scholarly journals Identification of two different coagulation phenotypes in people living with HIV with undetectable viral replication

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Asbjørn Fink ◽  
Andreas Dehlbæk Knudsen ◽  
Rebekka Faber Thudium ◽  
Jakob Hjorth Von Stemann ◽  
Shoaib Afzal ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Viral Replication ◽  
Smoking Status ◽  
Coagulation Factor ◽  
People Living With Hiv ◽  
Cross Sectional ◽  
Co Morbidity ◽  
Factor Ii ◽  
Living With Hiv ◽  
Infection Study

AbstractAltered coagulation has been reported in people living with HIV (PLWH) with ongoing viral replication and may predispose to cardiovascular diseases. However, less is known about coagulation in PLWH with undetectable viral replication. In a cross-sectional observational study, we investigated whether HIV infection with undetectable viral replication is independently associated with activated partial thromboplastin time (APTT) and coagulation factor II–VII–X concentrations out of reference. Logistic regression analyses were used to assess the association of HIV infection with APTT and coagulation factor II–VII–X, after adjusting for age, sex, smoking status, alcohol consumption, BMI, diabetes and hsCRP. 936 PLWH with undetectable viral replication from the Copenhagen Co-morbidity in HIV infection study (COCOMO-study) and 2955 uninfected controls were included. Higher prevalence of short APTT was found in PLWH compared to controls (13.5% vs. 7.6%, P < 0.001). Furthermore, higher prevalence of low coagulation factor II–VII–X was found in PLWH than in controls (9.6% vs. 7.4%, P = 0.022). HIV was independently associated with short APTT (adjusted odds ratio (aOR) 2.3 (95% CI 1.7–2.9), P < 0.001) and low coagulation factor II–VII–X (aOR 1.4 (95% CI 1.0–1.9), P = 0.046). Few participants among PLWH and controls had both short APTT and low coagulation factor II–VII–X, 2.1% vs. 0.8%, respectively. We found evidence of both procoagulant (short APTT) and anticoagulant (low coagulation factor II–VII–X) alterations in PLWH with undetectable viral replication, and our findings suggest that two different coagulation phenotypes exist in participants with treated HIV infection.

scholarly journals Knowledge, attitude and practice regarding mother-to-child transmission of HIV, its prevention, and associated factors among antenatal women attending a health care facility in district Srinagar, North India: a cross sectional study

2020 ◽  
Vol 7 (7) ◽  
pp. 2622
Author(s):  
Mohsina Mukhtar ◽  
Ruqia Quansar ◽  
Suhail N. Bhat ◽  
S. M. Salim Khan
Keyword(s):  
Health Care ◽  
Hiv Infection ◽  
Care Facility ◽  
Health Care Facilities ◽  
People Living With Hiv ◽  
Mother To Child Transmission ◽  
Child Transmission ◽  
Cross Sectional ◽  
Living With Hiv ◽  
Mother To Child

Background: HIV pandemic still remains an issue of major concern on a global scale with more than 37.9 million people estimated to be living with HIV in 2019 globally -an increase from 36.7 million in 2015. India has the third largest HIV epidemic in the world, with 2.1 million people living with HIV, with higher prevalence among men (0.25%) than women (0.19%) out of which children (15 years) accounts for 6.54%, while two fifth (40.5%) of total HIV infections are among females.Methods: A cross-sectional hospital based study was conducted over a time period of 03 months and a total of 366 pregnant women attending the health care facilities of Block Hazratbal were included in the study.Results: Among the study participants, only 15 (4.1%) women had not heard about HIV/AIDS, 314 (85.8%) were aware of sexual transmission as a mode of transmission and only half of the study subjects (50.8%) knew about MTCT, more than half of the subjects (68.3%) were aware that the transmission of HIV infection can occur during pregnancy.Conclusions: Although the study population showed adequate knowledge about HIV infection, there was a considerable lack of knowledge regarding mother-to-child transmission of HIV infection and its prevention.

scholarly journals The Association between CD-4 Level, Stress and Depression Symptoms among People Living with HIV/AIDS

2019 ◽  
Vol 7 (20) ◽  
pp. 3459-3463
Author(s):  
Elmeida Effendy ◽  
Mustafa M. Amin ◽  
Lidya De Vega ◽  
Nurul Utami
Keyword(s):  
Hiv Infection ◽  
Rating Scales ◽  
Psychiatric Morbidity ◽  
Self Report ◽  
Depression Symptoms ◽  
People Living With Hiv ◽  
Cross Sectional ◽  
Infected People ◽  
Living With Hiv ◽  
Hiv Aids

BACKGROUND: The lives of individuals diagnosed with HIV and the subsequent illness, AIDS, were often chaotic because these individuals deal with the physical, emotional, and interpersonal sequelae of this illness. Depressive symptoms and stress were common and impact on functioning, quality of life, and health status, highlighting the importance of diagnosis and treatment of patients with HIV infection. Psychiatric clinical practice and rating scales have come to play an ever-increasing role both in determining specific symptoms and diagnosing an individual condition. Descriptive reports of psychiatric morbidity among those with HIV infection, that relied primarily on self-report rating scales, described high rates of symptomatic depression and stress. AIM: This study aimed to determine the proportion of depression among people living with HIV/AIDS using the BDI-II and PSS to determine a relationship between symptoms of depression and stress with CD4 counts. METHODS: This study was a numerical correlative analytic study with a cross-sectional study approach that assessed the correlation between stress, depression and CD4 level in people with HIV/AIDS that were receiving ARV therapy in the Voluntary Counselling Test (VCT) Polyclinic of General Hospital Haji Medan by recruiting 46 subjects. CD4 level was examined in the Pramita Medan laboratory. RESULTS: When analysis of BDI-II level and CD4 scores were done, a significant correlation was found (P < 0.05). The strength of the relationship between the BDI score and the CD4 score was 0.548 revealing a positive correlation with moderate correlation strength CONCLUSION: We have shown a significant relationship between depression, stress and CD4 level among people with HIV/AIDS in Medan, Indonesia. Psychological distress may affect the immunity in infected people, leading to the disease progressivity.

scholarly journals The Relationship between HIV Duration, Insulin Resistance and Diabetes Risk

2021 ◽  
Vol 18 (8) ◽  
pp. 3926
Author(s):  
Eduard Tiozzo ◽  
Allan Rodriguez ◽  
Janet Konefal ◽  
Gary J. Farkas ◽  
Jennifer L. Maher ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Hiv Infection ◽  
Cross Sectional Study ◽  
People Living With Hiv ◽  
Model Assessment ◽  
Fasting Insulin ◽  
Long Term Effects ◽  
Cross Sectional ◽  
Living With Hiv ◽  
The Relationship

The risk of developing Type 2 Diabetes Mellitus in people living with HIV (PLWH) can be four times greater and can occur at an earlier age and even without the presence of obesity compared to those without HIV. Therefore, the purpose of this analytical cross-sectional study was to determine the relationship between HIV duration and glucose metabolism among PLWH. Eighty-two PLWH were categorized into shorter (≤15 years) or longer HIV duration (≥16 years) and then compared for differences in demographics, physical and clinical characteristics, biomarkers, and dietary intake. Compared to those with shorter HIV duration (n = 34), those with longer HIV duration (n = 48) were on average older (p = 0.02), reported lower consumption of alcohol (p = 0.05), had higher levels of homeostasis model assessment of insulin resistance (HOMA-IR, p = 0.02), were also more likely to be a woman (p = 0.06), and have higher levels of fasting insulin (p = 0.06). When adjusted for age and body weight, the levels of HOMA-IR and fasting insulin were higher (p = 0.02 and p = 0.04) with longer compared to shorter HIV duration, respectively. Longer exposure to HIV infection is associated with impaired insulin sensitivity. Continuing research aimed at the long-term effects of HIV infection and (antiretroviral therapy) is required.

scholarly journals Assessment of the Association of HIV Infection with Hepatic Steatosis or Fibrosis: a Cross-Sectional, Case-Control Study

2021 ◽  
Author(s):  
Paula Debroy ◽  
Sanjana Nagraj ◽  
Natalia Chamorro-Pareja ◽  
Neva Castro ◽  
Alejandro de Leon ◽  
...  
Keyword(s):  
Risk Factor ◽  
Hiv Infection ◽  
Hepatic Steatosis ◽  
Independent Risk Factor ◽  
People Living With Hiv ◽  
City Hospital ◽  
Advanced Fibrosis ◽  
Cross Sectional ◽  
Care Clinic ◽  
Living With Hiv

Abstract Background: Human immunodeficiency virus (HIV) infection and antiretroviral therapy have been associated with non-alcoholic fatty liver disease (NAFLD), but few studies have evaluated whether HIV infection is an independent risk factor for the development of hepatic steatosis and advanced liver fibrosis. Objectives: To study the prevalence and severity of hepatic steatosis and advanced fibrosis in people living with HIV and control outpatients. Methods: We conducted a cross-sectional analysis of relevant data from 875 pairs of individuals belonging to an HIV-dedicated outpatient clinic and an adult primary care clinic of an inner-city hospital. Hepatic Steatosis Index (HSI) and FIB-4 index were calculated as non-invasive measures of steatosis and fibrosis, respectively. A multivariate logistic regression analysis was performed to assess predictors of steatosis and advanced fibrosis. Results: The prevalence of hepatic steatosis, determined by HSI ≥36, was higher in HIV-negative subjects (71.5% vs. 65.4%, p=0.006). The prevalence of advanced fibrosis, determined by FIB-4 index ≥3.25, was higher in the HIV-positive group (7% vs. 1.7%, p <0.001). Multivariable analysis did not identify HIV infection to be an independent risk factor for hepatic steatosis (p=0.068) and advanced fibrosis. Conclusions: In this cohort, hepatic steatosis was more prevalent in non-HIV infected patients, while advanced fibrosis had a higher prevalence in people living with HIV. HIV infection was not found to be an independent risk factor for either hepatic steatosis or fibrosis.

scholarly journals Medications, Healthcare Workers and Laboratory Capabilities to Manage HIV Infection among Children from 10 Districts of Indonesia

2020 ◽  
pp. 1-14
Author(s):  
Max Joseph Herman ◽  
Siti Masitoh ◽  
Rini Sasanti Handayani
Keyword(s):  
Hiv Infection ◽  
Junior High School ◽  
Healthcare Workers ◽  
Cross Sectional Study ◽  
People Living With Hiv ◽  
Laboratory Equipment ◽  
Cross Sectional ◽  
Viral Loads ◽  
Living With Hiv ◽  
Hiv Aids

Aims: To identify the availability of Medications, Healthcare Workers and Laboratory Capabilities to manage HIV infection among children from 10 Districts of Indonesia to inform efforts to improve healthcare. Study Design: Cross-sectional study. Place and Duration of Study: Five provinces with the greatest number of People Living With HIV/ADS (PLWHA) in Indonesia: Jakarta, East Java, Bali, Papua and North Sumatera, between May and July 2015. Methodology: Study subjects were parents/caregivers of children living with HIV/AIDS CLWHA) The number of subjects was calculated by estimating a population proportion with absolute precision, excluding those that cannot communicate well and of CLWHA who lived independently. 267 respondents were taken proportionately from each district. This descriptive study was conducted by using pre-test questionnaires and checklists to observe the availability of ARV and OI medication, medical devices and laboratory reagents. Results: Data of 239 parents/caregivers out of 267 can be analyzed concerning their perception of the availability of ARVs and laboratory equipment. They are primarily their own parents (65.7%), more than half up to junior high school graduate (52.7%). The availability of medications at some hospitals are limited or unavailable. Nurses are still lacking and many who have not been trained. The comprehensiveness of the laboratory equipment and capabilities is still insufficient. The viral loads can only be examined in one hospital and CD4 cannot be counted in several hospitals. The availability of reagents is also very limited. There is no relation between respondents’ perception of the availability of ARVs and of the completeness of laboratory equipment with their education level (p>0.05). Conclusion: The availability of medications for HIV/AIDS must be assured and the number of trained nurses still need to be increased.

Prevalence of COVID-19-like Symptoms among People Living with HIV, and Using Antiretroviral Therapy for Prevention and Treatment

2020 ◽  
Vol 18 (5) ◽  
pp. 373-380 ◽  
Author(s):  
SeyedAhmad SeyedAlinaghi ◽  
Maryam Ghadimi ◽  
Mahboubeh Hajiabdolbaghi ◽  
Mehrnaz Rasoolinejad ◽  
Ladan Abbasian ◽  
...  
Keyword(s):  
Respiratory Symptoms ◽  
Antiretroviral Treatment ◽  
Clinical Symptoms ◽  
Cross Sectional Study ◽  
People Living With Hiv ◽  
Shortness Of Breath ◽  
Sectional Study ◽  
Limited Data ◽  
Cross Sectional ◽  
Living With Hiv

Background: COVID-19 has spread globally with remarkable speed, and currently, there is limited data available exploring any aspect of the intersection between HIV and SARSCoV- 2 co-infection. Objective: To estimate the prevalence of clinical symptoms associated with COVID-19 among people living with HIV (PLWH) in Tehran, Iran. Design: Cross-sectional study. Methods: A total of 200 PLWH were recruited through the positive club via sampling, and completed the symptom-based questionnaire for COVID-19, which was delivered by trained peers. Results: Of 200 participants, respiratory symptoms, including cough, sputum, and shortness of breath, were the most prevalent among participants, but only one person developed symptoms collectively suggested COVID-19 and sought treatments. Conclusions: It appears that existing infection with HIV or receiving antiretroviral treatment (ART) might reduce the susceptibility to the infection with SARS-CoV-2 or decrease the severity of the infection acquired. Further research is needed to understand causal mechanisms.

Metabolic Syndrome in HIV-patients in Antiretroviral Therapy

2020 ◽  
Vol 18 (6) ◽  
pp. 388-395
Author(s):  
Daniel Vargas-Pacherrez ◽  
Helma P. Cotrim ◽  
Leonardo Pires ◽  
Vitor Cunha ◽  
Vitor Coelho ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Antiretroviral Therapy ◽  
International Diabetes Federation ◽  
Cross Sectional Study ◽  
People Living With Hiv ◽  
Anthropometric Data ◽  
Cross Sectional ◽  
History Of ◽  
Family History Of Hypertension ◽  
Living With Hiv

Introduction: The global prevalence of metabolic syndrome (MS) among people living with HIV/AIDS varies from 20% to 33%. Objective: to estimate the prevalence of metabolic syndrome and associated factors in a group of HIV-infected patients on antiretroviral therapy. Methods: This is a cross-sectional study with HIV-infected patients from a reference center in Bahia, Brazil. We evaluated clinical, socio-demographic and anthropometric data. MS was defined according to the guidelines of International Diabetes Federation. Results: We evaluated 152 patients with mean age of 47.3±11.6 years, 59.2% male. The main comorbidities detected were diabetes (3.3%) hypertriglyceridemia (9.3%) and metabolic syndrome (MS,38.2%). Patients with MS were predominantly women (55.2% vs 31.9%; p=0.005), older [52.1 (10.4) vs 44.3 (11.3); p<0.001], and had overweight (74.1% vs 23.4%; p<0.001). After multivariate analysis MS remained associated with age (OR = 1.076; 95% CI: 1.030 – 1.125), female sex (OR = 2.452; 95% CI: 1.114 – 5.374) and family history of hypertension (OR = 3.678; 95% CI: 1.431 – 9.395). Conclusion: Almost half of the HIV-infected patients in Bahia presents with MS which seems to be driven by classical risk factors.

scholarly journals Stigma mastery in people living with HIV: gender similarities and theory

2021 ◽  
Author(s):  
Charles Patrick Namisi ◽  
John C. Munene ◽  
Rhoda K. Wanyenze ◽  
Anne R. Katahoire ◽  
Rosalinda M. Parkes-Ratanshi ◽  
...  
Keyword(s):  
Older Women ◽  
Social Exclusion ◽  
Theoretical Framework ◽  
People Living With Hiv ◽  
Negative Effects ◽  
Hiv Diagnosis ◽  
Cross Sectional ◽  
Age Related ◽  
Related Stigma ◽  
Living With Hiv

Abstract Aims This study aimed to determine the prevalence of, factors associated with, and to build a theoretical framework for understanding Internalsed HIV-related Stigma Mastery (IHSM). Methods A cross-sectional study nested within a 2014 Stigma Reduction Cohort in Uganda was used. The PLHIV Stigma Index version 2008, was used to collect data from a random sample of 666 people living with HIV (PLHIV) stratified by gender and age. SPSS24 with Amos27 softwares were used to build a sequential-mediation model. Results The majority of participants were women (65%), aged ≥ 40 years (57%). Overall, IHSM was 45.5% among PLHIV, that increased with age. Specifically, higher IHSM correlated with men and older women “masculine identities” self-disclosure of HIV-diagnosis to family, sharing experiences with peers. However, lower IHSM correlated with feminine gender, the experience of social exclusion stress, fear of future rejection, and fear of social intimacy. Thus, IHSM social exclusion with its negative effects and age-related cognition are integrated into a multidimensional IHSM theoretical framework with a good model-to-data fit. Conclusion Internalised HIV-related Stigma Mastery is common among men and older women. Specificially, “masculine identities” self-disclose their own HIV-positive diagnosis to their family, share experiences with peers to create good relationships for actualising or empowerment in stigma mastery. However, social exclusion exacerbates series of negative effects that finally undermine stigma mastery by young feminine identities. Thus, stigma mastery is best explained by an integrated empowerment framework, that has implications for future practice, policy, and stigma-related research that we discuss.

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