Integration column: Biofunctional polymeric nanoparticles for spatio-temporal control of drug delivery and biomedical applications

2009 ◽  
Vol 1 (7) ◽  
pp. 446 ◽  
Author(s):  
Dominique A. Rothenfluh ◽  
Jeffrey A. Hubbell
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Polymeric Nanoparticles ◽  
Temporal Control ◽  
Spatio Temporal

Spatio-temporal control on the delivery of triamcinolone acetonide using polymeric nanoparticles reduces steroid induced cataract

2019 ◽  
Vol 568 ◽  
pp. 118474 ◽  
Author(s):  
Dadi A. Srinivasarao ◽  
S. Sreenivasa Reddy ◽  
G. Bhanuprakash Reddy ◽  
Dhirendra S. Katti
Keyword(s):  
Triamcinolone Acetonide ◽  
Polymeric Nanoparticles ◽  
Temporal Control ◽  
Spatio Temporal

scholarly journals Spatio-Temporal Control of LbL Films for Biomedical Applications: From 2D to 3D

2015 ◽  
Vol 4 (6) ◽  
pp. 811-830 ◽  
Author(s):  
Claire Monge ◽  
Jorge Almodóvar ◽  
Thomas Boudou ◽  
Catherine Picart
Keyword(s):  
Biomedical Applications ◽  
Temporal Control ◽  
Lbl Films ◽  
Spatio Temporal ◽  
2D To 3D

scholarly journals Technology Overview and Current Biomedical Application of Polymeric Nanoparticles

2018 ◽  
Vol 8 (6) ◽  
pp. 285-295
Author(s):  
Gurpreet Singh ◽  
Abdul Faruk ◽  
Preet Mohinder Singh Bedi
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Polymeric Nanoparticles ◽  
Preparation Methods ◽  
Polymeric Nanoparticle ◽  
Potential Applications ◽  
Dialysis Method ◽  
Novel Drug ◽  
Current Potential

Polymeric nanoparticle are of great importance in the treatment of various diseases, due to the flexibility in the  modification of their structures. Recent advances in the field of nanotechnology facilitate the engineering of multifunctional polymeric nanoparticles. All the scientific efforts of the pharmaceuticals companies are mainly focusing on two basic aspects, one is to discover new molecules of potential therapeutic interest and second is to develop of a new drug delivery system. In the last few decades,  research and development (R&D) scientists has directed their efforts toward formulating novel drug delivery systems that includes sustained and controlled release, modified release and targeted drug release dosage forms. Application of nanoscience and nanotechnology has opened several new possibilities in development of formulation This review compiles the different preparation methods of polymeric nanoparticles and then briefly explained their current potential applications. Keywords: Polymeric nanoparticles, PLGA, Biomedical applications, Biodegradable, Dialysis method

scholarly journals Polymeric Nanogels as Versatile Nanoplatforms for Biomedical Applications

2019 ◽  
Vol 2019 ◽  
pp. 1-16 ◽  
Author(s):  
Fakhara Sabir ◽  
Muhammad Imran Asad ◽  
Maimoona Qindeel ◽  
Iqra Afzal ◽  
Muhammad Junaid Dar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Chemical Reactivity ◽  
Daily Basis ◽  
Delivery Systems ◽  
The Past ◽  
Future Challenges ◽  
Pros And Cons

Nanomaterials have found extensive biomedical applications in the past few years because of their small size, low molecular weight, larger surface area, enhanced biological, and chemical reactivity. Among these nanomaterials, nanogels (NGs) are promising drug delivery systems and are composed of cross-linked polymeric nanoparticles ranging from 100 to 200 nm. NGs represent an innovative zone of research with speedy developments taking place on a daily basis. An incredible amount of focus is placed on the fabrication of NGs with novel polymers to achieve better control over the drug release. This review article covers a number of aspects of NGs including their types, associated pros and cons, and methods of preparation along with technical and economical superiority and therapeutic efficacy over each other. The last part of review summarizes the applications of NGs in the drug delivery and treatment of various diseases including brain disease, cardiovascular diseases, oxidative stress, diabetes, cancer therapy, tissue engineering, gene therapy, inflammatory disorders, pain management, ophthalmic and autoimmune diseases, and their future challenges. NGs appear to be an outstanding nominee for drug delivery systems, and further study is required to explore their interactions at the cellular and molecular levels.

Spatio-temporal control strategy of drug delivery systems based nano structures

2017 ◽  
Vol 255 ◽  
pp. 176-201 ◽  
Author(s):  
Nahla Rahoui ◽  
Bo Jiang ◽  
Nadia Taloub ◽  
Yu Dong Huang
Keyword(s):  
Drug Delivery ◽  
Control Strategy ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Temporal Control ◽  
Nano Structures ◽  
Spatio Temporal

scholarly journals Poly(hydroxyalkanoates)-Based Polymeric Nanoparticles for Drug Delivery

2009 ◽  
Vol 2009 ◽  
pp. 1-10 ◽  
Author(s):  
Cesare Errico ◽  
Cristina Bartoli ◽  
Federica Chiellini ◽  
Emo Chiellini
Keyword(s):  
Drug Delivery ◽  
Size Distribution ◽  
Biomedical Applications ◽  
Polymeric Nanoparticles ◽  
Small Diameter ◽  
Processing Conditions ◽  
Theoretical Understanding ◽  
Dialysis Method ◽  
The One ◽  
Colloidal Formation

Poly (hydroxyalkanoates) (PHAs) have recently attracted a great deal of academic and industrial interest for their biodegradability and biocompatibility making them suitable for environmental and biomedical applications. Poly(3-hydroxybutyrate-) (PHB-) and Poly(DL-lactide-co-glycolide) (PLGA-) based nanoparticles were prepared using the dialysis method as yet unreported for the preparation of nanoparticles based on PHB. Processing conditions were varied in order to evaluate their influence on morphology, drug encapsulation, and size of nanoparticles. The relevant results obtained give a theoretical understanding of the phenomenon occurring during colloidal formation. The adopted procedure allows for a relatively small diameter and homogeneity in size distribution of the PHB nanoparticles to be obtained compared to other methods like the one based on solvent evaporation which leads to particles on microscale. The biocompatibility of PHB and relative nanoparticles was investigated and both exhibited very good cytocompatibility.

Environment-responsive Polymeric Nanoparticles as Drug Delivery Systems for Cancer Therapy

2013 ◽  
Vol 40 (10) ◽  
pp. 1039
Author(s):  
Yang YANG ◽  
Wen-Chuan SHE ◽  
Kui LUO ◽  
Zhong-Wei GU
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Delivery Systems

Biocompatible Polymers and their Potential Biomedical Applications: A Review

2019 ◽  
Vol 25 (34) ◽  
pp. 3608-3619 ◽  
Author(s):  
Uzma Arif ◽  
Sajjad Haider ◽  
Adnan Haider ◽  
Naeem Khan ◽  
Abdulaziz A. Alghyamah ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Biomedical Applications ◽  
Living System ◽  
Health Condition ◽  
The Body ◽  
Biocompatible Polymers ◽  
Nano Technology ◽  
Artificial Grafts ◽  
Immunological Reactions

Background: Biocompatible polymers are gaining great interest in the field of biomedical applications. The term biocompatibility refers to the suitability of a polymer to body and body fluids exposure. Biocompatible polymers are both synthetic (man-made) and natural and aid in the close vicinity of a living system or work in intimacy with living cells. These are used to gauge, treat, boost, or substitute any tissue, organ or function of the body. A biocompatible polymer improves body functions without altering its normal functioning and triggering allergies or other side effects. It encompasses advances in tissue culture, tissue scaffolds, implantation, artificial grafts, wound fabrication, controlled drug delivery, bone filler material, etc. Objectives: This review provides an insight into the remarkable contribution made by some well-known biopolymers such as polylactic-co-glycolic acid, poly(ε-caprolactone) (PCL), polyLactic Acid, poly(3- hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), Chitosan and Cellulose in the therapeutic measure for many biomedical applications. Methods: : Various techniques and methods have made biopolymers more significant in the biomedical fields such as augmentation (replaced petroleum based polymers), film processing, injection modeling, blow molding techniques, controlled / implantable drug delivery devices, biological grafting, nano technology, tissue engineering etc. Results: The fore mentioned techniques and other advanced techniques have resulted in improved biocompatibility, nontoxicity, renewability, mild processing conditions, health condition, reduced immunological reactions and minimized side effects that would occur if synthetic polymers are used in a host cell. Conclusion: Biopolymers have brought effective and attainable targets in pharmaceutics and therapeutics. There are huge numbers of biopolymers reported in the literature that has been used effectively and extensively.

Strategies for Conjugation of Biomolecules to Nanoparticles as Tumor Targeting Agents

2019 ◽  
Vol 25 (37) ◽  
pp. 3917-3926
Author(s):  
Sajjad Molavipordanjani ◽  
Seyed Jalal Hosseinimehr
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Medical Imaging ◽  
Cancer Diagnosis ◽  
Carbon Nanoparticles ◽  
Tumor Targeting ◽  
Polymeric Nanoparticles ◽  
Inorganic Nanoparticles ◽  
Active Targeting ◽  
Cancer Diagnosis And Therapy

Combination of nanotechnology, biochemistry, chemistry and biotechnology provides the opportunity to design unique nanoparticles for tumor targeting, drug delivery, medical imaging and biosensing. Nanoparticles conjugated with biomolecules such as antibodies, peptides, vitamins and aptamer can resolve current challenges including low accumulation, internalization and retention at the target site in cancer diagnosis and therapy through active targeting. In this review, we focus on different strategies for conjugation of biomolecules to nanoparticles such as inorganic nanoparticles (iron oxide, gold, silica and carbon nanoparticles), liposomes, lipid and polymeric nanoparticles and their application in tumor targeting.

Biomedical Applications of Natural Polymers for Drug Delivery

2014 ◽  
Vol 18 (2) ◽  
pp. 152-164 ◽  
Author(s):  
Mariana Chifiriuc ◽  
Alexandru Grumezescu ◽  
Valentina Grumezescu ◽  
Eugenia Bezirtzoglou ◽  
Veronica Lazar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Natural Polymers
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