Antioxidant and anti-inflammatory activity of a flavonoid-rich concentrate recovered from Opuntia ficus-indica juice

A flavonoid-rich concentrate (FRC) recovered from cactus pear juice is able to modulate intestinal oxidative stress biomarkers and inflammatory mediators suggesting that it could be an interesting natural ingredient to attenuate and prevent intestinal chronic inflammation.

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Anti-Inflammatory Activity of Isomaltodextrin in a C57BL/6NCrl Mouse Model with Lipopolysaccharide-Induced Low-Grade Chronic Inflammation

Nutrients ◽

10.3390/nu11112791 ◽

2019 ◽

Vol 11 (11) ◽

pp. 2791 ◽

Cited By ~ 2

Author(s):

Hann ◽

Zeng ◽

Zong ◽

Sakurai ◽

Taniguchi ◽

...

Keyword(s):

Mouse Model ◽

Protein Expression ◽

Tight Junction ◽

Chronic Inflammation ◽

Inflammatory Mediators ◽

Macrophage Infiltration ◽

Inflammatory Activity ◽

Low Grade ◽

Junction Protein ◽

Anti Inflammatory

：The purpose of this study was to identify the anti-inflammatory activity and mechanism of isomaltodextrin (IMD) in a C57BL/6NCrl mouse model with lipopolysaccharide (LPS)-induced systemic low-grade chronic inflammation and the effect on inflammation-induced potential risk of metabolic disorders. Pre-treatment of IMD decreased the production of pro-inflammatory mediators, TNF-α and MCP-1, and stimulated the production of the anti-inflammatory mediator, adiponectin by increasing the protein expression of peroxisome proliferator-activated receptor gamma (PPAR-γ) in the white adipose tissues. IMD administration reduced plasma concentrations of endotoxin, decreased macrophage infiltration into adipocytes, and increased expression of mucin 2, mucin 4, and the tight junction protein claudin 4. These results suggest that IMD administration exerted an anti-inflammatory effect on mice with LPS-induced inflammation, potentially by decreasing circulating endotoxin, suppressing pro-inflammatory mediators and macrophage infiltration, or by improving mucus or tight junction integrity. IMD exerted protein expression of insulin receptor subset-1 (IRS-1). IMD alleviated the disturbance of gut microflora in LPS-treated mice, as the number of B. bifidum, L. casei, and B. fragilis increased, and E. coli and C. difficile decreased, when compared to LPS-treated mice. The analysis of short chain fatty acids (SCFAs) further supported that the concentrations of acetic and butyric acids were positively correlated with IMD, as well as the number of beneficial bacteria. This study provides evidence that IMD possesses anti-inflammatory properties and exerts beneficial functions to prevent systemic low-grade chronic inflammation and reduces the risk of developing insulin resistance and associated metabolic diseases.

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Potential anti-inflammatory action of resveratrol and piperine in adjuvant-induced arthritis: Effect on pro-inflammatory cytokines and oxidative stress biomarkers

The Egyptian Rheumatologist ◽

10.1016/j.ejr.2019.08.003 ◽

2020 ◽

Vol 42 (1) ◽

pp. 71-77 ◽

Cited By ~ 5

Author(s):

Mona A. El-Ghazaly ◽

Noha A. Fadel ◽

Doaa H. Abdel-Naby ◽

Hassan A. Abd El-Rehim ◽

Hala F. Zaki ◽

...

Keyword(s):

Oxidative Stress ◽

Inflammatory Cytokines ◽

Oxidative Stress Biomarkers ◽

Adjuvant Induced Arthritis ◽

Stress Biomarkers ◽

Anti Inflammatory ◽

And Oxidative Stress ◽

Inflammatory Action ◽

Pro Inflammatory Cytokines

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Anti-inflammatory effect of natural heterocycle glucoside vicine obtained from Vicia faba L. its aglucone (divicine) their effect on some oxidative stress biomarkers in Albino rats

Free Radicals and Antioxidants ◽

10.5530/ax.2012.2.2.8 ◽

2012 ◽

Vol 2 (2) ◽

pp. 44-54 ◽

Cited By ~ 1

Author(s):

Mohammed Abdalla Hussein

Keyword(s):

Oxidative Stress ◽

Vicia Faba ◽

Albino Rats ◽

Oxidative Stress Biomarkers ◽

Stress Biomarkers ◽

Vicia Faba L ◽

Anti Inflammatory ◽

Inflammatory Effect

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OXIDATIVE STRESS BIOMARKERS IN EXPIRATED AIR OF HEALTHY HUMANS AND PROMISING TECHNIQUES OF THEIR ANALYSIS DURING SPACE FLIGHT

Aerospace and Environmental Medicine ◽

10.21687/0233-528x-2020-54-3-5-21 ◽

2020 ◽

pp. 5-21

Author(s):

L.N. Mukhamedieva ◽

◽

D.S. Tsarkov ◽

D.S. Ozerov ◽

G.Yu. Grigoriev ◽

...

Keyword(s):

Oxidative Stress ◽

Space Flight ◽

Oxidative Stress Biomarkers ◽

Stress Biomarkers ◽

Healthy Humans

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Association between Vitamin D Status, Oxidative Stress Biomarkers and Viral Load in Human Immunodeficiency Virus Type 1 Infection

Current HIV Research ◽

10.2174/1570162x15666171005170227 ◽

2017 ◽

Vol 15 (5) ◽

Cited By ~ 4

Author(s):

Tamires Flauzino ◽

Andrea N.C. Simao ◽

Elaine R.D. de Almeida ◽

Helena K. Morimoto ◽

Sayonara R. Oliveira ◽

...

Keyword(s):

Oxidative Stress ◽

Vitamin D ◽

Human Immunodeficiency Virus ◽

Viral Load ◽

Human Immunodeficiency Virus Type ◽

Vitamin D Status ◽

Oxidative Stress Biomarkers ◽

Stress Biomarkers ◽

Immunodeficiency Virus

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Oxidative Stress Biomarkers in Urine of Metal Carpentry Workers Can Be Diagnostic for Occupational Exposure to Low Level of Welding Fumes from Associated Metals

Cancers ◽

10.3390/cancers13133167 ◽

2021 ◽

Vol 13 (13) ◽

pp. 3167

Author(s):

Flavia Buonaurio ◽

Maria Luisa Astolfi ◽

Daniela Pigini ◽

Giovanna Tranfo ◽

Silvia Canepari ◽

...

Keyword(s):

Oxidative Stress ◽

Occupational Exposure ◽

Oxidation Products ◽

Control Group ◽

Welding Fumes ◽

Oxidative Stress Biomarkers ◽

Limit Values ◽

Stress Biomarkers ◽

Specificity And Sensitivity ◽

The Impact

Urinary concentrations of 16 different exposure biomarkers to metals were determined at the beginning and at the end of a working shift on a group of workers in the metal carpentry industry. Five different oxidative stress biomarkers were also measured, such as the oxidation products of RNA and DNA metabolized and excreted in the urine. The results of workers exposed to metals were compared to those of a control group. The metal concentrations found in these workers were well below the occupational exposure limit values and exceeded the mean concentrations of the same metals in the urine of the control group by a factor of four at maximum. Barium (Ba), mercury (Hg), lead (Pb) and strontium (Sr) were correlated with the RNA oxidative stress biomarker, 8-oxo-7, 8-dihydroguanosine (8-oxoGuo), which was found able to discriminate exposed workers from controls with a high level of specificity and sensitivity. The power of this early diagnostic technique was assessed by means of the ROC curve. Ba, rubidium (Rb), Sr, tellurium (Te), and vanadium (V) were correlated with the level of the protein oxidation biomarker 3-Nitrotyrosine (3-NO2Tyr), and Ba, beryllium (Be), copper (Cu), and Rb with 5-methylcytidine (5-MeCyt), an epigenetic marker of RNA damage. These effect biomarkers can help in identifying those workers that can be defined as “occupationally exposed” even at low exposure levels, and they can provide information about the impact that such doses have on their health.

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Antioxidants, lysosomes and elements status during the life cycle of sea trout Salmo trutta m. trutta L.

Scientific Reports ◽

10.1038/s41598-021-85127-3 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Natalia Kurhaluk ◽

Halyna Tkachenko

Keyword(s):

Oxidative Stress ◽

Lipid Peroxidation ◽

Muscle Tissue ◽

Salmo Trutta ◽

Protein Carbonyl ◽

Oxidative Modification ◽

Oxidative Stress Biomarkers ◽

Development Stages ◽

Stress Biomarkers ◽

Element Contents

AbstractThe aim of our study was to elucidate the effects of both development stages (parr, smolt, adult, spawner), and kelt as a survival form and sex (male, female) on the functional stability of the lysosomal complex, biomarkers of oxidative stress, and element contents in the muscle tissue of the sea trout (Salmo trutta m. trutta L.) sampled in the Pomerania region (northern Poland). We have evaluated the maximal activities of lysosomal enzymes (alanyl aminopeptidase, leucyl aminopeptidase, β-N-acetylglucosaminidase, and acid phosphatase), lipid peroxidation level, and protein carbonyl derivatives as indices of muscle tissue degradation. The relationship between lysosomal activity and oxidative stress biomarkers estimated by the lipid peroxidation level and protein carbonyl derivatives was also assessed, as well as the relationships between element levels and oxidative stress biomarkers. Trends of the main effects (i.e., the development stages and sex alone, the interaction of the sex and development stage simultaneously) on oxidative stress biomarkers, lysosomal functioning, and element contents in the muscle tissue were evaluated. The study has shown sex-related relationships between the pro- and antioxidant balance and the tissue type in the adult stage as well as modifications in the lysosomal functioning induced by long-term environmental stress associated with changing the habitats from freshwater to seawater and intense migrations. The highest level of toxic products generated in oxidative reactions and oxidative modification of proteins was noted in both the spawner stage and the kelt form. The holistic model of analysis of all parameters of antioxidant defense in all development stages and sex demonstrated the following dependencies for the level of lipid peroxidation, oxidative modification of proteins, lysosomal activities, and element contents: TBARS > OMP KD > OMP AD > TAC, AcP > NAG > LAP > AAP and Cu > Fe > Ca > Mn > Zn > Mg, respectively.

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