scholarly journals Mode of conception in relation to nausea and vomiting of pregnancy: a nested matched cohort study in Sweden

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Farnaz Bazargani ◽  
S. I. Iliadis ◽  
E. Elenis
Keyword(s):  
Cohort Study ◽  
Large Scale ◽  
Nausea And Vomiting ◽  
University Hospital ◽  
Matched Cohort ◽  
Chi Square ◽  
Study Objective ◽  
Matched Cohort Study ◽  
Chi Square Test

AbstractNausea and vomiting of pregnancy (NVP) is a common condition reported however inconclusively among pregnancies after assisted conception. The study objective was thus to explore whether NVP is associated to mode of conception or other in vitro fertilization (IVF)-related variables. This nested matched cohort study, originating from the BASIC-project, was conducted at the Uppsala University Hospital in Sweden between 2010 and 2016. IVF pregnancies (n = 210) and age and parity-matched women with spontaneous pregnancies (n = 420) comprised the study sample. The study outcome was self-reported NVP at gestational week 17. IVF treatment and pregnancy data were obtained after scrutinization of the medical records. NVP with or without medications was not associated with mode of conception (chi-square test, p = 0.889), even after adjusting for potential confounders. In a subgroup analysis among IVF pregnancies, NVP without medication was more frequently seen in the group who received cleavage stage embryos vs blastocysts (chi-square test, p = 0.019), exhibiting a marginally significant but strongly increased effect even after adjustment [crude RRR 3.82 (95% CI 1.23–11.92) and adjusted RRR 3.42 (95% CI 0.96–12.11)]. No difference in the rate of NVP with or without medication between women that underwent fresh and frozen/thawed embryo transfers as well as IVF or ICSI was observed. Conception through IVF is not associated with NVP. Transfer of a blastocyst may decrease the risk of developing NVP and further, large-scale prospective studies are required to validate this finding.

scholarly journals Prognosis of Critically Ill Patients With Acute Respiratory Failure Due To The SARS-CoV-2 501Y.V2 Variant: A Multicenter Retrospective Matched Cohort Study

2021 ◽  
Author(s):  
Bérénice Puech ◽  
Antoine Legrand ◽  
Olivier Simon ◽  
Chloé Combe ◽  
Marie-Christine Jaffar-Bandjee ◽  
...  
Keyword(s):  
Cohort Study ◽  
Respiratory Failure ◽  
Acute Respiratory Failure ◽  
Invasive Mechanical Ventilation ◽  
University Hospital ◽  
Original Strain ◽  
Reunion Island ◽  
Matched Cohort ◽  
Matched Cohort Study ◽  
Réunion Island

Abstract Background The aim of this study was to compare the prognosis of patients with acute respiratory failure (ARF) due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant 501Y.V2 to that of patients with ARF due to the original strain. Methods This retrospective matched cohort study included all consecutive patients who were hospitalized for ARF due to SARS-CoV-2 in Reunion Island University Hospital between March 2020 and March 2021. Twenty-eight in hospital mortality was evaluated before and after matching. Results A total of 218 patients with ARF due to SARS-CoV-2 were enrolled in the study. Of these, 83 (38.1%) were infected with the 501Y.V2 variant. During intensive care unit stay, 104 (47.7%) patients received invasive mechanical ventilation and 20 (9.2%) patients were supported by venovenous extracorporeal membrane oxygenation. Patients infected with the 501Y.V2 variant were younger (58 [51–68] vs. 67 [56–74] years old, P = 0.003), had less hypertension (54.2% vs 68.1%, P = 0.04), and had less chronic kidney disease (13.3% vs. 31.9%, P = 0.002) than patients infected with the original strain. After controlling for confounding variables (62 matched patients in each group), 28-day mortality was higher in the group of patients infected with the 501Y.V2 variant (30.6%) than in the group of patients infected with the original strain (19.4%, P = 0.04). Conclusion In Reunion Island, where SARS-CoV-2 incidence remained low until February 2021 and the health care system was never saturated, mortality was higher in patients with ARF infected with the 501Y.V2 variant than in patients infected with the original strain.

Emergency luteal phase in vitro maturation – a retrospective matched cohort study

2012 ◽  
Vol 98 (3) ◽  
pp. S9
Author(s):  
J.H. Hyman ◽  
W.-Y. Son ◽  
T. Sokal-Arnon ◽  
I. Roux ◽  
E. Shalom-Paz ◽  
...  
Keyword(s):  
Cohort Study ◽  
Luteal Phase ◽  
In Vitro Maturation ◽  
Matched Cohort ◽  
Matched Cohort Study

scholarly journals Prognosis of Critically Ill Patients with Acute Respiratory Failure Due to the SARS-CoV-2 501Y.V2 Variant: A Multicenter Retrospective Matched Cohort Study

2021 ◽  
Author(s):  
bérénice Puech ◽  
Antoine legrand ◽  
Olivier Simon ◽  
Chloe Combe ◽  
marie-christine jaffarbandjee ◽  
...  
Keyword(s):  
Cohort Study ◽  
Respiratory Failure ◽  
Acute Respiratory Failure ◽  
Invasive Mechanical Ventilation ◽  
University Hospital ◽  
Original Strain ◽  
Reunion Island ◽  
Matched Cohort ◽  
Matched Cohort Study ◽  
Réunion Island

Abstract Background: The aim of this study was to compare the prognosis of patients with acute respiratory failure (ARF) due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant 501Y.V2 to that of patients with ARF due to the original strain. Methods: This retrospective matched cohort study included all consecutive patients who were hospitalized for ARF due to SARS-CoV-2 in Reunion Island University Hospital between March 2020 and March 2021. Twenty-eight in hospital mortality was evaluated before and after matching.Results: A total of 218 patients with ARF due to SARS-CoV-2 were enrolled in the study. Of these, 83 (38.1%) were infected with the 501Y.V2 variant. During intensive care unit stay, 104 (47.7%) patients received invasive mechanical ventilation and 20 (9.2%) patients were supported by venovenous extracorporeal membrane oxygenation. Patients infected with the 501Y.V2 variant were younger (58 [51-68] vs. 67 [56-74] years old, P=0.003), had less hypertension (54.2% vs 68.1%, P=0.04), and had less chronic kidney disease (13.3% vs. 31.9%, P=0.002) than patients infected with the original strain. After controlling for confounding variables (62 matched patients in each group), 28-day mortality was higher in the group of patients infected with the 501Y.V2 variant (30.6%) than in the group of patients infected with the original strain (19.4%, P=0.04).Conclusion: In Reunion Island, where SARS-CoV-2 incidence remained low until February 2021 and the health care system was never saturated, mortality was higher in patients with ARF infected with the 501Y.V2 variant than in patients infected with the original strain.

scholarly journals Prestroke physical activity and outcomes after intracerebral haemorrhage in comparison to ischaemic stroke: protocol for a matched cohort study (part of PAPSIGOT)

BMJ Open ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. e053067
Author(s):  
Adam Viktorisson ◽  
Dongni Buvarp ◽  
Katharina S Sunnerhagen
Keyword(s):  
Physical Activity ◽  
Cohort Study ◽  
Ischaemic Stroke ◽  
Intracerebral Haemorrhage ◽  
Sample Size Calculation ◽  
University Hospital ◽  
Ethical Review ◽  
Stroke Severity ◽  
Matched Cohort ◽  
Matched Cohort Study

IntroductionPiling evidence suggests that a higher level of prestroke physical activity can decrease stroke severity, and reduce the risk of poststroke mortality. However, prior studies have only included ischaemic stroke cases, or a majority of such. We aim to investigate how premorbid physical activity influences admission stroke severity and poststroke mortality in patients with intracerebral haemorrhage, compared with ischaemic stroke. A prespecified analysis plan counteract some inherent biases in observational studies, and promotes transparency.Methods and analysisThis is a statistical analysis protocol for a matched cohort study, including all adult patients with intracerebral haemorrhage, and matched ischaemic stroke controls, treated at Sahlgrenska University Hospital in Sweden between 1 November 2014 and 30 June 2019. All patients have been identified in the Väststroke register, and the data file has been sent for merging with national registries. The follow-up of time for survival will be approximately 2–7 years. The sample size calculation indicates that a minimum of 628 patients with intracerebral haemorrhage is needed for power of 80% at an alpha level of 0.01. Multiple imputation by chained equations will be used to handle missing data. The entire cohort of patients with intracerebral haemorrhage will be matched with consecutive ischaemic stroke controls (1:3 ratio) using nearest neighbour propensity score matching. The association between prestroke physical activity and admission stroke severity will be evaluated using multivariable ordinal regression models, and risk for all-cause mortality will be analysed using multivariable Cox proportional-hazards models. Potential confounders include age, ethnicity, income, educational level, comorbidity, medical treatments, alcohol-related disorders, drug abuse and smoking.EthicsData collection for the Physical Activity Pre-Stroke In GOThenburg project was approved by the Regional Ethical Board on 4 May 2016. An additional application was approved by the National Ethical Review Authority on 7 July 2021.

scholarly journals The Effect of Growth Hormone on In Vitro Fertilization Outcomes During Ovarian Stimulation: A Matched Cohort Study

2021 ◽  
Author(s):  
Jillian Kurtz ◽  
Nicolle Clements ◽  
Allison Bloom ◽  
John J. Orris ◽  
Michael Glassner ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Cohort Study ◽  
In Vitro Fertilization ◽  
Ovarian Stimulation ◽  
Endometrial Thickness ◽  
Poor Responder ◽  
Matched Cohort ◽  
Vitro Fertilization ◽  
Matched Cohort Study

Abstract Background. While growth hormone (GH) is commonly used as an adjuvant treatment to controlled ovarian stimulation (COS) for in vitro fertilization (IVF) cycles, the data regarding its efficacy is inconsistent. Design. A retrospective matched cohort study of poor responder patients who underwent COS without the use of GH (COS-GH) subsequently followed by COS cycles that included adjuvant GH (COS+GH) treatment. Materials and Methods. A list of all patients having filled a prescription for GH from January 2018 – March 2020 was obtained. GH was administered daily at 3mg (9IU) starting on the first day of stimulation and ending on the day of trigger. Only women who had documentation of a previous cycle without the use of GH were included in the study. Results. 182 cycles (91 patients) were included in the study, and COS-GH cycles were compared to COS+GH cycles. The total dose of gonadotropins used (5757 vs 4252 mIU, p=0.002), duration of stimulation (10.4 vs 10.1 days, p=-.045), maximum Estradiol (E2) (2411 vs 1932 pg/ml, p=0.010), endometrial thickness (11.2 vs 10.6 mm, p=0.010), number of oocytes retrieved (14.2 vs 11.8, p=0.001), number of mature oocytes (11.1 vs 9.7, p=0.028), number of blastocysts (3.98 vs 2.56, p=<0.001) and number of usable blastocysts (2.5 vs 1.6, p=<0.001) were all significantly greater in the GH group. Conclusions. Adding GH to the COS protocol in poor responder patients may lead to improvements in the number of oocytes retrieved, number of mature oocytes, endometrial thickness, number of blastocysts, the number of usable blastocysts.

scholarly journals The association between bowel resection and the risk of nontyphoidal salmonella infection: a nationwide propensity score-matched cohort study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kuang-Tsu Yang ◽  
Sin-Ei Juang ◽  
Yao-Min Hung ◽  
James Cheng-Chung Wei ◽  
Hei-Tung Yip ◽  
...  
Keyword(s):  
Cohort Study ◽  
Propensity Score ◽  
Bowel Resection ◽  
Significant Risk ◽  
University Hospital ◽  
Control Group ◽  
Matched Cohort ◽  
Human Beings ◽  
Matched Cohort Study ◽  
Increased Risk

AbstractNontyphoidal salmonella (NTS) infection has a high mortality rate. Bowel resections affect gut microbiota and immune function, and the association between bowel resection and NTS infection in human beings has not been addressed. We conducted a nationwide propensity score (PS)-matched cohort study to clarify this association. Data from the Longitudinal Health Insurance Database of Taiwan were used to establish a case-cohort with bowel resections from 2000 to 2013. Informed consent was waived by the Institutional Review Board of China Medical University Hospital (CMUH104-REC2-115) because all personal identifying information used had been de-identified. Each case was matched with one control without any bowel resection according to age, gender, index date, and propensity score (PS). Cumulative incidences of and hazard ratios (HRs) for NTS infection development were analyzed. The incidence of NTS infection was greater in patients with a bowel resection than in the control group (2.97 vs. 1.92 per 10,000 person-years), with an adjusted hazard ratio (aHR) of 1.64 (95% CI = 1.08–2.48). The incidence of NTS infection increased significantly for cases with small bowel resections and right hemicolectomies. Age (31–40 and > 50 years), hypertension, chronic kidney disease, chronic obstructive pulmonary disease, and autoimmune diseases were significant risk factors of NTS infection. Stratification analysis revealed that patients without comorbidities were prone to NTS infection after bowel resections. The increased risk of developing NTS infection could be related to the bowel resection. Specific age groups and comorbidities also contribute to increased risk of NTS infection.

Sign in / Sign up

Export Citation Format

Share Document