold (HCoVs), is essential to understand protective immunity to COVID-19 and devise effective surveillance strategies. IgM, IgA and IgG levels against six SARS-CoV-2 and four HCoV antigens were quantified by Luminex, and antibody neutralization capacity was assessed by flow cytometry, in a cohort of health care workers followed-up for 6 months. Seroprevalence increased over time from 13.5% (month 0) and 15.6% (month 1) to 16.4% (month 6). Levels of antibodies, including those with neutralizing capacity, were stable over time, except IgG to nucleocapsid antigen and IgM levels that waned. After the peak response, anti-spike antibody levels increased from ∼150 days post-symptom onset in all individuals (73% for IgG), in the absence of any evidence of re-exposure. Pre-existing antibodies to alpha-HCoV were lower in individuals who subsequently seroconverted for SARS-CoV-2. IgG and IgA to HCoV were significantly higher in asymptomatic than symptomatic seropositive individuals. Thus, pre-existing cross-reactive HCoVs antibodies could have a protective effect against SARS-CoV-2 infection and COVID-19 disease.

scholarly journals Determinants of early antibody responses to COVID-19 mRNA vaccines in exposed and naive healthcare workers

2021 ◽  
Author(s):  
Gemma Moncunill ◽  
Ruth Aguilar ◽  
Marta Ribes ◽  
Natalia Ortega ◽  
Rocío Rubio ◽  
...  
Keyword(s):  
Health Care Workers ◽  
Healthcare Workers ◽  
Healthy Individuals ◽  
Wild Type ◽  
Post Vaccination ◽  
Neutralization Capacity ◽  
Care Workers ◽  
Neutralizing Capacity ◽  
One Year ◽  
Antibody Levels

Background Two doses of mRNA vaccination have shown >94% efficacy at preventing COVID-19 mostly in naive adults, but it is not clear if the second dose is needed to maximize effectiveness in those previously exposed to SARS-CoV-2 and what other factors affect responsiveness. Methods We measured IgA, IgG and IgM levels against SARS-CoV-2 spike (S) and nucleocapsid (N) antigens from the wild-type and S from the Alpha, Beta and Gamma variants of concern, after BNT162b2 (Pfizer/BioNTech) or mRNA-1273 (Moderna) vaccination in a cohort of health care workers (N=578). Neutralizing capacity and antibody avidity were evaluated. Data were analyzed in relation to COVID-19 history, comorbidities, vaccine doses, brand and adverse events. Findings Vaccination induced robust IgA and IgG levels against all S antigens. Neutralization capacity and S IgA and IgG levels were higher in mRNA-1273 vaccinees, previously SARS-CoV-2 exposed, particularly if symptomatic, and in those experiencing systemic adverse effects. A second dose in pre-exposed did not increase antibody levels. Smoking and comorbidities were associated with lower neutralization and antibody levels. Among fully vaccinated, 6.3% breakthroughs were detected up to 189 days post-vaccination. Among pre-exposed non-vaccinated, 90% were IgG seropositive more than 300 days post-infection. Interpretation Our data support administering a single-dose in pre-exposed healthy individuals. However, heterogeneity of responses suggests that personalized recommendations may be necessary depending on COVID-19 history and life-style. Higher mRNA-1273 immunogenicity would be beneficial for those expected to respond worse to vaccination. Persistence of antibody levels in pre-exposed unvaccinated indicates maintenance of immunity up to one year.

scholarly journals kinetics of anti-SARS-CoV-2 antibodies over time. Results of 10 month follow up in over 300 seropositive Health Care Workers

2021 ◽  
Author(s):  
Jose Felipe Varona ◽  
Rodrigo Madurga ◽  
Francisco Peñalver ◽  
Elena Abarca ◽  
Cristina Almirall ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Care Workers ◽  
Kinetics Of ◽  
Over Time

Occupy in Ireland: Impacts on activists and subsequent protest

2017 ◽  
Vol 25 (3) ◽  
pp. 250-273
Author(s):  
Anna Szolucha
Keyword(s):  
Empirical Analysis ◽  
Empirical Processes ◽  
Change Over Time ◽  
The Individual ◽  
The Impact ◽  
Over Time

I explore the impact that Occupy in Ireland had on subsequent campaigns and the lives of some of its core activists and analyse the interpretative processes through which they evaluated and modified the lessons and tactics of the protest. The picture that emerges from this empirical analysis is inherently complex and transient. It shows how the symbolic associations and framing of the encampments evolved and stalled the diffusion of their most recognisable practices and tactics such as assemblies. This observation highlights the importance of studying the empirical processes that explain how the interpretations of movements change over time, influencing the potential for the diffusion of tactics from one movement to another. Additionally, movement–movement influence may be constructed subjectively and hence, the individual engagement trajectories of activists can inform the analysis of how past protest influences future campaigns. Even though the practices and tactics that were most characteristic of the movement did not diffuse to subsequent protests, the analysis of the impacts of Occupy in Ireland suggests that the encampments functioned as a space for political training and experimentation which may have durable effects for future protest as well as its participants long after they left Occupy.

scholarly journals The impact of civil status on womencs wages in Brazil

2012 ◽  
Vol 42 (3) ◽  
pp. 457-487 ◽  
Author(s):  
Regina Madalozzo ◽  
Carolina Flores Gomes
Keyword(s):  
Marital Status ◽  
Single Women ◽  
Individual Characteristics ◽  
Consensual Union ◽  
Women's Wages ◽  
Civil Status ◽  
Using Data ◽  
The Individual ◽  
The Impact

Consensual union, also known as cohabitation, has become more frequent in recent decades in Brazil and many other countries. In this context, some studies have analyzed the impact of marriage on women's wages. This article analyzes the effects of marital status on Brazilian women's wages by specifically investigating the individual characteristics of these effects using data from the 2000 Brazilian Census Database. This study concludes that wages differ by up to 15 per cent between married and single women and up to 3 per cent between married and cohabiting women.

Measurement survey using acoustic measurement network and sound environment evaluation system by experience sampling

2021 ◽  
Vol 263 (1) ◽  
pp. 5063-5070
Author(s):  
Kengo Togashi ◽  
Akiko Sugahara ◽  
Yasuhiro Nagasawa ◽  
Yasuhiro Hiraguri ◽  
Kazunori Harada ◽  
...  
Keyword(s):  
Evaluation System ◽  
Experience Sampling ◽  
Individual Characteristics ◽  
Working Environment ◽  
Sound Environment ◽  
Open Plan ◽  
Trial Basis ◽  
The Individual ◽  
Intellectual Productivity ◽  
The Impact

The use of open-plan offices is increasing as they are effective in improving intellectual productivity by fostering a communication among workers. Previous research on the relationship between the indoor sound environment and intellectual productivity has mostly reported the impact of the sound environment on the tasks that individuals work on. However, there has been no research on the impact of sound environment on office spaces where multiple workers are actually working. In this study, we developed a system that can analyze the individual characteristics of workers in relation to the sound environment by simultaneously measuring their evaluation to the sound environment and the sound environment of the office. The system collected workers' evaluation of their impressions to the sound environment through a regular questionnaire using the experience sampling method. At the same time, it measured the sound environment of the office with multiple small measurement devices. The obtained sound environment evaluation data and the acoustic data of the office were stored in a single database. Finally, this system was run in a working environment to evaluate the sound environment on a trial basis.

scholarly journals QOLP-03. MEASURING CHANGE IN HEALTH-RELATED QUALITY OF LIFE: THE ADDED VALUE OF ANALYSIS ON THE INDIVIDUAL PATIENT LEVEL IN GLIOMA PATIENTS IN CLINICAL DECISION MAKING

2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi197-vi198 ◽  
Author(s):  
Marijke Coomans ◽  
Martin Taphoorn ◽  
Neil Aaronson ◽  
Brigitta Baumert ◽  
Martin van den Bent ◽  
...  
Keyword(s):  
Decision Making ◽  
Clinical Decision Making ◽  
Clinical Decision ◽  
Scale Item ◽  
Individual Patient Level ◽  
Patient Level ◽  
Related Quality ◽  
The Individual ◽  
The Impact ◽  
Over Time

Abstract BACKGROUND: Health-related quality of life (HRQoL) is an important outcome in glioma research, reflecting the impact of disease and treatment on a patient’s functioning and wellbeing. Data on changes in HRQoL scores provide important information for clinical decision-making, but different analytical methods may lead to different interpretations of the impact of treatment on HRQoL. This study aimed to study whether different methods to evaluate change in HRQoL result in different interpretations. Methods: HRQoL and sociodemographical/clinical data from 15 randomized clinical trials were combined. Change in HRQoL scores was analyzed: (1)at the group level, comparing mean changes in scale/item scores between treatment arms over time, (2)at the patient level per scale/item by calculating the percentage of patients that deteriorated, improved or remained stable on a scale/item per scale/item, and (3)at the individual patient level combining all scales/items. Results: Data were available for 3727 patients. At the group scale/item level (method 1), only the item ‘hair loss’ showed a significant and clinically relevant change (i.e. ≥10 points) over time, whereas change scores on the other scales/items showed a statistically significant change only (all p< .001, range in change score:0.1–6.2). Analyses on the patient level per scale (method 2) indicated that, while a large proportion of patients had stable HRQoL over time (range:27–84%), many patients deteriorated (range:6–43%) or improved (range:8–32%) on a specific scale/item. At the individual patient level (method 3), the majority of patients (86%) showed both deterioration and improvement, while only 1% of the patients remained stable on all scales. Conclusion: Different analytical methods of changes in HRQoL result in distinct interpretations of treatment effects, all of which may be relevant for clinical decision-making. Additional information about the joint impact of treatment on all outcomes may help patients and physicians to make the best treatment decision.

scholarly journals The Multiple Sclerosis Severity Score: fluctuations and prognostic ability in a longitudinal cohort of patients with MS

2019 ◽  
Vol 5 (1) ◽  
pp. 205521731983725 ◽  
Author(s):  
RH Gross ◽  
SH Sillau ◽  
AE Miller ◽  
C Farrell ◽  
SC Krieger
Keyword(s):  
Multiple Sclerosis ◽  
Severity Score ◽  
Mixed Model ◽  
Linear Models ◽  
Longitudinal Cohort ◽  
Kaplan Meier ◽  
The Individual ◽  
Survival Plot ◽  
The Impact ◽  
Over Time

Background The Multiple Sclerosis Severity Score (MSSS), combining the Expanded Disability Status Scale (EDSS) and disease duration, attempts to stratify multiple sclerosis (MS) patients based on their rate of progression. Its prognostic ability in the individual patient remains unproven. Objectives To assess the stability of MSSS within individual persons with MS in a longitudinal cohort, to evaluate whether certain factors influence MSSS variability, and to explore the ability of MSSS to predict future ambulatory function. Methods A single-center retrospective review was performed of patients following a single provider for at least 8 years. Mixed model regression modeled MSSS over time. A Kaplan–Meier survival plot was fitted, using change of baseline MSSS by at least one decile as the event. Cox modeling assessed the influence of baseline clinical and demographic factors on the hazard of changing MSSS by at least one decile. Linear models evaluated the impact of baseline EDSS, baseline MSSS, and other factors on the Timed 25-Foot Walk (T25FW). Results Out of 122 patients, 68 (55.7%) deviated from baseline MSSS by at least one decile. Final T25FW had slightly weaker correlation to baseline MSSS than to baseline EDSS, which was moderately strongly correlated with future log T25FW. Conclusion Individual MSSS scores often vary over time. Clinicians should exercise caution when using MSSS to prognosticate.

scholarly journals Impact of heated waters on water quality and macroinvertebrate community in the Narew River (Poland)

2017 ◽  
Vol 12 (1) ◽  
pp. 190-199 ◽  
Author(s):  
Elzbieta Krolak ◽  
Krzysztof Lewandowski ◽  
Zbigniew Kasprzykowski
Keyword(s):  
Diversity Index ◽  
Individual Characteristics ◽  
Macroinvertebrate Community ◽  
Water Parameters ◽  
Power Stations ◽  
Wiener Diversity Index ◽  
The Individual ◽  
The Impact ◽  
Dikerogammarus Haemobaphes ◽  
Sinanodonta Woodiana

AbstractThe effect of heated waters from coal-burning power stations on the water parameters and the occurrence of macroinvertebrates depends on the individual characteristics of the river to which the heated waters are discharged. The objective of the study was to assess the impact of heated water from the Ostrołęka Power Station on selected water properties and the macroinvertebrate community in the Narew River. Samples were collected in years: 2013-2016 along two river stretches: upstream and downstream of the canal. The water temperature was higher and the oxygen concentrations were lower at the downstream sites compared to the upstream sites of the canal. The values of conductivity, concentrations of nitrates, phosphates, chlorides and calcium were similar at the sampling sites. A total of 33 families of macrozoobenthos were found. The numbers of families were positively correlated with the temperature and conductivity and negatively correlated with oxygen. The heated waters were found to have no effect on the Shannon-Wiener diversity index. The inflow of heated waters increased the percentage of Gammaridae, represented by species Dikerogammarus haemobaphes (Eichwald, 1841) and decreased the percentage of Chironomidae. The presence of the thermophilous bivalve Sinanodonta woodiana (Lea, 1934) was noted downstream of the canal.

scholarly journals The course and predictors of perceived unsupportive responses by family and friends among women newly diagnosed with gynecological cancers

2018 ◽  
Vol 9 (4) ◽  
pp. 682-692 ◽  
Author(s):  
Sharon L Manne ◽  
Deborah A Kashy ◽  
David W Kissane ◽  
Melissa Ozga ◽  
Shannon Myers Virtue ◽  
...  
Keyword(s):  
Usual Care ◽  
Growth Models ◽  
Gynecologic Cancer ◽  
Psychological Adaptation ◽  
Individual Characteristics ◽  
Systematic Change ◽  
Related Factors ◽  
Counseling Intervention ◽  
The Individual ◽  
Over Time

Abstract Perceived unsupportive responses from close others play an important role in psychological adaptation of patients with cancer. Little is known about whether these negative responses change after someone experiences a serious life event, and even less is known about the individual characteristics and related factors that might contribute to both the levels of and changes in perceived unsupportive responses over the course of adaptation to an experience. This longitudinal study aimed to evaluate changes in perceived unsupportive behavior from family and friends among women newly with gynecologic cancer as well as initial demographic, disease, and psychological factors that predict the course of perceived unsupportive behavior over time. Women (N = 125) assigned to the usual care arm of a randomized clinical trial comparing a coping and communication intervention with a supportive counseling intervention to usual care completed six surveys over an 18 month period. Growth models using multilevel modeling were used to predict unsupportive responses over time. Average levels of perceived unsupportive responses from family and friends were low. Unsupportive responses varied from patient to patient, but patients did not report a systematic change in perceived unsupportive responses over time. Cultivating meaning and peace and coping efficacy were associated with fewer perceived unsupportive responses as well as reductions in perceived unsupportive responses over time. Emotional distress, cancer concerns, functional impairment, holding back sharing concerns, and cognitive and behavioral avoidance predicted higher perceived unsupportive responses over time. The findings are discussed in terms of the self-presentation theory and social network responses to persons undergoing difficult life events.

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