scholarly journals Retinol-Binding Protein, Transthyretin, and C-Reactive Protein in Extremely Low Birth Weight (ELBW) Infants

2005 ◽  
Vol 25 (11) ◽  
pp. 714-719 ◽  
Author(s):  
Namasivayam Ambalavanan ◽  
A Catharine Ross ◽  
Waldemar A Carlo
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Extremely Low Birth Weight ◽  
C Reactive Protein ◽  
Reactive Protein

Eleven Plasma Proteins as Indicators of Protein Nutritional Status in Very Low Birth Weight Infants

PEDIATRICS ◽  
1990 ◽  
Vol 86 (6) ◽  
pp. 916-921 ◽  
Author(s):  
Staffan K. T. Polberger ◽  
Göran A. Fex ◽  
Irene E. Axelsson ◽  
Niels C. R. Räihä
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Nutritional Status ◽  
Protein Intake ◽  
Plasma Proteins ◽  
Very Low Birth Weight ◽  
Binding Protein ◽  
Plasma Concentrations ◽  
Retinol Binding Protein ◽  
Low Birth Weight Infants

Concentrations of 11 plasma proteins were measured in 28 healthy, growing, very low birth weight, appropriate-for-gestational-age infants fed varying levels of human milk protein intake (range 1.7 to 3.9 g/kg per day). Significant positive correlations were found between ween mean protein intake and concentrations of 7 of the plasma proteins studied (transthyretin, retinol-binding protein, and transferrin: P < .001; vitamin D-binding protein and apolipoprotein B: P < .01; albumin and apolipoprotein A I: P < .05). A weak negative correlation with mean protein intake was seen for the plasma level of orosomucoid, whereas no significant correlations were found for the plasma concentrations of fibronectin and α1-antichymotrypsin. Protein intake, not energy intake, constituted the main contribution to the changes in the concentrations of transthyretin, retinol-binding protein, and transferrin. The levels of plasma transthyretin and transferrin were also strongly correlated with weight and length growth of the infants during the study as well as with other indicators of protein nutritional status such as preprandial concentrations of plasma amino acids and serum and urine urea. These data indicate that of the 11 plasma proteins studied, transthyretin, transferrin, and retinol-binding protein are the most suitable to evaluate protein nutritional status in very low birth weight infants.

scholarly journals Plasma Levels of Retinol, Retinol-binding Protein, all-trans Beta-Carotene and Cryptoxanthin in Low Birth Weight Infants.

1995 ◽  
Vol 41 (6) ◽  
pp. 595-606 ◽  
Author(s):  
Hideki MOJI ◽  
Takushi MURATA ◽  
Takao MORINOBU ◽  
Mitsuhiro MANAGO ◽  
Hiroshi TAMAI ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Plasma Levels ◽  
Binding Protein ◽  
Beta Carotene ◽  
Retinol Binding Protein ◽  
Low Birth Weight Infants

scholarly journals Early Origins of the Metabolic Syndrome: Role of Small Size at Birth, Early Postnatal Weight Gain, and Adult IGF-I

2012 ◽  
Vol 97 (8) ◽  
pp. 2637-2643 ◽  
Author(s):  
Gerthe F. Kerkhof ◽  
Ralph W. J. Leunissen ◽  
Anita C. S. Hokken-Koelega
Keyword(s):  
Metabolic Syndrome ◽  
Weight Gain ◽  
Birth Weight ◽  
Insulin Sensitivity ◽  
Low Birth Weight ◽  
Density Lipoprotein ◽  
Regression Analyses ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Igf I

Abstract Background: The relationship between low birth weight and increased risk for metabolic syndrome (MetS) in later life has been frequently described, but mechanisms underlying this association remain unknown. Methods: In 280 young adults of the PROGRAM study, aged 18–24 yr, we investigated associations of birth weight, gain in weight for length during early life, and adult IGF-I sd score (SDS), with number of MetS components (ordinal regression analyses), prevalence of MetS components and MetS (logistic regression analyses), and other metabolic parameters (linear regression analyses). Revised criteria of the National Cholesterol Educational Program (Adult Treatment Panel III) were used to determine components of MetS. The other metabolic parameters were C-reactive protein, insulin sensitivity, trunk fat mass, total cholesterol, and low-density lipoprotein cholesterol. Results: More gain in weight for length SDS in the first 3 months of life was significantly associated with an increased number of MetS components [odds ratio (OR) = 1.34], prevalence of low high-density lipoprotein cholesterol (OR = 1.49), prevalence of MetS (OR = 2.51), increased C-reactive protein levels, and lower insulin sensitivity (P = 0.007) at the age of 21 yr. Low birth weight SDS was associated with lower insulin sensitivity (P = 0.036), but low birth weight SDS and adult IGF-I SDS were not significantly associated with any of the MetS components or MetS prevalence at 21 yr. Conclusion: Our study demonstrates that higher gain in weight for length in the first 3 months of life is associated with a higher prevalence of MetS at 21 yr, whereas low birth weight and low adult IGF-I are not.

scholarly journals Use of a Computerized C-Reactive Protein (CRP) Based Sepsis Evaluation in Very Low Birth Weight (VLBW) Infants: A Five-Year Experience

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e78602 ◽  
Author(s):  
Sarah A. Coggins ◽  
James L. Wynn ◽  
Melissa L. Hill ◽  
James C. Slaughter ◽  
Asli Ozdas-Weitkamp ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
C Reactive Protein ◽  
Vlbw Infants ◽  
Reactive Protein

scholarly journals Rapid diagnostic testing platform for iron and vitamin A deficiency

2017 ◽  
Vol 114 (51) ◽  
pp. 13513-13518 ◽  
Author(s):  
Zhengda Lu ◽  
Dakota O’Dell ◽  
Balaji Srinivasan ◽  
Elizabeth Rey ◽  
Ruisheng Wang ◽  
...  
Keyword(s):  
Vitamin A ◽  
Binding Protein ◽  
Vitamin A Deficiency ◽  
Work Capacity ◽  
Diagnostic Methods ◽  
Retinol Binding Protein ◽  
Micronutrient Deficiencies ◽  
C Reactive Protein ◽  
Laptop Computer ◽  
Reactive Protein

Micronutrient deficiencies such as those of vitamin A and iron affect a third of the world’s population with consequences such as night blindness, higher child mortality, anemia, poor pregnancy outcomes, and reduced work capacity. Many efforts to prevent or treat these deficiencies are hampered by the lack of adequate, accessible, and affordable diagnostic methods that can enable better targeting of interventions. In this work, we demonstrate a rapid diagnostic test and mobile enabled platform for simultaneously quantifying iron (ferritin), vitamin A (retinol-binding protein), and inflammation (C-reactive protein) status. Our approach, enabled by combining multiple florescent markers and immunoassay approaches on a single test, allows us to provide accurate quantification in 15 min even though the physiological range of the markers of interest varies over five orders of magnitude. We report sensitivities of 88%, 100%, and 80% and specificities of 97%, 100%, and 97% for iron deficiency (ferritin <15 ng/mL or 32 pmol/L), vitamin A deficiency (retinol-binding protein <14.7 μg/mL or 0.70 μmol/L) and inflammation status (C-reactive protein >3.0 μg/mL or 120 nmol/L), respectively. This technology is suitable for point-of-care use in both resource-rich and resource-limited settings and can be read either by a standard laptop computer or through our previously developed NutriPhone technology. If implemented as either a population-level screening or clinical diagnostic tool, we believe this platform can transform nutritional status assessment and monitoring globally.

scholarly journals Faktor-Faktor yang Memengaruhi Status Nutrisi Akut Pascabedah

Sari Pediatri ◽  
2016 ◽  
Vol 16 (3) ◽  
pp. 215
Author(s):  
Yusrina Istanti ◽  
Antonius Pudjiadi ◽  
Abdul Latief ◽  
Sri Martuti ◽  
Moh. Supriatna ◽  
...  
Keyword(s):  
Binding Protein ◽  
Retinol Binding Protein ◽  
C Reactive Protein ◽  
Reactive Protein

Latar belakang. Malnutrisi sering ditemukan pada pasien pascabedah dan berhubungan dengan penurunan fungsi otot, respirasi, imun serta penyembuhan luka yang terganggu. Tindakan pembedahan merupakan stresor yang memicu respons metabolik sehingga berpengaruh terhadap luaran, termasuk status nutrisi.Tujuan. Mengetahui faktor-faktor yang memengaruhi status nutrisi akut pascabedah.Metode. Penelitian observasional analitik dilakukan di ICU anak tiga rumah sakit, yaitu RS Cipto Mangunkusumo, RS Dr Kariadi, dan RSUD Dr Muwardi. Dilakukan pemeriksaan kadar retinol binding protein (RBP) hari ke-1 dan ke-5 pascabedah sebagai indikator status nutrisi, kortisol, dan C-reactive protein (CRP) sebagai marker respons inflamasi. Status nutrisi berdasarkan antropometri dinilai, jenis, dan lama pembedahan dicatat. Dilakukan uji korelasi untuk melihat hubungan antara kortisol, CRP, dan RBP dengan kadar RBP hari ke-5. Uji kai kuadrat untuk melihat hubungan status nutrisi, jenis dan lama pembedahan dengan kadar RBP hari ke-5.Hasil. Selama kurun waktu 6 bulan didapatkan 39 subjek yang memenuhi kriteria inklusi dan 4 subjek dieksklusi. Penurunan kadar RBP hari ke-5 dijumpai pada 12 (34,4%) subjek. Didapatkan hubungan antara kadar kortisol, CRP, dan RBP hari ke-1 dengan kadar RBP hari ke-5 [r=-0,35 (p=0,04); r=-0,53 (p=0,001); r=0,42 (p=0,01)]. Tidak terdapat hubungan antara status nutrisi berdasarkan antropometri serta jenis dan lama pembedahan dengan kadar RBP hari ke-5 (p>0,05).Kesimpulan. Terdapat hubungan antara kadar RBP hari ke-1 dan ke-5 sebagai parameter status nutrisi akut pascabedah. Kadar RBP hari ke-5 tidak dipengaruhi oleh status nutrisi prabedah serta jenis dan lama pembedahan, tetapi oleh kadar kortisol dan CRP sebagai marker respons stres.

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