Recent Advances in the Cancer Bioimaging with Graphene Quantum Dots

2018 ◽  
Vol 25 (25) ◽  
pp. 2876-2893 ◽  
Author(s):  
Keheng Li ◽  
Xinna Zhao ◽  
Gang Wei ◽  
Zhiqiang Su
Keyword(s):  
Quantum Dots ◽  
Biomedical Applications ◽  
Cell Imaging ◽  
Graphene Quantum Dots ◽  
Biological Properties ◽  
Live Cells ◽  
Physical Chemical ◽  
Specific Cancer ◽  
Good Biocompatibility ◽  
Low Cytotoxicity

Fluorescent graphene quantum dots (GQDs) have attracted increasing interest in cancer bioimaging due to their stable photoluminescence (PL), high stability, low cytotoxicity, and good biocompatibility. In this review, we present the synthesis and chemical modification of GQDs firstly, and then introduce their unique physical, chemical, and biological properties like the absorption, PL, and cytotoxicity of GQDs. Finally and most importantly, the recent applications of GQDs in cancer bioimaging are demonstrated in detail, in which we focus on the biofunctionalization of GQDs for specific cancer cell imaging and real-time molecular imaging in live cells. We expect this work would provide valuable guides on the synthesis and modification of GQDs with adjustable properties for various biomedical applications in the future.

scholarly journals Facile synthesis of graphene quantum dots from glucan and their application as a deoxidizer and in cell imaging

2020 ◽  
pp. 174751982097393
Author(s):  
Jialu Shen ◽  
Weifeng Chen ◽  
Xiang Liu
Keyword(s):  
Quantum Dots ◽  
Driving Force ◽  
Biomedical Applications ◽  
Cell Imaging ◽  
Size Range ◽  
Graphene Quantum Dots ◽  
Reducing Agents ◽  
Facile Synthesis ◽  
Average Size

A facile and effective route to synthesize graphene quantum dots for cell imaging and as a deoxidizer by using glucan as a precursor is developed. AuNPs are successfully synthesized by mixing of graphene quantum dots and Au(III) salts without any additional reductants. The reducing driving force of these graphene quantum dots is much weaker than that of strong reducing agents such as NaBH4. The sizes of the as-synthesized AuNPs are much larger, with an average size of 15 nm. Notably, this size range is specifically useful and optimal for the application of AuNPs in biomedical applications. In addition, the as-synthesized graphene quantum dots are also successfully applied in cell imaging.

N,S Co-Doped Graphene Quantum Dots for Detection of Riboflavin and Cell Imaging

NANO ◽  
2021 ◽  
pp. 2150123
Author(s):  
Mengting Zhang ◽  
Xiaorong Li ◽  
Hong Xiao ◽  
Bin Zhao ◽  
Wei Bian
Keyword(s):  
Quantum Dots ◽  
Cell Imaging ◽  
Graphene Quantum Dots ◽  
Practical Application ◽  
X Ray ◽  
Pyrolysis Method ◽  
Doped Graphene ◽  
Low Cytotoxicity ◽  
Bright Blue Fluorescence ◽  
Bright Blue

Graphene quantum dots (GQDs) have been extensively used in biosensors and bioimaging. Heteroatom-doped GQDs can regulate material properties and endow them to improve structural and physicochemical properties. In this work, N,S-GQDs were prepared through a high-temperature pyrolysis method using L-cysteine and citric acid as the precursors. The morphology and structure of nanocomposites were identified by TEM, X-ray diffractometer (XRD), X-ray photoelectron spectrometer (XPS), and FTIR. The as-prepared N,S-GQDs show bright blue fluorescence with satisfactory fluorescence quantum yield. N,S-GQDs display significant response to riboflavin, achieving a low detection limit of 27[Formula: see text]nM. The reaction of N,S-GQDs to riboflavin is mainly governed by static quenching. The detection of riboflavin in real samples has been performed to demonstrate its practical application. The obtained N,S-GQDs have low cytotoxicity and have been applied successfully in cell imaging.

scholarly journals Influence of Graphene Quantum Dots Surface Charge on their Uptake and Clearance in Melanoma Cells

2021 ◽  
Author(s):  
Lakshmi Narashimhan Ramana ◽  
Le N.M. Dinh ◽  
Vipul Agarwal
Keyword(s):  
Quantum Dots ◽  
Surface Charge ◽  
Biomedical Applications ◽  
Graphene Quantum Dots ◽  
Melanoma Cells ◽  
Rapid Clearance

Graphene quantum dots (GQDs) continue to draw interest in biomedical applications. However, their efficacy gets compromised due to their rapid clearance from body. On one side, rapid clearance is desired...

scholarly journals Quick extracellular biosynthesis of low-cadmium ZnxCd1−xS quantum dots with full-visible-region tuneable high fluorescence and its application potential assessment in cell imaging

RSC Advances ◽  
2021 ◽  
Vol 11 (35) ◽  
pp. 21813-21823
Author(s):  
Shiyue Qi ◽  
Ji Chen ◽  
Xianwei Bai ◽  
Yahui Miao ◽  
Shuhui Yang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Energy Saving ◽  
Metal Nanoparticles ◽  
Cell Imaging ◽  
Visible Region ◽  
Extracellular Biosynthesis ◽  
Application Potential ◽  
Good Biocompatibility ◽  
High Fluorescence ◽  
Environmentally Sound

The biosynthesis of metal nanoparticles/QDs has been universally recognized as environmentally sound and energy-saving, generating less pollution and having good biocompatibility, which is most needed in biological and medical fields.

scholarly journals Organic dots (O-dots) for theranostic applications: preparation and surface engineering

RSC Advances ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 2253-2291
Author(s):  
Amin Shiralizadeh Dezfuli ◽  
Elmira Kohan ◽  
Sepand Tehrani Fateh ◽  
Neda Alimirzaei ◽  
Hamidreza Arzaghi ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Photodynamic Therapy ◽  
Photothermal Therapy ◽  
Biomedical Applications ◽  
Surface Engineering ◽  
Graphene Quantum Dots ◽  
Carbon Quantum Dots ◽  
Cargo Delivery ◽  
Bio Imaging ◽  
Theranostic Applications

Organic dots is a term used to represent materials including graphene quantum dots and carbon quantum dots because they rely on the presence of other atoms (O, H, and N) for their photoluminescence or fluorescence properties. Cargo delivery, bio-imaging, photodynamic therapy and photothermal therapy are major biomedical applications of organic dots.

MPA-capped CdTe quantum dots exposure causes neurotoxic effects in nematode Caenorhabditis elegans by affecting the transporters and receptors of glutamate, serotonin and dopamine at the genetic level, or by increasing ROS, or both

Nanoscale ◽  
2015 ◽  
Vol 7 (48) ◽  
pp. 20460-20473 ◽  
Author(s):  
Tianshu Wu ◽  
Keyu He ◽  
Qinglin Zhan ◽  
Shengjun Ang ◽  
Jiali Ying ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Caenorhabditis Elegans ◽  
Biomedical Applications ◽  
Biological Properties ◽  
Cdte Quantum Dots ◽  
Nematode Caenorhabditis Elegans ◽  
Neurotoxic Effects ◽  
Genetic Level

As quantum dots (QDs) are widely used in biomedical applications, the number of studies focusing on their biological properties is increasing.

scholarly journals Chlorine Modulation Fluorescent Performance of Seaweed-Derived Graphene Quantum Dots for Long-Wavelength Excitation Cell-Imaging Application

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4994
Author(s):  
Weitao Li ◽  
Ningjia Jiang ◽  
Bin Wu ◽  
Yuan Liu ◽  
Luoman Zhang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Cell Imaging ◽  
Graphene Quantum Dots ◽  
Toxic Metal ◽  
Disease Diagnosis ◽  
Excitation Wavelength ◽  
Chlorine Atoms ◽  
Long Wavelength ◽  
Imaging Application ◽  
Preliminary Application

Biological imaging is an essential means of disease diagnosis. However, semiconductor quantum dots that are used in bioimaging applications comprise toxic metal elements that are nonbiodegradable, causing serious environmental problems. Herein, we developed a novel ecofriendly solvothermal method that uses ethanol as a solvent and doping with chlorine atoms to prepare highly fluorescent graphene quantum dots (GQDs) from seaweed. The GQDs doped with chlorine atoms exhibit high-intensity white fluorescence. Thus, their preliminary application in bioimaging has been confirmed. In addition, clear cell imaging could be performed at an excitation wavelength of 633 nm.

Facile and Large-scale Synthesis of Graphene Quantum Dots Functionalized with Morpholine for Selective Targeting and Imaging of Lysosome

NANO ◽  
2021 ◽  
pp. 2150113
Author(s):  
Yingying Nie ◽  
Zengjie Fan
Keyword(s):  
Quantum Dots ◽  
Large Scale ◽  
Graphene Quantum Dots ◽  
Diagnosis And Treatment ◽  
Uniform Size ◽  
Scale Method ◽  
Selective Targeting ◽  
Application Potential ◽  
Good Biocompatibility ◽  
Imaging Properties

The lack of targeting selection to lysosome limits the application of graphene quantum dots (GQDs) in the diagnosis and treatment of lysosome-related disease. In this study, we developed a facile, environmentally friendly and large-scale method to prepare [Formula: see text]-aminomorpholine (Am)-modified GQDs (Am-GQDs) via a simple hydrothermal method. The physicochemical, optical, biocompatible and targeted imaging properties were evaluated systematically. The results indicated that the synthesized Am-GQDs had a uniform size distribution and the size was around 2[Formula: see text]nm. In addition, the synthesized Am-GQDs had excellent optical properties, fluorescent stability, and good biocompatibility. More importantly, they can selectively target and image lysosome in a relatively short coculture time with cells, demonstrating their application potential in the diagnosis and treatment of lysosomal-related diseases.

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