MPA-capped CdTe quantum dots exposure causes neurotoxic effects in nematode Caenorhabditis elegans by affecting the transporters and receptors of glutamate, serotonin and dopamine at the genetic level, or by increasing ROS, or both

Nanoscale ◽  
2015 ◽  
Vol 7 (48) ◽  
pp. 20460-20473 ◽  
Author(s):  
Tianshu Wu ◽  
Keyu He ◽  
Qinglin Zhan ◽  
Shengjun Ang ◽  
Jiali Ying ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Caenorhabditis Elegans ◽  
Biomedical Applications ◽  
Biological Properties ◽  
Cdte Quantum Dots ◽  
Nematode Caenorhabditis Elegans ◽  
Neurotoxic Effects ◽  
Genetic Level

As quantum dots (QDs) are widely used in biomedical applications, the number of studies focusing on their biological properties is increasing.

Recent Advances in the Cancer Bioimaging with Graphene Quantum Dots

2018 ◽  
Vol 25 (25) ◽  
pp. 2876-2893 ◽  
Author(s):  
Keheng Li ◽  
Xinna Zhao ◽  
Gang Wei ◽  
Zhiqiang Su
Keyword(s):  
Quantum Dots ◽  
Biomedical Applications ◽  
Cell Imaging ◽  
Graphene Quantum Dots ◽  
Biological Properties ◽  
Live Cells ◽  
Physical Chemical ◽  
Specific Cancer ◽  
Good Biocompatibility ◽  
Low Cytotoxicity

Fluorescent graphene quantum dots (GQDs) have attracted increasing interest in cancer bioimaging due to their stable photoluminescence (PL), high stability, low cytotoxicity, and good biocompatibility. In this review, we present the synthesis and chemical modification of GQDs firstly, and then introduce their unique physical, chemical, and biological properties like the absorption, PL, and cytotoxicity of GQDs. Finally and most importantly, the recent applications of GQDs in cancer bioimaging are demonstrated in detail, in which we focus on the biofunctionalization of GQDs for specific cancer cell imaging and real-time molecular imaging in live cells. We expect this work would provide valuable guides on the synthesis and modification of GQDs with adjustable properties for various biomedical applications in the future.

scholarly journals Biological effects, translocation, and metabolism of quantum dots in the nematode Caenorhabditis elegans

2016 ◽  
Vol 5 (4) ◽  
pp. 1003-1011 ◽  
Author(s):  
Dayong Wang
Keyword(s):  
Quantum Dots ◽  
Caenorhabditis Elegans ◽  
Recent Progress ◽  
Biological Effects ◽  
Assay System ◽  
Nematode Caenorhabditis Elegans ◽  
C Elegans

We summarize recent progress on the biological effects, translocation, and metabolism of QDs in thein vivoassay system ofC. elegans.

scholarly journals Superoxide dismutase 1 (SOD1) and cadmium: a three models approach to the comprehension of its neurotoxic effects

2021 ◽  
Vol 4 (s1) ◽  
Author(s):  
Federica Bovio ◽  
Barbara Sciandrone ◽  
Chiara Urani ◽  
Paola Fusi ◽  
Matilde Forcella ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Caenorhabditis Elegans ◽  
Recombinant Protein ◽  
Neuronal Cells ◽  
Expression Level ◽  
Superoxide Dismutase 1 ◽  
Biological Models ◽  
Nematode Caenorhabditis Elegans ◽  
E Coli ◽  
Neurotoxic Effects

In three different biological models, the recombinant protein expressed in E. coli, the neuronal cells SH-SY5Y and the nematode Caenorhabditis elegans, cadmium inhibits SOD1 activity without affecting its expression level.

scholarly journals Quantum dots exposure alters both development and function of D-type GABAergic motor neurons in nematode Caenorhabditis elegans

2015 ◽  
Vol 4 (2) ◽  
pp. 399-408 ◽  
Author(s):  
Yunli Zhao ◽  
Xiong Wang ◽  
Qiuli Wu ◽  
Yiping Li ◽  
Meng Tang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Caenorhabditis Elegans ◽  
Motor Neurons ◽  
Nematode Caenorhabditis Elegans ◽  
Cdte Qds ◽  
And Function

Both translocation into targeted neurons and developmental and functional alterations in targeted neurons contribute to CdTe QDs neurotoxicity.

scholarly journals Biomedical Applications of Carbon Nanomaterials: Fullerenes, Quantum Dots, Nanotubes, Nanofibers, and Graphene

Materials ◽  
2021 ◽  
Vol 14 (20) ◽  
pp. 5978
Author(s):  
Manish Gaur ◽  
Charu Misra ◽  
Awadh Bihari Yadav ◽  
Shiv Swaroop ◽  
Fionn Ó. Maolmhuaidh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Quantum Dots ◽  
Biomedical Applications ◽  
Carbon Nanomaterials ◽  
Drug Loading ◽  
Biological Properties ◽  
Dimensional Structure ◽  
Target Drug Delivery ◽  
Target Drug

Carbon nanomaterials (CNMs) have received tremendous interest in the area of nanotechnology due to their unique properties and flexible dimensional structure. CNMs have excellent electrical, thermal, and optical properties that make them promising materials for drug delivery, bioimaging, biosensing, and tissue engineering applications. Currently, there are many types of CNMs, such as quantum dots, nanotubes, nanosheets, and nanoribbons; and there are many others in development that promise exciting applications in the future. The surface functionalization of CNMs modifies their chemical and physical properties, which enhances their drug loading/release capacity, their ability to target drug delivery to specific sites, and their dispersibility and suitability in biological systems. Thus, CNMs have been effectively used in different biomedical systems. This review explores the unique physical, chemical, and biological properties that allow CNMs to improve on the state of the art materials currently used in different biomedical applications. The discussion also embraces the emerging biomedical applications of CNMs, including targeted drug delivery, medical implants, tissue engineering, wound healing, biosensing, bioimaging, vaccination, and photodynamic therapy.

scholarly journals Neurotoxicity of Nanomaterials: An Up-to-Date Overview

Nanomaterials ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 96 ◽  
Author(s):  
Daniel Teleanu ◽  
Cristina Chircov ◽  
Alexandru Grumezescu ◽  
Raluca Teleanu
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Quantum Dots ◽  
Cancer Therapy ◽  
Biomedical Applications ◽  
Environmental Science ◽  
Bulk Materials ◽  
Food And Agriculture ◽  
Neurotoxic Effects

The field of nanotechnology, through which nanomaterials are designed, characterized, produced, and applied, is rapidly emerging in various fields, including energy, electronics, food and agriculture, environmental science, cosmetics, and medicine. The most common biomedical applications of nanomaterials involve drug delivery, bioimaging, and gene and cancer therapy. Since they possess unique properties which are different than bulk materials, toxic effects and long-term impacts on organisms are not completely known. Therefore, the purpose of this review is to emphasize the main neurotoxic effects induced by nanoparticles, liposomes, dendrimers, carbon nanotubes, and quantum dots, as well as the key neurotoxicology assays to evaluate them.

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