Structural Brain Correlates of Loneliness among Older Adults

Abstract Ample evidence indicates that loneliness in old age is associated with poor bodily and mental health. However, little is known about structural cerebral correlates of loneliness in healthy older adults. We examined such correlates in a magnetic resonance imaging (MRI) subsample of 319 older adults aged 61 to 82 years drawn from the Berlin Aging Study II. Using voxel-based morphometry (VBM) and structural equation modeling (SEM), latent hierarchical regression analyses were performed to examine associations of (i) loneliness, (ii) a range of covariates, and (iii) loneliness by covariate interactions with latent brain volume estimates of brain structures known to be involved in processing, expressing, and regulating emotions. Results from whole-brain VBM analyses showed that individuals with higher loneliness scores tended to have smaller gray matter volumes in three clusters comprising (i) the left amygdala/anterior hippocampus, (ii) the left posterior parahippocampus and (iii) the left cerebellum. Significant associations and interactions between loneliness and latent factors for the amygdala and the hippocampus were confirmed with a region-of-interest (ROI)-based approach. These findings suggest that individual differences in loneliness among older adults are correlated with individual differences in the volumes of brain regions that are central to cognitive processing and emotional regulation, also after correcting for confounders such as social network size. We discuss possible mechanisms underlying these associations and their implications.

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Neuroimaging of Individual Differences: A Latent Variable Modeling Perspective

10.31234/osf.io/jryfm ◽

2018 ◽

Author(s):

Shelly Renee Cooper ◽

Joshua James Jackson ◽

Deanna Barch ◽

Todd Samuel Braver

Keyword(s):

Individual Differences ◽

Individual Difference ◽

Latent Variable ◽

Structural Equation ◽

Behavioral Measure ◽

Equation Modeling ◽

Latent Variable Modeling ◽

Psychometric Theory ◽

Human Connectome Project ◽

Neuroimaging Data

Neuroimaging data is being increasingly utilized to address questions of individual difference. When examined with task-related fMRI (t-fMRI), individual differences are typically investigated via correlations between the BOLD activation signal at every voxel and a particular behavioral measure. This can be problematic because: 1) correlational designs require evaluation of t-fMRI psychometric properties, yet these are not well understood; and 2) bivariate correlations are severely limited in modeling the complexities of brain-behavior relationships. Analytic tools from psychometric theory such as latent variable modeling (e.g., structural equation modeling) can help simultaneously address both concerns. This review explores the advantages gained from integrating psychometric theory and methods with cognitive neuroscience for the assessment and interpretation of individual differences. The first section provides background on classic and modern psychometric theories and analytics. The second section details current approaches to t-fMRI individual difference analyses and their psychometric limitations. The last section uses data from the Human Connectome Project to provide illustrative examples of how t-fMRI individual differences research can benefit by utilizing latent variable models.

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The Affiliative Role of Empathy in Everyday Interpersonal Interactions

10.31234/osf.io/whc43 ◽

2019 ◽

Author(s):

Whitney R. Ringwald ◽

Aidan G.C. Wright

Keyword(s):

Individual Differences ◽

Structural Equation ◽

Community Sample ◽

Empirical Support ◽

Interpersonal Behavior ◽

Equation Modeling ◽

Experimental Conditions ◽

Student Sample ◽

Ecological Momentary

Empathy theoretically serves an affiliative interpersonal function by satisfying motives for intimacy and union with others. Accordingly, empathy is expected to vary depending on the situation. Inconsistent empirical support for empathy’s affiliative role may be due to methodology focused on individual differences in empathy or differences between controlled experimental conditions, which fail to capture its dynamic and interpersonal nature. To address these shortcomings, we used ecological momentary assessment to establish typical patterns of empathy across everyday interactions. Associations among empathy, affect, and interpersonal behavior of self and interaction partner were examined in a student sample (N=330), then replicated in a pre-registered community sample (N=279). Multi-level structural equation modeling was used to distinguish individual differences in empathy from interaction-level effects. Results show people are more empathetic during positively-valanced interactions with others perceived as warm and when expressing warmth. By confirming the typically affiliative role of empathy, existing research to the contrary can be best understood as exceptions to the norm.

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Dynamics of Multimorbidity Resilience and Health Outcomes Over Time in Community-Residing Older Adults

Innovation in Aging ◽

10.1093/geroni/igaa057.3285 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

pp. 890-891

Author(s):

Yingzhi Xu ◽

Zahra Rahmaty ◽

Eleanor McConnell ◽

Tingzhong (Michelle) Xue ◽

Bada Kang ◽

...

Keyword(s):

Older Adults ◽

Health Outcomes ◽

Physical Health ◽

Social Life ◽

Structural Equation ◽

Equation Modeling ◽

Psychological Resilience ◽

Pain Level ◽

Reciprocal Relationships ◽

Over Time

Abstract Multimorbidity resilience may mitigate the adverse effects of multiple chronic diseases on older adults’ health. Wister et al.’s (2018) multimorbidity resilience index was developed and tested in a cross-sectional sample of older adults in Canada. Building on these findings, we examined the reciprocal relationships of resilience on outcomes to test these potentially mitigating effects in a community-based, U.S. sample of older adults over time. The study sample includes 1,054 older adults from waves 2 and 3 of the National Social Life, Health, and Aging Project (NSHAP) study (Waite et al 2020). Wister et al.’s (2018) index was mapped to NSHAP measures, and reciprocal relationships of multimorbidity resilience and health outcomes over a 5-year period was tested using structural equation modeling (SEM). Results indicated significant effects of multimorbidity resilience on self-rated physical health and pain. Interestingly, a better functional resilience at baseline conferred better self-rated physical health at follow-up, while better psychological resilience predicted lower pain level. By contrast, the influence of health outcomes on any domain of multimorbidity resilience was not detectable at all, supporting the direction of these associations from resilience to outcomes. The study systematically investigated the dynamic hypotheses between multimorbidity resilience and health outcomes. That is, whether they are determinants or consequences, or both. Our findings suggest multimorbidity resilience predicts subsequent 5-year change in health outcomes, especially self-rated physical health and pain level, but not vice versa, strengthening the evidence of the importance of resilience in the health of older adults.

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Family Solidarity, Social Support, Loneliness, and Well-Being Among Older Adults in Rural China

Innovation in Aging ◽

10.1093/geroni/igaa057.1023 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

pp. 319-320

Author(s):

Xiaoyan Zhang ◽

Merril Silverstein

Keyword(s):

Older Adults ◽

Life Satisfaction ◽

Adult Children ◽

Child Support ◽

Structural Equation ◽

Total Population ◽

Well Being ◽

Equation Modeling ◽

National Bureau ◽

Subjective Well Being

Abstract China is experiencing a large increase in elderly population. In 2019, China’s population aged 60 and above had reached 253 million, accounting for 18.1% of the total population (National Bureau of Statistics of China, 2020). By 2050, the number of adults aged 60+ would be up to 430 million, reaching one third of the total population (Du, Zhai & Chen, 2005). Considering such a rapid aging process and the existing large number of older adults in China, it becomes imperative to investigate how psychosocial factors affect this group’s subjective well-being. This study proposed that, among older adults, higher support received from each of the three relational sources (adult children, family and friends) were associated with reduced loneliness and improved well-being. Structural equation modeling was conducted using a sample of rural adults aged 60 and older (N= 1142) from the 2018 wave of data from the Longitudinal Study of Older Adults in Anhui Province, China. Findings indicated that support from adult children directly and indirectly decreased older adults’ depression and improved their life satisfaction through loneliness; while support from family members directly decreased depression but did not directly improve life satisfaction or indirectly improve well-being through loneliness. Although support from friends did not have a significant impact on older adults’ well-being, it indirectly improved well-being through reduced loneliness. Findings have implications for programs or interventions targeting both parent -adult-child support and friends support and reducing rural older adults’ loneliness.

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APOE ɛ4 Allele Moderates the Association Between Basal Forebrain Nuclei Volumes and Allocentric Navigation in Older Adults Without Dementia

Journal of Alzheimer s Disease ◽

10.3233/jad-215034 ◽

2022 ◽

pp. 1-17

Author(s):

Ondrej Lerch ◽

Martina Pařízková ◽

Martin Vyhnálek ◽

Zuzana Nedelská ◽

Jakub Hort ◽

...

Keyword(s):

Older Adults ◽

Basal Forebrain ◽

Medial Temporal Lobe ◽

Structural Equation ◽

Brain Aging ◽

Late Onset ◽

Brain Regions ◽

Real Space ◽

Complex Model ◽

E4 Allele

Background: Cholinergic deficit and medial temporal lobe (MTL) atrophy are hallmarks of Alzheimer’s disease (AD) leading to early allocentric spatial navigation (aSN) impairment. APOE ɛ4 allele (E4) is a major genetic risk factor for late-onset AD and contributes to cholinergic dysfunction. Basal forebrain (BF) nuclei, the major source of acetylcholine, project into multiple brain regions and, along with MTL and prefrontal cortex (PFC), are involved in aSN processing. Objective: We aimed to determine different contributions of individual BF nuclei atrophy to aSN in E4 positive and E4 negative older adults without dementia and assess whether they operate on aSN through MTL and PFC or independently from these structures. Methods: 120 participants (60 E4 positive, 60 E4 negative) from the Czech Brain Aging Study underwent structural MRI and aSN testing in real-space arena setting. Hippocampal and BF nuclei volumes and entorhinal cortex and PFC thickness were obtained. Associations between brain regions involved in aSN were assessed using MANOVA and complex model of mutual relationships was built using structural equation modelling (SEM). Results: Path analysis based on SEM modeling revealed that BF Ch1-2, Ch4p, and Ch4ai nuclei volumes were indirectly associated with aSN performance through MTL (pch1 - 2 = 0.039; pch4p = 0.042) and PFC (pch4ai = 0.044). In the E4 negative group, aSN was indirectly associated with Ch1-2 nuclei volumes (p = 0.015), while in the E4 positive group, there was indirect effect of Ch4p nucleus (p = 0.035). Conclusion: Our findings suggest that in older adults without dementia, BF nuclei affect aSN processing indirectly, through MTL and PFC, and that APOE E4 moderates these associations.

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Multiple Linear Regression-Structural Equation Modeling Based Development of the Integrated Model of Perceived Neighborhood Environment and Quality of Life of Community-Dwelling Older Adults: A Cross-Sectional Study in Nanjing, China

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph16244933 ◽

2019 ◽

Vol 16 (24) ◽

pp. 4933 ◽

Cited By ~ 1

Author(s):

Fan Zhang ◽

Dezhi Li

Keyword(s):

Quality Of Life ◽

Older Adults ◽

Structural Equation ◽

Daily Life ◽

Community Dwelling ◽

Neighborhood Environment ◽

Equation Modeling ◽

Community Dwelling Older Adults ◽

Perceived Neighborhood Environment

Due to the poor functioning in daily living activities, community-dwelling older adults spend more time in their neighborhood environment. The perceived neighborhood environment is crucial to their quality of life (QoL). To explore the complex influences of perceived neighborhood environment on QoL, a questionnaire was designed to measure their perception of each factor of neighborhood environment and each domain of QoL. Based on collected data, the reliability test was applied to revise the questionnaire. Multiple linear regression (MLR) and structural equation modeling (SEM) were adopted to hypothesize and test the integrated model for community-dwelling older adults. The results show that community-dwelling older adults’ perceptions of neighbor support, facilities related to physical exercise and recreation, and accessibility to facilities impact their overall QoL with diverse coefficients of 0.437, 0.312, and 0.295, respectively; neighbor support (0.207) on physical health; sidewalk condition (0.134), natural environment (0.260), and facilities related to daily life (0.165) on psychological health; and neighbor support (0.298), facilities related to daily life (0.206), and design-related safety (0.225) on social relationship. This revealed that perceptions of neighborhood environment have diverse impacts on their QoL. This study can provide targeted retrofit strategies for communities to enhance QoL of community-dwelling older adults efficiently.

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Older Adults in Rural Appalachia

The International Journal of Aging and Human Development ◽

10.1177/0091415017720891 ◽

2017 ◽

Vol 86 (4) ◽

pp. 364-381 ◽

Cited By ~ 3

Author(s):

Raven H. Weaver ◽

Karen A. Roberto ◽

Rosemary Blieszner

Keyword(s):

Older Adults ◽

Mixed Method ◽

Structural Equation ◽

Community Services ◽

Equation Modeling ◽

Care Needs ◽

Formal Services ◽

Future Care ◽

Rural Appalachia ◽

Informal Help

Little is known about how rural-dwelling older adults anticipate and plan for future care needs. Using a mixed-method explanatory design, structural equation modeling ( n = 535) revealed significant associations between concerns about using services on preference for type of help; preference was associated with likelihood of using future services. Content analysis of interview data from 19 older adults who needed but were not receiving help revealed how they conceptualize their need for assistance and anticipated future care arrangements. Nine older adults were not thinking about future care needs. While most older adults articulated preferences for informal help, they indicated some openness to formal assistance. Preferences did not always align with expectations for the future. Rather, concerns about burdening family and friends outweighed concerns about community services and influenced expectations of using formal services. Understanding rural older adults’ expectations for future care arrangements is necessary for advancing policy and implementing successful services options.

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Age as a Predictor of Burnout in Russian Public Librarians

Evidence Based Library and Information Practice ◽

10.18438/eblip29753 ◽

2020 ◽

Vol 15 (4) ◽

pp. 33-48

Author(s):

Nikita Kolachev ◽

Igor Novikov

Keyword(s):

Cognitive Control ◽

Older Workers ◽

Emotional Regulation ◽

Structural Equation ◽

Online Survey ◽

Assessment Tool ◽

Moscow Region ◽

Equation Modeling ◽

Emotional Control ◽

Public Librarians

Objective – Increasing life expectancy leads to an increase in the mean age of the workforce. The aging workforce implies new challenges for management and human resources. Existing findings on relations between age and burnout are controversial and scarce. Also, the problem of burnout amongst library workers in Russia has received little attention from researchers. Methods – The studied sample consisted of 620 public librarians from 166 public libraries of different regions (the Moscow region, Yaroslavl, Chelyabinsk, Novosibirsk, Astrakhan, and Republic of Buryatia) of the Russian Federation, who completed a self-reported online survey. For measuring burnout, a new Burnout Assessment Tool was implemented. To examine the associations of interest, we used structural equation modeling with a group correction approach. In addition, library location, general self-efficacy, and length of employment at the current workplace were utilized as predictors. All statistical analysis was performed in R. Results – Findings confirmed the hypotheses partially and revealed negative links between exhaustion, mental distance, and cognitive control and age, while reduced emotional control did not relate to age. Urban librarians tended to demonstrate higher levels of mental distance and had more significant problems with emotional regulation than their rural counterparts. Also, the non-Moscow region librarians did not demonstrate correlations between age and reduced cognitive control. Moreover, they showed a positive link between age and reduced emotional control. Conclusion – The current paper confirmed some previous results on the negative relations between burnout symptoms and chronological age. The results suggest the existence of higher risks of burnout for younger library workers. Potential mechanisms underlying the resilience of older workers are discussed.

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Using structural equation modeling in the understanding of functional disability in older adults

Revista Latino-Americana de Enfermagem ◽

10.1590/1518-8345.4555.3451 ◽

2021 ◽

Vol 29 ◽

Author(s):

Darlene Mara dos Santos Tavares ◽

Nayara Gomes Nunes Oliveira ◽

Flavia Aparecida Dias Marmo ◽

Joilson Meneguci

Keyword(s):

Older Adults ◽

Sedentary Behavior ◽

Structural Equation ◽

Functional Disability ◽

Depressive Symptomatology ◽

Age Groups ◽

Community Dwelling ◽

Likelihood Method ◽

Equation Modeling ◽

Cross Sectional

Objective: to analyze functional disability and its associated factors among community-dwelling older adults. Method: a cross-sectional study, conducted with 1,635 older adults distributed in the following age groups: 60 to 69, 70 to 79, and 80 years old or more, living in a health macro-region of the state of Minas Gerais. Descriptive and trajectory analysis was carried out (p<0.05). The parameters were estimated by the Maximum Likelihood method. Results: the highest percentage was female, with a monthly income of 1 minimum wage and living with a companion. In the age groups from 60 to 69 and from 70 to 79 years old, older adults with a partner predominated; and, among those aged 80 years old or more, widowed individuals prevailed. In the three groups, functional disability occurred hierarchically. Lower schooling, frailty and depressive symptomatology were factors directly associated with functional disability in the advanced activities; frailty and sedentary behavior were directly associated with functional disability in the instrumental activities. In the older adults aged between 60 and 69 years old and from 70 to 79 years old, sedentary behavior was associated with greater dependence on the basic activities. Conclusion: the expanded understanding of the factors in the functional disability of the older adults, according to age group, helps the health professional in the development of preventive measures for this disease.

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Longitudinal Relationships Between Subjective Cognitive Decline and Objective Memory: Depressive Symptoms Mediate Between-Person Associations

Journal of Alzheimer s Disease ◽

10.3233/jad-210230 ◽

2021 ◽

pp. 1-14

Author(s):

Nikki L. Hill ◽

Sakshi Bhargava ◽

Emily Bratlee-Whitaker ◽

Jennifer R. Turner ◽

Monique J. Brown ◽

...

Keyword(s):

Older Adults ◽

Depressive Symptoms ◽

Cognitive Decline ◽

Structural Equation ◽

Disease Risk ◽

Well Being ◽

Equation Modeling ◽

Subjective Cognitive Decline ◽

Future Research ◽

Over Time

Background: Subjective cognitive decline (SCD) may be an early indicator of cognitive impairment, but depressive symptoms can confound this relationship. Associations may be influenced by differences between individuals (i.e., between-persons) or how each individual changes in their experiences over time (i.e., within-persons). Objective: We examined depressive symptoms as a mediator of the between- and within-person associations of SCD and objective memory in older adults. Methods: Coordinated analyses were conducted across four datasets drawn from large longitudinal studies. Samples (range: n = 1,889 to n = 15,841) included participants 65 years of age or older with no dementia at baseline. We used multilevel structural equation modeling to examine the mediation of SCD and objective memory through depressive symptoms, as well as direct relationships among SCD, objective memory, and depressive symptoms. Results: Older adults who were more likely to report SCD had lower objective memory on average (between-person associations), and depressive symptoms partially mediated this relationship in three of four datasets. However, changes in depressive symptoms did not mediate the relationship between reports of SCD and declines in objective memory in three of four datasets (within-person associations). Conclusion: Individual differences in depressive symptoms, and not changes in an individual’s depressive symptoms over time, partially explain the link between SCD and objective memory. Older adults with SCD and depressive symptoms may be at greater risk for poor cognitive outcomes. Future research should explore how perceived changes in memory affect other aspects of psychological well-being, and how these relationships influence cognitive decline and Alzheimer’s disease risk.

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