Novel biocompatible fluorescent polymeric micelles based on 1,8-naphthalimide derivatives for cell imaging

2015 ◽  
Vol 6 (3) ◽  
pp. 364-368 ◽  
Author(s):  
Bei-Yu Liu ◽  
Wan-Xia Wu ◽  
Na Wang ◽  
Xiao-Qi Yu
Keyword(s):  
Self Assembly ◽  
Cell Imaging ◽  
Polymeric Micelles ◽  
Ph Sensor ◽  
Polymeric Micelle ◽  
Living Cells ◽  
Amphiphilic Block Copolymers ◽  
Good Potential ◽  
New Type ◽  
Good Biocompatibility

A new type of fluorescent polymeric micelle was developed by the aqueous self-assembly from amphiphilic block copolymers via click chemistry and showed good potential for application in cell imaging with good biocompatibility. Notably, P1 can readily serve as an excellent intracellular pH sensor in whole living cells based on PET inhibition

Enzyme-responsive polymeric micelles with fluorescence fabricated through aggregation-induced copolymer self-assembly for anticancer drug delivery

2020 ◽  
Vol 11 (48) ◽  
pp. 7704-7713
Author(s):  
Ke Yan ◽  
Shujing Zhang ◽  
Kun Zhang ◽  
Yalei Miao ◽  
Yudian Qiu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Self Assembly ◽  
Polymeric Micelles ◽  
Polymeric Micelle ◽  
Anticancer Drug Delivery ◽  
Hydrophobic Chain

The TPE moiety with AIE is employed as functional hydrophobic chain to induce copolymer self-assembly and form polymeric micelle that can show enzyme-responsive drug delivery.

scholarly journals Polymeric Micelles: A Novel Approach towards Nano-Drug Delivery System

2021 ◽  
Vol 18 (4) ◽  
pp. 629-649
Author(s):  
Rutuja Hemant Vinchurkar ◽  
Ashwin Bhanudas Kuchekar
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Inner Core ◽  
Polymeric Micelles ◽  
Solvent Polarity ◽  
Physicochemical Characteristics ◽  
Polymeric Micelle ◽  
Absorption Mechanism ◽  
Novel Approach ◽  
Poorly Soluble

Nano delivery systems, polymeric micelles represent one of the most promising delivery platforms for therapeutic compounds. It has shown that a poorly soluble molecule which has high potency and remarkable toxicity can be encapsulated with the polymeric micelle. There are various poorly soluble drugs used in micellar preparations, mostly for their anti-cancer activity. Drugs in the inner core protect the drug from degradation and allow drug accumulation in the tumour site in the case of cancer treatment. Block copolymers are chosen based on the physicochemical characteristics of medicinal drugs. The amphiphilic block copolymer structure has both lipophilic and hydrophilic blocks, which enclose tiny hydrophobic molecules. It is a targeted drug delivery method because of its high effectiveness for drug retention in tissue, prevention of enzymes from degradation, and improvement of the cellular absorption mechanism. In an experimental environment, variations in temperature and solvent polarity stimulate copolymer micelle self-assembly. This is a thermodynamically guided procedure in which self-assembly happens by converting polymeric micelles. These aggregates go from a non-equilibrium to a thermodynamically equilibrium state, and they stay stable for a long time. The balance of thermodynamic and kinetic forces is critical in micelles self-assembly because the kinetic process predicts assembly behaviour and hierarchical structure. The purpose of this special issue is to provide an updated overview of micelles, a number of polymers and drugs commonly used in micellar preparation and their application.

scholarly journals Polymeric Micelles: Morphology, Synthesis, and Pharmaceutical Application

2021 ◽  
Vol 290 ◽  
pp. 01029
Author(s):  
Kun Bai ◽  
Anda Wang
Keyword(s):  
Self Assembly ◽  
Polymeric Micelles ◽  
Drug Carriers ◽  
Amphiphilic Block Copolymers ◽  
Synthetic Methods ◽  
Fundamental Aspect ◽  
Stimuli Responsive ◽  
Medical Field ◽  
Future Developments ◽  
Pharmaceutical Application

Polymeric micelles (PMs) are nanosized core-shell molecules formed by the self-assembly of amphiphilic block copolymers. Their unique morphologies, biocompatibility have allowed them to serve as drug carriers and have found wide applications in the pharmaceutical industry. This review summarizes the recent progress of PM development and its applications in the pharmaceutical field. Firstly, we discussed the fundamentals of polymeric micelles, the formation mechanism, and their relative morphologies. Then we listed various common synthetic methods, including the solvent-free method, solvent-switch method, microfluid method, etc. Secondly, we illustrated the application of polymeric micelles in pharmaceutical applications on targeting, imaging, and stimuli-responsive drug release. In the end, we summarize the fundamental aspect of how to prepare polymeric micelles, their resulting morphology, and their applications in the medical field. Finally, we provide insights into polymeric micelles’ future developments on their longer shelf life and better environmental adaptability.

scholarly journals The emerging technology of biohybrid micro-robots: a review

2021 ◽  
Author(s):  
Zening Lin ◽  
Tao Jiang ◽  
Jianzhong Shang
Keyword(s):  
Self Assembly ◽  
Degrees Of Freedom ◽  
High Energy ◽  
Living Cells ◽  
Multiple Degrees Of Freedom ◽  
The Past ◽  
Great Prevalence ◽  
Performance Decline ◽  
High Energy Efficiency ◽  
Living Tissues

Abstract In the past few decades, robotics research has witnessed an increasingly high interest in miniaturized, intelligent, and integrated robots. The imperative component of a robot is the actuator that determines its performance. Although traditional rigid drives such as motors and gas engines have shown great prevalence in most macroscale circumstances, the reduction of these drives to the millimeter or even lower scale results in a significant increase in manufacturing difficulty accompanied by a remarkable performance decline. Biohybrid robots driven by living cells can be a potential solution to overcome these drawbacks by benefiting from the intrinsic microscale self-assembly of living tissues and high energy efficiency, which, among other unprecedented properties, also feature flexibility, self-repair, and even multiple degrees of freedom. This paper systematically reviews the development of biohybrid robots. First, the development of biological flexible drivers is introduced while emphasizing on their advantages over traditional drivers. Second, up-to-date works regarding biohybrid robots are reviewed in detail from three aspects: biological driving sources, actuator materials, and structures with associated control methodologies. Finally, the potential future applications and major challenges of biohybrid robots are explored. Graphic abstract

scholarly journals Quick extracellular biosynthesis of low-cadmium ZnxCd1−xS quantum dots with full-visible-region tuneable high fluorescence and its application potential assessment in cell imaging

RSC Advances ◽  
2021 ◽  
Vol 11 (35) ◽  
pp. 21813-21823
Author(s):  
Shiyue Qi ◽  
Ji Chen ◽  
Xianwei Bai ◽  
Yahui Miao ◽  
Shuhui Yang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Energy Saving ◽  
Metal Nanoparticles ◽  
Cell Imaging ◽  
Visible Region ◽  
Extracellular Biosynthesis ◽  
Application Potential ◽  
Good Biocompatibility ◽  
High Fluorescence ◽  
Environmentally Sound

The biosynthesis of metal nanoparticles/QDs has been universally recognized as environmentally sound and energy-saving, generating less pollution and having good biocompatibility, which is most needed in biological and medical fields.

Facile synthesis of mesoporous TiO2 film templated by block copolymer for photocatalytic applications

2021 ◽  
Author(s):  
Olufemi Olatidoye ◽  
Daria Thomas ◽  
Bishnu Bastakoti
Keyword(s):  
Thin Film ◽  
Block Copolymer ◽  
Ethylene Oxide ◽  
Tio2 Thin Film ◽  
Polymeric Micelles ◽  
Polymeric Micelle ◽  
Mesoporous Tio2 ◽  
Facile Synthesis ◽  
Vinyl Pyridine ◽  
Photocatalytic Applications

A facile synthesis of a mesoporous TiO2 thin film is reported using poly(styrene-2-vinyl pyridine-ethylene oxide) polymeric micelle as a synthetic template. As the Ti precursor strongly binds with polymeric micelles...

scholarly journals Synthesis and self-assembly of curcumin-modified amphiphilic polymeric micelles with antibacterial activity

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Caio H. N. Barros ◽  
Dishon W. Hiebner ◽  
Stephanie Fulaz ◽  
Stefania Vitale ◽  
Laura Quinn ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Self Assembly ◽  
Glycolic Acid ◽  
Extracellular Polymeric Substances ◽  
Polymeric Micelles ◽  
Polymeric Nanoparticles ◽  
Enhanced Resistance ◽  
Antimicrobial Nanoparticles ◽  
Good Penetration ◽  
Antibiofilm Agents

Abstract Background The ubiquitous nature of bacterial biofilms combined with the enhanced resistance towards antimicrobials has led to the development of an increasing number of strategies for biofilm eradication. Such strategies must take into account the existence of extracellular polymeric substances, which obstruct the diffusion of antibiofilm agents and assists in the maintenance of a well-defended microbial community. Within this context, nanoparticles have been studied for their drug delivery efficacy and easily customised surface. Nevertheless, there usually is a requirement for nanocarriers to be used in association with an antimicrobial agent; the intrinsically antimicrobial nanoparticles are most often made of metals or metal oxides, which is not ideal from ecological and biomedical perspectives. Based on this, the use of polymeric micelles as nanocarriers is appealing as they can be easily prepared using biodegradable organic materials. Results In the present work, micelles comprised of poly(lactic-co-glycolic acid) and dextran are prepared and then functionalised with curcumin. The effect of the functionalisation in the micelle’s physical properties was elucidated, and the antibacterial and antibiofilm activities were assessed for the prepared polymeric nanoparticles against Pseudomonas spp. cells and biofilms. It was found that the nanoparticles have good penetration into the biofilms, which resulted in enhanced antibacterial activity of the conjugated micelles when compared to free curcumin. Furthermore, the curcumin-functionalised micelles were efficient at disrupting mature biofilms and demonstrated antibacterial activity towards biofilm-embedded cells. Conclusion Curcumin-functionalised poly(lactic-co-glycolic acid)-dextran micelles are novel nanostructures with an intrinsic antibacterial activity tested against two Pseudomonas spp. strains that have the potential to be further exploited to deliver a secondary bioactive molecule within its core. Graphic Abstract

A versatile color and fluorescence pH sensor based on AIE and open-loop synergy effect: Crystal structure and its application in cell imaging

2021 ◽  
Vol 190 ◽  
pp. 109310
Author(s):  
Zengchen Liu ◽  
Like Wang ◽  
Wenping Zhu ◽  
Yongjie Ding ◽  
Shaohua Liu ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Cell Imaging ◽  
Ph Sensor ◽  
Open Loop ◽  
Synergy Effect

scholarly journals Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances

2021 ◽  
Vol 9 (1) ◽  
pp. 38-50
Author(s):  
Hien Phan ◽  
Vincenzo Taresco ◽  
Jacques Penelle ◽  
Benoit Couturaud
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Amphiphilic Block Copolymers ◽  
Stimuli Responsive ◽  
Site Specific ◽  
On Demand ◽  
Redox Agents

Stimuli-responsive amphiphilic block copolymers obtained by PISA have emerged as promising nanocarriers for enhancing site-specific and on-demand drug release in response to a range of stimuli such as pH, redox agents, light or temperature.

A tetraphenylethylene (TPE)-based supra-amphiphilic organoplatinum(ii) metallacycle and its self-assembly behaviour

2017 ◽  
Vol 1 (9) ◽  
pp. 1823-1828 ◽  
Author(s):  
Wei Zheng ◽  
Guang Yang ◽  
Shu-Ting Jiang ◽  
Nannan Shao ◽  
Guang-Qiang Yin ◽  
...  
Keyword(s):  
Self Assembly ◽  
Cell Imaging ◽  
Biological Application

A tetraphenylethylene (TPE)-based supra-amphiphilic organoplatinum(ii) metallacycle was successfully prepared, which presented biological application in cell imaging.

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